Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock.

Active and passive cigarette smoking and acute lung injury after severe blunt trauma. Am J Respir Crit Care Med (2011) 2.39

Racial and ethnic disparities in mortality from acute lung injury. Crit Care Med (2009) 2.14

Chronic alcohol ingestion primes the lung for bleomycin-induced fibrosis in mice. Alcohol Clin Exp Res (2013) 1.49

Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion (2014) 1.49

Chronic alcoholism alters systemic and pulmonary glutathione redox status. Am J Respir Crit Care Med (2007) 1.47

Zinc deficiency mediates alcohol-induced alveolar epithelial and macrophage dysfunction in rats. Am J Respir Cell Mol Biol (2008) 1.28

Chronic ethanol ingestion increases superoxide production and NADPH oxidase expression in the lung. Am J Respir Cell Mol Biol (2005) 1.24

Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats. Alcohol (2007) 1.24

The presence of resilience is associated with a healthier psychological profile in intensive care unit (ICU) nurses: results of a national survey. Int J Nurs Stud (2011) 1.21

Ethanol induces oxidative stress in alveolar macrophages via upregulation of NADPH oxidases. J Immunol (2012) 1.11

The epidemiology of acute respiratory distress syndrome in patients presenting to the emergency department with severe sepsis. Shock (2013) 1.10

Strategies to optimize analgesia and sedation. Crit Care (2008) 1.08

Healthcare disparities in critical illness. Crit Care Med (2013) 1.08

Alcohol-use disorders in the critically ill patient. Chest (2010) 1.07

Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury. Am J Physiol Gastrointest Liver Physiol (2012) 1.07

Inflection points in sepsis biology: from local defense to systemic organ injury. Am J Physiol Lung Cell Mol Physiol (2012) 1.06

Alcohol abuse and pulmonary disease. J Leukoc Biol (2009) 1.06

Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory response. Alcohol Clin Exp Res (2010) 1.03

An alternative method of acute lung injury classification for use in observational studies. Chest (2010) 1.02

Alcoholism causes alveolar macrophage zinc deficiency and immune dysfunction. Am J Respir Crit Care Med (2013) 1.00

Claudins: control of barrier function and regulation in response to oxidant stress. Antioxid Redox Signal (2011) 1.00

Chronic alcohol ingestion increases mortality and organ injury in a murine model of septic peritonitis. PLoS One (2013) 0.96

Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats. Alcohol Clin Exp Res (2011) 0.95

Claudins: Gatekeepers of lung epithelial function. Semin Cell Dev Biol (2015) 0.94

Cross-talk between pulmonary injury, oxidant stress, and gap junctional communication. Antioxid Redox Signal (2009) 0.94

Chronic ethanol ingestion increases nitric oxide production in the lung. Alcohol (2007) 0.93

Roles for claudins in alveolar epithelial barrier function. Ann N Y Acad Sci (2012) 0.92

Alcohol abuse enhances pulmonary edema in acute respiratory distress syndrome. Alcohol Clin Exp Res (2009) 0.91

Experimental models and emerging hypotheses for acute lung injury. Crit Care Clin (2011) 0.91

Prevalence and impact of alcohol and other drug use disorders on sedation and mechanical ventilation: a retrospective study. BMC Anesthesiol (2007) 0.91

High-performance detection and early prediction of septic shock for alcohol-use disorder patients. Ann Med Surg (Lond) (2016) 0.91

Blood alcohol content, injury severity, and adult respiratory distress syndrome. J Trauma Acute Care Surg (2014) 0.90

Genetic epidemiology of acute respiratory distress syndrome: implications for future prevention and treatment. Clin Chest Med (2006) 0.90

The acute respiratory distress syndrome. Proc (Bayl Univ Med Cent) (2015) 0.90

Alcohol causes alveolar epithelial oxidative stress by inhibiting the nuclear factor (erythroid-derived 2)-like 2-antioxidant response element signaling pathway. Am J Respir Cell Mol Biol (2013) 0.89

