Published in Cell Metab on October 01, 2007
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Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway. EMBO J (2010) 1.27
The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. Proc Natl Acad Sci U S A (2013) 1.26
Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. PLoS One (2009) 1.25
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The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior. J Biol Chem (2008) 1.19
Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension. Mol Metab (2013) 1.18
Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2014) 1.17
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Adaptive capacity to bacterial diet modulates aging in C. elegans. Cell Metab (2014) 1.15
Peroxisome metabolism and cellular aging. Traffic (2010) 1.13
A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging. Aging (Albany NY) (2010) 1.12
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SKN-1/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity. Toxicol Sci (2010) 1.11
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The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. J Clin Invest (2014) 1.10
Calorie restriction effects on silencing and recombination at the yeast rDNA. Aging Cell (2009) 1.10
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Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. Proc Natl Acad Sci U S A (2014) 1.10
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Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab (2012) 2.43
RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. J Biol Chem (2005) 2.32
The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins. Hum Mol Genet (2002) 2.32
Consuming fructose-sweetened beverages increases body adiposity in mice. Obes Res (2005) 2.18
Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited. J Biol Chem (2005) 1.45
Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum Mol Genet (2005) 1.40
The SmartBioPhone, a point of care vision under development through two European projects: OPTOLABCARD and LABONFOIL. Lab Chip (2009) 1.30
Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells. Hum Mol Genet (2005) 1.23
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nat Chem Biol (2013) 1.23
Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension. Mol Metab (2013) 1.18
In silico evidence for gluconeogenesis from fatty acids in humans. PLoS Comput Biol (2011) 1.18
Telomerase deficiency impairs glucose metabolism and insulin secretion. Aging (Albany NY) (2010) 1.17
Taste responses in mice lacking taste receptor subunit T1R1. J Physiol (2013) 1.15
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Vitamin E analogs, a novel group of "mitocans," as anticancer agents: the importance of being redox-silent. Mol Pharmacol (2007) 1.11
Vitamin E activates gene expression via the pregnane X receptor. Biochem Pharmacol (2003) 1.11
Statistical methods for comparing comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry results: metabolomic analysis of mouse tissue extracts. J Chromatogr A (2005) 1.10
Frataxin promotes antioxidant defense in a thiol-dependent manner resulting in diminished malignant transformation in vitro. Hum Mol Genet (2002) 1.07
Variable expression of Cre recombinase transgenes precludes reliable prediction of tissue-specific gene disruption by tail-biopsy genotyping. PLoS One (2007) 1.07
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Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension. Aging Cell (2013) 1.04
Mitochondrial DNA copy number and function decrease with age in the short-lived fish Nothobranchius furzeri. Aging Cell (2011) 1.03
Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans. PLoS One (2008) 1.03
Activation of mitochondrial energy metabolism protects against cardiac failure. Aging (Albany NY) (2010) 1.02
Functional peptide microarrays for specific and sensitive antibody diagnostics. Proteomics (2006) 1.01
Complete genome sequences of four mammalian isolates of Chlamydophila psittaci. J Bacteriol (2011) 1.01
High glucose-induced oxidative stress increases transient receptor potential channel expression in human monocytes. Diabetes (2010) 1.01
Dietary effects on body composition, glucose metabolism, and longevity are modulated by skeletal muscle mitochondrial uncoupling in mice. Aging Cell (2010) 1.00
Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture. J Nutr Biochem (2010) 1.00
Acetylsalicylic acid improves lipid-induced insulin resistance in healthy men. J Clin Endocrinol Metab (2005) 0.98
The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals. Biochem J (2010) 0.97
Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes. J Clin Endocrinol Metab (2004) 0.97
