Published in Crit Care Med on June 01, 2003
Acute Respiratory Distress Syndrome Clinical Network (ARDSNet) | NCT00000579
Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med (2007) 3.64
Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med (2012) 2.92
Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury. PLoS Biol (2005) 2.36
Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Crit Care Med (2016) 2.08
Acute lung injury: epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv (2010) 1.78
Acute respiratory distress syndrome: a historical perspective. Am J Respir Crit Care Med (2005) 1.69
Clinical risk conditions for acute lung injury in the intensive care unit and hospital ward: a prospective observational study. Crit Care (2007) 1.52
Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma (2010) 1.51
Therapeutic accessibility of caspase-mediated cell death as a key pathomechanism in indirect acute lung injury. Crit Care Med (2010) 1.49
Aspiration-induced lung injury. Crit Care Med (2011) 1.40
Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung. Am J Respir Cell Mol Biol (2009) 1.36
Relationship of acute lung inflammatory injury to Fas/FasL system. Am J Pathol (2005) 1.33
Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury. FASEB J (2012) 1.31
Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. FASEB J (2013) 1.26
Epithelial cell apoptosis and neutrophil recruitment in acute lung injury-a unifying hypothesis? What we have learned from small interfering RNAs. Mol Med (2008) 1.26
Critical role for the NLRP3 inflammasome during acute lung injury. J Immunol (2014) 1.25
Bench-to-bedside review: beta2-Agonists and the acute respiratory distress syndrome. Crit Care (2003) 1.23
Validation study of an automated electronic acute lung injury screening tool. J Am Med Inform Assoc (2009) 1.21
Genetic variation in the FAS gene and associations with acute lung injury. Am J Respir Crit Care Med (2010) 1.19
Acute respiratory distress syndrome. BMJ (2007) 1.18
Cost-effectiveness of implementing low-tidal volume ventilation in patients with acute lung injury. Chest (2009) 1.17
Pathogenesis of indirect (secondary) acute lung injury. Expert Rev Respir Med (2011) 1.16
Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo. Transl Res (2008) 1.14
Pharmacotherapy of acute lung injury and acute respiratory distress syndrome. Curr Med Chem (2008) 1.13
Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. Am J Respir Cell Mol Biol (2010) 1.13
Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. J Immunol (2008) 1.11
Acute respiratory distress syndrome: epidemiology and management approaches. Clin Epidemiol (2012) 1.07
Alcohol abuse and pulmonary disease. J Leukoc Biol (2009) 1.06
Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs. Am J Physiol Lung Cell Mol Physiol (2011) 1.05
Inflammation and immune-related candidate gene associations with acute lung injury susceptibility and severity: a validation study. PLoS One (2012) 1.04
Pulmonary inflammation triggered by ricin toxin requires macrophages and IL-1 signaling. J Immunol (2009) 1.04
Surfactant therapy for acute lung injury and acute respiratory distress syndrome. Crit Care Clin (2011) 1.04
Prevention of LPS-induced acute lung injury in mice by progranulin. Mediators Inflamm (2012) 1.02
An alternative method of acute lung injury classification for use in observational studies. Chest (2010) 1.02
Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury. Am J Respir Cell Mol Biol (2013) 1.02
Leukocyte ADAM17 regulates acute pulmonary inflammation. PLoS One (2011) 1.00
Protective ventilation of patients with acute respiratory distress syndrome. Crit Care (2004) 0.98
Surfactant for pediatric acute lung injury. Pediatr Clin North Am (2008) 0.94
Association of human NAD(P)H:quinone oxidoreductase 1 (NQO1) polymorphism with development of acute lung injury. J Cell Mol Med (2009) 0.92
A protective Hsp70-TLR4 pathway in lethal oxidant lung injury. J Immunol (2013) 0.91
Short women with severe sepsis-related acute lung injury receive lung protective ventilation less frequently: an observational cohort study. Crit Care (2011) 0.91
Dynamic surface activity of a fully synthetic phospholipase-resistant lipid/peptide lung surfactant. PLoS One (2007) 0.89
Attending to the lightness of numbers: toward the understanding of critical care epidemiology. Crit Care (2004) 0.89
Mortality Trends of Acute Respiratory Distress Syndrome in the United States from 1999 to 2013. Ann Am Thorac Soc (2016) 0.88
Genetic polymorphisms associated with acute lung injury. Pharmacogenomics (2009) 0.88
