Published in Cell on April 18, 2003
The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient. Cell (2005) 2.19
A system of repressor gradients spatially organizes the boundaries of Bicoid-dependent target genes. Cell (2012) 1.96
Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses. Aging Cell (2009) 1.72
Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface. Dev Biol (2007) 1.66
Genes affecting cell competition in Drosophila. Genetics (2006) 1.51
Shadow enhancers: frequently asked questions about distributed cis-regulatory information and enhancer redundancy. Bioessays (2011) 1.48
Cooperative regulation of growth by Yorkie and Mad through bantam. Dev Cell (2011) 1.46
Design flexibility in cis-regulatory control of gene expression: synthetic and comparative evidence. Dev Biol (2008) 1.45
TGF-beta-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. EMBO J (2004) 1.42
Control of Dpp morphogen signalling by a secreted feedback regulator. Nat Cell Biol (2010) 1.38
Groucho oligomerization is required for repression in vivo. Mol Cell Biol (2004) 1.36
Dpp signaling activity requires Pentagone to scale with tissue size in the growing Drosophila wing imaginal disc. PLoS Biol (2011) 1.24
Dpp spreading is required for medial but not for lateral wing disc growth. Nature (2015) 1.18
A conserved activation element in BMP signaling during Drosophila development. Nat Struct Mol Biol (2009) 1.18
Regulation of spalt expression in the Drosophila wing blade in response to the Decapentaplegic signaling pathway. Proc Natl Acad Sci U S A (2004) 1.16
Mechanisms of growth and homeostasis in the Drosophila wing. Annu Rev Cell Dev Biol (2009) 1.12
EvoD/Vo: the origins of BMP signalling in the neuroectoderm. Nat Rev Genet (2008) 1.10
Formation of the long range Dpp morphogen gradient. PLoS Biol (2011) 1.03
Multiple modular promoter elements drive graded brinker expression in response to the Dpp morphogen gradient. Development (2008) 1.02
Twisted gastrulation limits apoptosis in the distal region of the mandibular arch in mice. Dev Biol (2009) 1.00
Wingless directly represses DPP morphogen expression via an armadillo/TCF/Brinker complex. PLoS One (2007) 0.99
Mad is required for wingless signaling in wing development and segment patterning in Drosophila. PLoS One (2009) 0.97
Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo. Genes Dev (2008) 0.96
Phosphorylation of Mad controls competition between wingless and BMP signaling. Sci Signal (2011) 0.95
Logic of Wg and Dpp induction of distal and medial fates in the Drosophila leg. Development (2008) 0.94
Spatial discontinuity of optomotor-blind expression in the Drosophila wing imaginal disc disrupts epithelial architecture and promotes cell sorting. BMC Dev Biol (2010) 0.94
Hyperactive BMP signaling induced by ALK2(R206H) requires type II receptor function in a Drosophila model for classic fibrodysplasia ossificans progressiva. Dev Dyn (2012) 0.92
Autoregulatory feedback controls sequential action of cis-regulatory modules at the brinker locus. Dev Cell (2013) 0.91
A large bioactive BMP ligand with distinct signaling properties is produced by alternative proconvertase processing. Sci Signal (2012) 0.89
Brk regulates wing disc growth in part via repression of Myc expression. EMBO Rep (2013) 0.86
Functional analysis of saxophone, the Drosophila gene encoding the BMP type I receptor ortholog of human ALK1/ACVRL1 and ACVR1/ALK2. Genetics (2009) 0.85
Cell cycle arrest by a gradient of Dpp signaling during Drosophila eye development. BMC Dev Biol (2010) 0.85
Ancestral and conserved cis-regulatory architectures in developmental control genes. Dev Biol (2011) 0.84
Alternative trans-splicing of Caenorhabditis elegans sma-9/schnurri generates a short transcript that provides tissue-specific function in BMP signaling. BMC Mol Biol (2010) 0.84
Strategies for exploring TGF-β signaling in Drosophila. Methods (2014) 0.83
Activin receptor inhibition by Smad2 regulates Drosophila wing disc patterning through BMP-response elements. Development (2013) 0.82
Circadian period integrates network information through activation of the BMP signaling pathway. PLoS Biol (2013) 0.82
CTCF-dependent co-localization of canonical Smad signaling factors at architectural protein binding sites in D. melanogaster. Cell Cycle (2015) 0.81
Drosophila Follistatin exhibits unique structural modifications and interacts with several TGF-beta family members. Mech Dev (2007) 0.81
Manipulating the sensitivity of signal-induced repression: quantification and consequences of altered brinker gradients. PLoS One (2013) 0.78
Bipartite recognition of DNA by TCF/Pangolin is remarkably flexible and contributes to transcriptional responsiveness and tissue specificity of wingless signaling. PLoS Genet (2014) 0.77
