Published in Cell on May 05, 2006
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc Natl Acad Sci U S A (2007) 3.24
Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila. Proc Natl Acad Sci U S A (2014) 2.97
Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless. Cell (2009) 2.91
Active Wnt proteins are secreted on exosomes. Nat Cell Biol (2012) 2.81
Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver. Nature (2015) 2.77
A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol (2011) 2.68
Wnt signaling from development to disease: insights from model systems. Cold Spring Harb Perspect Biol (2009) 2.42
R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell (2008) 2.37
Sorting nexins provide diversity for retromer-dependent trafficking events. Nat Cell Biol (2011) 2.32
Wnt signal transduction pathways. Organogenesis (2008) 2.14
C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless. Dev Cell (2007) 2.10
Update on Wnt signaling in bone cell biology and bone disease. Gene (2011) 2.03
The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network. Dev Cell (2009) 1.99
Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling. Biochem J (2007) 1.95
Three decades of Wnts: a personal perspective on how a scientific field developed. EMBO J (2012) 1.89
Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation. Development (2012) 1.89
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Cell (2012) 1.89
Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc Natl Acad Sci U S A (2009) 1.86
The canonical Wnt signalling pathway and its APC partner in colon cancer development. Gut (2006) 1.86
Wntless functions in mature osteoblasts to regulate bone mass. Proc Natl Acad Sci U S A (2012) 1.85
The microRNA miR-8 is a conserved negative regulator of Wnt signaling. Proc Natl Acad Sci U S A (2008) 1.76
Wnt proteins. Cold Spring Harb Perspect Biol (2012) 1.70
Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development. J Bone Miner Res (2013) 1.64
Generation of mice with a conditional null allele for Wntless. Genesis (2010) 1.55
Olfactomedin domain-containing proteins: possible mechanisms of action and functions in normal development and pathology. Mol Neurobiol (2009) 1.54
WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. J Cell Sci (2010) 1.54
The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biol (2014) 1.52
Molecular regulation of kidney development: is the answer blowing in the Wnt? Pediatr Nephrol (2007) 1.52
Epithelial Wnt ligand secretion is required for adult hair follicle growth and regeneration. J Invest Dermatol (2012) 1.48
Lipid-independent secretion of a Drosophila Wnt protein. J Biol Chem (2008) 1.48
Presynaptic local signaling by a canonical wingless pathway regulates development of the Drosophila neuromuscular junction. J Neurosci (2008) 1.45
Wnt/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des (2013) 1.44
Wnt activation in nail epithelium couples nail growth to digit regeneration. Nature (2013) 1.41
The way Wnt works: components and mechanism. Growth Factors (2012) 1.37
Regulation of Wnt protein secretion and its role in gradient formation. EMBO Rep (2008) 1.35
Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45. Mol Biol Cell (2008) 1.34
Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells. Nat Commun (2013) 1.34
A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. Differentiation (2012) 1.31
Constitutive gene expression and the specification of tissue identity in adult planarian biology. Trends Genet (2011) 1.30
β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis. Gastroenterology (2015) 1.20
Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt. Pigment Cell Melanoma Res (2009) 1.19
Inducible progenitor-derived Wingless regulates adult midgut regeneration in Drosophila. EMBO J (2012) 1.18
Multiple Wnt genes are required for segmentation in the short-germ embryo of Tribolium castaneum. Curr Biol (2008) 1.18
Functional sphere profiling reveals the complexity of neuroblastoma tumor-initiating cell model. Neoplasia (2011) 1.15
SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless. Cell Res (2011) 1.13
Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis. J Invest Dermatol (2012) 1.13
Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila. EMBO J (2008) 1.12
The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis. EMBO Mol Med (2011) 1.10
β-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation! Hepatology (2014) 1.09
Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein. Development (2011) 1.09