PPARγ ligands regulate NADPH oxidase, eNOS, and barrier function in the lung following chronic alcohol ingestion. Alcohol Clin Exp Res (2011) 0.89

Na,K-ATPase expression is increased in the lungs of alcohol-fed rats. Alcohol Clin Exp Res (2008) 0.89

Ethanol alters alveolar fluid balance via Nadph oxidase (NOX) signaling to epithelial sodium channels (ENaC) in the lung. PLoS One (2013) 0.88

N-acetylcysteine improves group B streptococcus clearance in a rat model of chronic ethanol ingestion. Alcohol Clin Exp Res (2009) 0.88

Chronic-alcohol-abuse-induced oxidative stress in the development of acute respiratory distress syndrome. ScientificWorldJournal (2012) 0.88

Alcoholic lung disease. Alcohol Res Health (2008) 0.88

Alcohol primes the airway for increased interleukin-13 signaling. Alcohol Clin Exp Res (2008) 0.87

Pathoanatomy and clinical correlates of the immunoinflammatory response following orthopaedic trauma. J Am Acad Orthop Surg (2009) 0.86

Glutathione attenuates ethanol-induced alveolar macrophage oxidative stress and dysfunction by downregulating NADPH oxidases. Am J Physiol Lung Cell Mol Physiol (2014) 0.86

Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs. Am J Transplant (2014) 0.86

Non-invasive evaluation of pulmonary glutathione in the exhaled breath condensate of otherwise healthy alcoholics. Respir Med (2007) 0.85

Alcohol ingestion disrupts alveolar epithelial barrier function by activation of macrophage-derived transforming growth factor beta1. Respir Res (2013) 0.85

The effects of alcohol abuse on pulmonary alveolar-capillary barrier function in humans. Alcohol Alcohol (2008) 0.85

Alcohol screening scores and 90-day outcomes in patients with acute lung injury. Crit Care Med (2013) 0.84

The relative balance of GM-CSF and TGF-β1 regulates lung epithelial barrier function. Am J Physiol Lung Cell Mol Physiol (2015) 0.84

Alveolar type II cells from ethanol-fed rats produce a fibronectin-enriched extracellular matrix that promotes monocyte activation. Alcohol (2007) 0.83

Chronic alcohol ingestion changes the landscape of the alveolar epithelium. Biomed Res Int (2012) 0.83

Severity of acute illness is associated with baseline readiness to change in medical intensive care unit patients with unhealthy alcohol use. Alcohol Clin Exp Res (2011) 0.82

TGFβ1 mediates alcohol-induced Nrf2 suppression in lung fibroblasts. Alcohol Clin Exp Res (2014) 0.81

Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med (2016) 0.81

Facilitators and barriers to initiating change in medical intensive care unit survivors with alcohol use disorders: a qualitative study. J Crit Care (2013) 0.81

Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders. Am J Physiol Lung Cell Mol Physiol (2012) 0.80

Alcohol ingestion by donors amplifies experimental airway disease after heterotopic transplantation. Am J Respir Crit Care Med (2007) 0.80

Environmental risk factors for acute respiratory distress syndrome. Clin Chest Med (2014) 0.80

Alcoholism and critical illness: A review. World J Crit Care Med (2016) 0.79

Brief Versus Full Alcohol Use Disorders Identification Test in National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network Clinical Trials. Crit Care Med (2015) 0.79

Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 receptor. PLoS One (2012) 0.79

Pre-B-cell colony-enhancing factor and its clinical correlates with acute lung injury and sepsis. Chest (2011) 0.78

Delayed resuscitation with physostigmine increases end organ damage in alcohol intoxicated rats. Shock (2011) 0.78

Wine, spirits and the lung: good, bad or indifferent? Trans Am Clin Climatol Assoc (2006) 0.78

Relationship between alcohol use disorders, cortisol concentrations, and cytokine levels in patients with sepsis. Crit Care (2010) 0.78

Gastroduodenal perfusion and mortality in mechanical ventilation-dependent patients with systemic inflammatory response syndrome. Dig Dis Sci (2004) 0.77

