Published in Blood on November 01, 2002
Immunosenescence of ageing. J Pathol (2007) 3.32
Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol Endocrinol (2010) 2.67
Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science (2008) 2.59
Thymic involution and immune reconstitution. Trends Immunol (2009) 1.91
Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging. Blood (2006) 1.71
Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration. Blood (2005) 1.65
Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells. Blood (2007) 1.51
Cytokines, leptin, and stress-induced thymic atrophy. J Leukoc Biol (2008) 1.47
Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution. Proc Natl Acad Sci U S A (2016) 1.41
Changes in primary lymphoid organs with aging. Semin Immunol (2012) 1.40
Rejuvenation of the aging T cell compartment. Curr Opin Immunol (2009) 1.16
Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1. Proc Natl Acad Sci U S A (2006) 1.12
Clinical strategies to enhance T cell reconstitution. Semin Immunol (2007) 1.11
Differential requirement for mesenchyme in the proliferation and maturation of thymic epithelial progenitors. J Exp Med (2003) 1.10
Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation. Blood (2007) 1.10
Thymus involution and regeneration: two sides of the same coin? Nat Rev Immunol (2013) 0.99
Increased thymus- and decreased parathyroid-fated organ domains in Splotch mutant embryos. Dev Biol (2008) 0.97
The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond. J Leukoc Biol (2012) 0.97
The immunopathology of thymic GVHD. Semin Immunopathol (2008) 0.94
Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution. J Endocrinol (2009) 0.91
Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin. J Exp Med (2010) 0.89
Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses after murine allogeneic bone marrow transplantation. Blood (2008) 0.87
Thymic rejuvenation and aging. Curr Opin Immunol (2013) 0.86
Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: pre-clinical and clinical approaches. Semin Immunopathol (2008) 0.86
Thymic stromal lymphopoietin (TSLP) as a bridge between infection and atopy. Int J Clin Exp Pathol (2008) 0.85
Clinical strategies to enhance posttransplant immune reconstitution. Biol Blood Marrow Transplant (2008) 0.85
Thymic epithelial cell development and its dysfunction in human diseases. Biomed Res Int (2014) 0.83
Palifermin mediates immunoregulatory effects in addition to its cytoprotective effects in mice with acute graft-versus-host disease. J Clin Immunol (2008) 0.81
FOXN1 (GFP/w) reporter hESCs enable identification of integrin-β4, HLA-DR, and EpCAM as markers of human PSC-derived FOXN1(+) thymic epithelial progenitors. Stem Cell Reports (2014) 0.81
Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development. Blood (2009) 0.81
The thymus and the immune system: layered levels of control. J Thorac Oncol (2010) 0.81
Immunopathogenesis of feline immunodeficiency virus infection in the fetal and neonatal cat. Front Biosci (2007) 0.80
Greater than the sum of their parts: combination strategies for immune regeneration following allogeneic hematopoietic stem cell transplantation. Best Pract Res Clin Haematol (2011) 0.80
Peritransplant palifermin use and lymphocyte recovery after T-cell replete, matched related allogeneic hematopoietic cell transplantation. Am J Hematol (2011) 0.80
Up-regulation of intestinal epithelial cell derived IL-7 expression by keratinocyte growth factor through STAT1/IRF-1, IRF-2 pathway. PLoS One (2013) 0.79
Thymus: the next (re)generation. Immunol Rev (2016) 0.78
Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor. Blood (2008) 0.78
FSP1(+) fibroblast subpopulation is essential for the maintenance and regeneration of medullary thymic epithelial cells. Sci Rep (2015) 0.78
Thymic epithelial cell development and differentiation: cellular and molecular regulation. Protein Cell (2013) 0.77
Umbilical cord-derived mesenchymal stem cells regulate thymic epithelial cell development and function in Foxn1(-/-) mice. Cell Mol Immunol (2014) 0.77
Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts. Mol Ther (2015) 0.77
Palifermin for the protection and regeneration of epithelial tissues following injury: new findings in basic research and pre-clinical models. J Cell Mol Med (2013) 0.77
Keratinocyte growth factor up-regulates Interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo. Int J Clin Exp Pathol (2012) 0.77
A randomized controlled trial of palifermin (recombinant human keratinocyte growth factor) for the treatment of inadequate CD4+ T-lymphocyte recovery in patients with HIV-1 infection on antiretroviral therapy. J Acquir Immune Defic Syndr (2014) 0.76
Effect of palifermin in a murine model of graft-versus-host disease (GVHD) associated with Th2 cytokine production, autoantibody production, and glomerulonephritis. J Clin Immunol (2006) 0.76
Role of thymic stromal lymphopoietin (TSLP) in palifermin-mediated immune modulation and protection from acute murine graft-versus-host disease. J Clin Immunol (2010) 0.75
