Published in Nat Med on June 26, 2011
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med (2012) 11.14
Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34
Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann Oncol (2013) 9.68
Interactions between cancer stem cells and their niche govern metastatic colonization. Nature (2011) 6.94
Tumour exosome integrins determine organotropic metastasis. Nature (2015) 4.09
The perivascular niche regulates breast tumour dormancy. Nat Cell Biol (2013) 3.36
Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation. Cancer Cell (2012) 2.94
The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell (2012) 2.84
Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol (2014) 2.74
Tumor metastasis: moving new biological insights into the clinic. Nat Med (2013) 2.71
Unravelling the complexity of metastasis - molecular understanding and targeted therapies. Nat Rev Cancer (2011) 2.64
Origins of metastatic traits. Cancer Cell (2013) 2.49
CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma. Cancer Cell (2016) 2.32
Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature (2016) 2.11
Tumor cell dissemination: emerging biological insights from animal models and cancer patients. Cancer Cell (2013) 2.08
Metastatic stem cells: sources, niches, and vital pathways. Cell Stem Cell (2014) 1.88
Mechanisms governing metastatic dormancy and reactivation. Cell (2013) 1.81
Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep (2013) 1.78
The evolving concept of cancer and metastasis stem cells. J Cell Biol (2012) 1.76
Spherical cancer models in tumor biology. Neoplasia (2015) 1.75
Control of metastatic progression by microRNA regulatory networks. Nat Cell Biol (2013) 1.73
Breast cancer - one term, many entities? J Clin Invest (2011) 1.72
From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell (2014) 1.70
The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell (2015) 1.66
RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation. EMBO Mol Med (2014) 1.62
In vivo animal models for studying brain metastasis: value and limitations. Clin Exp Metastasis (2013) 1.52
Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol (2016) 1.49
Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance. Trends Cell Biol (2015) 1.48
A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nat Commun (2012) 1.47
Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers. Cell Adh Migr (2012) 1.41
The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov (2012) 1.40
Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT. Cell (2016) 1.36
What does the concept of the stem cell niche really mean today? BMC Biol (2012) 1.32
Breastmilk is a novel source of stem cells with multilineage differentiation potential. Stem Cells (2012) 1.31
Metastatic colonization by circulating tumour cells. Nature (2016) 1.31
The metastatic niche and stromal progression. Cancer Metastasis Rev (2012) 1.30
Tumor microenvironment: a main actor in the metastasis process. Clin Exp Metastasis (2012) 1.25
Evolution and dynamics of pancreatic cancer progression. Oncogene (2013) 1.25
Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood samples. Mol Cell Proteomics (2012) 1.24
Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. PLoS Genet (2013) 1.24
A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies. Nat Cell Biol (2014) 1.23
Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S. Nat Cell Biol (2014) 1.19
Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma. Cancer Res (2012) 1.19
Matricellular proteins: priming the tumour microenvironment for cancer development and metastasis. Br J Cancer (2013) 1.17
Annexin A2 heterotetramer: structure and function. Int J Mol Sci (2013) 1.17
Metastasis dormancy in estrogen receptor-positive breast cancer. Clin Cancer Res (2013) 1.15
Reproductive history and breast cancer risk. Breast Cancer (2012) 1.14
microRNA-mediated regulation of the tumor microenvironment. Cell Cycle (2013) 1.14
Extracellular matrix players in metastatic niches. EMBO J (2011) 1.13
PDGFRB promotes liver metastasis formation of mesenchymal-like colorectal tumor cells. Neoplasia (2013) 1.11
Matricellular proteins: a sticky affair with cancers. J Oncol (2012) 1.10
Breast cancer stem cells: Multiple capacities in tumor metastasis. Cancer Lett (2014) 1.07
Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. Elife (2014) 1.06
Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters. Proc Natl Acad Sci U S A (2016) 1.05
MetastamiRs: non-coding MicroRNAs driving cancer invasion and metastasis. Int J Mol Sci (2012) 1.04
Histone demethylase RBP2 is critical for breast cancer progression and metastasis. Cell Rep (2014) 1.04
Cell surface remodeling by plasmin: a new function for an old enzyme. J Biomed Biotechnol (2012) 1.04
Pharmacological modulation of beta-catenin and its applications in cancer therapy. J Cell Mol Med (2013) 1.03
Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program. J Clin Invest (2015) 1.03
Metastasis prevention by targeting the dormant niche. Nat Rev Cancer (2015) 1.03
