Published in J Biol Chem on April 07, 2003
Eukaryotic DNA ligases: structural and functional insights. Annu Rev Biochem (2008) 2.44
Recruitment of Saccharomyces cerevisiae Dnl4-Lif1 complex to a double-strand break requires interactions with Yku80 and the Xrs2 FHA domain. Genetics (2008) 1.12
APLF promotes the assembly and activity of non-homologous end joining protein complexes. EMBO J (2012) 1.09
Quality control of DNA break metabolism: in the 'end', it's a good thing. EMBO J (2008) 1.08
The dynamics of Ku70/80 and DNA-PKcs at DSBs induced by ionizing radiation is dependent on the complexity of damage. Nucleic Acids Res (2012) 1.01
Phosphorylation of linker histones by DNA-dependent protein kinase is required for DNA ligase IV-dependent ligation in the presence of histone H1. Proc Natl Acad Sci U S A (2005) 1.00
The spatial organization of non-homologous end joining: from bridging to end joining. DNA Repair (Amst) (2014) 0.99
Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts. Nucleic Acids Res (2005) 0.98
A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining. Nucleic Acids Res (2008) 0.98
Electron microscopy visualization of DNA-protein complexes formed by Ku and DNA ligase IV. DNA Repair (Amst) (2011) 0.90
Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ. Antioxid Redox Signal (2010) 0.90
2-Step purification of the Ku DNA repair protein expressed in Escherichia coli. Protein Expr Purif (2006) 0.87
Structural biology of DNA repair: spatial organisation of the multicomponent complexes of nonhomologous end joining. J Nucleic Acids (2010) 0.84
The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks. Cell Rep (2013) 0.82
Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF. Nucleic Acids Res (2008) 0.80
Resolution of complex ends by Nonhomologous end joining - better to be lucky than good? Genome Integr (2012) 0.76
The Architectural Chromatin Factor High Mobility Group A1 Enhances DNA Ligase IV Activity Influencing DNA Repair. PLoS One (2016) 0.75
Consider the workhorse: Nonhomologous end-joining in budding yeast. Biochem Cell Biol (2016) 0.75
Regulation of non-homologous end joining via post-translational modifications of components of the ligation step. Curr Genet (2016) 0.75
Protection of Arabidopsis blunt-ended telomeres is mediated by a physical association with the Ku heterodimer. Plant Cell (2017) 0.75
Major clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the SMART study. J Infect Dis (2008) 6.73
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol Cell (2008) 6.60
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res (2004) 6.38
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet (2003) 6.03
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa. N Engl J Med (2015) 5.30
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell (2004) 5.29
gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle (2010) 3.56
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer (2007) 3.54
The role of double-strand break repair - insights from human genetics. Nat Rev Genet (2006) 3.25
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nat Genet (2007) 3.08
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J (2006) 3.05
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. EMBO J (2009) 2.94
Lopinavir/ritonavir monotherapy or plus zidovudine and lamivudine in antiretroviral-naive HIV-infected patients. AIDS (2008) 2.84
A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Res (2004) 2.55
DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J (2006) 2.48
Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO J (2011) 2.46
Fanconi syndrome and renal failure induced by tenofovir: a first case report. Am J Kidney Dis (2002) 2.41
Multiphoton-FLIM quantification of the EGFP-mRFP1 FRET pair for localization of membrane receptor-kinase interactions. Biophys J (2004) 2.37
A heterotrimeric PCNA in the hyperthermophilic archaeon Sulfolobus solfataricus. Mol Cell (2003) 2.34
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biol (2007) 2.28
Identification of a DNA nonhomologous end-joining complex in bacteria. Science (2002) 2.27
Combination therapy with telaprevir for chronic hepatitis C virus genotype 1 infection in patients with HIV: a randomized trial. Ann Intern Med (2013) 2.25
Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nat Cell Biol (2006) 2.20
Once-daily darunavir/ritonavir vs. lopinavir/ritonavir in treatment-naive, HIV-1-infected patients: 96-week analysis. AIDS (2009) 2.15
Interactions between atazanavir-ritonavir and tenofovir in heavily pretreated human immunodeficiency virus-infected patients. Antimicrob Agents Chemother (2004) 2.14
MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. PLoS One (2010) 2.05
Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine. Science (2004) 2.04
Phenotypic or genotypic resistance testing for choosing antiretroviral therapy after treatment failure: a randomized trial. AIDS (2002) 2.03
A dark yellow fluorescent protein (YFP)-based Resonance Energy-Accepting Chromoprotein (REACh) for Förster resonance energy transfer with GFP. Proc Natl Acad Sci U S A (2006) 1.98
Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway. Hum Mol Genet (2004) 1.95
Nbs1 is required for ATR-dependent phosphorylation events. EMBO J (2004) 1.95
Once-a-day highly active antiretroviral therapy in treatment-naive HIV-1-infected adults in Senegal. AIDS (2003) 1.94
Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor. EMBO J (2002) 1.92
Monitoring conformational changes of proteins in cells by fluorescence lifetime imaging microscopy. Biochem J (2003) 1.89
Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. J Biol Chem (2003) 1.83
Campylobacter bacteremia: clinical features and factors associated with fatal outcome. Clin Infect Dis (2008) 1.82
Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection. J Infect Dis (2005) 1.80
Long-term hepatitis B virus dynamics in HIV-hepatitis B virus-co-infected patients treated with tenofovir disoproxil fumarate. AIDS (2005) 1.80
Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Nat Genet (2011) 1.76
Major role of hepatitis B genotypes in liver fibrosis during coinfection with HIV. AIDS (2006) 1.76
Non-homologous end-joining factors of Saccharomyces cerevisiae. FEMS Microbiol Rev (2004) 1.70
The impact of heterochromatin on DSB repair. Biochem Soc Trans (2009) 1.65
Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells. Mol Cell (2004) 1.64
Structure of a NHEJ polymerase-mediated DNA synaptic complex. Science (2007) 1.60
Subclinical cardiac abnormalities in human immunodeficiency virus-infected men receiving antiretroviral therapy. Am J Cardiol (2008) 1.59
Structure and function of a mycobacterial NHEJ DNA repair polymerase. J Mol Biol (2006) 1.58
Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. J Biol Chem (2004) 1.55
PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication. Mol Cell (2013) 1.50
Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos. J Biol Chem (2006) 1.50
Nonhomologous end-joining in bacteria: a microbial perspective. Annu Rev Microbiol (2007) 1.49
53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J (2009) 1.47
[Anal canal squamous-cell carcinomas in HIV positive patients: clinical features, treatments and prognosis]. Gastroenterol Clin Biol (2002) 1.46
An Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity. DNA Repair (Amst) (2010) 1.46
Selenium: a double-edged sword for defense and offence in cancer. Arch Toxicol (2010) 1.46
XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation. Nucleic Acids Res (2008) 1.44
Fluorescence lifetime and polarization-resolved imaging in cell biology. Curr Opin Biotechnol (2009) 1.43
Identifying Ureters In Situ Under Fluorescence During Laparoscopic and Open Colorectal Surgery. Ann Surg (2016) 1.39
Domain structure of a NHEJ DNA repair ligase from Mycobacterium tuberculosis. J Mol Biol (2005) 1.37
Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42. Mol Biol Cell (2007) 1.36
An image analysis-based approach for automated counting of cancer cell nuclei in tissue sections. Cytometry A (2003) 1.34
NHEJ protects mycobacteria in stationary phase against the harmful effects of desiccation. DNA Repair (Amst) (2007) 1.34
Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair. Mol Cancer Ther (2010) 1.34
Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms. Hum Mol Genet (2004) 1.33
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest. Oncogene (2002) 1.33
Role of DNA repair by nonhomologous-end joining in Bacillus subtilis spore resistance to extreme dryness, mono- and polychromatic UV, and ionizing radiation. J Bacteriol (2007) 1.33
Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining. PLoS Genet (2006) 1.31
Intravital imaging of tumour vascular networks using multi-photon fluorescence microscopy. Adv Drug Deliv Rev (2005) 1.31
The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity. Cell Cycle (2005) 1.30
Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest. Mol Cell Biol (2010) 1.30
Imaging molecular interactions by multiphoton FLIM. Biol Cell (2004) 1.30
The role of the DNA damage response pathways in brain development and microcephaly: insight from human disorders. DNA Repair (Amst) (2008) 1.27
An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells. Cell Cycle (2007) 1.27
DNA double-strand break repair by homologous recombination. Mutat Res (2004) 1.27
Persistence of multidrug-resistant HIV-1 without antiretroviral treatment 2 years after sexual transmission. Antivir Ther (2004) 1.26
The Th17/Treg ratio, IL-1RA and sCD14 levels in primary HIV infection predict the T-cell activation set point in the absence of systemic microbial translocation. PLoS Pathog (2013) 1.24
Understanding the limitations of radiation-induced cell cycle checkpoints. Crit Rev Biochem Mol Biol (2011) 1.22
Pneumonia in HIV-infected persons: increased risk with cigarette smoking and treatment interruption. Am J Respir Crit Care Med (2008) 1.21
Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Mol Cell Biol (2005) 1.21
Antagonism of EGFR and HER3 enhances the response to inhibitors of the PI3K-Akt pathway in triple-negative breast cancer. Sci Signal (2014) 1.20
Incidence of lipodystrophy and metabolic disorders in patients starting non-nucleoside reverse transcriptase inhibitors in Benin. Antivir Ther (2009) 1.20
The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits. J Biol Chem (2006) 1.20
Imaging proteins in vivo using fluorescence lifetime microscopy. Mol Biosyst (2007) 1.19
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK. DNA Repair (Amst) (2007) 1.19
Harmonising the response to DSBs: a new string in the ATM bow. DNA Repair (Amst) (2005) 1.17
Suboptimal adherence to darunavir/ritonavir has minimal effect on efficacy compared with lopinavir/ritonavir in treatment-naive, HIV-infected patients: 96 week ARTEMIS data. J Antimicrob Chemother (2010) 1.17
Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced MRI. NMR Biomed (2002) 1.16
PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome. Mol Cell (2013) 1.15
Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic patients. Antivir Ther (2004) 1.14