Focus on the lung. Alcohol Res Health (2010) 0.76

Alcohol abuse and smoking alter inflammatory mediator production by pulmonary and systemic immune cells. Am J Physiol Lung Cell Mol Physiol (2016) 0.76

A longitudinal investigation of alcohol use over the course of the year following medical-surgical intensive care unit admission. Psychosomatics (2013) 0.76

Peroxisome Proliferator-Activated Receptor γ Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction. Am J Respir Cell Mol Biol (2016) 0.76

The impact of cardiac dysfunction on acute respiratory distress syndrome and mortality in mechanically ventilated patients with severe sepsis and septic shock: an observational study. J Crit Care (2014) 0.76

Power of Place: Intravascular Superoxide Dismutase for Prevention of Acute Respiratory Distress Syndrome. Am J Respir Cell Mol Biol (2017) 0.75

Chronic alcohol exposure, infection, extended circulating white blood cells differentiated by flow cytometry and neutrophil CD64 expression: a prospective, descriptive study of critically ill medical patients. Ann Intensive Care (2012) 0.75

Alcohol and lung injury and immunity. Alcohol (2016) 0.75

The role of donor chronic alcohol abuse in the development of primary graft dysfunction in lung transplant recipients. Am J Med Sci (2015) 0.75

Plasminogen Activator Inhibitor-1 is Critical in Alcohol-enhanced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol (2017) 0.75

Alcohol and the Lung. Alcohol Res (2017) 0.75

Organ-Organ Crosstalk and Alcoholic Liver Disease. Biomolecules (2017) 0.75

The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med (2003) 32.30

Incidence and outcomes of acute lung injury. N Engl J Med (2005) 21.56

Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med (2006) 9.52

Training mentors of clinical and translational research scholars: a randomized controlled trial. Acad Med (2014) 3.47

Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit Care Med (2007) 3.31

An appraisal of multivariable logistic models in the pulmonary and critical care literature. Chest (2003) 3.17

Accurate characterization of extravascular lung water in acute respiratory distress syndrome. Crit Care Med (2008) 2.94

Incidence of acute lung injury in the United States. Crit Care Med (2003) 2.93

Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med (2007) 2.79

Causes and timing of death in patients with ARDS. Chest (2005) 2.72

Collaterals dramatically alter stroke risk in intracranial atherosclerosis. Ann Neurol (2011) 2.62

Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Am J Respir Crit Care Med (2004) 2.49

Evaluation of a standardized order form for the withdrawal of life support in the intensive care unit. Crit Care Med (2004) 2.42

Ventilation of patients with acute lung injury and acute respiratory distress syndrome: has new evidence changed clinical practice? Crit Care Med (2004) 2.33

A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury. Crit Care Med (2011) 2.27

Barriers to providing lung-protective ventilation to patients with acute lung injury. Crit Care Med (2004) 2.20

Effect of acute lung injury and acute respiratory distress syndrome on outcome in critically ill trauma patients. Crit Care Med (2004) 2.20

Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27-28 April 2006. Intensive Care Med (2007) 2.18

Predictors of hospital mortality in a population-based cohort of patients with acute lung injury. Crit Care Med (2008) 2.09

Multisociety Task Force for Critical Care Research: key issues and recommendations. Crit Care Med (2012) 2.05

Cytokines and alcohol. Alcohol Clin Exp Res (2006) 2.04

The association between body mass index and clinical outcomes in acute lung injury. Chest (2007) 1.96

Integrating palliative and critical care: evaluation of a quality-improvement intervention. Am J Respir Crit Care Med (2008) 1.96

Hypercapnic acidosis and mortality in acute lung injury. Crit Care Med (2006) 1.93

A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury. Crit Care Med (2012) 1.92

The case for 24/7 in-house intensivist coverage. Am J Respir Crit Care Med (2010) 1.89

Intensivist physician staffing and the process of care in academic medical centres. Qual Saf Health Care (2007) 1.89

Extravascular lung water in patients with severe sepsis: a prospective cohort study. Crit Care (2005) 1.86