Epithelial LTβR signaling controls the population size of the progenitors of medullary thymic epithelial cells in neonatal mice. Sci Rep (2017) 0.75
Chemical castration of melanoma patients does not increase the frequency of tumor-specific CD4 and CD8 T cells after peptide vaccination. J Immunother (2013) 0.75
Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity (2005) 23.00
A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78
Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol (2001) 5.95
Control of regulatory T cell lineage commitment and maintenance. Immunity (2009) 4.63
Developmental regulation of Foxp3 expression during ontogeny. J Exp Med (2005) 4.32
Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med (2009) 3.13
Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol (2008) 2.98
Characterization of mouse and human B7-H3 genes. J Immunol (2002) 2.86
Regulation of immunity by self-reactive T cells. Nature (2005) 2.63
Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation. J Exp Med (2010) 2.44
Surgical removal of the primary tumor increases overall survival in patients with metastatic breast cancer: analysis of the 1988-2003 SEER data. Ann Surg Oncol (2007) 2.36
The role of the transcription factor Foxp3 in the development of regulatory T cells. Immunol Rev (2006) 2.36
Differentiation of regulatory Foxp3+ T cells in the thymic cortex. Proc Natl Acad Sci U S A (2008) 2.24
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells. Nat Immunol (2013) 2.21
Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea. Development (2003) 2.18
Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J Immunol (2009) 2.17
Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol (2013) 2.13
Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development. Nat Immunol (2007) 2.08
Control of immune homeostasis by naturally arising regulatory CD4+ T cells. Curr Opin Immunol (2003) 2.04
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease. J Clin Invest (2007) 2.02
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92
Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy. Hepatology (2014) 1.87
Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins. Curr Biol (2005) 1.79
Wnt signaling in B-cell neoplasia. Oncogene (2003) 1.73
Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors. Blood (2004) 1.68
Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth. J Cell Biol (2011) 1.68
Regulation of leukemic cell adhesion, proliferation, and survival by beta-catenin. Blood (2002) 1.65
Uncoupling of proliferation and Stat5 activation in thymic stromal lymphopoietin-mediated signal transduction. J Immunol (2002) 1.65
Wnts induce migration and invasion of myeloma plasma cells. Blood (2005) 1.58
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J Biol Chem (2009) 1.56
Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer. Cancer Res (2005) 1.56
Existence of the canonical Wnt signaling pathway in the human trabecular meshwork. Invest Ophthalmol Vis Sci (2012) 1.53
Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair. Adv Cancer Res (2004) 1.48
Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation. J Immunol (2007) 1.46
Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation. J Bone Miner Res (2004) 1.45
Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2. J Biol Chem (2004) 1.43
Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure. J Clin Invest (2008) 1.39
Molecular orchestration of differentiation and function of regulatory T cells. Genes Dev (2009) 1.38
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor. Nat Immunol (2011) 1.36
A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation. J Immunol (2002) 1.35
Increased TSLP availability restores T- and B-cell compartments in adult IL-7 deficient mice. Blood (2007) 1.34
Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration. Hepatology (2005) 1.31
Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. Mol Cell Biol (2008) 1.27
Thymocyte expression of cathepsin L is essential for NKT cell development. Nat Immunol (2002) 1.27
Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands. J Exp Med (2002) 1.27
Keratinocyte growth factor expression and activity in cancer: implications for use in patients with solid tumors. J Natl Cancer Inst (2006) 1.27
Contrasting models of promiscuous gene expression by thymic epithelium. J Exp Med (2005) 1.24
Lack of Foxp3 function and expression in the thymic epithelium. J Exp Med (2007) 1.22
Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation. J Immunol (2008) 1.20
Myocilin is a modulator of Wnt signaling. Mol Cell Biol (2009) 1.14
Gene expression profile signatures indicate a role for Wnt signaling in endothelial commitment from embryonic stem cells. Circ Res (2006) 1.14
Interleukin-15 interactions with interleukin-15 receptor complexes: characterization and species specificity. Cytokine (2002) 1.13
