Published in PLoS One on December 31, 2009
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A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol (2009) 3.44
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Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin. Nat Immunol (2012) 2.40
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Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol (2008) 2.29
Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J Natl Cancer Inst (2008) 2.25
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CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major. J Immunol (2002) 2.16
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Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment. Eur J Neurosci (2006) 2.15
Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc Natl Acad Sci U S A (2009) 2.12
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Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene. Mol Cell Biol (2004) 1.99
Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development. PLoS One (2008) 1.86
Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone. Proc Natl Acad Sci U S A (2007) 1.85
Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. Cancer Res (2005) 1.83
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci (2012) 1.82
Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development (2008) 1.79
Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc Natl Acad Sci U S A (2002) 1.70
Neurotrophins in the ear: their roles in sensory neuron survival and fiber guidance. Prog Brain Res (2004) 1.66
In vivo restoration of physiological levels of truncated TrkB.T1 receptor rescues neuronal cell death in a trisomic mouse model. Neuron (2006) 1.64
IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice. J Immunol (2009) 1.63
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol (2007) 1.62
Homeodomain protein Dlx3 induces phosphorylation-dependent p63 degradation. Cell Cycle (2009) 1.62
Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Nat Genet (2002) 1.60
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The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells. Immunity (2008) 1.55
Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects. Development (2008) 1.55
Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc Natl Acad Sci U S A (2012) 1.55
BRCA2 deficiency in mice leads to meiotic impairment and infertility. Development (2003) 1.55
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proc Natl Acad Sci U S A (2013) 1.48
TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity. J Invest Dermatol (2012) 1.47
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Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene. Cancer Res (2003) 1.46
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production. Blood (2010) 1.44
Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration. Proc Natl Acad Sci U S A (2004) 1.42
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Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration. FASEB J (2009) 1.41
Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium. Development (2006) 1.41
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A (2011) 1.41
Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. PLoS Genet (2008) 1.37
Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet (2010) 1.35
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Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Development (2008) 1.32
Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele. Proc Natl Acad Sci U S A (2004) 1.31
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nat Neurosci (2010) 1.29
Monocyte chemoattractant protein-1 (MCP-1), not MCP-3, is the primary chemokine required for monocyte recruitment in mouse peritonitis induced with thioglycollate or zymosan A. J Immunol (2009) 1.28
Host-derived tumor endothelial marker 8 promotes the growth of melanoma. Cancer Res (2009) 1.27
Disruption of axo-glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axons. Proc Natl Acad Sci U S A (2006) 1.27
Direct interaction with Hoxd proteins reverses Gli3-repressor function to promote digit formation downstream of Shh. Development (2004) 1.27
A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses. J Immunol (2010) 1.26
Interleukin 1alpha promotes Th1 differentiation and inhibits disease progression in Leishmania major-susceptible BALB/c mice. J Exp Med (2003) 1.26
Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. J Neurosci Methods (2004) 1.25
Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration. Nat Med (2013) 1.25
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A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin. J Cell Biol (2006) 1.24
SIVQ-aided laser capture microdissection: A tool for high-throughput expression profiling. J Pathol Inform (2011) 1.24
ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3. Proc Natl Acad Sci U S A (2007) 1.21
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A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses. Proc Natl Acad Sci U S A (2010) 1.20
Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss. Nat Neurosci (2013) 1.18
Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice. Oncogene (2003) 1.18
The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development. Blood (2012) 1.17
beta-Catenin has sequential roles in the survival and specification of ventral dermis. Development (2008) 1.17
Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma. Haematologica (2011) 1.16
Mutant mice reveal the molecular and cellular basis for specific sensory connections to inner ear epithelia and primary nuclei of the brain. Hear Res (2005) 1.15
Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life. Proc Natl Acad Sci U S A (2010) 1.14
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Approaching solid tumor heterogeneity on a cellular basis by tissue proteomics using laser capture microdissection and biological mass spectrometry. J Proteome Res (2009) 1.11
Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. J Cell Biol (2009) 1.11
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Novel tumor necrosis factor-knockout mice that lack Peyer's patches. Eur J Immunol (2005) 1.09
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Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Mol Cell Biol (2004) 1.08
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