Published in Diabetes on March 01, 2003
Inflammation and insulin resistance. J Clin Invest (2006) 18.76
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med (2005) 10.88
Type 2 diabetes as an inflammatory disease. Nat Rev Immunol (2011) 8.30
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol (2010) 6.64
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol (2011) 6.53
Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). Annu Rev Immunol (2009) 5.91
Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol (2013) 3.55
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest (2013) 3.47
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med (2011) 3.31
Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci (2006) 2.85
Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology (2006) 2.82
Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol (2012) 2.75
Inflammatory mechanisms in the regulation of insulin resistance. Mol Med (2008) 2.71
Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing (2005) 1.99
Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis. Diabetologia (2009) 1.96
Association between systemic inflammation and incident diabetes in HIV-infected patients after initiation of antiretroviral therapy. Diabetes Care (2010) 1.86
Inflammation and the incidence of type 2 diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care (2010) 1.80
Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes. J Immunol (2010) 1.78
Adiponectin, change in adiponectin, and progression to diabetes in the Diabetes Prevention Program. Diabetes (2008) 1.78
Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care (2013) 1.77
Sensing damage by the NLRP3 inflammasome. Immunol Rev (2011) 1.69
The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia. Endocrinology (2008) 1.68
The major inflammatory mediator interleukin-6 and obesity. Inflamm Res (2009) 1.67
The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol (2009) 1.66
Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome. Mol Cell Endocrinol (2009) 1.65
Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes. Diabetes (2012) 1.62
Adipokines mediate inflammation and insulin resistance. Front Endocrinol (Lausanne) (2013) 1.62
Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol (2007) 1.61
Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets. Proc Natl Acad Sci U S A (2004) 1.60
The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice. J Clin Invest (2010) 1.57
Relation of regional gray and white matter volumes to current BMI and future increases in BMI: a prospective MRI study. Int J Obes (Lond) (2011) 1.56
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience (2013) 1.55
Gut microbiome composition is linked to whole grain-induced immunological improvements. ISME J (2012) 1.54
Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proc Natl Acad Sci U S A (2008) 1.52
Adipocytokines in obesity and metabolic disease. J Endocrinol (2014) 1.49
Toll-like receptors regulate B cell cytokine production in patients with diabetes. Diabetologia (2010) 1.48
Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies. Front Endocrinol (Lausanne) (2013) 1.47
Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity. J Exp Med (2015) 1.39
Accelerated increase in serum interleukin-1 receptor antagonist starts 6 years before diagnosis of type 2 diabetes: Whitehall II prospective cohort study. Diabetes (2010) 1.38
Obesity, inflammatory markers, and endometrial cancer risk: a prospective case-control study. Endocr Relat Cancer (2010) 1.35
Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus. Mol Med (2011) 1.34
Dietary polyphenols as potential nutraceuticals in management of diabetes: a review. J Diabetes Metab Disord (2013) 1.32
Effects of inhibition of interleukin-6 signalling on insulin sensitivity and lipoprotein (a) levels in human subjects with rheumatoid diseases. PLoS One (2010) 1.32
Cysteine redox potential determines pro-inflammatory IL-1beta levels. PLoS One (2009) 1.30
Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention. Diabetes Metab Syndr Obes (2010) 1.28
Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Diabetologia (2008) 1.23
The Role of NLR-related Protein 3 Inflammasome in Host Defense and Inflammatory Diseases. Int Neurourol J (2012) 1.23
Vascular biology of metabolic syndrome. J Vasc Surg (2011) 1.21
The use of high-sensitivity assays for C-reactive protein in clinical practice. Nat Clin Pract Cardiovasc Med (2008) 1.21
Serological evidence of infections and Type 2 diabetes: the MultiEthnic Study of Atherosclerosis. Diabet Med (2009) 1.20
TLR cross-talk specifically regulates cytokine production by B cells from chronic inflammatory disease patients. J Immunol (2009) 1.16
Translating advances from the basic biology of aging into clinical application. Exp Gerontol (2012) 1.16
Evidence that kidney function but not type 2 diabetes determines retinol-binding protein 4 serum levels. Diabetes (2008) 1.16
The ubiquitous interleukin-6: a time for reappraisal. Cardiovasc Diabetol (2010) 1.16
Circulating levels of TNF-α are associated with impaired glucose tolerance, increased insulin resistance, and ethnicity: the Insulin Resistance Atherosclerosis Study. J Clin Endocrinol Metab (2012) 1.15
Inflammatory concepts of obesity. Int J Inflam (2011) 1.14
Intensive care unit-acquired weakness (ICUAW) and muscle wasting in critically ill patients with severe sepsis and septic shock. J Cachexia Sarcopenia Muscle (2010) 1.11
The NLRP3 Inflammasome as a novel player of the intercellular crosstalk in metabolic disorders. Mediators Inflamm (2013) 1.11
Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study. PLoS One (2011) 1.11
Circulating oxidized LDL and inflammation in extreme pediatric obesity. Obesity (Silver Spring) (2011) 1.10
