Published in Mol Cell Biol on April 26, 2010
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell (2013) 1.93
Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response. EMBO J (2012) 1.91
Pathways for genome integrity in G2 phase of the cell cycle. Biomolecules (2012) 1.44
A Newfound association between MDC1 functional polymorphism and lung cancer risk in Chinese. PLoS One (2014) 1.42
Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair (Amst) (2012) 1.37
Understanding the limitations of radiation-induced cell cycle checkpoints. Crit Rev Biochem Mol Biol (2011) 1.22
CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1. Nucleic Acids Res (2010) 1.16
Requirement for DNA ligase IV during embryonic neuronal development. J Neurosci (2011) 1.01
The histone variant macroH2A1.1 is recruited to DSBs through a mechanism involving PARP1. FEBS Lett (2012) 0.95
Visualisation of γH2AX foci caused by heavy ion particle traversal; distinction between core track versus non-track damage. PLoS One (2013) 0.94
Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest. Mol Cell Biol (2011) 0.93
Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks. Cell Rep (2015) 0.90
53BP1 contributes to a robust genomic stability in human fibroblasts. Aging (Albany NY) (2011) 0.90
p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system. PLoS One (2011) 0.88
The Mre11 complex suppresses oncogene-driven breast tumorigenesis and metastasis. Mol Cell (2013) 0.87
Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol (2015) 0.87
Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase. Nucleic Acids Res (2012) 0.87
A role for homologous recombination proteins in cell cycle regulation. Cell Cycle (2015) 0.87
Non-homologous end joining mediated DNA repair is impaired in the NUP98-HOXD13 mouse model for myelodysplastic syndrome. Leuk Res (2012) 0.87
Activation of DNA Damage Response Pathways during Lytic Replication of KSHV. Viruses (2015) 0.83
Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint. J Biol Chem (2014) 0.80
Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs. PLoS Genet (2016) 0.80
Diminished origin-licensing capacity specifically sensitizes tumor cells to replication stress. Mol Cancer Res (2013) 0.79
The 53BP1 homolog in C. elegans influences DNA repair and promotes apoptosis in response to ionizing radiation. PLoS One (2013) 0.79
Suppression of BRCA1 sensitizes cells to proteasome inhibitors. Cell Death Dis (2014) 0.78
Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair. PLoS One (2015) 0.78
Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic Subunit. PLoS One (2015) 0.76
Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model. PLoS One (2015) 0.75
ATR promotes cilia signalling: links to developmental impacts. Hum Mol Genet (2016) 0.75
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science (1998) 8.74
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol (2005) 8.27
MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature (2003) 6.81
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res (2004) 6.38
Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol (2003) 6.36
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet (2003) 6.03
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell (2006) 5.62
DNA double-strand break repair: all's well that ends well. Annu Rev Genet (2006) 5.59
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell (2006) 5.33
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell (2004) 5.29
53BP1, a mediator of the DNA damage checkpoint. Science (2002) 5.00
Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol Cell Biol (2002) 4.27
Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest. Mol Cell (2001) 3.74
Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair (Amst) (2006) 3.61
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J (2006) 3.05
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. EMBO J (2009) 2.94
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat Cell Biol (2010) 2.88
A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Res (2004) 2.55
Mechanism of DNA double-strand break repair by non-homologous end joining. DNA Repair (Amst) (2005) 2.53
Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses. EMBO J (1998) 2.32
Chromosome breakage after G2 checkpoint release. J Cell Biol (2007) 2.25
Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J Biol Chem (2003) 2.03
Nonhomologous end joining and V(D)J recombination require an additional factor. Proc Natl Acad Sci U S A (2003) 1.84
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol (2004) 1.82
ATR/Mec1: coordinating fork stability and repair. Curr Opin Cell Biol (2009) 1.64
Radiosensitivity in ataxia-telangiectasia: anomalies in radiation-induced cell cycle delay. Int J Radiat Biol (1994) 1.61
53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J (2009) 1.47
Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability. DNA Repair (Amst) (2006) 1.32
The two edges of the ATM sword: co-operation between repair and checkpoint functions. Radiother Oncol (2005) 1.10
Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase. Oncogene (2007) 0.97
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci U S A (2003) 6.82
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol Cell (2008) 6.60
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res (2004) 6.38
Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol (2003) 6.36
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet (2003) 6.03
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell (2004) 5.29
gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle (2010) 3.56
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer (2007) 3.54
The role of double-strand break repair - insights from human genetics. Nat Rev Genet (2006) 3.25