Asymmetric distribution of Spalt in Drosophila wing squamous and columnar epithelia ensures correct cell morphogenesis. Sci Rep (2016) 0.77
BMPs regulate msx gene expression in the dorsal neuroectoderm of Drosophila and vertebrates by distinct mechanisms. PLoS Genet (2014) 0.77
EGFR-dependent downregulation of Capicua and the establishment of Drosophila dorsoventral polarity. Fly (Austin) (2012) 0.77
Dpp-expressing and non-expressing cells: two different populations of growing cells in Drosophila. PLoS One (2015) 0.75
spalt is functionally conserved in Locusta and Drosophila to promote wing growth. Sci Rep (2017) 0.75
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature (2002) 14.63
An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc Natl Acad Sci U S A (2007) 12.13
Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. Cell (2006) 4.09
The many faces and functions of β-catenin. EMBO J (2012) 3.85
Beta-catenin hits chromatin: regulation of Wnt target gene activation. Nat Rev Mol Cell Biol (2009) 3.67
Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature (2002) 3.67
dMyc transforms cells into super-competitors. Cell (2004) 3.66
Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell (2002) 3.42
The Decapentaplegic morphogen gradient: from pattern formation to growth regulation. Nat Rev Genet (2007) 3.04
Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development. Nature (2002) 2.98
Complex cell rearrangements during intersegmental vessel sprouting and vessel fusion in the zebrafish embryo. Dev Biol (2008) 2.83
Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Curr Biol (2002) 2.54
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo. Cell (2006) 2.47
Wingless secretion promotes and requires retromer-dependent cycling of Wntless. Nat Cell Biol (2008) 2.43
Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster. PLoS Biol (2009) 2.25
Transcription in the absence of histone H3.3. Curr Biol (2009) 2.24
Semaphorin-PlexinD1 signaling limits angiogenic potential via the VEGF decoy receptor sFlt1. Dev Cell (2011) 2.23
Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med (2009) 2.12
Transcription under the control of nuclear Arm/beta-catenin. Curr Biol (2006) 2.11
In vivo imaging reveals different cellular functions for FGF and Dpp signaling in tracheal branching morphogenesis. Dev Cell (2002) 1.87
Deterministic protein inference for shotgun proteomics data provides new insights into Arabidopsis pollen development and function. Genome Res (2009) 1.83
Expansion-repression mechanism for scaling the Dpp activation gradient in Drosophila wing imaginal discs. Curr Biol (2011) 1.79
Genome-wide analysis of alternative pre-mRNA splicing. J Biol Chem (2007) 1.78
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell (2002) 1.77
Model for the regulation of size in the wing imaginal disc of Drosophila. Mech Dev (2006) 1.76
Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. Mol Cell (2004) 1.73
Fluorescent fusion protein knockout mediated by anti-GFP nanobody. Nat Struct Mol Biol (2011) 1.71
A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Dev Cell (2004) 1.60
Wnt trafficking: new insights into Wnt maturation, secretion and spreading. Traffic (2010) 1.60
Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein. Nat Cell Biol (2003) 1.59
Exploring the effects of mechanical feedback on epithelial topology. Development (2010) 1.59
Distinct cellular mechanisms of blood vessel fusion in the zebrafish embryo. Curr Biol (2011) 1.57
Genetic control of cell intercalation during tracheal morphogenesis in Drosophila. Curr Biol (2004) 1.55
Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila. Dev Cell (2005) 1.53
Porcupine-mediated lipidation is required for Wnt recognition by Wls. Dev Biol (2011) 1.51
A universal method for automated gene mapping. Genome Biol (2005) 1.50
Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin. Curr Biol (2005) 1.50
Wingful, an extracellular feedback inhibitor of Wingless. Genes Dev (2002) 1.48
The hypothalamic neuropeptide oxytocin is required for formation of the neurovascular interface of the pituitary. Dev Cell (2011) 1.46
Helping Wingless take flight: how WNT proteins are secreted. Nat Rev Mol Cell Biol (2007) 1.42
Control of Dpp morphogen signalling by a secreted feedback regulator. Nat Cell Biol (2010) 1.38
A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivo. Blood (2009) 1.37
Tip-cell migration controls stalk-cell intercalation during Drosophila tracheal tube elongation. Curr Biol (2008) 1.32
Refined LexA transactivators and their use in combination with the Drosophila Gal4 system. Proc Natl Acad Sci U S A (2010) 1.31
Vascular morphogenesis in the zebrafish embryo. Dev Biol (2009) 1.30
