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SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A (2009) 2.07

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DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution. Nat Methods (2012) 1.85

Early embryonic chromosome instability results in stable mosaic pattern in human tissues. PLoS One (2010) 1.32

Quality control: Genome maintenance in pluripotent stem cells. J Cell Biol (2014) 1.27

Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes. PLoS One (2013) 1.26

Characterizing complex structural variation in germline and somatic genomes. Trends Genet (2011) 1.25

Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells. EMBO Mol Med (2014) 1.17

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Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential. EMBO J (2016) 0.82

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High-Sensitivity Mass Spectrometry for Probing Gene Translation in Single Embryonic Cells in the Early Frog (Xenopus) Embryo. Front Cell Dev Biol (2016) 0.76

Impact of retrotransposons in pluripotent stem cells. Mol Cells (2012) 0.76

Controlled somatic and germline copy number variation in the mouse model. Curr Genomics (2010) 0.76

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Cancer quasispecies and stem-like adaptive aneuploidy. F1000Res (2013) 0.75

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Global variation in copy number in the human genome. Nature (2006) 57.50

Detection of large-scale variation in the human genome. Nat Genet (2004) 49.18

Large-scale copy number polymorphism in the human genome. Science (2004) 34.64

A high-resolution survey of deletion polymorphism in the human genome. Nat Genet (2005) 16.99

Common deletion polymorphisms in the human genome. Nat Genet (2006) 15.66

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A mouse for all reasons. Cell (2007) 9.01

Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles. Am J Hum Genet (2008) 5.53

Genomic rearrangements and sporadic disease. Nat Genet (2007) 5.28

Germline rates of de novo meiotic deletions and duplications causing several genomic disorders. Nat Genet (2007) 4.59

A public gene trap resource for mouse functional genomics. Nat Genet (2004) 3.96

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature (1991) 3.83

Genomic rearrangements and gene copy-number alterations as a cause of nervous system disorders. Neuron (2006) 3.65

Breakpoint identification and smoothing of array comparative genomic hybridization data. Bioinformatics (2004) 2.85

Recurrent DNA copy number variation in the laboratory mouse. Nat Genet (2007) 2.40

Recurrent DNA inversion rearrangements in the human genome. Proc Natl Acad Sci U S A (2007) 2.29

Genomic segmental polymorphisms in inbred mouse strains. Nat Genet (2004) 1.93

Mapping segmental and sequence variations among laboratory mice using BAC array CGH. Genome Res (2005) 1.71

Chromosomal integrity maintained in five human embryonic stem cell lines after prolonged in vitro culture. Chromosome Res (2006) 1.39

Current status of chromosomal abnormalities in mouse embryonic stem cell lines used in Japan. Comp Med (2006) 1.29

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Gene conversions and unequal crossovers between CYP21 (steroid 21-hydroxylase gene) and CYP21P involve different mechanisms. Proc Natl Acad Sci U S A (1995) 1.20

Induction of pluripotency: from mouse to human. Cell (2007) 1.01

Requirement of bic/microRNA-155 for normal immune function. Science (2007) 16.24

Identification of mammalian microRNA host genes and transcription units. Genome Res (2004) 14.63

p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05

A conditional knockout resource for the genome-wide study of mouse gene function. Nature (2011) 9.93

The knockout mouse project. Nat Genet (2004) 7.80

microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity (2007) 6.72

Chromosomal transposition of PiggyBac in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2008) 4.98

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature (2011) 4.92

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res (2003) 4.83

Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods (2009) 4.27

A public gene trap resource for mouse functional genomics. Nat Genet (2004) 3.96

The molecular clock mediates leptin-regulated bone formation. Cell (2005) 3.88

The European dimension for the mouse genome mutagenesis program. Nat Genet (2004) 3.84

Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods (2009) 3.68

An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Cell Stem Cell (2010) 3.60

Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells (2010) 3.53

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell (2013) 3.47

Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell (2009) 3.45

The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res (2006) 3.40

The IKMC web portal: a central point of entry to data and resources from the International Knockout Mouse Consortium. Nucleic Acids Res (2010) 3.23

ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A (2008) 3.15

Molecular mechanisms governing Pcdh-gamma gene expression: evidence for a multiple promoter and cis-alternative splicing model. Genes Dev (2002) 3.14

TranscriptSNPView: a genome-wide catalog of mouse coding variation. Nat Genet (2006) 3.10

Generation of an inducible and optimized piggyBac transposon system. Nucleic Acids Res (2007) 3.09

Functional genetic analysis of mouse chromosome 11. Nature (2003) 2.87

A hyperactive piggyBac transposase for mammalian applications. Proc Natl Acad Sci U S A (2011) 2.68

The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome (2012) 2.65

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nat Cell Biol (2010) 2.55

Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. Cancer Cell (2003) 2.49

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development (2004) 2.45

Evidence that meiotic sex chromosome inactivation is essential for male fertility. Curr Biol (2010) 2.36

PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice. Science (2010) 2.31

Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells. Nature (2004) 2.29

Gamma protocadherins are required for survival of spinal interneurons. Neuron (2002) 2.23

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res (2013) 2.20

Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation (2012) 2.14

Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project. Mamm Genome (2012) 2.12

Tools for targeted manipulation of the mouse genome. Physiol Genomics (2002) 2.08

Dual RMCE for efficient re-engineering of mouse mutant alleles. Nat Methods (2010) 2.05

Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays. Nat Biotechnol (2002) 2.04

A genome-wide, end-sequenced 129Sv BAC library resource for targeting vector construction. Genomics (2005) 2.02

Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster. Mol Cell Biol (2008) 2.01

Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proc Natl Acad Sci U S A (2011) 1.97

Transposon-mediated genome manipulation in vertebrates. Nat Methods (2009) 1.96

Polybromo protein BAF180 functions in mammalian cardiac chamber maturation. Genes Dev (2004) 1.93

Distinct and complementary information provided by use of tissue and DNA microarrays in the study of breast tumor markers. Am J Pathol (2002) 1.89

Mutagenic insertion and chromosome engineering resource (MICER). Nat Genet (2004) 1.88

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature (2006) 1.81

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet (2011) 1.71

Chromosomal mobilization and reintegration of Sleeping Beauty and PiggyBac transposons. Genesis (2009) 1.68

Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia. Mol Cell Biol (2007) 1.66

Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Genes Dev (2005) 1.65

Accessing data from the International Mouse Phenotyping Consortium: state of the art and future plans. Mamm Genome (2012) 1.63

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice. J Clin Invest (2011) 1.59

Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability. Mol Cell Biol (2010) 1.51

Knock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapy. Proc Natl Acad Sci U S A (2004) 1.51

Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development. Genes Dev (2006) 1.49

Mobilization of giant piggyBac transposons in the mouse genome. Nucleic Acids Res (2011) 1.49

A piggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells. Genome Res (2009) 1.48

p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci U S A (2006) 1.48

Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control. Mol Cell Biol (2002) 1.46

Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei. Proc Natl Acad Sci U S A (2007) 1.46

Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers. Mol Cell Biol (2005) 1.46

The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development. Proc Natl Acad Sci U S A (2005) 1.44

Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: phenotypic consequences of gene dosage imbalance. Mol Cell Biol (2003) 1.42

Complex haplotypes, copy number polymorphisms and coding variation in two recently divergent mouse strains. Nat Genet (2005) 1.42

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. Hum Mol Genet (2010) 1.42

A targeted X-linked CMV-Cre line. Genesis (2002) 1.36

A resource of vectors and ES cells for targeted deletion of microRNAs in mice. Nat Biotechnol (2011) 1.36

Null and conditional semaphorin 3B alleles using a flexible puroDeltatk loxP/FRT vector. Genesis (2005) 1.36

A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention. Cancer Cell (2013) 1.35

ATP-citrate lyase deficiency in the mouse. J Biol Chem (2003) 1.35

A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization. Genome Res (2004) 1.32

COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast. Mol Cell Biol (2003) 1.26

Increased bone mass is an unexpected phenotype associated with deletion of the calcitonin gene. J Clin Invest (2002) 1.24

A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesis. Genesis (2007) 1.22

The Y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice. Curr Biol (2011) 1.22

Novel lethal mouse mutants produced in balancer chromosome screens. Gene Expr Patterns (2006) 1.21

Loss of TSLC1 causes male infertility due to a defect at the spermatid stage of spermatogenesis. Mol Cell Biol (2006) 1.19

Induced mitotic recombination of p53 in vivo. Proc Natl Acad Sci U S A (2007) 1.18

Reduced penetrance of craniofacial anomalies as a function of deletion size and genetic background in a chromosome engineered partial mouse model for Smith-Magenis syndrome. Hum Mol Genet (2004) 1.16

Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. Am J Pathol (2003) 1.16

Conditional inactivation of p63 by Cre-mediated excision. Genesis (2002) 1.16

Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin. PLoS Genet (2009) 1.16

Gene structure and functional analysis of the mouse nidogen-2 gene: nidogen-2 is not essential for basement membrane formation in mice. Mol Cell Biol (2002) 1.12

A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening. Nat Methods (2011) 1.11

Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis. Am J Pathol (2006) 1.11

Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes. Proc Natl Acad Sci U S A (2005) 1.08

Aurora B -TACC1 protein complex in cytokinesis. Oncogene (2004) 1.07

Floxin, a resource for genetically engineering mouse ESCs. Nat Methods (2009) 1.07

Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis (2003) 1.07

Olfactory bulb hypoplasia in Prokr2 null mice stems from defective neuronal progenitor migration and differentiation. Eur J Neurosci (2007) 1.06

Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice. Blood (2013) 1.06