Chronic obstructive pulmonary disease and glucose metabolism: a bitter sweet symphony. Cardiovasc Diabetol (2012) 1.09
The outliers become a stampede as immunometabolism reaches a tipping point. Immunol Rev (2012) 1.08
NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases. Redox Biol (2015) 1.08
Cross-sectional relations of multiple inflammatory biomarkers to peripheral arterial disease: The Framingham Offspring Study. Atherosclerosis (2008) 1.08
Helicobacter pylori infection and diabetes: is it a myth or fact? World J Gastroenterol (2014) 1.08
The lack of utility of circulating biomarkers of inflammation and endothelial dysfunction for type 2 diabetes risk prediction among postmenopausal women: the Women's Health Initiative Observational Study. Arch Intern Med (2010) 1.08
Diabetes mellitus, glycated haemoglobin and C-peptide levels in relation to pancreatic cancer risk: a study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Diabetologia (2011) 1.08
Diabetic periodontitis: a model for activated innate immunity and impaired resolution of inflammation. Periodontol 2000 (2007) 1.08
Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling. Cell Calcium (2010) 1.07
Association of cardiac and vascular changes with ambient PM2.5 in diabetic individuals. Part Fibre Toxicol (2010) 1.07
Adipose and liver expression of interleukin (IL)-1 family members in morbid obesity and effects of weight loss. Mol Med (2011) 1.06
Palmitate and insulin synergistically induce IL-6 expression in human monocytes. Cardiovasc Diabetol (2010) 1.03
Intracellular sensing of microbes and danger signals by the inflammasomes. Immunol Rev (2011) 1.03
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age. Proc Natl Acad Sci U S A (2015) 1.03
Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. J Immunol (2006) 1.02
Interactive changes between macrophages and adipocytes. Clin Vaccine Immunol (2010) 1.02
siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle. Diabetes (2008) 1.02
Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity. Am J Physiol Endocrinol Metab (2013) 1.02
Interleukin-1β regulates fat-liver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability. PLoS One (2013) 1.01
C-Reactive protein, insulin resistance, and metabolic syndrome in a population with a high burden of subclinical infection: insights from the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. Diabetes Care (2008) 1.01
Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice. Endocrinology (2013) 1.01
Inflammatory cytokines in diabetic nephropathy. J Diabetes Res (2015) 1.01
Generalizability of dietary patterns associated with incidence of type 2 diabetes mellitus. Am J Clin Nutr (2009) 1.00
Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation. Clin Exp Immunol (2012) 1.00
Zinc and regulation of inflammatory cytokines: implications for cardiometabolic disease. Nutrients (2012) 0.99
Effects of mode and intensity on the acute exercise-induced IL-6 and CRP responses in a sedentary, overweight population. Eur J Appl Physiol (2010) 0.99
Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity. Diabetes (2015) 0.98
The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes. Cell Calcium (2011) 0.95
Addition of inflammatory biomarkers did not improve diabetes prediction in the community: the framingham heart study. J Am Heart Assoc (2012) 0.95
A preliminary evaluation of efficacy and safety of Wharton's jelly mesenchymal stem cell transplantation in patients with type 2 diabetes mellitus. Stem Cell Res Ther (2014) 0.93
B cells as under-appreciated mediators of non-auto-immune inflammatory disease. Cytokine (2010) 0.93
Increased serum CXCL1 and CXCL5 are linked to obesity, hyperglycemia, and impaired islet function. J Endocrinol (2014) 0.93
Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons. J Neuroinflammation (2014) 0.93
C-reactive protein and glucose regulation in familial longevity. Age (Dordr) (2011) 0.93
Polycystic ovary syndrome in the pediatric population. Metab Syndr Relat Disord (2010) 0.93
Immune deficiency could be an early risk factor for altered insulin sensitivity in antiretroviral-naive HIV-1-infected patients: the ANRS COPANA cohort. Antivir Ther (2012) 0.92
The gp130 receptor cytokine family: regulators of adipocyte development and function. Curr Pharm Des (2011) 0.92
Inhibition of vagally mediated immune-to-brain signaling by vanadyl sulfate speeds recovery from sickness. Proc Natl Acad Sci U S A (2005) 0.92
Satellite cells derived from obese humans with type 2 diabetes and differentiated into myocytes in vitro exhibit abnormal response to IL-6. PLoS One (2012) 0.92
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab (2007) 7.07
Lung cancer susceptibility locus at 5p15.33. Nat Genet (2008) 5.99
Diets with high or low protein content and glycemic index for weight-loss maintenance. N Engl J Med (2010) 5.86
Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition. J Natl Cancer Inst (2005) 4.45
Body size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst (2006) 4.17
Healthy living is the best revenge: findings from the European Prospective Investigation Into Cancer and Nutrition-Potsdam study. Arch Intern Med (2009) 4.15
An accurate risk score based on anthropometric, dietary, and lifestyle factors to predict the development of type 2 diabetes. Diabetes Care (2007) 4.14
Fruit and vegetable intake and overall cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst (2010) 3.98
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Application of a new statistical method to derive dietary patterns in nutritional epidemiology. Am J Epidemiol (2004) 3.85
Adiponectin and protection against type 2 diabetes mellitus. Lancet (2003) 3.79
Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet (2003) 3.53
Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study. BMJ (2005) 3.48
Critical review: vegetables and fruit in the prevention of chronic diseases. Eur J Nutr (2012) 3.48
The association of pattern of lifetime alcohol use and cause of death in the European prospective investigation into cancer and nutrition (EPIC) study. Int J Epidemiol (2013) 3.23
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet (2010) 3.21
Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer. Hepatology (2014) 3.06
Consumption of vegetables and fruits and risk of breast cancer. JAMA (2005) 3.02
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Nat Genet (2010) 2.96
Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC). Int J Cancer (2004) 2.96
Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr (2009) 2.93
Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Int J Cancer (2006) 2.89
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest (2003) 2.87
Meat consumption and prospective weight change in participants of the EPIC-PANACEA study. Am J Clin Nutr (2010) 2.87
Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer. J Clin Oncol (2013) 2.87
Dietary pattern, inflammation, and incidence of type 2 diabetes in women. Am J Clin Nutr (2005) 2.82
Hepatocellular carcinoma risk factors and disease burden in a European cohort: a nested case-control study. J Natl Cancer Inst (2011) 2.63
Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes (2012) 2.62
Smoking and risk for amyotrophic lateral sclerosis: analysis of the EPIC cohort. Ann Neurol (2009) 2.56
Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst (2005) 2.53
Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr (2008) 2.53
Genome-wide association study identifies new prostate cancer susceptibility loci. Hum Mol Genet (2011) 2.51
Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis. Arch Intern Med (2007) 2.47
Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer (2010) 2.47
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab (2012) 2.43
Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study. Eur Heart J (2011) 2.42
Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes (2008) 2.41
Novel biomarkers for pre-diabetes identified by metabolomics. Mol Syst Biol (2012) 2.39
Plasma selenium concentration and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Clin Nutr (2008) 2.35
RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem (2005) 2.32
The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins. Hum Mol Genet (2002) 2.32
Consuming fructose-sweetened beverages increases body adiposity in mice. Obes Res (2005) 2.18
Air pollution and risk of lung cancer in a prospective study in Europe. Int J Cancer (2006) 2.17
The evaluation of the diet/disease relation in the EPIC study: considerations for the calibration and the disease models. Int J Epidemiol (2008) 2.11
Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke. Circulation (2008) 2.08
Association between adiponectin and mediators of inflammation in obese women. Diabetes (2003) 2.05
Comparison of two statistical approaches to predict all-cause mortality by dietary patterns in German elderly subjects. Br J Nutr (2005) 2.04
Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition. Gut (2011) 2.03
Metabolic effects of dietary fiber consumption and prevention of diabetes. J Nutr (2008) 2.03
N-acetyltransferase 2 phenotype, occupation, and bladder cancer risk: results from the EPIC cohort. Cancer Epidemiol Biomarkers Prev (2013) 2.01
Obesity and cancer. Proc Nutr Soc (2008) 2.00
Is concordance with World Cancer Research Fund/American Institute for Cancer Research guidelines for cancer prevention related to subsequent risk of cancer? Results from the EPIC study. Am J Clin Nutr (2012) 1.98
Body mass index history and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Am J Clin Nutr (2006) 1.98
Validity of a short questionnaire to assess physical activity in 10 European countries. Eur J Epidemiol (2011) 1.95
Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study. BMJ (2011) 1.94
Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Arch Intern Med (2010) 1.88
Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on cardiovascular risk factors: the diet, obesity, and genes (DiOGenes) study: a randomized, controlled trial. Circulation (2011) 1.88
Healthy lifestyle behaviors and all-cause mortality among adults in the United States. Prev Med (2012) 1.87
Adherence to the World Cancer Research Fund/American Institute for Cancer Research guidelines and risk of death in Europe: results from the European Prospective Investigation into Nutrition and Cancer cohort study1,4. Am J Clin Nutr (2013) 1.84
Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Am J Clin Nutr (2010) 1.83
Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women. Cancer Res (2007) 1.82
The role of smoking and diet in explaining educational inequalities in lung cancer incidence. J Natl Cancer Inst (2009) 1.81
Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition. Int J Cancer (2010) 1.78
Meat consumption and mortality--results from the European Prospective Investigation into Cancer and Nutrition. BMC Med (2013) 1.77
Body mass index and the risk for Crohn's disease and ulcerative colitis: data from a European Prospective Cohort Study (The IBD in EPIC Study). Am J Gastroenterol (2013) 1.77
Risk of hypertension among women in the EPIC-Potsdam Study: comparison of relative risk estimates for exploratory and hypothesis-oriented dietary patterns. Am J Epidemiol (2003) 1.76
Assessing improvement in disease prediction using net reclassification improvement: impact of risk cut-offs and number of risk categories. Eur J Epidemiol (2012) 1.75