Published in Stroke on April 10, 2003
The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ (2010) 7.93
Anatomical mapping of white matter hyperintensities (WMH): exploring the relationships between periventricular WMH, deep WMH, and total WMH burden. Stroke (2004) 3.80
Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study. Stroke (2010) 3.75
Cognitive impact of subcortical vascular and Alzheimer's disease pathology. Ann Neurol (2006) 2.62
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. BMC Med Genet (2007) 2.51
Structural brain changes in migraine. JAMA (2012) 2.47
Prevalence and determinants of subclinical brain infarction: the Northern Manhattan Study. Neurology (2007) 2.40
25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology (2009) 2.39
The Secondary Prevention of Small Subcortical Strokes (SPS3) study. Int J Stroke (2011) 2.35
Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study. Neurology (2007) 2.05
Chronic kidney disease is associated with white matter hyperintensity volume: the Northern Manhattan Study (NOMAS). Stroke (2007) 1.96
Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study. Stroke (2005) 1.91
Longitudinal MRI and cognitive change in healthy elderly. Neuropsychology (2007) 1.88
Cerebral white matter: neuroanatomy, clinical neurology, and neurobehavioral correlates. Ann N Y Acad Sci (2008) 1.85
White matter hyperintensities and subclinical infarction: associations with psychomotor speed and cognitive flexibility. Stroke (2008) 1.84
MRI of carotid atherosclerosis: clinical implications and future directions. Nat Rev Cardiol (2010) 1.78
The relationship between blood pressure and cognitive function. Nat Rev Cardiol (2010) 1.66
Subclinical left ventricular dysfunction and silent cerebrovascular disease: the Cardiovascular Abnormalities and Brain Lesions (CABL) study. Circulation (2013) 1.61
White matter hyperintensities and dynamics of postural control. Magn Reson Imaging (2009) 1.60
Intima-media thickness and regional cerebral blood flow in older adults. Stroke (2009) 1.56
Migraine is associated with an increased risk of deep white matter lesions, subclinical posterior circulation infarcts and brain iron accumulation: the population-based MRI CAMERA study. Cephalalgia (2010) 1.56
Clinical prediction of functional outcome after ischemic stroke: the surprising importance of periventricular white matter disease and race. Stroke (2008) 1.52
Patent foramen ovale, subclinical cerebrovascular disease, and ischemic stroke in a population-based cohort. J Am Coll Cardiol (2013) 1.52
Effect of white matter lesions on manual dexterity in healthy middle-aged persons. Neurology (2015) 1.50
Small Brain Lesions and Incident Stroke and Mortality: A Cohort Study. Ann Intern Med (2015) 1.49
Risk factor profile for chronic kidney disease is similar to risk factor profile for small artery disease. J Hypertens (2011) 1.45
Vascular basis for brain degeneration: faltering controls and risk factors for dementia. Nutr Rev (2010) 1.44
Vascular and cognitive functions associated with cardiovascular disease in the elderly. J Clin Exp Neuropsychol (2008) 1.33
Inflammatory biomarkers of vascular risk as correlates of leukoariosis. Stroke (2009) 1.32
Association of serum soluble receptor for advanced glycation end-products with subclinical cerebrovascular disease: the Northern Manhattan Study (NOMAS). Atherosclerosis (2011) 1.17
Calcium and vitamin D intakes may be positively associated with brain lesions in depressed and nondepressed elders. Nutr Res (2008) 1.16
The epidemiology of silent brain infarction: a systematic review of population-based cohorts. BMC Med (2014) 1.14
Cerebrovascular disease and patterns of cerebral oxygenation during sleep in elders. Biol Res Nurs (2009) 1.11
Extent of white matter lesions is related to acute subcortical infarcts and predicts further stroke risk in patients with first ever ischaemic stroke. J Neurol Neurosurg Psychiatry (2005) 1.11
Clinical Interaction between Brain and Kidney in Small Vessel Disease. Cardiol Res Pract (2011) 1.10
Incidence of stroke symptoms among adults with chronic kidney disease: results from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Nephrol Dial Transplant (2011) 1.08
LA volumes and reservoir function are associated with subclinical cerebrovascular disease: the CABL (Cardiovascular Abnormalities and Brain Lesions) study. JACC Cardiovasc Imaging (2013) 1.08
Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin II hypertension. J Neurosci (2012) 1.06
The myth of the normal, average human brain--the ICBM experience: (1) subject screening and eligibility. Neuroimage (2008) 1.02
Comparison of the inflammatory burden of truly asymptomatic carotid atheroma with atherosclerotic plaques contralateral to symptomatic carotid stenosis: an ultra small superparamagnetic iron oxide enhanced magnetic resonance study. J Neurol Neurosurg Psychiatry (2007) 1.00
Correlation between severity of obstructive sleep apnea and prevalence of silent cerebrovascular lesions. J Clin Sleep Med (2008) 0.99
A quantitative systematic review of domain-specific cognitive impairment in lacunar stroke. Neurology (2013) 0.96
Low medication adherence and the incidence of stroke symptoms among individuals with hypertension: the REGARDS study. J Clin Hypertens (Greenwich) (2011) 0.96
Multimodal markers of inflammation in the subcortical ischemic vascular disease type of vascular cognitive impairment. Stroke (2014) 0.96
Deep multi-scale location-aware 3D convolutional neural networks for automated detection of lacunes of presumed vascular origin. Neuroimage Clin (2017) 0.94
Age-related white matter changes. J Aging Res (2011) 0.93
Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study. Circulation (2012) 0.93
MRI-detected white matter lesions: do they really matter? J Neural Transm (Vienna) (2011) 0.92
Report of stroke-like symptoms predicts incident cognitive impairment in a stroke-free cohort. Neurology (2013) 0.92
Extreme deep white matter hyperintensity volumes are associated with African American race. Cerebrovasc Dis (2014) 0.91
Stroke genetics: a review and update. J Stroke (2014) 0.91
Structural imaging measures of brain aging. Neuropsychol Rev (2014) 0.91
Relationship of hypertension, blood pressure, and blood pressure control with white matter abnormalities in the Women's Health Initiative Memory Study (WHIMS)-MRI trial. J Clin Hypertens (Greenwich) (2010) 0.90
Integrated diagnostics: proceedings from the 9th biennial symposium of the International Society for Strategic Studies in Radiology. Eur Radiol (2012) 0.89
Silent cerebral infarcts associated with cardiac disease and procedures. Nat Rev Cardiol (2013) 0.89
Risk of "silent stroke" in patients older than 60 years: risk assessment and clinical perspectives. Clin Interv Aging (2010) 0.89
Immunological profile of silent brain infarction and lacunar stroke. PLoS One (2013) 0.86
Discriminating between silent cerebral infarction and deep white matter hyperintensity using combinations of three types of magnetic resonance images: a multicenter observer performance study. Neuroradiology (2008) 0.86
Polymorphisms of the renin-angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology. J Neurol Neurosurg Psychiatry (2007) 0.86
Prognostic Impact of Cerebral Small Vessel Disease on Stroke Outcome. J Stroke (2015) 0.86
Reduced blood flow in normal white matter predicts development of leukoaraiosis. J Cereb Blood Flow Metab (2015) 0.85
Interactive relations of blood pressure and age to subclinical cerebrovascular disease. J Hypertens (2012) 0.85
Extracting and summarizing white matter hyperintensities using supervised segmentation methods in Alzheimer's disease risk and aging studies. Hum Brain Mapp (2014) 0.85
Association of right-to-left shunt with frontal white matter lesions in T2-weighted MR imaging of stroke patients. Neuroradiology (2009) 0.85
The relationship between executive dysfunction and post-stroke mortality: a population-based cohort study. BMJ Open (2012) 0.85
Computer-aided diagnosis for detection of lacunar infarcts on MR images: ROC analysis of radiologists' performance. J Digit Imaging (2012) 0.85
Age differences in periventricular and deep white matter lesions. Neurobiol Aging (2015) 0.84
Selective factor XIIa inhibition attenuates silent brain ischemia: application of molecular imaging targeting coagulation pathway. JACC Cardiovasc Imaging (2012) 0.84
Cerebral white matter and retinal arterial health in hypertension and type 2 diabetes mellitus. Int J Hypertens (2013) 0.84
Neglect performance in acute stroke is related to severity of white matter hyperintensities. Cerebrovasc Dis (2014) 0.84
