Published in Mol Cell Biol on March 01, 2003
RNA polymerase is poised for activation across the genome. Nat Genet (2007) 9.57
Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans. Nat Rev Genet (2012) 4.37
NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly. Genes Dev (2008) 3.69
NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila. Mol Cell Biol (2008) 3.11
Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation. Biochim Biophys Acta (2010) 2.86
Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element. Mol Cell Biol (2004) 2.49
Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB gene. Mol Cell Biol (2006) 2.40
Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev (2004) 2.35
Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II. Proc Natl Acad Sci U S A (2004) 2.01
Control of transcriptional elongation. Annu Rev Genet (2013) 1.92
Regulating the regulators: the pervasive effects of Pol II pausing on stimulus-responsive gene networks. Genes Dev (2012) 1.91
Transcriptional and posttranscriptional regulation of HIV-1 gene expression. Cold Spring Harb Perspect Med (2012) 1.88
Promoter proximal pausing on genes in metazoans. Chromosoma (2008) 1.64
Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex. Proc Natl Acad Sci U S A (2010) 1.55
A simplified miRNA-based gene silencing method for Drosophila melanogaster. Dev Biol (2008) 1.54
Extensive polymerase pausing during Drosophila axis patterning enables high-level and pliable transcription. Genes Dev (2013) 1.43
A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Mol Cell Proteomics (2010) 1.41
Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II. Nat Neurosci (2011) 1.39
Molecular characterization of Drosophila NELF. Nucleic Acids Res (2005) 1.37
A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS. Proc Natl Acad Sci U S A (2005) 1.36
RNA polymerase II C-terminal domain: Tethering transcription to transcript and template. Chem Rev (2013) 1.35
Using ChIP-chip and ChIP-seq to study the regulation of gene expression: genome-wide localization studies reveal widespread regulation of transcription elongation. Methods (2009) 1.23
Control of HIV latency by epigenetic and non-epigenetic mechanisms. Curr HIV Res (2011) 1.23
The Spt4-Spt5 complex: a multi-faceted regulator of transcription elongation. Biochim Biophys Acta (2012) 1.11
Identification of a regulator of transcription elongation as an accessory factor for the human Mediator coactivator. Proc Natl Acad Sci U S A (2007) 1.10
Up-regulation of P-TEFb by the MEK1-extracellular signal-regulated kinase signaling pathway contributes to stimulated transcription elongation of immediate early genes in neuroendocrine cells. Mol Cell Biol (2007) 1.05
Phosphorylation of the RNA polymerase II C-terminal domain by TFIIH kinase is not essential for transcription of Saccharomyces cerevisiae genome. Proc Natl Acad Sci U S A (2009) 1.04
Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat. Mol Cell Biol (2014) 1.03
Pausing of RNA polymerase II regulates mammalian developmental potential through control of signaling networks. Mol Cell (2015) 1.03
The two steps of poly(A)-dependent termination, pausing and release, can be uncoupled by truncation of the RNA polymerase II carboxyl-terminal repeat domain. Mol Cell Biol (2004) 1.02
Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis. PLoS One (2009) 1.01
Gene-specific recruitment of positive and negative elongation factors during stimulated transcription of the MKP-1 gene in neuroendocrine cells. Nucleic Acids Res (2007) 1.00
Defining NELF-E RNA binding in HIV-1 and promoter-proximal pause regions. PLoS Genet (2014) 0.99
Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration. J Biol Chem (2009) 0.98
Genetic and genomic analyses of RNA polymerase II-pausing factor in regulation of mammalian transcription and cell growth. J Biol Chem (2011) 0.97
Lost in transcription: molecular mechanisms that control HIV latency. Viruses (2013) 0.96
Unusual combinatorial involvement of poly-A/T tracts in organizing genes and chromatin in Dictyostelium. Genome Res (2012) 0.96
Cofactor of BRCA1 modulates androgen-dependent transcription and alternative splicing. J Steroid Biochem Mol Biol (2007) 0.95
RNA polymerase II transcription elongation and Pol II CTD Ser2 phosphorylation: A tail of two kinases. Nucleus (2014) 0.94