Features of medullary thymic epithelium implicate postnatal development in maintaining epithelial heterogeneity and tissue-restricted antigen expression. J Immunol (2006) 1.12
Olmsted syndrome: exploration of the immunological phenotype. Orphanet J Rare Dis (2013) 1.11
Visualization and identification of IL-7 producing cells in reporter mice. PLoS One (2009) 1.11
Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules. J Biol Chem (2001) 1.10
Differential regulation of cathepsin S and cathepsin L in interferon gamma-treated macrophages. J Exp Med (2003) 1.08
MicroRNA-29 in the adaptive immune system: setting the threshold. Cell Mol Life Sci (2012) 1.07
Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis. Blood (2011) 1.02
Wnt signaling and neurite outgrowth: insights and questions. Cancer Sci (2007) 1.00
Wnt/Frizzled signaling in Ewing sarcoma. Pediatr Blood Cancer (2004) 1.00
Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice. J Autoimmun (2012) 1.00
The absence of platelet-derived growth factor-B in circulating cells promotes immune and inflammatory responses in atherosclerosis-prone ApoE-/- mice. Am J Pathol (2005) 0.99
Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling. Cell Signal (2013) 0.99
Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate. Dev Biol (2008) 0.98
Cutting edge: TCR revision occurs in germinal centers. J Immunol (2004) 0.98
Duration of antigen expression in vivo following DNA immunization modifies the magnitude, contraction, and secondary responses of CD8+ T lymphocytes. J Immunol (2007) 0.98
MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection. J Immunol (2012) 0.97
A VEGF165-induced phenotypic switch from increased vessel density to increased vessel diameter and increased endothelial NOS activity. Microvasc Res (2006) 0.95
Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes. Arthritis Rheum (2002) 0.95
VHL loss of function and its impact on oncogenic signaling networks in clear cell renal cell carcinoma. Int J Biochem Cell Biol (2008) 0.95
Growth factor expression in a murine model of cryoglobulinemia. Kidney Int (2003) 0.95
Functional consequences of Wnt-induced dishevelled 2 phosphorylation in canonical and noncanonical Wnt signaling. J Biol Chem (2013) 0.94
Cervical thymus in the mouse. J Immunol (2006) 0.93
Deletion of the fcgamma receptor IIb in thymic stromal lymphopoietin transgenic mice aggravates membranoproliferative glomerulonephritis. Am J Pathol (2003) 0.92
Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors. Cell Signal (2012) 0.92
Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells. J Cell Physiol (2012) 0.92
NKG2D splice variants: a reexamination of adaptor molecule associations. Immunogenetics (2006) 0.92
FGFR2IIIb signaling regulates thymic epithelial differentiation. Dev Dyn (2007) 0.91
An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression. Eur J Immunol (2013) 0.91
SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells. Stem Cells (2012) 0.90
Loss-of-function point mutations and two-furin domain derivatives provide insights about R-spondin2 structure and function. Cell Signal (2009) 0.90
Oral interferon-alpha treatment of mice with cryoglobulinemic glomerulonephritis. Am J Kidney Dis (2002) 0.88
Lessons from thymic epithelial heterogeneity: FoxN1 and tissue-restricted gene expression by extrathymic, endodermally derived epithelium. J Immunol (2009) 0.87
Rapid chemokinetic movement and the invasive potential of lung cancer cells; a functional molecular study. BMC Cancer (2006) 0.87
An organized medullary epithelial structure in the normal thymus expresses molecules of respiratory epithelium and resembles the epithelial thymic rudiment of nude mice. J Immunol (2005) 0.87
Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells. PLoS One (2012) 0.86
Rapamycin increases survival in ALS mice lacking mature lymphocytes. Mol Neurodegener (2013) 0.86
Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism. Eur J Immunol (2012) 0.86
Lymphatic endothelial murine chloride channel calcium-activated 1 is a ligand for leukocyte LFA-1 and Mac-1. J Immunol (2010) 0.86
SFRP1 promoter methylation and expression in human trabecular meshwork cells. Exp Eye Res (2012) 0.84
sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration. Arch Biochem Biophys (2011) 0.84
No evidence for a role of rare CYP27B1 functional variations in multiple sclerosis. Ann Neurol (2013) 0.84
Clinico-pathologic characteristics of patients with hepatic lymphoma diagnosed using image-guided liver biopsy techniques. Leuk Lymphoma (2011) 0.82
Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis. Kidney Int (2004) 0.81
Thymic stromal lymphopoietin transgenic mice develop cryoglobulinemia and hepatitis with similarities to human hepatitis C liver disease. Am J Pathol (2007) 0.81
Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes. Proc Natl Acad Sci U S A (2002) 0.81
Identification of a peptide binding motif for secreted frizzled-related protein-1. Peptides (2004) 0.81