Attenuation of estrogen receptor alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor.

PubWeight™: 2.35‹?› | Rank: Top 2%

🔗 View Article (PMC 515291)

Published in Genes Dev on September 01, 2004

Authors

Sarah E Aiyar1, Jian-long Sun, Ashley L Blair, Christopher A Moskaluk, Yun-zhe Lu, Qi-Nong Ye, Yuki Yamaguchi, Amitava Mukherjee, Da-ming Ren, Hiroshi Handa, Rong Li

Author Affiliations

1: Department of Biochemistry and Molecular Genetics, School of Medicine, University of Virginia, Charlottesville, Virginia 22908-0733, USA.

Articles citing this

RNA polymerase is poised for activation across the genome. Nat Genet (2007) 9.57

RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nat Genet (2007) 9.56

NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly. Genes Dev (2008) 3.69

NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila. Mol Cell Biol (2008) 3.11

Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation. Biochim Biophys Acta (2010) 2.86

Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB gene. Mol Cell Biol (2006) 2.40

Genomic analyses of transcription factor binding, histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters. Mol Cell Biol (2007) 2.33

Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling. Proc Natl Acad Sci U S A (2009) 1.83

Promoter proximal pausing on genes in metazoans. Chromosoma (2008) 1.64

A global view of transcriptional regulation by nuclear receptors: gene expression, factor localization, and DNA sequence analysis. Nucl Recept Signal (2008) 1.62

Postrecruitment regulation of RNA polymerase II directs rapid signaling responses at the promoters of estrogen target genes. Mol Cell Biol (2008) 1.60

Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex. Proc Natl Acad Sci U S A (2010) 1.55

Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway. J Clin Invest (2009) 1.39

Molecular characterization of Drosophila NELF. Nucleic Acids Res (2005) 1.37

A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS. Proc Natl Acad Sci U S A (2005) 1.36

BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes. Mol Cell Biol (2013) 1.35

Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL. Neoplasia (2007) 1.33

Promoter proximal pausing and the control of gene expression. Curr Opin Genet Dev (2011) 1.26

Transcriptional regulation of BRCA1 expression by a metabolic switch. Nat Struct Mol Biol (2010) 1.25

Kinetic competition between elongation rate and binding of NELF controls promoter-proximal pausing. Mol Cell (2013) 1.19

Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription. Cell Rep (2014) 1.19

Genome-wide analysis of alternative promoters of human genes using a custom promoter tiling array. BMC Genomics (2008) 1.15

What goes on behind closed doors: physiological versus pharmacological steroid hormone actions. Bioessays (2008) 1.11

Human negative elongation factor activates transcription and regulates alternative transcription initiation. J Biol Chem (2009) 1.09

Transcription termination factor Pcf11 limits the processivity of Pol II on an HIV provirus to repress gene expression. Genes Dev (2007) 1.04

HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb. Cancer Res (2008) 1.01

Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis. PLoS One (2009) 1.01

Gene-specific recruitment of positive and negative elongation factors during stimulated transcription of the MKP-1 gene in neuroendocrine cells. Nucleic Acids Res (2007) 1.00

Hormone-regulated transcriptomes: lessons learned from estrogen signaling pathways in breast cancer cells. Mol Cell Endocrinol (2013) 0.99

Hepatitis B virus X protein and the estrogen receptor variant lacking exon 5 inhibit estrogen receptor signaling in hepatoma cells. Nucleic Acids Res (2006) 0.98

Genetic and genomic analyses of RNA polymerase II-pausing factor in regulation of mammalian transcription and cell growth. J Biol Chem (2011) 0.97

Ready, pause, go: regulation of RNA polymerase II pausing and release by cellular signaling pathways. Trends Biochem Sci (2015) 0.96

Negative elongation factor accelerates the rate at which heat shock genes are shut off by facilitating dissociation of heat shock factor. Mol Cell Biol (2011) 0.96

Cofactor of BRCA1 modulates androgen-dependent transcription and alternative splicing. J Steroid Biochem Mol Biol (2007) 0.95

Cotranscriptional splicing potentiates the mRNA production from a subset of estradiol-stimulated genes. Mol Cell Biol (2008) 0.92

FHL1 interacts with oestrogen receptors and regulates breast cancer cell growth. J Cell Mol Med (2011) 0.92

Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription. J Biol Chem (2013) 0.92

Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells. Int J Biol Sci (2007) 0.91

Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle. Proc Natl Acad Sci U S A (2013) 0.91

NELF potentiates gene transcription in the Drosophila embryo. PLoS One (2010) 0.89