Negative elongation factor-mediated suppression of RNA polymerase II elongation of Kaposi's sarcoma-associated herpesvirus lytic gene expression. J Virol (2012) 0.93
TDP-43 is a transcriptional repressor: the testis-specific mouse acrv1 gene is a TDP-43 target in vivo. J Biol Chem (2011) 0.93
Structural studies on the RNA-recognition motif of NELF E, a cellular negative transcription elongation factor involved in the regulation of HIV transcription. Biochem J (2006) 0.93
DSIF contributes to transcriptional activation by DNA-binding activators by preventing pausing during transcription elongation. Nucleic Acids Res (2007) 0.92
Pol II docking and pausing at growth and stress genes in C. elegans. Cell Rep (2014) 0.91
Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells. Int J Biol Sci (2007) 0.91
Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle. Proc Natl Acad Sci U S A (2013) 0.91
Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline. Development (2013) 0.89
Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation. J Biol Chem (2012) 0.88
A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties. J Biol Chem (2013) 0.86
Differential glioma-associated tumor antigen expression profiles of human glioma cells grown in hypoxia. PLoS One (2012) 0.83
Divergence of a conserved elongation factor and transcription regulation in budding and fission yeast. Genome Res (2016) 0.82
Splitting hares and tortoises: a classification of neuronal immediate early gene transcription based on poised RNA polymerase II. Neuroscience (2013) 0.81
Characterization of hampin/MSL1 as a node in the nuclear interactome. Biochem Biophys Res Commun (2007) 0.80
Translational Initiation at a Non-AUG Start Codon for Human and Mouse Negative Elongation Factor-B. PLoS One (2015) 0.80
RNA polymerase II pausing as a context-dependent reader of the genome. Biochem Cell Biol (2015) 0.77
Minireview: nuclear receptor coregulators of the p160 family: insights into inflammation and metabolism. Mol Endocrinol (2015) 0.77
Architecture and RNA binding of the human negative elongation factor. Elife (2016) 0.77
CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription. Transcription (2015) 0.76
Drosophila suppressor of sable protein [Su(s)] promotes degradation of aberrant and transposon-derived RNAs. Mol Cell Biol (2009) 0.76
Transcription elongation control by the 7SK snRNP complex: Releasing the pause. Cell Cycle (2016) 0.76
Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration. PLoS One (2012) 0.76
Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II. Nucleic Acids Res (2016) 0.76
Functional interplay between PPM1G and the transcription elongation machinery. RNA Dis (2016) 0.76
NELF-E is recruited to DNA double-strand break sites to promote transcriptional repression and repair. EMBO Rep (2017) 0.75
Enforcing the pause: transcription factor Sp3 limits productive elongation by RNA polymerase II. Cell Cycle (2013) 0.75
Kmt5a Controls Hepatic Metabolic Pathways by Facilitating RNA Pol II Release from Promoter-Proximal Regions. Cell Rep (2017) 0.75
DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. Genes Dev (1998) 6.96
Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro. Genes Dev (1997) 6.88
NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Cell (1999) 6.34
P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II. Mol Cell Biol (2000) 5.64
Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae. Genes Dev (1998) 5.16
The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription. Nature (2001) 5.14
P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. Genes Dev (1997) 5.13
7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. Nature (2001) 5.11
RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol (2002) 5.04
Basic mechanisms of transcript elongation and its regulation. Annu Rev Biochem (1997) 4.63
Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro. EMBO J (1998) 4.08
P-TEFb kinase recruitment and function at heat shock loci. Genes Dev (2000) 4.07
High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation. Genes Dev (2000) 3.79
The Paf1 complex physically and functionally associates with transcription elongation factors in vivo. EMBO J (2002) 3.44
Tackling Tat. J Mol Biol (1999) 3.13
Flavopiridol inhibits P-TEFb and blocks HIV-1 replication. J Biol Chem (2000) 3.13
The molecular biology of hepatitis delta virus. Annu Rev Biochem (1995) 2.92