Bioinformatics insights into acute lung injury/acute respiratory distress syndrome. Clin Transl Med (2012) 0.87
CD11c+ alveolar macrophages are a source of IL-23 during lipopolysaccharide-induced acute lung injury. Shock (2013) 0.86
Antisense oligonucleotide treatment enhances the recovery of acute lung injury through IL-10-secreting M2-like macrophage-induced expansion of CD4+ regulatory T cells. J Immunol (2013) 0.83
Short-term effects of combining upright and prone positions in patients with ARDS: a prospective randomized study. Crit Care (2011) 0.83
The NAMPT promoter is regulated by mechanical stress, signal transducer and activator of transcription 5, and acute respiratory distress syndrome-associated genetic variants. Am J Respir Cell Mol Biol (2014) 0.82
Protein-based therapies for acute lung injury: targeting neutrophil extracellular traps. Expert Opin Ther Targets (2014) 0.81
Acute lung injury: is the intensive care unit the tip of the iceberg? Crit Care Med (2003) 0.80
ATF3 protects pulmonary resident cells from acute and ventilator-induced lung injury by preventing Nrf2 degradation. Antioxid Redox Signal (2015) 0.80
A role for forkhead box A1 in acute lung injury. Inflammation (2009) 0.80
Automated alerting and recommendations for the management of patients with preexisting hypoxia and potential acute lung injury: a pilot study. Anesthesiology (2013) 0.80
Incidence and Outcomes of Acute Respiratory Distress Syndrome: A Nationwide Registry-Based Study in Taiwan, 1997 to 2011. Medicine (Baltimore) (2015) 0.78
Clinical Aspects of Acute Lung Insufficiency (ALI/TRALI). Transfus Med Hemother (2008) 0.78
B7H3 ameliorates LPS-induced acute lung injury via attenuation of neutrophil migration and infiltration. Sci Rep (2016) 0.77
Psychometric properties of Patient Reported Outcome Measures (PROMs) in patients diagnosed with Acute Respiratory Distress Syndrome (ARDS). Health Qual Life Outcomes (2016) 0.77
A practical approach to adult acute respiratory distress syndrome. Indian J Crit Care Med (2010) 0.77
Olprinone decreases elevated concentrations of cytokine-induced neutrophil chemoattractant-1 in septic rats. J Anesth (2008) 0.76
Lung inflammation and damage induced by extracellular histones. Inflamm Cell Signal (2015) 0.75
Design of Surfactant Protein B Peptide Mimics Based on the Saposin Fold for Synthetic Lung Surfactants. Biomed Hub (2016) 0.75
Peripheral leukocytapheresis attenuates acute lung injury induced by lipopolysaccharide in vivo. Mediators Inflamm (2012) 0.75
Acute lung injury outside the ICU: a significant problem. Crit Care (2007) 0.75
Protective effect of carvacrol on acute lung injury induced by lipopolysaccharide in mice. Inflammation (2014) 0.75
Alveolar instability (atelectrauma) is not identified by arterial oxygenation predisposing the development of an occult ventilator-induced lung injury. Intensive Care Med Exp (2015) 0.75
Acute respiratory distress syndrome; A rare complication caused by usage of ruxolitinib. Respir Med Case Rep (2017) 0.75
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med (2000) 48.03
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med (2013) 39.56
Incidence and outcomes of acute lung injury. N Engl J Med (2005) 21.56
Acute respiratory distress syndrome: the Berlin Definition. JAMA (2012) 21.04
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med (2013) 17.37
Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med (2006) 9.52
Use of intensive care at the end of life in the United States: an epidemiologic study. Crit Care Med (2004) 9.06
Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med (2015) 6.06
Hospital volume and the outcomes of mechanical ventilation. N Engl J Med (2006) 5.67
Critical care and the global burden of critical illness in adults. Lancet (2010) 5.55
Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury. Am J Respir Crit Care Med (2011) 5.24
Critical care's great leap forward? Crit Care Med (2006) 4.90
Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA (2008) 4.19
Statistical evaluation of ventilator-free days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome. Crit Care Med (2002) 3.87
Recommendations for end-of-life care in the intensive care unit: a consensus statement by the American College [corrected] of Critical Care Medicine. Crit Care Med (2008) 3.85
Tidal volume reduction in patients with acute lung injury when plateau pressures are not high. Am J Respir Crit Care Med (2005) 3.69
The myth of the workforce crisis. Why the United States does not need more intensivist physicians. Am J Respir Crit Care Med (2015) 3.43