Module discovery by exhaustive search for densely connected, co-expressed regions in biomolecular interaction networks. PLoS One (2010) 0.86

A phosphotyrosine switch determines the antitumor activity of ERβ. J Clin Invest (2014) 0.86

A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties. J Biol Chem (2013) 0.86

Transcription factor Sp3 represses expression of p21CIP¹ via inhibition of productive elongation by RNA polymerase II. Mol Cell Biol (2013) 0.82

A Role of CREB in BRCA1 Constitutive Promoter Activity and Aromatase Basal Expression. Int J Biomed Sci (2008) 0.80

Translational Initiation at a Non-AUG Start Codon for Human and Mouse Negative Elongation Factor-B. PLoS One (2015) 0.80

Pausing for thought: disrupting the early transcription elongation checkpoint leads to developmental defects and tumourigenesis. Bioessays (2013) 0.79

RNA polymerase II pausing as a context-dependent reader of the genome. Biochem Cell Biol (2015) 0.77

Architecture and RNA binding of the human negative elongation factor. Elife (2016) 0.77

Trihydrophobin 1 phosphorylation by c-Src regulates MAPK/ERK signaling and cell migration. PLoS One (2012) 0.76

Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction. J Biol Chem (2015) 0.76

Enforcing the pause: transcription factor Sp3 limits productive elongation by RNA polymerase II. Cell Cycle (2013) 0.75

Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development. Nat Commun (2016) 0.75

Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer. Oncotarget (2016) 0.75

Articles cited by this

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods (2003) 18.51

Putting tumours in context. Nat Rev Cancer (2001) 12.37

An extensive network of coupling among gene expression machines. Nature (2002) 11.84

The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev (2000) 11.65

Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell (2000) 11.10

Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell (2003) 10.42

Combinatorial control of gene expression by nuclear receptors and coregulators. Cell (2002) 8.01

A unified theory of gene expression. Cell (2002) 7.61

NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Cell (1999) 6.34

Mechanisms of estrogen action. Physiol Rev (2001) 5.97

A slow RNA polymerase II affects alternative splicing in vivo. Mol Cell (2003) 5.82

Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol Cell (2000) 5.79

Transcription elongation factors repress transcription initiation from cryptic sites. Science (2003) 5.18

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev (1996) 5.17

Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae. Genes Dev (1998) 5.16

Endocrine-responsive breast cancer and strategies for combating resistance. Nat Rev Cancer (2002) 4.57

Disassembly of transcriptional regulatory complexes by molecular chaperones. Science (2002) 4.20

Estrogen receptor pathways to AP-1. J Steroid Biochem Mol Biol (2000) 3.96

High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation. Genes Dev (2000) 3.79

NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. Genes Dev (2003) 3.65

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. EMBO J (1999) 3.50

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription. Cell (1991) 3.46

The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation. Mol Cell (2000) 3.23

Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo. Science (2003) 3.22

RNA polymerase II elongation through chromatin. Nature (2000) 2.94

Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor. Nat Cell Biol (2001) 2.93

The mRNA assembly line: transcription and processing machines in the same factory. Curr Opin Cell Biol (2002) 2.89

Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster. Genes Dev (2000) 2.78

Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence. Proc Natl Acad Sci U S A (1989) 2.60

Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. Mol Cell Biol (2002) 2.59

Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. Mol Endocrinol (1997) 2.58

BRCA1 inhibition of estrogen receptor signaling in transfected cells. Science (1999) 2.54

The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. J Biol Chem (2001) 2.45

A superfamily of potentially oncogenic hormone receptors. Nature (1987) 2.40

Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. Mol Cell Biol (2003) 2.21

Taking the study of cancer cell survival to a new dimension. Cell (2002) 2.03

Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II. Proc Natl Acad Sci U S A (2004) 2.01

BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. J Cell Biol (2001) 1.96

Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms. Mol Cell (2003) 1.95

A regulator of transcriptional elongation controls vertebrate neuronal development. Nature (2000) 1.87

Role of direct interaction in BRCA1 inhibition of estrogen receptor activity. Oncogene (2001) 1.82

FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. Mol Cell (2000) 1.82

CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. Mol Cell (2003) 1.75

Ligand-independent activation of steroid hormone receptors. J Mol Med (Berl) (1998) 1.63

SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1. J Biol Chem (1997) 1.58

BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor. Proc Natl Acad Sci U S A (2001) 1.56

