Testing the Critical Window Hypothesis of Timing and Duration of Estradiol Treatment on Hypothalamic Gene Networks in Reproductively Mature and Aging Female Rats.

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Published in Endocrinology on May 27, 2015

Authors

Weiling Yin1, Sean M Maguire1, Brian Pham1, Alexandra N Garcia1, Nguyen-Vy Dang1, Jingya Liang1, Andrew Wolfe1, Hans A Hofmann1, Andrea C Gore1

Author Affiliations

1: Division of Pharmacology and Toxicology (W.Y., B.P., N.-V.D., J.L., A.C.G.), Departments of Integrative Biology (S.M.M., H.A.H.) and Psychology (A.N.G., A.C.G.), and Institute for Neuroscience (H.A.H., A.C.G.), The University of Texas at Austin, Austin, Texas 78712; and Johns Hopkins University School of Medicine (A.W.), Baltimore, Maryland 21287.

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A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell (1998) 3.89

CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell (1998) 3.86

Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci U S A (2005) 3.79

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Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature (1998) 3.38

Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity. Proc Natl Acad Sci U S A (2000) 2.83

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Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proc Natl Acad Sci U S A (2007) 2.59

Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B. Endocrinology (2007) 2.57

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Effects of aging on central and peripheral mammalian clocks. Proc Natl Acad Sci U S A (2002) 2.38

Retracted Changes in energy balance and body composition at menopause: a controlled longitudinal study. Ann Intern Med (1995) 2.28

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Menopause in nonhuman primates? Biol Reprod (2008) 1.52

The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat. J Endocrinol (1995) 1.49

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Neurokinin B gene expression is increased in the arcuate nucleus of ovariectomized rats. Neuroendocrinology (1994) 1.23

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Release of luteinizing hormone induced by estrogen injection into ovariectomized rats. Endocrinology (1971) 1.17

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The regulation of neuroendocrine function: Timing is everything. Horm Behav (2006) 1.12

Changes in prodynorphin gene expression and neuronal morphology in the hypothalamus of postmenopausal women. J Neuroendocrinol (2008) 1.11

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Assessment of follicle destruction in chemical-induced ovarian toxicity. Annu Rev Pharmacol Toxicol (1996) 1.06

Circadian organization of the estrous cycle of the golden hamster. Proc Natl Acad Sci U S A (1976) 1.05

Effects of leptin and melanocortin signaling interactions on pubertal development and reproduction. Endocrinology (2012) 1.03

The effects of ovarian steroids on food and water intake and body weight in the female rat. Acta Endocrinol (Copenh) (1973) 1.02

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Novel localization of NMDA receptors within neuroendocrine gonadotropin-releasing hormone terminals. Exp Biol Med (Maywood) (2007) 0.92

Neuroendocrine control of the transition to reproductive senescence: lessons learned from the female rodent model. Neuroendocrinology (2012) 0.90

Thyroid dysfunction in perimenopausal and postmenopausal women. Menopause Int (2007) 0.89

Accelerated ovarian failure: a novel, chemically induced animal model of menopause. Brain Res (2011) 0.89

Effect of estrogen on the expression of Cry1 and Cry2 mRNAs in the suprachiasmatic nucleus of female rats. Neurosci Res (2001) 0.89

Quantitative autoradiographic assessment of 3H-estradiol uptake in immunocytochemically characterized pituitary cells. Cell Tissue Res (1976) 0.88

MicroRNAs in the aging female brain: a putative mechanism for age-specific estrogen effects. Endocrinology (2013) 0.87

De novo synthesis of steroids and oxysterols in adipocytes. J Biol Chem (2013) 0.87

Thyroid function and postmenopause. Gynecol Endocrinol (2003) 0.86

Distribution of estrogen receptor-immunoreactive cells in monkey hypothalamus: relationship to neurones containing luteinizing hormone-releasing hormone and tyrosine hydroxylase. Neuroendocrinology (1995) 0.86