Published in Curr Biol on November 22, 2005
Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31
Proximal events in Wnt signal transduction. Nat Rev Mol Cell Biol (2009) 6.66
Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Proc Natl Acad Sci U S A (2007) 3.16
GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem Sci (2009) 2.87
Wnt signaling from development to disease: insights from model systems. Cold Spring Harb Perspect Biol (2009) 2.42
Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell (2007) 2.41
PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv Cancer Res (2009) 2.32
Can we safely target the WNT pathway? Nat Rev Drug Discov (2014) 2.31
LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin. Proc Natl Acad Sci U S A (2008) 2.14
Update on Wnt signaling in bone cell biology and bone disease. Gene (2011) 2.03
Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Breast Cancer Res (2007) 1.93
Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6. PLoS One (2009) 1.87
Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem (2008) 1.83
Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia. Proc Natl Acad Sci U S A (2011) 1.62
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J (2007) 1.55
siRNA-mediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survival. Neoplasia (2007) 1.51
Wnt/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des (2013) 1.44
Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling. Cold Spring Harb Perspect Biol (2012) 1.43
From individual Wnt pathways towards a Wnt signalling network. Philos Trans R Soc Lond B Biol Sci (2008) 1.37
The way Wnt works: components and mechanism. Growth Factors (2012) 1.37
Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. J Biol Chem (2006) 1.33
Maternal obesity, inflammation, and fetal skeletal muscle development. Biol Reprod (2009) 1.25
Aging of signal transduction pathways, and pathology. Exp Cell Res (2008) 1.16
Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death. Free Radic Biol Med (2010) 1.13
WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3. Br J Pharmacol (2014) 1.07
Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling. Oncogene (2008) 1.07
Oct-3/4 regulates stem cell identity and cell fate decisions by modulating Wnt/β-catenin signalling. EMBO J (2010) 1.05
Segregation of myoblast fusion and muscle-specific gene expression by distinct ligand-dependent inactivation of GSK-3β. Cell Mol Life Sci (2010) 0.99
Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation. Cell Res (2011) 0.97
Wnt/β-catenin Signaling in Normal and Cancer Stem Cells. Cancers (Basel) (2011) 0.94
Skeletal muscle stem cells from animals I. Basic cell biology. Int J Biol Sci (2010) 0.93
Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling. Elife (2015) 0.90
Androgen-induced PSA expression requires not only activation of AR but also endogenous IGF-I or IGF-I/PI3K/Akt signaling in human prostate cancer epithelial cells. Prostate (2010) 0.90
Threonine 393 of beta-catenin regulates interaction with Axin. J Cell Biochem (2009) 0.89
OSTM1 regulates beta-catenin/Lef1 interaction and is required for Wnt/beta-catenin signaling. Cell Signal (2008) 0.89
Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice. Exp Brain Res (2012) 0.86
Wnt pathway activation by ADP-ribosylation. Nat Commun (2016) 0.84
Wnt and Frizzled RNA expression in human mesenchymal and embryonic (H7) stem cells. J Mol Signal (2008) 0.84
Protease-activated receptor-1 (PAR1) acts via a novel Galpha13-dishevelled axis to stabilize beta-catenin levels. J Biol Chem (2010) 0.84
Wnt signaling: the good and the bad. Acta Biochim Biophys Sin (Shanghai) (2008) 0.84
Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled. Exp Mol Med (2009) 0.83
Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes. Open Biol (2014) 0.82
Frizzled receptors signal through G proteins. Cell Signal (2013) 0.82
Mouse induced pluripotent stem cell microenvironment generates epithelial-mesenchymal transition in mouse Lewis lung cancer cells. Am J Cancer Res (2014) 0.82
Overstimulation can create health problems due to increases in PI3K/Akt/GSK3 insensitivity and GSK3 activity. Springerplus (2014) 0.81
Heterotrimeric Go protein links Wnt-Frizzled signaling with ankyrins to regulate the neuronal microtubule cytoskeleton. Development (2014) 0.81
Leukemia stem cells: the root of chronic myeloid leukemia. Protein Cell (2015) 0.81
Signaling of human frizzled receptors to the mating pathway in yeast. PLoS One (2007) 0.80
Application of on-line nanoLC-IT-TOF in the identification of serum β-catenin complex in mice scald model. PLoS One (2012) 0.79