Anaerobic C-ring cleavage of genistein and daidzein by Eubacterium ramulus. FEMS Microbiol Lett (2002) 0.96
Impaired respiration is positively correlated with decreased life span in Caenorhabditis elegans models of Friedreich Ataxia. FASEB J (2007) 0.96
Adiponectin is independently associated with insulin sensitivity in women with polycystic ovary syndrome. Clin Endocrinol (Oxf) (2004) 0.93
Small-molecule targeting of the mitochondrial compartment with an endogenously cleaved reversible tag. Chembiochem (2009) 0.93
Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa. PLoS One (2012) 0.93
Quantitative multiplexed profiling of cellular signaling networks using phosphotyrosine-specific DNA-tagged SH2 domains. Nat Methods (2006) 0.93
A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression. Cancer Res (2007) 0.92
Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth. J Biol Chem (2011) 0.91
Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart. PLoS One (2013) 0.91
Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects. Curr Cancer Drug Targets (2004) 0.91
Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice. Am J Physiol Endocrinol Metab (2008) 0.91
Improved glucose metabolism in mice lacking alpha-tocopherol transfer protein. Eur J Nutr (2007) 0.91
Modulation of Cyp3a11 mRNA expression by alpha-tocopherol but not gamma-tocotrienol in mice. Free Radic Biol Med (2005) 0.90
BIOCLAIMS standard diet (BIOsd): a reference diet for nutritional physiology. Genes Nutr (2012) 0.89
Low-dose lithium uptake promotes longevity in humans and metazoans. Eur J Nutr (2011) 0.88
Homologous metabolic and gene activating routes for vitamins E and K. Mol Aspects Med (2003) 0.87
Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance. J Endocrinol (2007) 0.87
Antioxidant supplements in exercise: worse than useless? Am J Physiol Endocrinol Metab (2012) 0.86
Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress. Free Radic Biol Med (2010) 0.86
Rice bran extract protects from mitochondrial dysfunction in guinea pig brains. Pharmacol Res (2013) 0.83
Predictors of abnormal glucose metabolism in women with polycystic ovary syndrome. Eur J Endocrinol (2006) 0.83
Network-based integration of molecular and physiological data elucidates regulatory mechanisms underlying adaptation to high-fat diet. Genes Nutr (2015) 0.83
White adipose tissue reference network: a knowledge resource for exploring health-relevant relations. Genes Nutr (2014) 0.83
L-Theanine extends lifespan of adult Caenorhabditis elegans. Eur J Nutr (2012) 0.83
Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity. Proc Natl Acad Sci U S A (2007) 0.82
Specific alterations of carbohydrate metabolism are associated with hepatocarcinogenesis in mitochondrially impaired mice. Hum Mol Genet (2011) 0.81
Serum vaspin concentrations are decreased after exercise-induced oxidative stress. Obes Facts (2010) 0.81
Opposing effects of dietary sugar and saturated fat on cardiovascular risk factors and glucose metabolism in mitochondrially impaired mice. Eur J Nutr (2010) 0.81
Extension of life span by impaired glucose metabolism in Caenorhabditis elegans is accompanied by structural rearrangements of the transcriptomic network. PLoS One (2013) 0.80
Prevailing negative soil biota effect and no evidence for local adaptation in a widespread Eurasian grass. PLoS One (2011) 0.79
Gustatory sensory cells express a receptor responsive to protein breakdown products (GPR92). Histochem Cell Biol (2013) 0.79
Bioactivation of selenocysteine derivatives by beta-lyases present in common gastrointestinal bacterial species. Int J Vitam Nutr Res (2009) 0.79
High activity enables life on a high-sugar diet: blood glucose regulation in nectar-feeding bats. Proc Biol Sci (2011) 0.79
In vitro fermented nuts exhibit chemopreventive effects in HT29 colon cancer cells. Br J Nutr (2011) 0.79
Dual role of the mitochondrial protein frataxin in astrocytic tumors. Lab Invest (2011) 0.78
Development of peptide microarrays for epitope mapping of antibodies against the human TSH receptor. J Immunol Methods (2006) 0.78
Intracellular degradation of somatostatin-14 following somatostatin-receptor3-mediated endocytosis in rat insulinoma cells. FEBS J (2008) 0.77
High baseline vitamin C levels do not prevent a positive outcome of a lifestyle intervention: response to Thamer et al. Diabetes Care (2010) 0.76
ω-Hydroxylation of phylloquinone by CYP4F2 is not increased by α-tocopherol. Mol Nutr Food Res (2013) 0.76
Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner. Aging (Albany NY) (2013) 0.76
Impaired mitochondrial activity and insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med (2004) 0.75