Published in Science on February 04, 2005
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Structural basis for cAMP-mediated allosteric control of the catabolite activator protein. Proc Natl Acad Sci U S A (2009) 2.39
Crystal structure and allosteric activation of protein kinase C βII. Cell (2011) 2.19
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Mapping the structure and conformational movements of proteins with transition metal ion FRET. Nat Methods (2009) 1.92
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Evolution of allostery in the cyclic nucleotide binding module. Genome Biol (2007) 1.44
Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philos Trans R Soc Lond B Biol Sci (2012) 1.40
Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors. Cancer Res (2008) 1.39
Structure and allostery of the PKA RIIβ tetrameric holoenzyme. Science (2012) 1.35
An electrostatic network and long-range regulation of Src kinases. Protein Sci (2008) 1.30
Contribution of non-catalytic core residues to activity and regulation in protein kinase A. J Biol Chem (2009) 1.29
A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. PLoS Comput Biol (2008) 1.29
Signaling through dynamic linkers as revealed by PKA. Proc Natl Acad Sci U S A (2013) 1.28
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure. EMBO J (2008) 1.27
PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A (2010) 1.24
Reversible acetylation and inactivation of Mycobacterium tuberculosis acetyl-CoA synthetase is dependent on cAMP. Biochemistry (2011) 1.17
Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. PLoS One (2011) 1.14
Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design. Mol Cell Proteomics (2010) 1.12
Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities. J Biol Chem (2009) 1.12
Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function. Proc Natl Acad Sci U S A (2014) 1.09
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Growth factor regulation of estrogen receptor coregulator PELP1 functions via Protein Kinase A pathway. Mol Cancer Res (2008) 1.07
3-D structure and dynamics of protein kinase B-new mechanism for the allosteric regulation of an AGC kinase. J Chem Biol (2009) 1.05
Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations. J Biol Chem (2010) 1.05
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. Biochem J (2006) 1.04
Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance. J Mol Biol (2006) 1.04
Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone. Proc Natl Acad Sci U S A (2010) 1.04
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Subcellular localization and biological actions of activated RSK1 are determined by its interactions with subunits of cyclic AMP-dependent protein kinase. Mol Cell Biol (2006) 1.03
Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis. Nat Struct Mol Biol (2012) 1.02
Localization and quaternary structure of the PKA RIβ holoenzyme. Proc Natl Acad Sci U S A (2012) 1.02
A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP. Protein Sci (2005) 1.01
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Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme. Structure (2011) 1.01
Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase. Nature (2010) 1.00
Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase. Mol Cell Proteomics (2010) 1.00
Selectivity in enrichment of cAMP-dependent protein kinase regulatory subunits type I and type II and their interactors using modified cAMP affinity resins. Mol Cell Proteomics (2008) 1.00
Phosphodiesterases catalyze hydrolysis of cAMP-bound to regulatory subunit of protein kinase A and mediate signal termination. Mol Cell Proteomics (2010) 0.99
Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling. Biophys J (2014) 0.98
A measured approach: determining the PLCγ1 docking site on Itk using a biochemical ruler. J Mol Biol (2012) 0.95
Conservation, variability and the modeling of active protein kinases. PLoS One (2007) 0.95
Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. Arch Biochem Biophys (2013) 0.95
Dissecting the cAMP-inducible allosteric switch in protein kinase A RIalpha. Protein Sci (2010) 0.94
The PKARIalpha subunit of protein kinase A modulates the activation of p90RSK1 and its function. J Biol Chem (2009) 0.94
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A tool set to map allosteric networks through the NMR chemical shift covariance analysis. Sci Rep (2014) 0.93
Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain. Biochim Biophys Acta (2006) 0.93
A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J Mol Biol (2011) 0.92
The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes. PLoS Pathog (2014) 0.92
Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: insights for cGMP-dependent protein kinase agonist design. Biochemistry (2014) 0.91
ATP competitive protein kinase C inhibitors demonstrate distinct state-dependent inhibition. PLoS One (2011) 0.90
Gating of the MlotiK1 potassium channel involves large rearrangements of the cyclic nucleotide-binding domains. Proc Natl Acad Sci U S A (2011) 0.90
The cAMP pathway and the control of adrenocortical development and growth. Mol Cell Endocrinol (2011) 0.90
Dissecting the mechanism of Epac activation via hydrogen-deuterium exchange FT-IR and structural modeling. Biochemistry (2006) 0.90
Evolutionary paths of the cAMP-dependent protein kinase (PKA) catalytic subunits. PLoS One (2013) 0.90
Structural insights into mis-regulation of protein kinase A in human tumors. Proc Natl Acad Sci U S A (2015) 0.89
The pharmacology of cyclic nucleotide-gated channels: emerging from the darkness. Curr Pharm Des (2006) 0.89
R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry. J Mol Biol (2007) 0.88
Analysis of conformational changes during activation of protein kinase Pak2 by amide hydrogen/deuterium exchange. J Biol Chem (2008) 0.88
