Published in Development on June 01, 2003
Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol (2009) 6.66
Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82. Am J Hum Genet (2010) 4.95
Planar cell polarity signaling: from fly development to human disease. Annu Rev Genet (2008) 3.43
Principles of planar polarity in animal development. Development (2011) 2.94
Wnt5a functions in planar cell polarity regulation in mice. Dev Biol (2007) 2.85
Frizzled6 controls hair patterning in mice. Proc Natl Acad Sci U S A (2004) 2.54
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. Proc Natl Acad Sci U S A (2008) 2.52
Planar cell polarity signaling: the developing cell's compass. Cold Spring Harb Perspect Biol (2009) 2.02
Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development (2011) 1.71
Planar cell polarity signaling in vertebrates. Bioessays (2007) 1.62
Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells. Proc Natl Acad Sci U S A (2005) 1.50
Shaping sound in space: the regulation of inner ear patterning. Development (2012) 1.48
Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis. EMBO J (2005) 1.43
The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2. J Biol Chem (2012) 1.39
Order from disorder: Self-organization in mammalian hair patterning. Proc Natl Acad Sci U S A (2006) 1.37
Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity. PLoS Biol (2004) 1.33
Eya1-Six1 interaction is sufficient to induce hair cell fate in the cochlea by activating Atoh1 expression in cooperation with Sox2. Dev Cell (2012) 1.30
Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea. J Assoc Res Otolaryngol (2011) 1.27
Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Dev Cell (2010) 1.25
Primary cilia in planar cell polarity regulation of the inner ear. Curr Top Dev Biol (2008) 1.23
Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development. PLoS One (2012) 1.22
Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases. Neural Dev (2009) 1.21
Line up and listen: Planar cell polarity regulation in the mammalian inner ear. Semin Cell Dev Biol (2009) 1.18
Shaping the mammalian auditory sensory organ by the planar cell polarity pathway. Int J Dev Biol (2007) 1.17
Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS One (2008) 1.14
Planar cell polarity signaling: coordination of cellular orientation across tissues. Wiley Interdiscip Rev Dev Biol (2013) 1.11
Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS Biol (2012) 1.10
Toward a systems biology of mouse inner ear organogenesis: gene expression pathways, patterns and network analysis. Genetics (2007) 1.10
Alternative Wnt pathways and receptors. Cold Spring Harb Perspect Biol (2012) 1.09
Cells, molecules and morphogenesis: the making of the vertebrate ear. Brain Res (2006) 1.09
Comprehensive Wnt-related gene expression during cochlear duct development in chicken. J Comp Neurol (2008) 1.02
The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling. J Biol Chem (2012) 0.98
Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2. J Neurosci (2013) 0.97
A balance of form and function: planar polarity and development of the vestibular maculae. Semin Cell Dev Biol (2013) 0.96
Cartilage to bone transitions in health and disease. J Endocrinol (2013) 0.93
The Wnt-dependent signaling pathways as target in oncology drug discovery. Invest New Drugs (2006) 0.93
Mouse models for dissecting vertebrate planar cell polarity signaling in the inner ear. Brain Res (2009) 0.92
The mechanisms of planar cell polarity, growth and the Hippo pathway: some known unknowns. Dev Biol (2013) 0.92
Wnt signaling during cochlear development. Semin Cell Dev Biol (2013) 0.91
The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility. Nat Commun (2012) 0.91
Fuz regulates craniofacial development through tissue specific responses to signaling factors. PLoS One (2011) 0.90
Maintained expression of the planar cell polarity molecule Vangl2 and reformation of hair cell orientation in the regenerating inner ear. J Assoc Res Otolaryngol (2010) 0.90
A historical to present-day account of efforts to answer the question: "what puts the brakes on mammalian hair cell regeneration?". Hear Res (2013) 0.89
Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells. PLoS Genet (2011) 0.89
Making sense of Wnt signaling-linking hair cell regeneration to development. Front Cell Neurosci (2015) 0.88
Sensory hair cell development and regeneration: similarities and differences. Development (2015) 0.88
Development and evolution of the vestibular sensory apparatus of the mammalian ear. J Vestib Res (2005) 0.87
ACF7 is a hair-bundle antecedent, positioned to integrate cuticular plate actin and somatic tubulin. J Neurosci (2014) 0.86
In Vivo Cochlear Hair Cell Generation and Survival by Coactivation of β-Catenin and Atoh1. J Neurosci (2015) 0.86
BMP/SMAD signaling regulates the cell behaviors that drive the initial dorsal-specific regional morphogenesis of the otocyst. Dev Biol (2010) 0.84
Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization. Development (2013) 0.83
Blocking Dishevelled signaling in the noncanonical Wnt pathway in sea urchins disrupts endoderm formation and spiculogenesis, but not secondary mesoderm formation. Dev Dyn (2009) 0.83
Requirement for Dlgh-1 in planar cell polarity and skeletogenesis during vertebrate development. PLoS One (2013) 0.83