The evolution of the Wnt pathway. Cold Spring Harb Perspect Biol (2012) 1.06
Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence. BMC Neurosci (2010) 1.05
Wnt signaling in neuromuscular junction development. Cold Spring Harb Perspect Biol (2012) 1.05
A dedicated Wnt secretion factor. Cell (2006) 1.04
Palmitoylation regulates epidermal homeostasis and hair follicle differentiation. PLoS Genet (2009) 1.04
Tumor hypoxia blocks Wnt processing and secretion through the induction of endoplasmic reticulum stress. Mol Cell Biol (2008) 1.04
Wnt signal from multiple tissues and lin-3/EGF signal from the gonad maintain vulval precursor cell competence in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2007) 1.04
Cancer becomes wasteful: emerging roles of exosomes(†) in cell-fate determination. J Extracell Vesicles (2013) 1.04
Wntless is required for peripheral lung differentiation and pulmonary vascular development. Dev Biol (2013) 1.03
Drosophila S2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes. Traffic (2012) 1.03
A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion. EMBO Rep (2011) 1.02
Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells. EMBO J (2010) 1.02
Precise regulation of porcupine activity is required for physiological Wnt signaling. J Biol Chem (2012) 1.02
To Wnt or not to Wnt: the bone and joint health dilemma. Nat Rev Rheumatol (2013) 1.01
Systematic Evaluation of Drosophila CRISPR Tools Reveals Safe and Robust Alternatives to Autonomous Gene Drives in Basic Research. G3 (Bethesda) (2015) 1.01
Endocytosis, signaling, and beyond. Cold Spring Harb Perspect Biol (2014) 1.01
Expression of Gpr177, a Wnt trafficking regulator, in mouse embryogenesis. Dev Dyn (2010) 1.00
Genetic epidemiology of age-related osteoporosis and its clinical applications. Nat Rev Rheumatol (2010) 0.99
Drugging the cancer stem cell compartment: lessons learned from the hedgehog and Wnt signal transduction pathways. Annu Rev Pharmacol Toxicol (2011) 0.97
p24 proteins are required for secretion of Wnt ligands. EMBO Rep (2011) 0.97
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis (2016) 0.97
PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation. PLoS One (2012) 0.96
Roles of N-glycosylation and lipidation in Wg secretion and signaling. Dev Biol (2012) 0.96
Role and regulation of β-catenin signaling during physiological liver growth. Gene Expr (2014) 0.95
Xenopus Wntless and the retromer complex cooperate to regulate XWnt4 secretion. Mol Cell Biol (2009) 0.95
Wnt signaling in cancer. Oncogene (2016) 0.95
Wnt and the Wnt signaling pathway in bone development and disease. Front Biosci (Landmark Ed) (2014) 0.94
Wnt signaling controls the stem cell-like asymmetric division of the epithelial seam cells during C. elegans larval development. Dev Biol (2010) 0.94
Wnts produced by Osterix-expressing osteolineage cells regulate their proliferation and differentiation. Proc Natl Acad Sci U S A (2014) 0.94
Differential palmit(e)oylation of Wnt1 on C93 and S224 residues has overlapping and distinct consequences. PLoS One (2011) 0.94
A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice. Bone Res (2013) 0.94
Intra-epithelial requirement of canonical Wnt signaling for tooth morphogenesis. J Biol Chem (2013) 0.94
Wnt/β-catenin Signaling in Normal and Cancer Stem Cells. Cancers (Basel) (2011) 0.94
Fatty acyl donor selectivity in membrane bound O-acyltransferases and communal cell fate decision-making. Biochem Soc Trans (2015) 0.94
Lipid-modified morphogens: functions of fats. Curr Opin Genet Dev (2009) 0.93
Identification of an endocytosis motif in an intracellular loop of Wntless protein, essential for its recycling and the control of Wnt protein signaling. J Biol Chem (2011) 0.92
Regulation of developmental intercellular signalling by intracellular trafficking. EMBO J (2011) 0.91
β-catenin-dependent Wnt signaling in C. elegans: teaching an old dog a new trick. Cold Spring Harb Perspect Biol (2012) 0.91
Wls is expressed in the epidermis and regulates embryonic hair follicle induction in mice. PLoS One (2012) 0.90
Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses. PLoS Pathog (2013) 0.90
Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair. Blood (2013) 0.90
Wnt/β-catenin signaling in kidney injury and repair: a double-edged sword. Lab Invest (2015) 0.90
Wntless in Wnt secretion: molecular, cellular and genetic aspects. Front Biol (Beijing) (2012) 0.89