Gender differences in outcomes among patients with symptomatic intracranial arterial stenosis. Stroke (2007) 1.81

Factors associated with nurse assessment of the quality of dying and death in the intensive care unit. Crit Care Med (2004) 1.77

Intensive care unit-acquired neuromyopathy and corticosteroids in survivors of persistent ARDS. Intensive Care Med (2008) 1.76

The association between BMI and plasma cytokine levels in patients with acute lung injury. Chest (2010) 1.75

Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med (2007) 1.73

Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials. Crit Care Med (2010) 1.71

Diurnal variation in glutathione and cysteine redox states in human plasma. Am J Clin Nutr (2007) 1.66

ARDSNet lower tidal volume ventilatory strategy may generate intrinsic positive end-expiratory pressure in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med (2002) 1.65

Mentoring translational science investigators. JAMA (2012) 1.65

The acute pulmonary inflammatory response to the graded severity of smoke inhalation injury. Crit Care Med (2012) 1.62

Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury. Intensive Care Med (2008) 1.61

Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock. Crit Care Med (2010) 1.60

Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium. Crit Care Med (2012) 1.59

Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage. J Immunol (2005) 1.59

The alcoholic lung: epidemiology, pathophysiology, and potential therapies. Am J Physiol Lung Cell Mol Physiol (2007) 1.58

Effect of intensive care unit organizational model and structure on outcomes in patients with acute lung injury. Am J Respir Crit Care Med (2007) 1.58

Effect of age on the development of ARDS in trauma patients. Chest (2003) 1.57

Clinical decisions. Care of an unresponsive patient with a poor prognosis. N Engl J Med (2009) 1.56

Strategies for Developing and Recognizing Faculty Working in Quality Improvement and Patient Safety. Acad Med (2017) 1.55

Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome. Ann Intern Med (2002) 1.49

Chronic alcohol ingestion primes the lung for bleomycin-induced fibrosis in mice. Alcohol Clin Exp Res (2013) 1.49

Chronic alcoholism alters systemic and pulmonary glutathione redox status. Am J Respir Crit Care Med (2007) 1.47

Plasma granulocyte colony-stimulating factor levels correlate with clinical outcomes in patients with acute lung injury. Crit Care Med (2009) 1.47

Bronchoalveolar lavage neuregulin-1 is elevated in acute lung injury and correlates with inflammation. Eur Respir J (2012) 1.46

Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies. Chest (2006) 1.45

Glutathione replacement preserves the functional surfactant phospholipid pool size and decreases sepsis-mediated lung dysfunction in ethanol-fed rats. Alcohol Clin Exp Res (2002) 1.40

Transforming growth factor beta1 expression and activation is increased in the alcoholic rat lung. Am J Respir Crit Care Med (2004) 1.39

Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats. Proc Natl Acad Sci U S A (2010) 1.38

Angiogenic and lymphangiogenic microvessel density in breast carcinoma: correlation with clinicopathologic parameters and VEGF-family gene expression. Mod Pathol (2005) 1.34

Integrating palliative and critical care: description of an intervention. Crit Care Med (2006) 1.34

Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury. Crit Care Med (2011) 1.31

Insulin resistance is associated with decreased quadriceps muscle strength in nondiabetic adults aged >or=70 years. Diabetes Care (2009) 1.29

Zinc deficiency mediates alcohol-induced alveolar epithelial and macrophage dysfunction in rats. Am J Respir Cell Mol Biol (2008) 1.28

Chronic alcohol abuse, acute respiratory distress syndrome, and multiple organ dysfunction. Crit Care Med (2003) 1.27

GM-CSF receptor expression and signaling is decreased in lungs of ethanol-fed rats. Am J Physiol Lung Cell Mol Physiol (2006) 1.26

Neuromuscular sequelae of critical illness. N Engl J Med (2003) 1.25

Chronic ethanol ingestion increases superoxide production and NADPH oxidase expression in the lung. Am J Respir Cell Mol Biol (2005) 1.24