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nat Genet (2007) 3.08
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J (2006) 3.05
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. EMBO J (2009) 2.94
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat Cell Biol (2010) 2.88
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. J Biol Chem (2006) 2.66
A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Res (2004) 2.55
DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J (2006) 2.48
Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO J (2011) 2.46
Identification of a DNA nonhomologous end-joining complex in bacteria. Science (2002) 2.27
Chromosome breakage after G2 checkpoint release. J Cell Biol (2007) 2.25
Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nat Cell Biol (2006) 2.20
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Biochem J (2002) 2.18
Organization of interphase microtubules in fission yeast analyzed by electron tomography. Dev Cell (2007) 2.00
Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway. Hum Mol Genet (2004) 1.95
Nbs1 is required for ATR-dependent phosphorylation events. EMBO J (2004) 1.95
Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response. EMBO J (2012) 1.91
Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. J Biol Chem (2003) 1.83
Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Nat Genet (2011) 1.76
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. Biochem J (2002) 1.74
DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin. Nucleic Acids Res (2011) 1.72
53BP1-mediated DNA double strand break repair: insert bad pun here. DNA Repair (Amst) (2011) 1.67
The impact of heterochromatin on DSB repair. Biochem Soc Trans (2009) 1.65
Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells. Mol Cell (2004) 1.64
ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. J Biol Chem (2002) 1.56
DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: implications for radiosensitivity testing. Clin Cancer Res (2008) 1.51
53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J (2009) 1.47
Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. Cancer Res (2007) 1.47
An Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity. DNA Repair (Amst) (2010) 1.46
XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation. Nucleic Acids Res (2008) 1.44
Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair. Mol Cancer Ther (2010) 1.34
Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms. Hum Mol Genet (2004) 1.33
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest. Oncogene (2002) 1.33
Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability. DNA Repair (Amst) (2006) 1.32
Artemis links ATM to double strand break rejoining. Cell Cycle (2005) 1.30
Efficient rejoining of radiation-induced DNA double-strand breaks in centromeric DNA of human cells. J Biol Chem (2002) 1.29
The role of the DNA damage response pathways in brain development and microcephaly: insight from human disorders. DNA Repair (Amst) (2008) 1.27
An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells. Cell Cycle (2007) 1.27
Radiation-induced DNA damage responses. Radiat Prot Dosimetry (2007) 1.27
Understanding the limitations of radiation-induced cell cycle checkpoints. Crit Rev Biochem Mol Biol (2011) 1.22
The role of homologous recombination in radiation-induced double-strand break repair. Radiother Oncol (2011) 1.21
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK. DNA Repair (Amst) (2007) 1.19
Harmonising the response to DSBs: a new string in the ATM bow. DNA Repair (Amst) (2005) 1.17
CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1. Nucleic Acids Res (2010) 1.16
Inducible response required for repair of low-dose radiation damage in human fibroblasts. Proc Natl Acad Sci U S A (2010) 1.16
The two edges of the ATM sword: co-operation between repair and checkpoint functions. Radiother Oncol (2005) 1.10
X-irradiation of cells on glass slides has a dose doubling impact. DNA Repair (Amst) (2007) 1.07
Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome. PLoS Genet (2012) 1.06
PRKDC mutations in a SCID patient with profound neurological abnormalities. J Clin Invest (2013) 1.06
Cellular and clinical impact of haploinsufficiency for genes involved in ATR signaling. Am J Hum Genet (2007) 1.06
Ku stimulation of DNA ligase IV-dependent ligation requires inward movement along the DNA molecule. J Biol Chem (2003) 1.05
The limitations of the G1-S checkpoint. Cancer Res (2010) 1.02
The heterochromatic barrier to DNA double strand break repair: how to get the entry visa. Int J Mol Sci (2012) 1.02
The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst) (2004) 1.01
Requirement for DNA ligase IV during embryonic neuronal development. J Neurosci (2011) 1.01
Homologous recombination protects mammalian cells from replication-associated DNA double-strand breaks arising in response to methyl methanesulfonate. DNA Repair (Amst) (2010) 1.01
CHD chromatin remodelling enzymes and the DNA damage response. Mutat Res (2013) 1.01
Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection. Nucleic Acids Res (2013) 1.00
Phosphorylation of linker histones by DNA-dependent protein kinase is required for DNA ligase IV-dependent ligation in the presence of histone H1. Proc Natl Acad Sci U S A (2005) 1.00
Opposing roles for 53BP1 during homologous recombination. Nucleic Acids Res (2013) 0.99
Irradiation induced foci (IRIF) as a biomarker for radiosensitivity. Mutat Res (2011) 0.99
Enhanced fidelity for rejoining radiation-induced DNA double-strand breaks in the G2 phase of Chinese hamster ovary cells. Nucleic Acids Res (2004) 0.99
Clinical impact of ATR checkpoint signalling failure in humans. Cell Cycle (2003) 0.99
A noncatalytic function of the ligation complex during nonhomologous end joining. J Cell Biol (2013) 0.96