A conserved signaling cassette regulates hair patterning from Drosophila to man. Proc Natl Acad Sci U S A (2004) 0.83
The role of glypicans in Wnt inhibitory factor-1 activity and the structural basis of Wif1's effects on Wnt and Hedgehog signaling. PLoS Genet (2012) 0.83
Non-cell-autonomous planar cell polarity propagation in the auditory sensory epithelium of vertebrates. Dev Biol (2011) 0.82
Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea. PLoS One (2016) 0.81
Patterning skin by planar cell polarity: the multi-talented hair designer. Exp Dermatol (2012) 0.78
Auditory hair cell centrioles undergo confined Brownian motion throughout the developmental migration of the kinocilium. Biophys J (2013) 0.78
Wnt pathway regulation of intestinal stem cells. J Physiol (2016) 0.78
Genetic Correction of Induced Pluripotent Stem Cells From a Deaf Patient With MYO7A Mutation Results in Morphologic and Functional Recovery of the Derived Hair Cell-Like Cells. Stem Cells Transl Med (2016) 0.77
Assessment criteria for rotated stereociliary bundles in the guinea pig cochlea. Otol Neurotol (2008) 0.77
Bedraggled, a putative transporter, influences the tissue polarity complex during the R3/R4 fate decision in the Drosophila eye. Genetics (2007) 0.77
ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice. Proc Natl Acad Sci U S A (2016) 0.76
Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans. Scientifica (Cairo) (2017) 0.75
Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats. Neural Plast (2016) 0.75
Requirement of DLG1 for cardiovascular development and tissue elongation during cochlear, enteric, and skeletal development: possible role in convergent extension. PLoS One (2015) 0.75
Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea. Front Mol Neurosci (2017) 0.75
Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell (2004) 5.04
Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature (2003) 4.56
WNTs in the vertebrate nervous system: from patterning to neuronal connectivity. Nat Rev Neurosci (2005) 3.39
Math1 regulates development of the sensory epithelium in the mammalian cochlea. Nat Neurosci (2004) 2.93
Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development. Nat Neurosci (2004) 2.81
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci (2006) 2.73
Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia. Nat Cell Biol (2010) 2.67
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. Proc Natl Acad Sci U S A (2008) 2.52
Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling. Nat Struct Biol (2002) 2.32
Development of tonotopy in the auditory periphery. Hear Res (2011) 2.32
Identification and characterization of a non-satellite cell muscle resident progenitor during postnatal development. Nat Cell Biol (2010) 2.25
Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat Neurosci (2010) 2.18
From placode to polarization: new tunes in inner ear development. Development (2004) 2.12
A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J Cell Biol (2004) 1.90
Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy. Hepatology (2014) 1.87
Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release. J Cell Biol (2006) 1.85
WNT-3, expressed by motoneurons, regulates terminal arborization of neurotrophin-3-responsive spinal sensory neurons. Neuron (2002) 1.81
Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins. Curr Biol (2005) 1.79
Wnt signaling in B-cell neoplasia. Oncogene (2003) 1.73
Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene. Hum Mol Genet (2004) 1.73
Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti. J Neurosci (2006) 1.68
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase. Proc Natl Acad Sci U S A (2004) 1.68
Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth. J Cell Biol (2011) 1.68
Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin. Blood (2002) 1.65
Wnt signaling during synaptic development and plasticity. Curr Opin Neurobiol (2011) 1.65
Noncanonical Wnt signaling and neural polarity. Annu Rev Neurosci (2006) 1.63
Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment. Dev Dyn (2007) 1.61
Stem cell therapy for the inner ear: recent advances and future directions. Trends Amplif (2012) 1.58
Wnts induce migration and invasion of myeloma plasma cells. Blood (2005) 1.58
Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea. Development (2007) 1.58
Regulation of thymic epithelium by keratinocyte growth factor. Blood (2002) 1.57
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J Biol Chem (2009) 1.56
Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer. Cancer Res (2005) 1.56
Fibroblast growth factor signaling regulates pillar cell development in the organ of corti. J Neurosci (2002) 1.54
Existence of the canonical Wnt signaling pathway in the human trabecular meshwork. Invest Ophthalmol Vis Sci (2012) 1.53
Outcomes after percutaneous coronary intervention of ostial lesions in the era of drug-eluting stents. Catheter Cardiovasc Interv (2009) 1.51
Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J Neurosci (2008) 1.50
Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Adv Cancer Res (2004) 1.48
Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons. Mol Cell Neurosci (2002) 1.47
Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation. J Bone Miner Res (2004) 1.45
Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2. J Biol Chem (2004) 1.43
Impact of concomitant heart failure on outcomes in patients undergoing percutaneous coronary interventions: analysis of the Melbourne Interventional Group registry. Eur J Heart Fail (2011) 1.41
A role for Wnt/beta-catenin signaling in lens epithelial differentiation. Dev Biol (2003) 1.39
Early versus delayed percutaneous coronary intervention in patients with non-ST elevation acute coronary syndromes. Coron Artery Dis (2016) 1.39
Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure. J Clin Invest (2008) 1.39
Sox2 induces neuronal formation in the developing mammalian cochlea. J Neurosci (2010) 1.32
Planar and vertical signals control cellular differentiation and patterning in the mammalian cochlea. J Neurosci (2003) 1.32
Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin. Proc Natl Acad Sci U S A (2008) 1.32
Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration. Hepatology (2005) 1.31
Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II. Proc Natl Acad Sci U S A (2011) 1.30
Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans. J Neurosci (2008) 1.30
Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. Mol Cell Biol (2008) 1.27
Keratinocyte growth factor expression and activity in cancer: implications for use in patients with solid tumors. J Natl Cancer Inst (2006) 1.27
A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea. Development (2012) 1.25
Cellular growth and rearrangement during the development of the mammalian organ of Corti. Dev Dyn (2004) 1.23
Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Development (2010) 1.23
Planar cell polarity and a potential role for a Wnt morphogen gradient in stereociliary bundle orientation in the mammalian inner ear. J Neurobiol (2005) 1.20
Myosin II regulates extension, growth and patterning in the mammalian cochlear duct. Development (2009) 1.19
Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis. Development (2010) 1.18
Scrib regulates PAK activity during the cell migration process. Hum Mol Genet (2008) 1.17
Molecular mechanisms of inner ear development. Cold Spring Harb Perspect Biol (2012) 1.16
Myocilin is a modulator of Wnt signaling. Mol Cell Biol (2009) 1.14
Otic mesenchyme cells regulate spiral ganglion axon fasciculation through a Pou3f4/EphA4 signaling pathway. Neuron (2012) 1.14
Gene expression profile signatures indicate a role for Wnt signaling in endothelial commitment from embryonic stem cells. Circ Res (2006) 1.14
Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2. Development (2009) 1.14
Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton. Nat Cell Biol (2013) 1.13
Schwann cells as regulators of nerve development. J Physiol Paris (2001) 1.13
Defining skeletal muscle resident progenitors and their cell fate potentials. Development (2013) 1.12
Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling. J Biol Chem (2002) 1.11
Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules. J Biol Chem (2001) 1.10
Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis. J Clin Invest (2012) 1.09
Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol (2013) 1.09
Rbpj regulates development of prosensory cells in the mammalian inner ear. Dev Biol (2011) 1.08
The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea. Dev Biol (2013) 1.07
Mapping brucellosis increases relative to elk density using hierarchical Bayesian models. PLoS One (2010) 1.04
Revisiting planar cell polarity in the inner ear. Semin Cell Dev Biol (2013) 1.04
Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting. Proc Natl Acad Sci U S A (2011) 1.03
CD44 is a marker for the outer pillar cells in the early postnatal mouse inner ear. J Assoc Res Otolaryngol (2010) 1.03
Expression of the boc gene during murine embryogenesis. Dev Dyn (2002) 1.01
The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss. J Neurosci (2012) 1.01
Wnt signaling and neurite outgrowth: insights and questions. Cancer Sci (2007) 1.00
Wnt/Frizzled signaling in Ewing sarcoma. Pediatr Blood Cancer (2004) 1.00
Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system. Eur J Neurosci (2007) 1.00
Knock-in mouse model for resistance to thyroid hormone (RTH): an RTH mutation in the thyroid hormone receptor beta gene disrupts cochlear morphogenesis. J Assoc Res Otolaryngol (2002) 0.99
Cilia, Wnt signaling, and the cytoskeleton. Cilia (2012) 0.99
Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling. Cell Signal (2013) 0.99
Proliferative responses to growth factors decline rapidly during postnatal maturation of mammalian hair cell epithelia. Eur J Neurosci (2007) 0.99
Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate. Dev Biol (2008) 0.98
Specification of cell fate in the mammalian cochlea. Birth Defects Res C Embryo Today (2009) 0.98
c-Jun N-terminal kinase (JNK) cooperates with Gsk3beta to regulate Dishevelled-mediated microtubule stability. BMC Cell Biol (2007) 0.96
Dishevelled stabilization by the ciliopathy protein Rpgrip1l is essential for planar cell polarity. J Cell Biol (2012) 0.96
Cytoskeletal changes in actin and microtubules underlie the developing surface mechanical properties of sensory and supporting cells in the mouse cochlea. Development (2012) 0.96