Clinical outcome in IL-10- and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation. J Allergy Clin Immunol (2012) 1.30
In vivo analysis reveals a highly stereotypic morphogenetic pathway of vascular anastomosis. Dev Cell (2013) 1.30
Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins. Mech Dev (2005) 1.29
A screen for genes expressed in Drosophila imaginal discs. Int J Dev Biol (2002) 1.29
Generating and navigating proteome maps using mass spectrometry. Nat Rev Mol Cell Biol (2010) 1.29
Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas. Cancer Res (2010) 1.28
Regulation of organ growth by morphogen gradients. Cold Spring Harb Perspect Biol (2010) 1.28
A versatile platform for creating a comprehensive UAS-ORFeome library in Drosophila. Development (2013) 1.25
Dpp signaling activity requires Pentagone to scale with tissue size in the growing Drosophila wing imaginal disc. PLoS Biol (2011) 1.24
Recombinases and their use in gene activation, gene inactivation, and transgenesis. Methods Mol Biol (2008) 1.21
Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size. Development (2012) 1.20
WNT secretion and signalling in human disease. Trends Mol Med (2012) 1.19
A conserved activation element in BMP signaling during Drosophila development. Nat Struct Mol Biol (2009) 1.18
Probing transcription-specific outputs of β-catenin in vivo. Genes Dev (2011) 1.18
Zona pellucida domain proteins remodel the apical compartment for localized cell shape changes. Dev Cell (2010) 1.18
Polychaetoid/ZO-1 is required for cell specification and rearrangement during Drosophila tracheal morphogenesis. Curr Biol (2006) 1.16
A family of genes encoding zona pellucida (ZP) domain proteins is expressed in various epithelial tissues during Drosophila embryogenesis. Gene Expr Patterns (2004) 1.14
Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels. Development (2008) 1.14
VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nat Commun (2013) 1.13
Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila. EMBO J (2008) 1.12
Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. Am J Hum Genet (2013) 1.11
A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component. Genetics (2005) 1.09
A genetic screen for hedgehog targets involved in the maintenance of the Drosophila anteroposterior compartment boundary. Genetics (2003) 1.07
A unique Extradenticle recruitment mode in the Drosophila Hox protein Ultrabithorax. Proc Natl Acad Sci U S A (2007) 1.07
The tip cell concept 10 years after: new players tune in for a common theme. Exp Cell Res (2013) 1.07
Identification and in vivo role of the Armadillo-Legless interaction. Development (2004) 1.06
Antagonistic growth regulation by Dpp and Fat drives uniform cell proliferation. Dev Cell (2011) 1.04
BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival. Mol Cell Biol (2004) 1.03
Formation of the long range Dpp morphogen gradient. PLoS Biol (2011) 1.03
The hedgehog signaling pathway: where did it come from? PLoS Biol (2009) 1.02
A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK. PLoS One (2009) 1.02
A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion. EMBO Rep (2011) 1.02
Dpp signaling directs cell motility and invasiveness during epithelial morphogenesis. Curr Biol (2010) 1.02
Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells. EMBO J (2010) 1.02
Blood flow changes coincide with cellular rearrangements during blood vessel pruning in zebrafish embryos. PLoS One (2013) 1.02
Requirement for Pangolin/dTCF in Drosophila Wingless signaling. Proc Natl Acad Sci U S A (2003) 1.01
The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development. PLoS One (2010) 1.01
Maternal-effect loci involved in Drosophila oogenesis and embryogenesis: P element-induced mutations on the third chromosome. Int J Dev Biol (2002) 1.00
A high-throughput template for optimizing Drosophila organ culture with response-surface methods. Development (2013) 0.99
The ubiquitin-like protein HUB1 forms SDS-resistant complexes with cellular proteins in the absence of ATP. EMBO Rep (2003) 0.99
The ISWI-containing NURF complex regulates the output of the canonical Wingless pathway. EMBO Rep (2009) 0.99
Enhancer blocking and transvection at the Drosophila apterous locus. Genetics (2008) 0.99
The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis. Development (2011) 0.99
Renal tubule development in Drosophila: a closer look at the cellular level. J Am Soc Nephrol (2005) 0.98
Signal-induced repression: the exception or the rule in developmental signaling? Dev Cell (2008) 0.98
The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control. Mech Dev (2009) 0.97
gammaCOP is required for apical protein secretion and epithelial morphogenesis in Drosophila melanogaster. PLoS One (2008) 0.96