Published in Ann Intern Med on January 01, 2002
Acute Respiratory Distress Syndrome Clinical Network (ARDSNet) | NCT00000579
A Study Promoting Critical Illness Recovery in the Elderly-- Pilot (ASPIRE) | NCT02963558
MIND-ICU Study: Delirium and Dementia in Veterans Surviving ICU Care | NCT00400062
Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med (2010) 2.28
Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis. Crit Care (2009) 1.94
Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials. Crit Care Med (2010) 1.71
Acute respiratory distress syndrome: a historical perspective. Am J Respir Crit Care Med (2005) 1.69
Predictors of mortality in acute lung injury during the era of lung protective ventilation. Thorax (2008) 1.65
Factors that predict outcome of intensive care treatment in very elderly patients: a review. Crit Care (2005) 1.37
Respiratory impairment and the aging lung: a novel paradigm for assessing pulmonary function. J Gerontol A Biol Sci Med Sci (2011) 1.28
The pulmonary physician in critical care. 5: Acute lung injury and the acute respiratory distress syndrome: definitions and epidemiology. Thorax (2002) 1.27
Liberation and animation for ventilated ICU patients: the ABCDE bundle for the back-end of critical care. Crit Care (2010) 1.23
Acute respiratory distress syndrome. BMJ (2007) 1.18
Toward an integrated research agenda for critical illness in aging. Am J Respir Crit Care Med (2010) 1.10
Prediction of death and prolonged mechanical ventilation in acute lung injury. Crit Care (2007) 1.07
Aging and the pathogenic response to burn. Aging Dis (2011) 1.01
Understanding and reducing disability in older adults following critical illness. Crit Care Med (2015) 0.96
Aging and animal models of systemic insult: trauma, burn, and sepsis. Shock (2009) 0.96
Severe sepsis and septic shock in the elderly: An overview. World J Crit Care Med (2012) 0.91
Genetic epidemiology of acute respiratory distress syndrome: implications for future prevention and treatment. Clin Chest Med (2006) 0.90
The acute respiratory distress syndrome. Proc (Bayl Univ Med Cent) (2015) 0.90
Fibroproliferative changes on high-resolution CT in the acute respiratory distress syndrome predict mortality and ventilator dependency: a prospective observational cohort study. BMJ Open (2012) 0.90
Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation. Aging Dis (2012) 0.89
Genetic determinants and ethnic disparities in sepsis-associated acute lung injury. Proc Am Thorac Soc (2005) 0.89
Weaning from mechanical ventilation: a cross-sectional study of reference values and the discriminative validity of aging. J Phys Ther Sci (2015) 0.86
Bacteria-specific neutrophil dysfunction associated with interferon-stimulated gene expression in the acute respiratory distress syndrome. PLoS One (2011) 0.84
Susceptibility to ventilator induced lung injury is increased in senescent rats. Crit Care (2013) 0.83
Clinical characteristics and outcome of very elderly patients ≥90 years in intensive care: a retrospective observational study. Ann Intensive Care (2015) 0.82
[Intensive care medicine for the oldest old--progress or mistake?]. Wien Klin Wochenschr (2007) 0.77
Treatment intensity, age and outcome in medical ICU patients: results of a French administrative database. Ann Intensive Care (2016) 0.77
A Markov computer simulation model of the economics of neuromuscular blockade in patients with acute respiratory distress syndrome. BMC Med Inform Decis Mak (2006) 0.77
CT predictors of mortality in pathology confirmed ARDS. Eur Radiol (2010) 0.76
Acute respiratory distress syndrome. BMJ Clin Evid (2010) 0.76
Extremes of Interferon-Stimulated Gene Expression Associate with Worse Outcomes in the Acute Respiratory Distress Syndrome. PLoS One (2016) 0.75
Differences in the prognosis among severe trauma and medical patients requiring mechanical ventilation. Int J Burns Trauma (2013) 0.75
Acute respiratory distress syndrome. BMJ Clin Evid (2007) 0.75
Efficacy of treadmill exercises on arterial blood oxygenation, oxygen consumption and walking distance in healthy elderly people: a controlled trial. BMC Geriatr (2016) 0.75
Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism. Metabolomics (2016) 0.75
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med (2000) 48.03
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
Acute respiratory distress syndrome: the Berlin Definition. JAMA (2012) 21.04
Comparison of two fluid-management strategies in acute lung injury. N Engl J Med (2006) 19.54
Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med (2008) 14.40
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell (2007) 12.52
Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med (2004) 11.78
Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA (2004) 11.27
Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med (2006) 9.52
Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med (2012) 9.19
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33
Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med (2006) 7.97
Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA (2003) 6.24
Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet (2007) 6.07
Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med (2005) 5.76
Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial. JAMA (2012) 5.27
Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury. Am J Respir Crit Care Med (2011) 5.24
Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion. Crit Care Med (2005) 5.16
Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA (2011) 5.08
Costs associated with delirium in mechanically ventilated patients. Crit Care Med (2004) 4.75
Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med (2010) 4.69
Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA (2012) 4.67
Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study. J Clin Oncol (2009) 4.54
Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. Intensive Care Med (2008) 4.21
Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology (2006) 4.03
Statistical evaluation of ventilator-free days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome. Crit Care Med (2002) 3.87
Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment. Crit Care Med (2005) 3.85
Principles of human subjects protections applied in an opt-out, de-identified biobank. Clin Transl Sci (2010) 3.84
The role of open-lung biopsy in ARDS. Chest (2004) 3.46
A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury. Crit Care Med (2005) 3.44
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol (2010) 3.43
Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol (2009) 3.39
Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med (2014) 3.39
Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J Am Soc Nephrol (2005) 3.38
Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit Care Med (2007) 3.31
Randomized clinical trial of activated protein C for the treatment of acute lung injury. Am J Respir Crit Care Med (2008) 3.28
Relative biological effectiveness (RBE) values for proton beam therapy. Int J Radiat Oncol Biol Phys (2002) 3.21
The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med (2012) 3.18
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. Oncologist (2011) 3.05
Attitudes and perceptions of patients towards methods of establishing a DNA biobank. Cell Tissue Bank (2007) 3.05
A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients. Cancer Res (2009) 3.00
Challenges in end-of-life care in the ICU: statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003: executive summary. Crit Care Med (2004) 2.95
Deviations from evidence-based clinical management guidelines increase mortality in critically injured trauma patients*. Crit Care Med (2012) 2.86
Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med (2010) 2.86
Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma (2010) 2.82
Excess body weight is not independently associated with outcome in mechanically ventilated patients with acute lung injury. Ann Intern Med (2004) 2.80
Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med (2007) 2.79
Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals. Crit Care Med (2009) 2.77
Atrial Fibrillation Is an Independent Predictor of Mortality in Critically Ill Patients. Crit Care Med (2015) 2.77
Findings on the portable chest radiograph correlate with fluid balance in critically ill patients. Chest (2002) 2.77
Causes and timing of death in patients with ARDS. Chest (2005) 2.72
Large-scale implementation of sedation and delirium monitoring in the intensive care unit: a report from two medical centers. Crit Care Med (2005) 2.72
The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. Am J Respir Crit Care Med (2012) 2.72
A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med (2013) 2.68
Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury. Crit Care Med (2002) 2.62
Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury. Am J Respir Crit Care Med (2006) 2.61
Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS. Chest (2007) 2.58
Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med (2011) 2.55
Current opinions regarding the importance, diagnosis, and management of delirium in the intensive care unit: a survey of 912 healthcare professionals. Crit Care Med (2004) 2.50
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A (2012) 2.50
Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury. Am J Respir Crit Care Med (2004) 2.49
Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis. Crit Care Med (2004) 2.48
Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med (2003) 2.44
Evaluation of a standardized order form for the withdrawal of life support in the intensive care unit. Crit Care Med (2004) 2.42
Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney disease. Am Heart J (2012) 2.42
Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. Crit Care Med (2011) 2.40
Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion. Cancer Res (2011) 2.40
Reengineering the national clinical and translational research enterprise: the strategic plan of the National Clinical and Translational Science Awards Consortium. Acad Med (2010) 2.38
A protocol for high-frequency oscillatory ventilation in adults: results from a roundtable discussion. Crit Care Med (2007) 2.38
Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med (2011) 2.36
A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med (2010) 2.31
Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome. Crit Care Med (2007) 2.31
Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med (2010) 2.28
Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock. Crit Care Med (2003) 2.27
The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis. Crit Care Med (2004) 2.24
Barriers to providing lung-protective ventilation to patients with acute lung injury. Crit Care Med (2004) 2.20