Risk factors of migraine-related brain white matter hyperintensities: an investigation of 186 patients. J Headache Pain (2011) 0.84
Consensus statement for diagnosis of subcortical small vessel disease. J Cereb Blood Flow Metab (2016) 0.84
Perspectives for preventive screening with total body MRI. Eur Radiol (2007) 0.83
A uniform approach to modeling risk factor relationships for ischemic lesion prevalence and extent: the Women's Health Initiative Magnetic Resonance Imaging study. Neuroepidemiology (2009) 0.83
Current status and future perspectives of magnetic resonance high-field imaging: a summary. Neuroimaging Clin N Am (2012) 0.83
Association between carotid plaque characteristics and cerebral white matter lesions: one-year follow-up study by MRI. PLoS One (2011) 0.83
Molecular disorganization of axons adjacent to human lacunar infarcts. Brain (2015) 0.83
Association of Dietary Protein Consumption With Incident Silent Cerebral Infarcts and Stroke: The Atherosclerosis Risk in Communities (ARIC) Study. Stroke (2015) 0.82
African Caribbeans have greater subclinical cerebrovascular disease than Europeans: this is associated with both their elevated resting and ambulatory blood pressure and their hyperglycaemia. J Hypertens (2013) 0.82
What stroke symptoms tell us: association of risk factors and individual stroke symptoms in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. J Stroke Cerebrovasc Dis (2012) 0.82
White matter disease as a biomarker for long-term cerebrovascular disease and dementia. Curr Treat Options Cardiovasc Med (2014) 0.82
Genetics of age-related white matter lesions from linkage to genome wide association studies. J Neurol Sci (2012) 0.82
Usefulness of the second derivative of the finger photoplethysmogram for assessment of end-organ damage: the J-SHIPP study. Hypertens Res (2016) 0.82
Risk of recurrent stroke in patients with silent brain infarction in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) imaging substudy. Stroke (2012) 0.81
The 2006 William Feinberg lecture: shifting the paradigm from stroke to global vascular risk estimation. Stroke (2007) 0.81
Stroke prevention and cognitive reserve: emerging approaches to modifying risk and delaying onset of dementia. Front Neurol (2013) 0.80
Association of annular calcification and aortic valve sclerosis with brain findings on magnetic resonance imaging in community dwelling older adults: the cardiovascular health study. J Am Coll Cardiol (2011) 0.80
Imaging small vessel-associated white matter changes in aging. Neuroscience (2013) 0.80
Small deep white matter lesions are associated with right-to-left shunts in migraineurs. J Neurol (2010) 0.80
Association between Serum Alkaline Phosphatase Level and Cerebral Small Vessel Disease. PLoS One (2015) 0.80
Relationship between Systemic and Cerebral Vascular Disease and Brain Structure Integrity in Normal Elderly Individuals. J Alzheimers Dis (2015) 0.80
Refinement of Imaging Predictors of Recurrent Events following Transient Ischemic Attack and Minor Stroke. PLoS One (2013) 0.79
Diet and Neuroimaging Markers of Cerebrovascular Disease. Curr Nutr Rep (2013) 0.79
Major risk factors for the appearance of white-matter lesions on MRI in hypertensive patients with controlled blood pressure. Vasc Health Risk Manag (2012) 0.79
Investigating silent strokes in hypertensives: a magnetic resonance imaging study (ISSYS): rationale and protocol design. BMC Neurol (2013) 0.79
Diastolic blood pressure levels and ischemic stroke incidence in older adults with white matter lesions. J Gerontol A Biol Sci Med Sci (2010) 0.79
Cognition and Hemodynamics. Curr Cardiovasc Risk Rep (2012) 0.79
SOLUBLE CD40 LIGAND IN DEMENTIA. Drugs Future (2009) 0.79
Relative risk values of age, acrolein, IL-6 and CRP as markers of periventricular hyperintensities: a cross-sectional study. BMJ Open (2014) 0.78
Voxel Level Survival Analysis of Grey Matter Volume and Incident Mild Cognitive Impairment or Alzheimer's Disease. J Alzheimers Dis (2015) 0.78
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med (2014) 18.12
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32
Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med (2003) 10.61
Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med (2012) 10.16
Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA (2010) 9.52
