Combined optical trapping and single-molecule fluorescence.

Optical trapping. Rev Sci Instrum (2004) 7.15

Fluorescence-force spectroscopy maps two-dimensional reaction landscape of the holliday junction. Science (2007) 2.49

Simultaneous, coincident optical trapping and single-molecule fluorescence. Nat Methods (2004) 2.20

Interlaced optical force-fluorescence measurements for single molecule biophysics. Biophys J (2006) 1.75

Force as a useful variable in reactions: unfolding RNA. Annu Rev Biophys Biomol Struct (2004) 1.39

Detecting force-induced molecular transitions with fluorescence resonant energy transfer. Angew Chem Int Ed Engl (2007) 1.39

See me, feel me: methods to concurrently visualize and manipulate single DNA molecules and associated proteins. Nucleic Acids Res (2008) 1.11

Dissecting elastic heterogeneity along DNA molecules coated partly with Rad51 using concurrent fluorescence microscopy and optical tweezers. Biophys J (2006) 1.07

Forcing a connection: impacts of single-molecule force spectroscopy on in vivo tension sensing. Biopolymers (2011) 0.92

Single-molecule studies of riboswitch folding. Biochim Biophys Acta (2014) 0.85

Future challenges in single-molecule fluorescence and laser trap approaches to studies of molecular motors. Dev Cell (2012) 0.83

DNA Y structure: a versatile, multidimensional single molecule assay. Nano Lett (2014) 0.79

Combined single-molecule force and fluorescence measurements for biology. J Biol (2003) 0.78

A marriage of techniques. J Biol (2003) 0.78

Studying DNA-protein interactions with single-molecule Förster resonance energy transfer. Protoplasma (2013) 0.78

IOFF generally extends fluorophore longevity in the presence of an optical trap. Curr Pharm Biotechnol (2009) 0.75

Single-Molecule Total Internal Reflection Fluorescence Microscopy. Cold Spring Harb Protoc (2016) 0.75

Simultaneous observation of individual ATPase and mechanical events by a single myosin molecule during interaction with actin. Cell (1998) 3.79

An automated two-dimensional optical force clamp for single molecule studies. Biophys J (2002) 3.57

Single-molecule imaging of RNA polymerase-DNA interactions in real time. Biophys J (1999) 3.03

Structural and biochemical characterization of a fluorogenic rhodamine-labeled malarial protease substrate. Biochemistry (2002) 1.36

Imaging and nano-manipulation of single biomolecules. Biophys Chem (1997) 1.34

Optical trapping. Rev Sci Instrum (2004) 7.15

Direct observation of base-pair stepping by RNA polymerase. Nature (2005) 6.29

Ubiquitous transcriptional pausing is independent of RNA polymerase backtracking. Cell (2003) 3.92

Kinesin moves by an asymmetric hand-over-hand mechanism. Science (2003) 3.83

An automated two-dimensional optical force clamp for single molecule studies. Biophys J (2002) 3.57

Nanomechanical measurements of the sequence-dependent folding landscapes of single nucleic acid hairpins. Proc Natl Acad Sci U S A (2006) 3.56

Sequence-resolved detection of pausing by single RNA polymerase molecules. Cell (2006) 3.50

Backtracking by single RNA polymerase molecules observed at near-base-pair resolution. Nature (2003) 3.50

Direct measurement of the full, sequence-dependent folding landscape of a nucleic acid. Science (2006) 3.49

Direct observation of hierarchical folding in single riboswitch aptamers. Science (2008) 3.22

Passive all-optical force clamp for high-resolution laser trapping. Phys Rev Lett (2005) 3.13

Coordination of opposite-polarity microtubule motors. J Cell Biol (2002) 3.04

Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro. Nat Cell Biol (2006) 2.73

Stepping and stretching. How kinesin uses internal strain to walk processively. J Biol Chem (2003) 2.60

High-resolution, single-molecule measurements of biomolecular motion. Annu Rev Biophys Biomol Struct (2007) 2.58

Applied force reveals mechanistic and energetic details of transcription termination. Cell (2008) 2.45

Simultaneous, coincident optical trapping and single-molecule fluorescence. Nat Methods (2004) 2.20

Sequence-dependent pausing of single lambda exonuclease molecules. Science (2003) 1.88

Backsteps induced by nucleotide analogs suggest the front head of kinesin is gated by strain. Proc Natl Acad Sci U S A (2006) 1.85

Forward and reverse motion of single RecBCD molecules on DNA. Biophys J (2004) 1.82