Estrogens in the causation of breast, endometrial and ovarian cancers - evidence and hypotheses from epidemiological findings. J Steroid Biochem Mol Biol (2000) 1.49

Estrogens and cell-cycle regulation in breast cancer. Trends Endocrinol Metab (2001) 1.43

ERAP140, a conserved tissue-specific nuclear receptor coactivator. Mol Cell Biol (2002) 1.34

Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activating protein SH3 domain. Mol Cell Biol (1994) 1.28

Elongation inhibition by DRB sensitivity-inducing factor is regulated by the A20 promoter via a novel negative element and NF-kappaB. Mol Cell Biol (2004) 1.28

Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity. Oncogene (1998) 1.22

Characterization of the proximal estrogen-responsive element of human cathepsin D gene. Mol Endocrinol (1994) 1.14

Transcription elongation: the 'Foggy' is liftingellipsis. Curr Biol (2001) 1.13

Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a potent transcriptional repression domain. J Biol Chem (2004) 1.11

Characterization of a novel trans-activation domain of BRCA1 that functions in concert with the BRCA1 C-terminal (BRCT) domain. J Biol Chem (2000) 1.06

JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction. Genes Dev (2002) 1.06

Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity. Mol Endocrinol (1996) 1.02

Enhancement of human estrogen receptor activity by SPT6: a potential coactivator. Mol Endocrinol (1995) 1.00

Identification and characterization of estrogen receptor variants in prostate cancer cell lines. J Steroid Biochem Mol Biol (2000) 0.88

Articles by these authors

Identification of a primary target of thalidomide teratogenicity. Science (2010) 7.09

Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science (2005) 6.88

An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis. Science (2010) 6.47

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nat Struct Mol Biol (2013) 4.04

Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science (2003) 3.92

Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J Clin Invest (2007) 3.89

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast. Nature (2010) 3.72

NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. Genes Dev (2003) 3.65

Cdx2 as a marker of epithelial intestinal differentiation in the esophagus. Am J Surg Pathol (2003) 3.59

Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Mol Cell (2005) 3.46

EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell (2009) 3.40

Aneuploidy underlies rapid adaptive evolution of yeast cells deprived of a conserved cytokinesis motor. Cell (2008) 3.26

Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions. Circulation (2008) 2.98

P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation. Mol Cell (2006) 2.92

A 20-gene model for molecular nodal staging of bladder cancer: development and prospective assessment. Lancet Oncol (2011) 2.89

The structural basis of actin filament branching by the Arp2/3 complex. J Cell Biol (2008) 2.82

The RickA protein of Rickettsia conorii activates the Arp2/3 complex. Nature (2004) 2.73

Motility and segregation of Hsp104-associated protein aggregates in budding yeast. Cell (2011) 2.72

Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p. Cell Host Microbe (2008) 2.68

Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity. Cell (2007) 2.61

Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. Mol Cell Biol (2002) 2.59

Robust cell polarity is a dynamic state established by coupling transport and GTPase signaling. J Cell Biol (2004) 2.56

Transcriptional pausing caused by NELF plays a dual role in regulating immediate-early expression of the junB gene. Mol Cell Biol (2006) 2.40

Rho1 directs formin-mediated actin ring assembly during budding yeast cytokinesis. Curr Biol (2002) 2.38

The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration. J Cell Biol (2012) 2.34

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.). Br J Haematol (2013) 2.33

Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. Proc Natl Acad Sci U S A (2003) 2.31

Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn's disease. Gastroenterology (2005) 2.30

The Ran GTPase mediates chromatin signaling to control cortical polarity during polar body extrusion in mouse oocytes. Dev Cell (2007) 2.27

NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs. Mol Cell (2007) 2.24

MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol Chem (2002) 2.22

Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. Mol Cell Biol (2003) 2.21

ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. J Clin Invest (2008) 2.16

Redox regulation of NF-kappaB activation: distinct redox regulation between the cytoplasm and the nucleus. Antioxid Redox Signal (2005) 2.16

Mapping dynamic protein interactions in MAP kinase signaling using live-cell fluorescence fluctuation spectroscopy and imaging. Proc Natl Acad Sci U S A (2007) 2.06

miR-99 family of MicroRNAs suppresses the expression of prostate-specific antigen and prostate cancer cell proliferation. Cancer Res (2011) 2.02

RhoGDI2 is an invasion and metastasis suppressor gene in human cancer. Cancer Res (2002) 2.01

Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II. Proc Natl Acad Sci U S A (2004) 2.01

Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma. Am J Pathol (2002) 1.94

Mitochondrial translocation of cofilin is an early step in apoptosis induction. Nat Cell Biol (2003) 1.94