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Incidental findings on brain MRI in the general population. N Engl J Med (2007) 8.59
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation (2006) 8.18
Epidemiology of Parkinson's disease. Lancet Neurol (2006) 8.13
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Host polymorphisms in interleukin 4, complement factor H, and C-reactive protein associated with nasal carriage of Staphylococcus aureus and occurrence of boils. J Infect Dis (2008) 7.45
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39
Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study. Eur Heart J (2006) 6.31
Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet (2008) 5.89
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
The Rotterdam Study: objectives and design update. Eur J Epidemiol (2007) 5.78
Silent brain infarcts: a systematic review. Lancet Neurol (2007) 5.76
A comparison of two doses of aspirin (30 mg vs. 283 mg a day) in patients after a transient ischemic attack or minor ischemic stroke. The Dutch TIA Trial Study Group. N Engl J Med (1991) 5.69
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48
Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol (2006) 5.39
Alcohol consumption and risk of dementia: the Rotterdam Study. Lancet (2002) 5.32
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32
Genomewide association studies of stroke. N Engl J Med (2009) 5.29
Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet (2009) 5.20
Correlation between genetic and geographic structure in Europe. Curr Biol (2008) 5.02
The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial. J Hypertens (2003) 4.91
Physical activity, including walking, and cognitive function in older women. JAMA (2004) 4.90
Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet (2009) 4.78
Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study. Lancet Neurol (2006) 4.77
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
High serum uric acid as a novel risk factor for type 2 diabetes. Diabetes Care (2007) 4.69
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56
Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies. Lancet (2010) 4.46
Selecting patients with atrial fibrillation for anticoagulation: stroke risk stratification in patients taking aspirin. Circulation (2004) 4.45
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat Genet (2009) 4.38
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. PLoS Genet (2009) 4.24
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Dietary intake of antioxidants and risk of Alzheimer disease. JAMA (2002) 4.01
Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol (2012) 3.93
Lipid-related markers and cardiovascular disease prediction. JAMA (2012) 3.91
Effect of age on stroke prevention therapy in patients with atrial fibrillation: the atrial fibrillation investigators. Stroke (2009) 3.89
Long-term mortality after stroke among adults aged 18 to 50 years. JAMA (2013) 3.84
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet (2009) 3.80
Genome-wide association study of PR interval. Nat Genet (2010) 3.73
Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Common carotid intima-media thickness measurements in cardiovascular risk prediction: a meta-analysis. JAMA (2012) 3.67
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55
Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. Diabetes (2008) 3.54
Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study. Eur Heart J (2004) 3.52
The Rotterdam Study: 2010 objectives and design update. Eur J Epidemiol (2009) 3.44
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Inflammatory proteins in plasma and the risk of dementia: the rotterdam study. Arch Neurol (2004) 3.38
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Cerebral small-vessel disease and decline in information processing speed, executive function and memory. Brain (2005) 3.34
Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med (2004) 3.32
Coronary calcification improves cardiovascular risk prediction in the elderly. Circulation (2005) 3.28
Corticosteroids and the risk of atrial fibrillation. Arch Intern Med (2006) 3.28
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Incidence and prognosis of transient neurological attacks. JAMA (2007) 3.21