Regulation of cancer metastasis by cell-free miRNAs. Biochim Biophys Acta (2014) 1.02
Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer (2014) 1.01
Targeting constitutively activated β1 integrins inhibits prostate cancer metastasis. Mol Cancer Res (2013) 1.01
The wound healing, chronic fibrosis, and cancer progression triad. Physiol Genomics (2014) 0.99
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Mol Med (2015) 0.99
Active roles of tumor stroma in breast cancer metastasis. Int J Breast Cancer (2012) 0.98
Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization. Cell Rep (2015) 0.96
Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal tumor microenvironment. Oncogenesis (2013) 0.96
Binding of αvβ1 and αvβ6 integrins to tenascin-C induces epithelial-mesenchymal transition-like change of breast cancer cells. Oncogenesis (2013) 0.95
Emerging Biological Principles of Metastasis. Cell (2017) 0.94
Emerging roles of the tumor-associated stroma in promoting tumor metastasis. Cell Adh Migr (2012) 0.94
Rat mammary extracellular matrix composition and response to ibuprofen treatment during postpartum involution by differential GeLC-MS/MS analysis. J Proteome Res (2012) 0.94
Cancer stem cells and their role in metastasis. Pharmacol Ther (2013) 0.93
The difference in prognostic factors between early recurrence and late recurrence in estrogen receptor-positive breast cancer: nodal stage differently impacts early and late recurrence. PLoS One (2013) 0.93
New Findings on Breast Cancer Stem Cells: A Review. J Breast Cancer (2015) 0.92
Targeting ECM Disrupts Cancer Progression. Front Oncol (2015) 0.92
IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis (2013) 0.92
Circulating fibronectin controls tumor growth. Neoplasia (2013) 0.92
Oncogenic micro-RNAs and Renal Cell Carcinoma. Front Oncol (2014) 0.92
Distinctive properties of metastasis-initiating cells. Genes Dev (2016) 0.91
Pazopanib inhibits the activation of PDGFRβ-expressing astrocytes in the brain metastatic microenvironment of breast cancer cells. Am J Pathol (2013) 0.91
Surviving at a distance: organ specific metastasis. Trends Cancer (2015) 0.90
Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche. Cancer Discov (2014) 0.90
A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype. Breast Cancer Res (2014) 0.90
Oncogenic signaling by tyrosine kinases of the SRC family in advanced colorectal cancer. Am J Cancer Res (2012) 0.89
How integrins control breast biology. Curr Opin Cell Biol (2013) 0.89
The Role of Cancer Stem Cells in the Organ Tropism of Breast Cancer Metastasis: A Mechanistic Balance between the "Seed" and the "Soil"? Int J Breast Cancer (2011) 0.89
Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. PLoS One (2013) 0.89
Harnessing the complexity of gene expression data from cancer: from single gene to structural pathway methods. Biol Direct (2012) 0.88
Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling. Oncogene (2015) 0.88
Harnessing the genome for characterization of G-protein coupled receptors in cancer pathogenesis. FEBS J (2013) 0.87
The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells. EMBO Rep (2012) 0.87
Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy. Breast Cancer Res (2015) 0.87
Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial-Mesenchymal Transition. Trends Cell Biol (2015) 0.87
Stromal biomarkers in breast cancer development and progression. Clin Exp Metastasis (2012) 0.86
Integrated extracellular matrix signaling in mammary gland development and breast cancer progression. Histol Histopathol (2014) 0.86
Identification of novel metastasis suppressor signaling pathways for breast cancer. Cell Cycle (2012) 0.86
Cancer cell invasion driven by extracellular matrix remodeling is dependent on the properties of cancer-associated fibroblasts. J Cancer Res Clin Oncol (2015) 0.86
Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and "swarm intelligence". Cancer Metastasis Rev (2013) 0.86
A cell-ECM screening method to predict breast cancer metastasis. Integr Biol (Camb) (2015) 0.85
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol (2004) 24.63
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev (2003) 20.77
Genes that mediate breast cancer metastasis to lung. Nature (2005) 19.85
Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell (1998) 19.05
A multigenic program mediating breast cancer metastasis to bone. Cancer Cell (2003) 16.86
Microenvironmental regulation of metastasis. Nat Rev Cancer (2008) 15.76
Defining the epithelial stem cell niche in skin. Science (2003) 14.93
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell (2007) 14.87
Endogenous human microRNAs that suppress breast cancer metastasis. Nature (2008) 14.37
Nanog safeguards pluripotency and mediates germline development. Nature (2007) 13.01
Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res (2005) 11.52
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med (2009) 10.88
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol (2007) 9.36
The extracellular matrix: not just pretty fibrils. Science (2009) 8.52