Brain transcriptome variation among behaviorally distinct strains of zebrafish (Danio rerio). BMC Genomics (2012) 0.89
The long and the short of Wnt signaling in C. elegans. Curr Opin Genet Dev (2008) 0.89
Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis. J Exp Med (2013) 0.89
Functional genomic identification of genes required for male gonadal differentiation in Caenorhabditis elegans. Genetics (2010) 0.89
Transmission, Development, and Plasticity of Synapses. Genetics (2015) 0.89
Wnt signaling regulates pulp volume and dentin thickness. J Bone Miner Res (2014) 0.89
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature (2003) 26.58
An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc Natl Acad Sci U S A (2007) 12.13
The many faces and functions of β-catenin. EMBO J (2012) 3.85
Beta-catenin hits chromatin: regulation of Wnt target gene activation. Nat Rev Mol Cell Biol (2009) 3.67
dMyc transforms cells into super-competitors. Cell (2004) 3.66
Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell (2002) 3.42
The Decapentaplegic morphogen gradient: from pattern formation to growth regulation. Nat Rev Genet (2007) 3.04
Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development. Nature (2002) 2.98
Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. Dev Cell (2010) 2.84
Centrosome maturation and duplication in C. elegans require the coiled-coil protein SPD-2. Dev Cell (2004) 2.60
Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Curr Biol (2002) 2.54
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo. Cell (2006) 2.47
Wingless secretion promotes and requires retromer-dependent cycling of Wntless. Nat Cell Biol (2008) 2.43
Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster. PLoS Biol (2009) 2.25
Transcription in the absence of histone H3.3. Curr Biol (2009) 2.24
Transcription under the control of nuclear Arm/beta-catenin. Curr Biol (2006) 2.11
Deterministic protein inference for shotgun proteomics data provides new insights into Arabidopsis pollen development and function. Genome Res (2009) 1.83
Drosophila sex-peptide stimulates female innate immune system after mating via the Toll and Imd pathways. Curr Biol (2005) 1.81
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell (2002) 1.77
Model for the regulation of size in the wing imaginal disc of Drosophila. Mech Dev (2006) 1.76
Wnt trafficking: new insights into Wnt maturation, secretion and spreading. Traffic (2010) 1.60
A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Dev Cell (2004) 1.60
Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity. J Cell Biol (2003) 1.60
Exploring the effects of mechanical feedback on epithelial topology. Development (2010) 1.59
Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. Cell (2003) 1.58
Porcupine-mediated lipidation is required for Wnt recognition by Wls. Dev Biol (2011) 1.51
A universal method for automated gene mapping. Genome Biol (2005) 1.50
Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin. Curr Biol (2005) 1.50
Wingful, an extracellular feedback inhibitor of Wingless. Genes Dev (2002) 1.48
Helping Wingless take flight: how WNT proteins are secreted. Nat Rev Mol Cell Biol (2007) 1.42
Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition. Dev Cell (2010) 1.36
Refined LexA transactivators and their use in combination with the Drosophila Gal4 system. Proc Natl Acad Sci U S A (2010) 1.31
Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins. Mech Dev (2005) 1.29
A screen for genes expressed in Drosophila imaginal discs. Int J Dev Biol (2002) 1.29
Generating and navigating proteome maps using mass spectrometry. Nat Rev Mol Cell Biol (2010) 1.29
Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas. Cancer Res (2010) 1.28
Regulation of organ growth by morphogen gradients. Cold Spring Harb Perspect Biol (2010) 1.28
A versatile platform for creating a comprehensive UAS-ORFeome library in Drosophila. Development (2013) 1.25
Recombinases and their use in gene activation, gene inactivation, and transgenesis. Methods Mol Biol (2008) 1.21
Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size. Development (2012) 1.20
WNT secretion and signalling in human disease. Trends Mol Med (2012) 1.19
Probing transcription-specific outputs of β-catenin in vivo. Genes Dev (2011) 1.18
Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels. Development (2008) 1.14
Intraductal oncocytic papillary neoplasm of the pancreas: a radio-pathological case study. JOP (2010) 1.13
Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila. EMBO J (2008) 1.12