Mutations of the PAX6 gene detected in patients with a variety of optic-nerve malformations. Am J Hum Genet (2003) 1.94

Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: the JALSG AML201 Study. Blood (2010) 1.93

Tissues from population-based cancer registries: a novel approach to increasing research potential. Hum Pathol (2005) 1.92

MicroRNA-204/211 alters epithelial physiology. FASEB J (2010) 1.83

TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis. Proc Natl Acad Sci U S A (2003) 1.82

Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy. Nature (2012) 1.82

Gastric cancers overexpress S100A calcium-binding proteins. Cancer Res (2002) 1.81

Unusual variants of Alexander's disease. Ann Neurol (2005) 1.76

Dual modes of cdc42 recycling fine-tune polarized morphogenesis. Dev Cell (2009) 1.73

Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes. Nat Cell Biol (2011) 1.73

CK20 and CK7 protein expression in colorectal cancer: demonstration of the utility of a population-based tissue microarray. Hum Pathol (2005) 1.72

Monitoring the safety of quadrivalent human papillomavirus vaccine: findings from the Vaccine Safety Datalink. Vaccine (2011) 1.70

Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited. Mol Biol Cell (2011) 1.68

Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease. Gastroenterology (2005) 1.66

Local injury to the endometrium in controlled ovarian hyperstimulation cycles improves implantation rates. Fertil Steril (2007) 1.65

Actin-driven chromosomal motility leads to symmetry breaking in mammalian meiotic oocytes. Nat Cell Biol (2008) 1.65

DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation. Genes Dev (2009) 1.64

microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells. Biochem Biophys Res Commun (2010) 1.63

The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T cells. J Immunol (2002) 1.63

Symmetry breaking in the life cycle of the budding yeast. Cold Spring Harb Perspect Biol (2009) 1.62

Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis. Gastroenterology (2003) 1.61

Cortactin regulates cell migration through activation of N-WASP. J Cell Sci (2004) 1.61

Spontaneous cell polarization: undermining determinism. Nat Cell Biol (2003) 1.59

A randomized comparison of 4 courses of standard-dose multiagent chemotherapy versus 3 courses of high-dose cytarabine alone in postremission therapy for acute myeloid leukemia in adults: the JALSG AML201 Study. Blood (2010) 1.57

A new staging system to predict prognosis of patients with multiple myeloma in an era of novel therapeutic agents. Eur J Haematol (2014) 1.55

Control of chemokine gradients by the retinal pigment epithelium. Invest Ophthalmol Vis Sci (2008) 1.55

ARPC1/Arc40 mediates the interaction of the actin-related protein 2 and 3 complex with Wiskott-Aldrich syndrome protein family activators. J Biol Chem (2004) 1.53

Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions. PLoS Biol (2005) 1.52

NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes. Mol Cell Biol (2005) 1.52

Cell cycle-regulated trafficking of Chs2 controls actomyosin ring stability during cytokinesis. Mol Biol Cell (2005) 1.49

Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. Mod Pathol (2011) 1.48

Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor. Genes Dev (2003) 1.47

Dynamics of yeast Myosin I: evidence for a possible role in scission of endocytic vesicles. Curr Biol (2004) 1.47

Large-scale molecular and tissue microarray analysis of mesothelin expression in common human carcinomas. Hum Pathol (2003) 1.44

Interpretation of RET immunostaining in follicular lesions of the thyroid. Am J Clin Pathol (2002) 1.43

Actin depolymerization drives actomyosin ring contraction during budding yeast cytokinesis. Dev Cell (2012) 1.41

Magnetically promoted rapid immunoreactions using functionalized fluorescent magnetic beads: a proof of principle. Clin Chem (2014) 1.41

Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet (2003) 1.40

Serum protein profiles in myasthenia gravis. Ann Thorac Surg (2009) 1.39

General regulatory factors (GRFs) as genome partitioners. J Biol Chem (2002) 1.39

Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet. Circ Res (2009) 1.39

Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. Mol Cell Biol (2004) 1.38

Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis. Neoplasia (2005) 1.38

Primary Plasma Cell Leukemia in the Era of Novel Agents: A Multicenter Study of the Japanese Society of Myeloma. Acta Haematol (2015) 1.38

Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer. Curr Opin Cell Biol (2010) 1.38

A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease. Nat Med (2008) 1.38

Molecular characterization of Drosophila NELF. Nucleic Acids Res (2005) 1.37

A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis. J Biol Chem (2004) 1.37