Published in PLoS Genet on February 03, 2011
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Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet (2012) 4.05
Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nat Genet (2012) 3.77
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet (2011) 3.46
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Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes. Nat Genet (2011) 3.20
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. Nat Genet (2012) 3.19
Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression. Science (2014) 3.16
Interpreting noncoding genetic variation in complex traits and human disease. Nat Biotechnol (2012) 3.01
Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue. PLoS Genet (2011) 2.68
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A statistical framework for joint eQTL analysis in multiple tissues. PLoS Genet (2013) 2.46
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Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments. Nat Biotechnol (2013) 2.33
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Putative cis-regulatory drivers in colorectal cancer. Nature (2014) 1.92
The continuing value of twin studies in the omics era. Nat Rev Genet (2012) 1.88
Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet (2011) 1.83
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. PLoS Genet (2011) 1.83
The UK Adult Twin Registry (TwinsUK Resource). Twin Res Hum Genet (2012) 1.81
Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4. Nat Genet (2012) 1.78
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Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet (2012) 1.77
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Expression quantitative trait loci analysis identifies associations between genotype and gene expression in human intestine. Gastroenterology (2013) 1.69
Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nat Genet (2012) 1.64
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet (2011) 1.60
Cell-type, allelic, and genetic signatures in the human pancreatic beta cell transcriptome. Genome Res (2013) 1.58
Genetic control of gene expression in whole blood and lymphoblastoid cell lines is largely independent. Genome Res (2011) 1.58
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CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation. J Exp Med (2014) 1.49
Interactions between glucocorticoid treatment and cis-regulatory polymorphisms contribute to cellular response phenotypes. PLoS Genet (2011) 1.49
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Gene expression changes with age in skin, adipose tissue, blood and brain. Genome Biol (2013) 1.34
The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Nat Genet (2013) 1.31
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genet (2011) 1.30
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nat Genet (2013) 1.29
Extent, causes, and consequences of small RNA expression variation in human adipose tissue. PLoS Genet (2012) 1.28
Effect of catechol-o-methyltransferase-gene (COMT) variants on experimental and acute postoperative pain in 1,000 women undergoing surgery for breast cancer. Anesthesiology (2013) 1.27
Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet (2014) 1.27
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Accounting for population stratification in DNA methylation studies. Genet Epidemiol (2014) 1.25
A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS. BMC Genomics (2011) 1.25
The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue. PLoS One (2013) 1.25
Variants affecting exon skipping contribute to complex traits. PLoS Genet (2012) 1.24
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nat Genet (2015) 1.23
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet (2016) 1.22
Expression quantitative trait loci: present and future. Philos Trans R Soc Lond B Biol Sci (2013) 1.20
The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits. PLoS One (2011) 1.18
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. Hum Mol Genet (2014) 1.16
Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood. Eur J Hum Genet (2012) 1.15
Genetic effects on gene expression across human tissues. Nature (2017) 1.13
Evaluating the impact of sequencing depth on transcriptome profiling in human adipose. PLoS One (2013) 1.11
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells. Cell (2016) 1.10
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension. Hum Mol Genet (2014) 1.10
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Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types. Hum Mol Genet (2014) 1.08
Identification of genetic variants associated with alternative splicing using sQTLseekeR. Nat Commun (2014) 1.08
Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma. Front Genet (2013) 1.08
Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus. Gastroenterology (2014) 1.08
Prediction of Causal Candidate Genes in Coronary Artery Disease Loci. Arterioscler Thromb Vasc Biol (2015) 1.08
Buccals are likely to be a more informative surrogate tissue than blood for epigenome-wide association studies. Epigenetics (2013) 1.08
Finding genes and variants for lipid levels after genome-wide association analysis. Curr Opin Lipidol (2012) 1.08
Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4. Diabetologia (2013) 1.07
Cis and trans effects of human genomic variants on gene expression. PLoS Genet (2014) 1.06
Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. Cancer Res (2013) 1.06
Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs. BMC Genomics (2014) 1.06
Progress in the genetics of polygenic brain disorders: significant new challenges for neurobiology. Neuron (2013) 1.05
Sex-biased genetic effects on gene regulation in humans. Genome Res (2012) 1.05
Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study. PLoS One (2012) 1.03
Global properties and functional complexity of human gene regulatory variation. PLoS Genet (2013) 1.02
Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer. Hum Mol Genet (2012) 1.02
Functional genomic annotation of genetic risk loci highlights inflammation and epithelial biology networks in CKD. J Am Soc Nephrol (2014) 1.01
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. Nat Commun (2014) 1.00
QuASAR: quantitative allele-specific analysis of reads. Bioinformatics (2014) 0.99
Association of the type 2 diabetes mellitus susceptibility gene, TCF7L2, with schizophrenia in an Arab-Israeli family sample. PLoS One (2012) 0.99
Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3. Nat Genet (2012) 0.98
Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects. PLoS Genet (2012) 0.97
Association of Parkinson disease with structural and regulatory variants in the HLA region. Am J Hum Genet (2013) 0.96
The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression. Mol Psychiatry (2013) 0.95
Genomic modulators of the immune response. Trends Genet (2012) 0.94
Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Hum Mol Genet (2014) 0.94
Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing. Mol Psychiatry (2013) 0.93
Impact of natural genetic variation on gene expression dynamics. PLoS Genet (2013) 0.93
Post genome-wide association studies functional characterization of prostate cancer risk loci. BMC Genomics (2013) 0.91
Genomic modulators of gene expression in human neutrophils. Nat Commun (2015) 0.91
Cis-acting polymorphisms affect complex traits through modifications of microRNA regulation pathways. PLoS One (2012) 0.91
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Mapping the genetic architecture of gene expression in human liver. PLoS Biol (2008) 19.44
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Mapping determinants of human gene expression by regional and genome-wide association. Nature (2005) 17.24
The fine-scale structure of recombination rate variation in the human genome. Science (2004) 17.05
Understanding mechanisms underlying human gene expression variation with RNA sequencing. Nature (2010) 16.86
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
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Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature (2007) 14.43
A survey of genetic human cortical gene expression. Nat Genet (2007) 12.04
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
Common regulatory variation impacts gene expression in a cell type-dependent manner. Science (2009) 11.28
Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat Genet (2007) 11.09
Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet (2010) 10.75
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet (2008) 9.52
A genotype calling algorithm for the Illumina BeadArray platform. Bioinformatics (2007) 8.03
An atlas of combinatorial transcriptional regulation in mouse and man. Cell (2010) 6.24
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Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet (2010) 3.63
A Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies. PLoS Comput Biol (2010) 3.23
Geographical genomics of human leukocyte gene expression variation in southern Morocco. Nat Genet (2009) 2.38
From gene expression to disease risk. Nat Genet (2008) 1.69
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Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics (2009) 190.94
Mapping short DNA sequencing reads and calling variants using mapping quality scores. Genome Res (2008) 157.44
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Accurate whole human genome sequencing using reversible terminator chemistry. Nature (2008) 90.20
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Finding the missing heritability of complex diseases. Nature (2009) 67.95
The Pfam protein families database. Nucleic Acids Res (2004) 56.46
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
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Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet (2008) 43.63
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
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Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
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Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet (2008) 16.92
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Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
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