Missed opportunities during family conferences about end-of-life care in the intensive care unit. Am J Respir Crit Care Med (2005) 3.40
Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med (2014) 3.39
Barriers to implementing protocol-based sepsis resuscitation in the emergency department--results of a national survey. Crit Care Med (2007) 3.28
Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury. Am J Respir Crit Care Med (2004) 3.19
The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med (2012) 3.18
Family satisfaction with family conferences about end-of-life care in the intensive care unit: increased proportion of family speech is associated with increased satisfaction. Crit Care Med (2004) 3.18
CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J Clin Invest (2009) 2.96
Effect of a quality-improvement intervention on end-of-life care in the intensive care unit: a randomized trial. Am J Respir Crit Care Med (2010) 2.94
Reducing deep sedation and delirium in acute lung injury patients: a quality improvement project. Crit Care Med (2013) 2.89
An Official ATS/AACN/ACCP/ESICM/SCCM Policy Statement: Responding to Requests for Potentially Inappropriate Treatments in Intensive Care Units. Am J Respir Crit Care Med (2015) 2.86
Causes and timing of death in patients with ARDS. Chest (2005) 2.72
Lung protective mechanical ventilation and two year survival in patients with acute lung injury: prospective cohort study. BMJ (2012) 2.69
Low caloric intake is associated with nosocomial bloodstream infections in patients in the medical intensive care unit. Crit Care Med (2004) 2.65
Do intensivist staffing patterns influence hospital mortality following ICU admission? A systematic review and meta-analyses. Crit Care Med (2013) 2.64
Effects of recruitment maneuvers in patients with acute lung injury and acute respiratory distress syndrome ventilated with high positive end-expiratory pressure. Crit Care Med (2003) 2.63
Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement project. Arch Phys Med Rehabil (2010) 2.61
Prioritizing the organization and management of intensive care services in the United States: the PrOMIS Conference. Crit Care Med (2007) 2.42
Evaluation of a standardized order form for the withdrawal of life support in the intensive care unit. Crit Care Med (2004) 2.42
A protocol for high-frequency oscillatory ventilation in adults: results from a roundtable discussion. Crit Care Med (2007) 2.38
Airway pressures, tidal volumes, and mortality in patients with acute respiratory distress syndrome. Crit Care Med (2005) 2.37
Beyond mortality: future clinical research in acute lung injury. Am J Respir Crit Care Med (2010) 2.28
Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock. Crit Care Med (2003) 2.27
Effect of acute lung injury and acute respiratory distress syndrome on outcome in critically ill trauma patients. Crit Care Med (2004) 2.20
Barriers to providing lung-protective ventilation to patients with acute lung injury. Crit Care Med (2004) 2.20
Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27-28 April 2006. Intensive Care Med (2007) 2.18
Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest (2009) 2.17
Predictors of hospital mortality in a population-based cohort of patients with acute lung injury. Crit Care Med (2008) 2.09
Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomes. Chest (2003) 2.05
Fluid balance, diuretic use, and mortality in acute kidney injury. Clin J Am Soc Nephrol (2011) 2.00
The effect of a quality improvement intervention on perceived sleep quality and cognition in a medical ICU. Crit Care Med (2013) 2.00
The association between body mass index and clinical outcomes in acute lung injury. Chest (2007) 1.96
Hypercapnic acidosis and mortality in acute lung injury. Crit Care Med (2006) 1.93
A multicenter mortality prediction model for patients receiving prolonged mechanical ventilation. Crit Care Med (2012) 1.92
Recruitment maneuvers for acute lung injury: a systematic review. Am J Respir Crit Care Med (2008) 1.91
Use of intravenous infusion sedation among mechanically ventilated patients in the United States. Crit Care Med (2009) 1.90
Studying communication about end-of-life care during the ICU family conference: development of a framework. J Crit Care (2002) 1.90
Cost and incidence of social comorbidities in low-risk patients with community-acquired pneumonia admitted to a public hospital. Chest (2003) 1.82
Effects of leukoreduced blood on acute lung injury after trauma: a randomized controlled trial. Crit Care Med (2008) 1.82