A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component. Genetics (2005) 1.09
A genetic screen for hedgehog targets involved in the maintenance of the Drosophila anteroposterior compartment boundary. Genetics (2003) 1.07
Identification and in vivo role of the Armadillo-Legless interaction. Development (2004) 1.06
Antagonistic growth regulation by Dpp and Fat drives uniform cell proliferation. Dev Cell (2011) 1.04
Haemodynamic consequences of changing bicarbonate and calcium concentrations in haemodialysis fluids. Nephrol Dial Transplant (2008) 1.03
Formation of the long range Dpp morphogen gradient. PLoS Biol (2011) 1.03
The hedgehog signaling pathway: where did it come from? PLoS Biol (2009) 1.02
Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells. EMBO J (2010) 1.02
A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion. EMBO Rep (2011) 1.02
A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK. PLoS One (2009) 1.02
Requirement for Pangolin/dTCF in Drosophila Wingless signaling. Proc Natl Acad Sci U S A (2003) 1.01
Maternal-effect loci involved in Drosophila oogenesis and embryogenesis: P element-induced mutations on the third chromosome. Int J Dev Biol (2002) 1.00
A high-throughput template for optimizing Drosophila organ culture with response-surface methods. Development (2013) 0.99
The ISWI-containing NURF complex regulates the output of the canonical Wingless pathway. EMBO Rep (2009) 0.99
Signal-induced repression: the exception or the rule in developmental signaling? Dev Cell (2008) 0.98
The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control. Mech Dev (2009) 0.97
A proteome catalog of Drosophila melanogaster: an essential resource for targeted quantitative proteomics. Fly (Austin) (2007) 0.94
Transcription in the absence of histone H3.2 and H3K4 methylation. Curr Biol (2012) 0.94
BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling. Mech Dev (2006) 0.93
Systematic screening of a Drosophila ORF library in vivo uncovers Wnt/Wg pathway components. Dev Cell (2013) 0.92
Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth. BMC Dev Biol (2008) 0.92
Expression of MAGE-C1/CT7 and MAGE-C2/CT10 predicts lymph node metastasis in melanoma patients. PLoS One (2011) 0.92
Identification of an endocytosis motif in an intracellular loop of Wntless protein, essential for its recycling and the control of Wnt protein signaling. J Biol Chem (2011) 0.92
Functional characterization of Drosophila microRNAs by a novel in vivo library. Genetics (2012) 0.91
Comment on "Dynamics of dpp signaling and proliferation control". Science (2012) 0.91
The PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3. Mech Dev (2009) 0.90
Fine analysis of spontaneous MAGE-C1/CT7-specific immunity in melanoma patients. Proc Natl Acad Sci U S A (2010) 0.89
The expression of SPARC in human tumors is consistent with its role during cell competition. Commun Integr Biol (2011) 0.86
Cell biology. Cytonemes show their colors. Science (2011) 0.85
Structure-function analysis of Eiger, the Drosophila TNF homolog. Cell Res (2009) 0.85
Cell-sorting at the A/P boundary in the Drosophila wing primordium: a computational model to consolidate observed non-local effects of Hh signaling. PLoS Comput Biol (2011) 0.85
Wnt/β-catenin signaling regulates sequential fate decisions of murine cortical precursor cells. Stem Cells (2015) 0.83
Occupational health risks of pathologists--results from a nationwide online questionnaire in Switzerland. BMC Public Health (2012) 0.82
Sphingolipid depletion impairs endocytic traffic and inhibits Wingless signaling. Mech Dev (2013) 0.81
Wnt lipid modifications: not as saturated as we thought. Dev Cell (2006) 0.81
Efficacy of alemtuzumab and gemcitabine in a patient with enteropathy-type T-cell lymphoma. Br J Haematol (2008) 0.81
Coop functions as a corepressor of Pangolin and antagonizes Wingless signaling. Genes Dev (2010) 0.80
A reverse genetic screen in Drosophila using a deletion-inducing mutagen. Genome Biol (2004) 0.80
FLP-Mapping: a universal, cost-effective, and automatable method for gene mapping. Methods Mol Biol (2007) 0.79
The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription. Development (2013) 0.79
Morphogen gradients: expand and repress. Curr Biol (2011) 0.79
Haemodynamic consequences of changing potassium concentrations in haemodialysis fluids. BMC Nephrol (2011) 0.78
Manipulating the sensitivity of signal-induced repression: quantification and consequences of altered brinker gradients. PLoS One (2013) 0.78