Phosphorylation of PPP(S/T)P motif of the free LRP6 intracellular domain is not required to activate the Wnt/beta-catenin pathway and attenuate GSK3beta activity. J Cell Biochem (2009) 0.79
Transforming growth factor β1 increase of hydroxysteroid dehydrogenase proteins is partly suppressed by red clover isoflavones in human primary prostate cancer-derived stromal cells. Carcinogenesis (2011) 0.79
Induction of Gsk3β-β-TrCP interaction is required for late phase stabilization of β-catenin in canonical Wnt signaling. J Biol Chem (2014) 0.78
Natural Functions of PLIN2 Mediating Wnt/LiCl Signaling and Glycogen Synthase Kinase 3 (GSK3)/GSK3 Substrate-Related Effects Are Modulated by Lipid. Mol Cell Biol (2015) 0.78
Chronic over-nutrition and dysregulation of GSK3 in diseases. Nutr Metab (Lond) (2016) 0.77
Kermit interacts with Gαo, Vang, and motor proteins in Drosophila planar cell polarity. PLoS One (2013) 0.77
Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation. PLoS One (2012) 0.77
Practical lessons from theoretical models about the somitogenesis. Gene Regul Syst Bio (2007) 0.76
Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression. Cancer Cell Int (2008) 0.76
Wnt/β-Catenin Signaling Regulates the Expression of the Ammonium Permease Gene RHBG in Human Cancer Cells. PLoS One (2015) 0.76
Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with β-Catenin and Chromatin Remodelling. Stem Cells (2016) 0.75
The Wnt Blows: On the Functional Role of Wnt Signaling in Mycobacterium tuberculosis Infection and Beyond. Front Immunol (2016) 0.75
Heterotrimeric G protein signaling in polycystic kidney disease. Physiol Genomics (2016) 0.75
Expression Pattern of Axin2 During Chicken Development. PLoS One (2016) 0.75
The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation. Genes Dev (2017) 0.75
Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J Cell Biol (2003) 2.77
Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. J Biol Chem (2002) 2.49
A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system. Nucleic Acids Res (2004) 2.31
Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea. Development (2003) 2.18
Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway. J Biol Chem (2005) 1.97
Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy. Hepatology (2014) 1.87
Structure of a lipid droplet protein; the PAT family member TIP47. Structure (2004) 1.85
Functional studies on native and mutated forms of perilipins. A role in protein kinase A-mediated lipolysis of triacylglycerols. J Biol Chem (2002) 1.78
Wnt signaling in B-cell neoplasia. Oncogene (2003) 1.73
Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth. J Cell Biol (2011) 1.68
Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin. Blood (2002) 1.65
Wnts induce migration and invasion of myeloma plasma cells. Blood (2005) 1.58
Regulation of thymic epithelium by keratinocyte growth factor. Blood (2002) 1.57
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J Biol Chem (2009) 1.56
Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer. Cancer Res (2005) 1.56
Functional compensation for adipose differentiation-related protein (ADFP) by Tip47 in an ADFP null embryonic cell line. J Biol Chem (2006) 1.53
Existence of the canonical Wnt signaling pathway in the human trabecular meshwork. Invest Ophthalmol Vis Sci (2012) 1.53
Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets. J Cell Sci (2012) 1.48
Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Adv Cancer Res (2004) 1.48
Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation. J Bone Miner Res (2004) 1.45
The central role of perilipin a in lipid metabolism and adipocyte lipolysis. IUBMB Life (2004) 1.45
Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2. J Biol Chem (2004) 1.43
dictyBase: a new Dictyostelium discoideum genome database. Nucleic Acids Res (2004) 1.42
Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure. J Clin Invest (2008) 1.39
Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration. Hepatology (2005) 1.31
Diverse cytopathologies in mitochondrial disease are caused by AMP-activated protein kinase signaling. Mol Biol Cell (2007) 1.28
Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. Mol Cell Biol (2008) 1.27
Receptor-dependent and tyrosine phosphatase-mediated inhibition of GSK3 regulates cell fate choice. Dev Cell (2002) 1.27
Keratinocyte growth factor expression and activity in cancer: implications for use in patients with solid tumors. J Natl Cancer Inst (2006) 1.27
Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT. J Biol Chem (2005) 1.22
Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes. J Biol Chem (2003) 1.21
Myocilin is a modulator of Wnt signaling. Mol Cell Biol (2009) 1.14