Genes that mediate breast cancer metastasis to the brain. Nature (2009) 8.23
Systemic spread is an early step in breast cancer. Cancer Cell (2008) 7.91
Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res (2008) 7.65
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature (2007) 7.05
Tumor self-seeding by circulating cancer cells. Cell (2009) 6.66
The metastatic niche: adapting the foreign soil. Nat Rev Cancer (2009) 5.28
Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell (2009) 5.24
GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell (2006) 4.98
Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci U S A (2000) 4.71
BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell (2010) 4.66
High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res (2005) 4.61
Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell (2008) 4.45
Subtypes of breast cancer show preferential site of relapse. Cancer Res (2008) 4.38
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol (2004) 3.87
The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA. Mol Cell Biol (2001) 2.87
C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell (2006) 2.87
Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. J Natl Cancer Inst (2007) 2.75
Function of RNA-binding protein Musashi-1 in stem cells. Exp Cell Res (2005) 2.62
Temporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiency. Cancer Res (2000) 2.58
Mice develop normally without tenascin. Genes Dev (1992) 2.35
Tenascin-C induced signaling in cancer. Cancer Lett (2006) 2.21
Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth. Eur J Cancer (2010) 2.13
Signal transducer and activator of transcription-5 activation and breast cancer prognosis. J Clin Oncol (2004) 2.04
Generation of an environmental niche for neural stem cell development by the extracellular matrix molecule tenascin C. Development (2004) 1.83
Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression. Eur J Cancer (2002) 1.68
Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers. Int J Cancer (2004) 1.60
Intestinal stem cells in mammals and Drosophila. Cell Stem Cell (2009) 1.58
Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. J Biol Chem (2009) 1.57
Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression. J Mammary Gland Biol Neoplasia (2008) 1.45
Tenascin expression in cancer cells and stroma of human breast cancer and its prognostic significance. Clin Cancer Res (1995) 1.40
Discovery of chromone-based inhibitors of the transcription factor STAT5. Chembiochem (2008) 1.34
Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival. Mol Cancer (2010) 1.31
Tenascin mediates human glioma cell migration and modulates cell migration on fibronectin. J Cell Sci (1996) 1.31
The tenascin-C knockout revisited. J Cell Sci (1999) 1.13
Growth promoting signaling by tenascin-C [corrected]. Cancer Res (2004) 0.99
Laminin and tenascin assembly and expression regulate HC11 mouse mammary cell differentiation. J Cell Sci (1994) 0.99
Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. J Biol Chem (2004) 0.98
Tenascin C in stem cell niches: redundant, permissive or instructive? Cells Tissues Organs (2007) 0.93
Disparities in the survival improvement of recurrent breast cancer. Breast Cancer (2009) 0.90
Distinct gene-expression profiles characterize mammary tumors developed in transgenic mice expressing constitutively active and C-terminally truncated variants of STAT5. BMC Genomics (2009) 0.84
Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell (2003) 25.94
Genes that mediate breast cancer metastasis to lung. Nature (2005) 19.85
Cancer metastasis: building a framework. Cell (2006) 19.67
A multigenic program mediating breast cancer metastasis to bone. Cancer Cell (2003) 16.86
Endogenous human microRNAs that suppress breast cancer metastasis. Nature (2008) 14.37
Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer (2009) 14.17
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer (2003) 8.35
Genes that mediate breast cancer metastasis to the brain. Nature (2009) 8.23
Molecular basis of metastasis. N Engl J Med (2008) 8.19
TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell (2008) 7.60
Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc Natl Acad Sci U S A (2006) 7.26
Epithelial-mesenchymal transitions: twist in development and metastasis. Cell (2004) 7.14
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature (2007) 7.05
Tumor self-seeding by circulating cancer cells. Cell (2009) 6.66
Genetic determinants of cancer metastasis. Nat Rev Genet (2007) 6.38
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell (2004) 6.35
Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Invest (2005) 6.10
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. Nat Genet (2009) 5.65
Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature (2002) 5.25
Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell (2009) 5.24
A CXCL1 paracrine network links cancer chemoresistance and metastasis. Cell (2012) 4.89
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell (2009) 4.81
TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell (2005) 4.46
Differential exoprotease activities confer tumor-specific serum peptidome patterns. J Clin Invest (2006) 4.37
Roles of TGFbeta in metastasis. Cell Res (2009) 4.35
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci U S A (2005) 4.20
Subtle variations in Pten dose determine cancer susceptibility. Nat Genet (2010) 4.19
Lung metastasis genes couple breast tumor size and metastatic spread. Proc Natl Acad Sci U S A (2007) 3.92
E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression. Cell (2002) 3.87
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell (2009) 3.76
Lobectomy by video-assisted thoracic surgery (VATS) versus thoracotomy for lung cancer. J Thorac Cardiovasc Surg (2009) 3.76
Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res (2007) 3.63
Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci U S A (2003) 3.61
A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature (2011) 3.60
A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell (2003) 3.57
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev (2008) 3.50
Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell (2013) 3.33
Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell (2006) 3.31
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. Cancer Cell (2011) 3.23
Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol Cell (2007) 3.23
Is cancer a disease of self-seeding? Nat Med (2006) 3.19
Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes Dev (2011) 3.04
Nomogram for predicting the risk of local recurrence after breast-conserving surgery for ductal carcinoma in situ. J Clin Oncol (2010) 2.97
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat Med (2012) 2.95
Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation. Cancer Cell (2012) 2.94
C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell (2006) 2.87
ID genes mediate tumor reinitiation during breast cancer lung metastasis. Proc Natl Acad Sci U S A (2007) 2.85
The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell (2012) 2.84
Results of chest wall resection and reconstruction with and without rigid prosthesis. Ann Thorac Surg (2006) 2.77
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell (2011) 2.64
A FoxO-Smad synexpression group in human keratinocytes. Proc Natl Acad Sci U S A (2006) 2.60
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev (2009) 2.59
Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis. Cell (2012) 2.50
Origins of metastatic traits. Cancer Cell (2013) 2.49
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell (2009) 2.45
The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation. Cell Stem Cell (2013) 2.33
Use of video-assisted thoracic surgery for lobectomy in the elderly results in fewer complications. Ann Thorac Surg (2008) 2.33
The influence of margin width and volume of disease near margin on benefit of radiation therapy for women with DCIS treated with breast-conserving therapy. Ann Surg (2010) 2.26
Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer Discov (2012) 2.23
Sorting out breast-cancer gene signatures. N Engl J Med (2007) 2.22
Heterogenic loss of the wild-type BRCA allele in human breast tumorigenesis. Ann Surg Oncol (2007) 2.19
A grading system of lung adenocarcinomas based on histologic pattern is predictive of disease recurrence in stage I tumors. Am J Surg Pathol (2010) 2.15
Pilot study of 68Ga-DOTA-F(ab')2-trastuzumab in patients with breast cancer. Nucl Med Commun (2013) 2.12
Video-assisted thoracoscopic surgery (VATS) lobectomy: catastrophic intraoperative complications. J Thorac Cardiovasc Surg (2011) 2.11
Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer Prev Res (Phila) (2011) 2.09
Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Mol Cell (2002) 2.05
Nucleocytoplasmic shuttling of signal transducers. Nat Rev Mol Cell Biol (2004) 2.04
Determination of the presence and extent of pure ductal carcinoma in situ by mammography and magnetic resonance imaging. Breast J (2005) 2.04
Small cell lung cancer. J Natl Compr Canc Netw (2013) 2.04
Preoperative 18[F]-fluorodeoxyglucose positron emission tomography standardized uptake values predict survival after esophageal adenocarcinoma resection. Ann Thorac Surg (2006) 2.03
Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene. J Biol Chem (2001) 1.99
Dynamic regulation of alternative splicing by silencers that modulate 5' splice site competition. Cell (2008) 1.91
MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes Dev (2011) 1.85
NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes. Mol Cell Biol (2007) 1.84
Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype. Cancer Cell (2008) 1.82
A poised chromatin platform for TGF-β access to master regulators. Cell (2011) 1.81
Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways. Structure (2012) 1.77
Clinical implications of cancer self-seeding. Nat Rev Clin Oncol (2011) 1.77
IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis. J Cell Biol (2008) 1.76