Cost savings attributable to reductions in intensive care unit length of stay for mechanically ventilated patients. Med Care (2008) 1.81
Variations in rates of tracheostomy in the critically ill trauma patient. Crit Care Med (2006) 1.79
Physician attitudes toward regionalization of adult critical care: a national survey. Crit Care Med (2009) 1.79
Effectiveness of medical resident education in mechanical ventilation. Am J Respir Crit Care Med (2002) 1.79
Low tidal volume ventilation does not increase sedation use in patients with acute lung injury. Crit Care Med (2005) 1.77
Intensive care unit-acquired neuromyopathy and corticosteroids in survivors of persistent ARDS. Intensive Care Med (2008) 1.76
Timing of low tidal volume ventilation and intensive care unit mortality in acute respiratory distress syndrome. A prospective cohort study. Am J Respir Crit Care Med (2015) 1.76
Rehabilitation therapy and outcomes in acute respiratory failure: an observational pilot project. J Crit Care (2009) 1.72
Age-, sex-, and race-based differences among patients enrolled versus not enrolled in acute lung injury clinical trials. Crit Care Med (2010) 1.71
Lung size mismatch in bilateral lung transplantation is associated with allograft function and bronchiolitis obliterans syndrome. Chest (2011) 1.68
Feasibility of very high-frequency ventilation in adults with acute respiratory distress syndrome. Crit Care Med (2008) 1.68
ARDSNet lower tidal volume ventilatory strategy may generate intrinsic positive end-expiratory pressure in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med (2002) 1.65
The value of positive end-expiratory pressure and Fio₂ criteria in the definition of the acute respiratory distress syndrome. Crit Care Med (2011) 1.64
Tidal volume delivery during high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome. Crit Care Med (2007) 1.64
Acute respiratory distress syndrome after trauma: development and validation of a predictive model. Crit Care Med (2012) 1.62
Mechanical ventilation after lung transplantation. An international survey of practices and preferences. Ann Am Thorac Soc (2014) 1.61
Improving palliative care for patients in the intensive care unit. J Palliat Med (2005) 1.60
Vancomycin-sensitive and vancomycin-resistant enterococcal infections in the ICU: attributable costs and outcomes. Intensive Care Med (2002) 1.60
Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium. Crit Care Med (2012) 1.59
Higher PEEP in patients with acute lung injury: a systematic review and meta-analysis. Respir Care (2011) 1.59
Effect of intensive care unit organizational model and structure on outcomes in patients with acute lung injury. Am J Respir Crit Care Med (2007) 1.58
Effect of age on the development of ARDS in trauma patients. Chest (2003) 1.57
Clinical decisions. Care of an unresponsive patient with a poor prognosis. N Engl J Med (2009) 1.56
Perceived barriers to therapeutic hypothermia for patients resuscitated from cardiac arrest: a qualitative study of emergency department and critical care workers. Crit Care Med (2010) 1.56
Long-term survival after hospitalization for community-acquired and healthcare-associated pneumonia. Respiration (2009) 1.54
Lung size mismatch and survival after single and bilateral lung transplantation. Ann Thorac Surg (2013) 1.54
Changing pattern of ventilator settings in patients without acute lung injury: changes over 11 years in a single institution. Chest (2004) 1.54
Mortality among patients admitted to strained intensive care units. Am J Respir Crit Care Med (2013) 1.53
Knowledge translation interventions for critically ill patients: a systematic review*. Crit Care Med (2013) 1.53
A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation. Crit Care Med (2011) 1.52
Improving use of targeted temperature management after out-of-hospital cardiac arrest: a stepped wedge cluster randomized controlled trial. Crit Care Med (2015) 1.52
Nighttime cross-coverage is associated with decreased intensive care unit mortality. A single-center study. Am J Respir Crit Care Med (2014) 1.50
Bench-to-bedside review: mobilizing patients in the intensive care unit--from pathophysiology to clinical trials. Crit Care (2009) 1.49
Proposed quality measures for palliative care in the critically ill: a consensus from the Robert Wood Johnson Foundation Critical Care Workgroup. Crit Care Med (2006) 1.48
Transferring critically ill patients out of hospital improves the standardized mortality ratio: a simulation study. Chest (2007) 1.47