Single-molecule studies of RNA polymerase: motoring along. Annu Rev Biochem (2008) 1.80

Single-molecule, motion-based DNA sequencing using RNA polymerase. Science (2006) 1.69

Binding and translocation of termination factor rho studied at the single-molecule level. J Mol Biol (2012) 1.58

Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II. Proc Natl Acad Sci U S A (2012) 1.51

A universal pathway for kinesin stepping. Nat Struct Mol Biol (2011) 1.43

E. coli NusG inhibits backtracking and accelerates pause-free transcription by promoting forward translocation of RNA polymerase. J Mol Biol (2010) 1.36

Picocalorimetry of transcription by RNA polymerase. Biophys J (2005) 1.33

Direct observation of the binding state of the kinesin head to the microtubule. Nature (2009) 1.32

Folding and unfolding single RNA molecules under tension. Curr Opin Chem Biol (2008) 1.26

Pulling on the nascent RNA during transcription does not alter kinetics of elongation or ubiquitous pausing. Mol Cell (2006) 1.26

Statistical kinetics of macromolecular dynamics. Biophys J (2005) 1.24

Optical tweezers study life under tension. Nat Photonics (2011) 1.22

Single-molecule studies of RNA polymerase: one singular sensation, every little step it takes. Mol Cell (2011) 1.21

Measurement of the effective focal shift in an optical trap. Opt Lett (2005) 1.19

Eg5 steps it up! Cell Div (2006) 1.18

Resource Letter: LBOT-1: Laser-based optical tweezers. Am J Phys (2003) 1.17

Structure of the transcriptional network controlling white-opaque switching in Candida albicans. Mol Microbiol (2013) 1.14

Direct observation of cotranscriptional folding in an adenine riboswitch. Science (2012) 1.13

Reconstructing folding energy landscapes by single-molecule force spectroscopy. Annu Rev Biophys (2014) 1.12

The importance of lattice defects in katanin-mediated microtubule severing in vitro. Biophys J (2002) 1.07

Folding energy landscape of the thiamine pyrophosphate riboswitch aptamer. Proc Natl Acad Sci U S A (2012) 1.07

Identification and characterization of a previously undescribed family of sequence-specific DNA-binding domains. Proc Natl Acad Sci U S A (2013) 1.03

Precision steering of an optical trap by electro-optic deflection. Opt Lett (2008) 1.00

Applied force provides insight into transcriptional pausing and its modulation by transcription factor NusA. Mol Cell (2011) 0.97

Force and premature binding of ADP can regulate the processivity of individual Eg5 dimers. Biophys J (2009) 0.92

Direct measurements of kinesin torsional properties reveal flexible domains and occasional stalk reversals during stepping. Proc Natl Acad Sci U S A (2009) 0.91

Kinesin steps do not alternate in size. Biophys J (2007) 0.90

Transcription factors TFIIF and TFIIS promote transcript elongation by RNA polymerase II by synergistic and independent mechanisms. Proc Natl Acad Sci U S A (2014) 0.88

A not-so-cheap stunt. Science (2002) 0.88

On the origin of kinesin limping. Biophys J (2009) 0.88

Morphometric assessment of collagen accumulation in germinal matrix vessels of premature human neonates. Neuropathol Appl Neurobiol (2005) 0.87

Efficient reconstitution of transcription elongation complexes for single-molecule studies of eukaryotic RNA polymerase II. Transcription (2012) 0.85

Electrostatics of nucleic acid folding under conformational constraint. J Am Chem Soc (2012) 0.85

Anatomical analysis of the developing cerebral vasculature in premature neonates: absence of precapillary arteriole-to-venous shunts. Pediatr Res (2002) 0.82

Subependymal veins in premature neonates: implications for hemorrhage. Pediatr Neurol (2004) 0.81

Single-molecule studies of RNAPII elongation. Biochim Biophys Acta (2012) 0.80

An optical apparatus for rotation and trapping. Methods Enzymol (2010) 0.79

Not so lame after all: kinesin still walks with a hobbled head. J Gen Physiol (2007) 0.78

Temporal expression pattern of cerebrovascular endothelial cell alkaline phosphatase during human gestation. J Neuropathol Exp Neurol (2002) 0.78

Attitudes and expectations about music therapy for premature infants among staff in a neonatal intensive care unit. Altern Ther Health Med (2004) 0.78

Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets. Nucleic Acids Res (2013) 0.78

Germinal matrix cells associate with veins and a glial scaffold in the human fetal brain. Brain Res Dev Brain Res (2005) 0.75

UK defence group's structure could limit its usefulness. Nature (2009) 0.75