Analysis of protein kinase autophosphorylation using expressed protein ligation and computational modeling. J Am Chem Soc (2008) 0.88
Structure of yeast regulatory subunit: a glimpse into the evolution of PKA signaling. Structure (2010) 0.88
Structural insight into nucleotide recognition by human death-associated protein kinase. Acta Crystallogr D Biol Crystallogr (2009) 0.88
Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A. Anal Chem (2006) 0.87
Yeast 3-phosphoinositide-dependent protein kinase-1 (PDK1) orthologs Pkh1-3 differentially regulate phosphorylation of protein kinase A (PKA) and the protein kinase B (PKB)/S6K ortholog Sch9. J Biol Chem (2011) 0.87
Sensing domain dynamics in protein kinase A-I{alpha} complexes by solution X-ray scattering. J Biol Chem (2009) 0.87
On the Application of Molecular-Dynamics Based Markov State Models to Functional Proteins. J Chem Theory Comput (2014) 0.86
Divergence of protein kinase A catalytic subunits in Cryptococcus neoformans and Cryptococcus gattii illustrates evolutionary reconfiguration of a signaling cascade. Eukaryot Cell (2006) 0.86
Identifying critical non-catalytic residues that modulate protein kinase A activity. PLoS One (2009) 0.86
Allostery through the computational microscope: cAMP activation of a canonical signalling domain. Nat Commun (2015) 0.85
Exploring the interaction between the protein kinase A catalytic subunit and caveolin-1 scaffolding domain with shotgun scanning, oligomer complementation, NMR, and docking. Protein Sci (2006) 0.85
Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling. Biophys J (2015) 0.84
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Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIα activation in response to cAMP binding. J Biol Chem (2014) 0.83
A cancer-derived mutation in the PSTAIRE helix of cyclin-dependent kinase 2 alters the stability of cyclin binding. Biochim Biophys Acta (2010) 0.82
Phosphodiesterase function and endocrine cells: links to human disease and roles in tumor development and treatment. Curr Opin Pharmacol (2011) 0.82
Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry. J Biol Chem (2009) 0.82
p90 ribosomal S6 kinase 1 (RSK1) and the catalytic subunit of protein kinase A (PKA) compete for binding the pseudosubstrate region of PKAR1alpha: role in the regulation of PKA and RSK1 activities. J Biol Chem (2010) 0.82
PKA RIα homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease. Structure (2013) 0.82
Phosphoryl Transfer Reaction Snapshots in Crystals: INSIGHTS INTO THE MECHANISM OF PROTEIN KINASE A CATALYTIC SUBUNIT. J Biol Chem (2015) 0.81
Structural and mechanistic insights into the bifunctional enzyme isocitrate dehydrogenase kinase/phosphatase AceK. Philos Trans R Soc Lond B Biol Sci (2012) 0.81
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Targeting protein kinase A in cancer therapy: an update. EXCLI J (2014) 0.80
Structure and dynamics underlying elementary ligand binding events in human pacemaking channels. Elife (2016) 0.80
Proteolytic regulation of the mitochondrial cAMP-dependent protein kinase. Biochemistry (2012) 0.79
The identification of novel cyclic AMP-dependent protein kinase anchoring proteins using bioinformatic filters and peptide arrays. Protein Eng Des Sel (2010) 0.79
The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol (2007) 13.99
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00
Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proc Natl Acad Sci U S A (2006) 4.09
Structural and functional diversity of the microbial kinome. PLoS Biol (2007) 3.74
PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell (2007) 3.19
The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module. Proc Natl Acad Sci U S A (2007) 2.65
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature (2005) 2.54
A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A (2008) 2.51
The cAMP binding domain: an ancient signaling module. Proc Natl Acad Sci U S A (2004) 2.32
A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell (2006) 2.27
Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase. Nat Struct Biol (2002) 2.07
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Dynamics connect substrate recognition to catalysis in protein kinase A. Nat Chem Biol (2010) 1.95
ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem (2010) 1.91
cAMP activation of PKA defines an ancient signaling mechanism. Proc Natl Acad Sci U S A (2006) 1.79
Initial evaluation of a direct detection device detector for single particle cryo-electron microscopy. J Struct Biol (2011) 1.77
Defining the conserved internal architecture of a protein kinase. Biochim Biophys Acta (2009) 1.76
Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol (2013) 1.75
Applications of direct detection device in transmission electron microscopy. J Struct Biol (2007) 1.70
Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure. J Mol Biol (2003) 1.68
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol (2007) 1.66
Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy. Proc Natl Acad Sci U S A (2011) 1.65
Designing isoform-specific peptide disruptors of protein kinase A localization. Proc Natl Acad Sci U S A (2003) 1.61
PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity. Science (2007) 1.61
Allosteric activation of functionally asymmetric RAF kinase dimers. Cell (2013) 1.60
Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. J Phys Chem B (2007) 1.55
Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Mol Biol (2004) 1.51
Active pixel sensor array as a detector for electron microscopy. Ultramicroscopy (2005) 1.49
The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. J Biol Chem (2008) 1.47
Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. Proteins (2002) 1.45
Evolution of allostery in the cyclic nucleotide binding module. Genome Biol (2007) 1.44
Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc Natl Acad Sci U S A (2011) 1.44
A-kinase-interacting protein localizes protein kinase A in the nucleus. Proc Natl Acad Sci U S A (2005) 1.43
Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev (2013) 1.40
Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family. J Mol Evol (2002) 1.38
Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity. Structure (2010) 1.36
Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A. J Mol Biol (2002) 1.36
Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase. J Mol Biol (2005) 1.35
PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells. Kidney Int (2003) 1.35
Structure and allostery of the PKA RIIβ tetrameric holoenzyme. Science (2012) 1.35
Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol (2014) 1.34
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proc Natl Acad Sci U S A (2003) 1.33
Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism. J Mol Biol (2004) 1.32
Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange. Protein Sci (2005) 1.32
Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nat Cell Biol (2007) 1.31
Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1. J Biol Chem (2002) 1.30
A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. PLoS Comput Biol (2008) 1.29
Dynamics of cAPK type IIbeta activation revealed by enhanced amide H/2H exchange mass spectrometry (DXMS). J Mol Biol (2003) 1.29
Contribution of non-catalytic core residues to activity and regulation in protein kinase A. J Biol Chem (2009) 1.29
Signaling through dynamic linkers as revealed by PKA. Proc Natl Acad Sci U S A (2013) 1.28
An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proc Natl Acad Sci U S A (2011) 1.27
Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification. J Biol Chem (2004) 1.27
Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. Chem Biol (2007) 1.23
Consequences of lysine 72 mutation on the phosphorylation and activation state of cAMP-dependent kinase. J Biol Chem (2004) 1.23
Global consequences of activation loop phosphorylation on protein kinase A. J Biol Chem (2009) 1.21
Related protein-protein interaction modules present drastically different surface topographies despite a conserved helical platform. J Mol Biol (2003) 1.20
Regulation of cAMP-dependent protein kinase activity by glutathionylation. J Biol Chem (2002) 1.20
cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP. J Biol Chem (2003) 1.17
RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B. Structure (2004) 1.16
Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem (2012) 1.14
Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking. Proc Natl Acad Sci U S A (2003) 1.12
Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design. Mol Cell Proteomics (2010) 1.12
RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B. Cancer Res (2006) 1.12
C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change. J Biol Chem (2004) 1.12
A chimeric mechanism for polyvalent trans-phosphorylation of PKA by PDK1. Protein Sci (2009) 1.11
Congenital disease SNPs target lineage specific structural elements in protein kinases. Proc Natl Acad Sci U S A (2008) 1.11
Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix. Protein Sci (2005) 1.11
A transition path ensemble study reveals a linchpin role for Mg(2+) during rate-limiting ADP release from protein kinase A. Biochemistry (2009) 1.10
Kinases and pseudokinases: lessons from RAF. Mol Cell Biol (2014) 1.10
Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space. J Biol Chem (2012) 1.08
Structural basis for peptide binding in protein kinase A. Role of glutamic acid 203 and tyrosine 204 in the peptide-positioning loop. J Biol Chem (2002) 1.08
Comparative surface geometry of the protein kinase family. Protein Sci (2009) 1.08
Differential effects of substrate on type I and type II PKA holoenzyme dissociation. Biochemistry (2004) 1.07
Dynamic binding of PKA regulatory subunit RI alpha. Structure (2006) 1.07
Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions. J Mol Biol (2004) 1.07
D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. J Biol Chem (2009) 1.06
A molecular switch for targeting between endoplasmic reticulum (ER) and mitochondria: conversion of a mitochondria-targeting element into an ER-targeting signal in DAKAP1. J Biol Chem (2008) 1.05
Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations. J Biol Chem (2010) 1.05
Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. J Biol Chem (2010) 1.04
Characterization of a direct detection device imaging camera for transmission electron microscopy. Ultramicroscopy (2010) 1.03
Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures. J Mol Biol (2009) 1.03
A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. J Biol Chem (2012) 1.02
Solution scattering reveals large differences in the global structures of type II protein kinase A isoforms. J Mol Biol (2006) 1.02
Localization and quaternary structure of the PKA RIβ holoenzyme. Proc Natl Acad Sci U S A (2012) 1.02
A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP. Protein Sci (2005) 1.01
Protein kinase resource: an integrated environment for phosphorylation research. Proteins (2006) 1.01
Phosphoryl transfer by protein kinase A is captured in a crystal lattice. J Am Chem Soc (2013) 1.01
Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme. Structure (2011) 1.01
Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure (2011) 1.01
Conserved spatial patterns across the protein kinase family. Biochim Biophys Acta (2007) 1.00
Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase. Mol Cell Proteomics (2010) 1.00
The rate of NF-κB nuclear translocation is regulated by PKA and A kinase interacting protein 1. PLoS One (2011) 0.99
Pseudokinases: functional insights gleaned from structure. Structure (2009) 0.99
Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). J Biol Chem (2011) 0.98