Angiotensin II mediates glutathione depletion, transforming growth factor-beta1 expression, and epithelial barrier dysfunction in the alcoholic rat lung. Am J Physiol Lung Cell Mol Physiol (2005) 1.24

Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats. Alcohol (2007) 1.24

Narcotic and benzodiazepine use after withdrawal of life support: association with time to death? Chest (2004) 1.21

Cost-effectiveness of implementing low-tidal volume ventilation in patients with acute lung injury. Chest (2009) 1.17

Measurement issues related to data collection on the World Wide Web. ANS Adv Nurs Sci (2003) 1.17

Shortening the Miles to the Milestones: Connecting EPA-Based Evaluations to ACGME Milestone Reports for Internal Medicine Residency Programs. Acad Med (2016) 1.16

Intratumoral heterogeneity of immunohistochemical marker expression in breast carcinoma: a tissue microarray-based study. Appl Immunohistochem Mol Morphol (2010) 1.15

Postextubation dysphagia is persistent and associated with poor outcomes in survivors of critical illness. Crit Care (2011) 1.15

Granulocyte/macrophage colony-stimulating factor treatment improves alveolar epithelial barrier function in alcoholic rat lung. Am J Physiol Lung Cell Mol Physiol (2003) 1.14

Zinc supplementation restores PU.1 and Nrf2 nuclear binding in alveolar macrophages and improves redox balance and bacterial clearance in the lungs of alcohol-fed rats. Alcohol Clin Exp Res (2011) 1.10

HIV-1-transgene expression in rats decreases alveolar macrophage zinc levels and phagocytosis. Am J Respir Cell Mol Biol (2008) 1.08

Collateral circulation in symptomatic intracranial atherosclerosis. J Cereb Blood Flow Metab (2010) 1.08

The prevalence and impact of post traumatic stress disorder and burnout syndrome in nurses. Depress Anxiety (2009) 1.07

Efficacy of parenteral nutrition supplemented with glutamine dipeptide to decrease hospital infections in critically ill surgical patients. JPEN J Parenter Enteral Nutr (2008) 1.07

Alcohol abuse and pulmonary disease. J Leukoc Biol (2009) 1.06

The effect of an intensive care unit staffing model on tidal volume in patients with acute lung injury. Crit Care (2008) 1.06

HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction. AIDS Res Ther (2009) 1.05

Axial elongation following cataract surgery during the first year of life in the infant Aphakia Treatment Study. Invest Ophthalmol Vis Sci (2012) 1.05

PEEP or no PEEP--lung recruitment may be the solution. N Engl J Med (2006) 1.04

Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory response. Alcohol Clin Exp Res (2010) 1.03

Oxidant-induced atrogin-1 and transforming growth factor-beta1 precede alcohol-related myopathy in rats. Muscle Nerve (2007) 1.02

Alcohol use disorders increase the risk for mechanical ventilation in medical patients. Alcohol Clin Exp Res (2007) 1.02

Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats. Am J Physiol Lung Cell Mol Physiol (2013) 1.01

Alcoholism causes alveolar macrophage zinc deficiency and immune dysfunction. Am J Respir Crit Care Med (2013) 1.00

Metabolomics of bronchoalveolar lavage differentiate healthy HIV-1-infected subjects from controls. AIDS Res Hum Retroviruses (2014) 1.00

The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation. Surgery (2011) 0.99

Recruitment and retention in academic medicine--what junior faculty and trainees want department chairs to know. Am J Med Sci (2012) 0.99

Alcohol abuse, the alveolar macrophage and pneumonia. Am J Med Sci (2012) 0.98

Healthy HIV-1-infected individuals on highly active antiretroviral therapy harbor HIV-1 in their alveolar macrophages. AIDS Res Hum Retroviruses (2015) 0.97

Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration. Am J Physiol Heart Circ Physiol (2008) 0.97

Effect of HIV-1-related protein expression on cardiac and skeletal muscles from transgenic rats. AIDS Res Ther (2008) 0.96

Multisociety task force for critical care research: key issues and recommendations. Am J Respir Crit Care Med (2012) 0.96