A highly purified RNA polymerase II elongation control system. J Biol Chem (2001) 2.84
Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster. Genes Dev (2000) 2.78
Domains in the SPT5 protein that modulate its transcriptional regulatory properties. Mol Cell Biol (2000) 2.74
Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex. Mol Cell Biol (2002) 2.60
Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. Mol Cell Biol (2002) 2.59
Requirement for E. coli NusG protein in factor-dependent transcription termination. Cell (1992) 2.22
Structure and function of the human transcription elongation factor DSIF. J Biol Chem (1999) 2.19
NusG, a new Escherichia coli elongation factor involved in transcriptional antitermination by the N protein of phage lambda. J Biol Chem (1992) 2.19
Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbfbeta. Mol Cell Biol (1998) 2.13
BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. J Cell Biol (2001) 1.96
A regulator of transcriptional elongation controls vertebrate neuronal development. Nature (2000) 1.87
DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation. J Biol Chem (2000) 1.85
Spt5 cooperates with human immunodeficiency virus type 1 Tat by preventing premature RNA release at terminator sequences. Mol Cell Biol (2002) 1.82
HIV-1 Tat: coping with negative elongation factors. Curr Opin Immunol (1999) 1.81
KOW: a novel motif linking a bacterial transcription factor with ribosomal proteins. Trends Biochem Sci (1996) 1.74
A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription. EMBO J (1999) 1.73
Stimulation of RNA polymerase II elongation by hepatitis delta antigen. Science (2001) 1.66
Phosphorylation of the RNA polymerase II carboxy-terminal domain by the Bur1 cyclin-dependent kinase. Mol Cell Biol (2001) 1.61
Novel domains and orthologues of eukaryotic transcription elongation factors. Nucleic Acids Res (2002) 1.60
The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo. Development (2002) 1.55
SPT genes: key players in the regulation of transcription, chromatin structure and other cellular processes. J Biochem (2001) 1.34
Tat-SF1 protein associates with RAP30 and human SPT5 proteins. Mol Cell Biol (1999) 1.27
Dissection of the transactivation function of the transcription factor encoded by the eye developmental gene PAX6. J Biol Chem (1998) 1.19
Comparative analysis of a novel gene from the Wolf-Hirschhorn/Pitt-Rogers-Danks syndrome critical region. Genomics (1999) 1.15
Transcription elongation: the 'Foggy' is liftingellipsis. Curr Biol (2001) 1.13
Activation of the cyclin-dependent kinase CTDK-I requires the heterodimerization of two unstable subunits. J Biol Chem (2000) 0.99
Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13. Hum Genet (2000) 0.93
Identification of a primary target of thalidomide teratogenicity. Science (2010) 7.09
NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. Genes Dev (2003) 3.65
Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Mol Cell (2005) 3.46
P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation. Mol Cell (2006) 2.92
Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. Mol Cell Biol (2002) 2.59
Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB gene. Mol Cell Biol (2006) 2.40
Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev (2004) 2.35
Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.). Br J Haematol (2013) 2.33
Identification of Hsp90 as a stimulatory host factor involved in influenza virus RNA synthesis. J Biol Chem (2002) 2.31
NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs. Mol Cell (2007) 2.24
MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem (2002) 2.22
Redox regulation of NF-kappaB activation: distinct redox regulation between the cytoplasm and the nucleus. Antioxid Redox Signal (2005) 2.16
Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II. Proc Natl Acad Sci U S A (2004) 2.01
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell (2013) 1.95
Mutations of the PAX6 gene detected in patients with a variety of optic-nerve malformations. Am J Hum Genet (2003) 1.94
Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types. Glycobiology (2006) 1.69
Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells. Blood (2008) 1.66
DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation. Genes Dev (2009) 1.64
Natural killer cell biology: an update and future directions. J Allergy Clin Immunol (2013) 1.56
Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons. Science (2008) 1.56
A new staging system to predict prognosis of patients with multiple myeloma in an era of novel therapeutic agents. Eur J Haematol (2014) 1.55
NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes. Mol Cell Biol (2005) 1.52
Detection of autoantibodies to precursor proteins of desmogleins in sera of a patient with Bowen carcinoma. Acta Derm Venereol (2014) 1.50
Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor. Genes Dev (2003) 1.47
Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression. Proc Natl Acad Sci U S A (2002) 1.44
Magnetically promoted rapid immunoreactions using functionalized fluorescent magnetic beads: a proof of principle. Clin Chem (2014) 1.41
A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science (2009) 1.40
Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. Mol Cell Biol (2004) 1.38
Primary Plasma Cell Leukemia in the Era of Novel Agents: A Multicenter Study of the Japanese Society of Myeloma. Acta Haematol (2015) 1.38
Molecular characterization of Drosophila NELF. Nucleic Acids Res (2005) 1.37
Spatial redox regulation of a critical cysteine residue of NF-kappa B in vivo. J Biol Chem (2002) 1.36
Nonfucosylated therapeutic IgG1 antibody can evade the inhibitory effect of serum immunoglobulin G on antibody-dependent cellular cytotoxicity through its high binding to FcgammaRIIIa. Clin Cancer Res (2006) 1.34
Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells. Genes Cells (2003) 1.34
Differential regulation of NF-kappaB by elongation factors is determined by core promoter type. Mol Cell Biol (2007) 1.33
A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Genes Dev (2009) 1.33
Biological activity of barbados cherry (acerola fruits, fruit of Malpighia emarginata DC) extracts and fractions. Phytother Res (2004) 1.32
Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair. J Biol Chem (2007) 1.32
Sialidase and malignancy: a minireview. Glycoconj J (2004) 1.32
Transcription elongation factors DSIF and NELF: promoter-proximal pausing and beyond. Biochim Biophys Acta (2012) 1.31
Matrix metalloproteinase-7 facilitates insulin-like growth factor bioavailability through its proteinase activity on insulin-like growth factor binding protein 3. Cancer Res (2004) 1.29
Elongation inhibition by DRB sensitivity-inducing factor is regulated by the A20 promoter via a novel negative element and NF-kappaB. Mol Cell Biol (2004) 1.28
A FOXO-Pak1 transcriptional pathway controls neuronal polarity. Genes Dev (2010) 1.27
Knock-down of 25 kDa subunit of cleavage factor Im in Hela cells alters alternative polyadenylation within 3'-UTRs. Nucleic Acids Res (2006) 1.26
A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9. Nat Struct Mol Biol (2009) 1.26
NTP-driven translocation by human RNA polymerase II. J Biol Chem (2003) 1.24
A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity. Nucleic Acids Res (2008) 1.22
A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains. J Biol Chem (2002) 1.20
Emotional memories are not all created equal: evidence for selective memory enhancement. Learn Mem (2006) 1.19
Migration of CX3CR1-positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritis. Arthritis Rheum (2002) 1.18
The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: therapeutic implications in tumor angiogenesis. J Cell Physiol (2009) 1.18
Multicenter validation of a reproducible flow cytometric score for the diagnosis of low-grade myelodysplastic syndromes: results of a European LeukemiaNET study. Haematologica (2012) 1.18
Effects of endogenous DNA base lesions on transcription elongation by mammalian RNA polymerase II. Implications for transcription-coupled DNA repair and transcriptional mutagenesis. J Biol Chem (2002) 1.18
Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol Cell Biol (2004) 1.15
Importance of Vp1 calcium-binding residues in assembly, cell entry, and nuclear entry of simian virus 40. J Virol (2003) 1.15
Primary bilateral adrenal diffuse large B-cell lymphoma demonstrating adrenal failure. Intern Med (2010) 1.14
Promoter-proximal pausing and its release: molecular mechanisms and physiological functions. Exp Cell Res (2010) 1.13
High Th1/Th2 ratio in patients with chronic idiopathic thrombocytopenic purpura. Eur J Haematol (2003) 1.12
GABP, HCF-1 and YY1 are involved in Rb gene expression during myogenesis. Genes Cells (2005) 1.11