Gene expression profile signatures indicate a role for Wnt signaling in endothelial commitment from embryonic stem cells. Circ Res (2006) 1.14
Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules. J Biol Chem (2001) 1.10
GSK3 at the edge: regulation of developmental specification and cell polarization. Curr Drug Targets (2006) 1.09
A G alpha-dependent pathway that antagonizes multiple chemoattractant responses that regulate directional cell movement. Genes Dev (2004) 1.08
Galpha-mediated inhibition of developmental signal response. Curr Biol (2002) 1.07
Perilipins: lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection. Biochimie (2013) 1.06
Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism. Amino Acids (2008) 1.04
Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex. Dis Model Mech (2010) 1.02
Oscillatory signaling and network responses during the development of Dictyostelium discoideum. Ageing Res Rev (2008) 1.01
Wnt signaling and neurite outgrowth: insights and questions. Cancer Sci (2007) 1.00
Wnt/Frizzled signaling in Ewing sarcoma. Pediatr Blood Cancer (2004) 1.00
Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2. J Cell Sci (2010) 0.99
Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling. Cell Signal (2013) 0.99
Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate. Dev Biol (2008) 0.98
Nonadaptive regulation of ERK2 in Dictyostelium: implications for mechanisms of cAMP relay. Mol Biol Cell (2006) 0.98
A Rab21/LIM-only/CH-LIM complex regulates phagocytosis via both activating and inhibitory mechanisms. EMBO J (2005) 0.97
VHL loss of function and its impact on oncogenic signaling networks in clear cell renal cell carcinoma. Int J Biochem Cell Biol (2008) 0.95
Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes. Arthritis Rheum (2002) 0.95
Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling. J Biol Chem (2013) 0.94
Genomic database resources for Dictyostelium discoideum. Nucleic Acids Res (2002) 0.93
Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells. J Cell Physiol (2012) 0.92
Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. Cell Signal (2012) 0.92
SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells. Stem Cells (2012) 0.90
Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function. Cell Signal (2009) 0.90
The COP9 signalosome regulates cell proliferation of Dictyostelium discoideum. Eur J Cell Biol (2006) 0.89
Combinatorial cell-specific regulation of GSK3 directs cell differentiation and polarity in Dictyostelium. Development (2011) 0.89
Rapid chemokinetic movement and the invasive potential of lung cancer cells; a functional molecular study. BMC Cancer (2006) 0.87
Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells. PLoS One (2012) 0.86
SFRP1 promoter methylation and expression in human trabecular meshwork cells. Exp Eye Res (2012) 0.84
sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration. Arch Biochem Biophys (2011) 0.84
TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing. J Cell Sci (2012) 0.82
Identification of a peptide binding motif for secreted frizzled-related protein-1. Peptides (2004) 0.81
Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay. J Cell Sci (2013) 0.80
Proliferation and pluripotency of human embryonic stem cells maintained on type I collagen. Stem Cells Dev (2010) 0.80
Biochemical responses to chemoattractants in Dictyostelium: ligand-receptor interactions and downstream kinase activation. Methods Mol Biol (2009) 0.80
The application of the Cre-loxP system for generating multiple knock-out and knock-in targeted loci. Methods Mol Biol (2013) 0.79
An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum. J Cell Sci (2014) 0.79
Atypical protein kinase Cι is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2. J Biol Chem (2013) 0.79
Purification and Wnt-inhibitory activities of secreted frizzled-related proteins. Methods Mol Biol (2008) 0.78
Chemoattractant stimulation of TORC2 is regulated by receptor/G protein-targeted inhibitory mechanisms that function upstream and independently of an essential GEF/Ras activation pathway in Dictyostelium. Mol Biol Cell (2013) 0.77
Different CHD chromatin remodelers are required for expression of distinct gene sets and specific stages during development of Dictyostelium discoideum. Development (2013) 0.77
The role of centrosomal casein kinase 1 delta in neurite outgrowth and beyond. Cell Cycle (2011) 0.75
Analysis of chromatin organization by deep sequencing technologies. Methods Mol Biol (2013) 0.75
RECURRENT CENTRAL SEROUS CHORIORETINOPATHY ASSOCIATED WITH RETINITIS PIGMENTOSA TREATED WITH CARBONIC ANHYDRASE INHIBITORS. Retin Cases Brief Rep (2016) 0.75