Published in Blood on May 10, 2005
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Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med (2007) 8.23
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Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. J Clin Invest (2008) 6.15
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
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TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. Am J Hum Genet (2008) 4.12
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Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita. Blood (2007) 3.86
Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci U S A (2007) 3.67
Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol (2008) 3.57
Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study. Gastroenterology (2013) 3.55
Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. J Cell Biochem (2007) 3.53
Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA. Nat Genet (2002) 3.50
Telomeres and telomerase. Philos Trans R Soc Lond B Biol Sci (2004) 3.13
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Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein. Cell (2004) 2.91
Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. Mol Cell (2003) 2.78
Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet (2003) 2.76
Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood (2003) 2.73
cis-Acting packaging signals in the influenza virus PB1, PB2, and PA genomic RNA segments. J Virol (2005) 2.50
New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene (2002) 2.46
Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci U S A (2009) 2.44
The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging (Albany NY) (2008) 2.35
Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings. PLoS One (2011) 2.30
Viral RNA is required for the association of APOBEC3G with human immunodeficiency virus type 1 nucleoprotein complexes. J Virol (2005) 2.29
DNA damage signalling prevents deleterious telomere addition at DNA breaks. Nat Cell Biol (2009) 2.05
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci U S A (2005) 2.01
A bulged stem tethers Est1p to telomerase RNA in budding yeast. Genes Dev (2002) 1.95
The Asia-Pacific consensus on ulcerative colitis. J Gastroenterol Hepatol (2010) 1.93
CD27 expression promotes long-term survival of functional effector-memory CD8+ cytotoxic T lymphocytes in HIV-infected patients. J Exp Med (2004) 1.92
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Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood. Proc Natl Acad Sci U S A (2011) 1.88
DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution. Nat Methods (2012) 1.85
A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein. Proc Natl Acad Sci U S A (2004) 1.83
World Gastroenterology Organization Practice Guidelines for the diagnosis and management of IBD in 2010. Inflamm Bowel Dis (2010) 1.82
Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2002. Soc Sci Med (2013) 1.81
Telomere length measurement-caveats and a critical assessment of the available technologies and tools. Mutat Res (2011) 1.79
A molecular switch underlies a human telomerase disease. Proc Natl Acad Sci U S A (2002) 1.79
Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study. PLoS One (2011) 1.78
Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology (2010) 1.73
Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell (2009) 1.72
Mutational analyses of packaging signals in influenza virus PA, PB1, and PB2 genomic RNA segments. J Virol (2007) 1.72
Telomere length is associated with disease severity and declines with age in dyskeratosis congenita. Haematologica (2011) 1.71
Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart disease. JAMA (2010) 1.71
Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J Cell Biol (2004) 1.71
Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions. Mol Cell Biol (2004) 1.69
Dynamics of telomerase activity in response to acute psychological stress. Brain Behav Immun (2009) 1.68
Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA. Cancer Res (2004) 1.66
Counting of Rif1p and Rif2p on Saccharomyces cerevisiae telomeres regulates telomere length. Mol Cell Biol (2004) 1.66
Synchrony of telomere length among hematopoietic cells. Exp Hematol (2010) 1.63
Mutations in the SBDS gene in acquired aplastic anemia. Blood (2007) 1.62
RNA structure and packaging signals in the 5' leader region of the human immunodeficiency virus type 1 genome. J Virol (2002) 1.60
Telomerase levels control the lifespan of human T lymphocytes. Blood (2003) 1.59
Functional characterization of natural telomerase mutations found in patients with hematologic disorders. Blood (2006) 1.57
A spectrum of severe familial liver disorders associate with telomerase mutations. PLoS One (2009) 1.57
Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes. PLoS Genet (2012) 1.57
Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. Mol Cell (2007) 1.56
A novel pseudoknot element is essential for the action of a yeast telomerase. Genes Dev (2003) 1.55
Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol (2013) 1.55
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol (2006) 1.54
Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res (2013) 1.53
Identification of sister chromatids by DNA template strand sequences. Nature (2009) 1.53
Evidence for segment-nonspecific packaging of the influenza a virus genome. J Virol (2002) 1.51
Comprehensive structure-function analysis of the core domain of human telomerase RNA. Mol Cell Biol (2003) 1.49
Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia. Hum Mol Genet (2003) 1.48
Defective assembly of influenza A virus due to a mutation in the polymerase subunit PA. J Virol (2006) 1.45
Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls. Cytometry (2002) 1.43
Visualization of actin filaments and monomers in somatic cell nuclei. Mol Biol Cell (2013) 1.40
Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes. J Immunol (2010) 1.40
Differentiation between intestinal tuberculosis and Crohn's disease in endoscopic biopsy specimens by polymerase chain reaction. Am J Gastroenterol (2002) 1.39
Detection of a novel nonsense mutation in the interleukin 2 receptor gamma gene causing X-linked severe combined immunodeficiency. Ann Allergy Asthma Immunol (2006) 1.39
Telomere length measurements in leukocyte subsets by automated multicolor flow-FISH. Cytometry A (2003) 1.36
Estimating human hematopoietic stem cell kinetics using granulocyte telomere lengths. Exp Hematol (2004) 1.33
Functional characterization of telomerase RNA variants found in patients with hematologic disorders. Blood (2004) 1.33
Socioeconomic status and cell aging in children. Soc Sci Med (2012) 1.32
Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. PLoS Genet (2011) 1.29
Telomere length in subpopulations of human hematopoietic cells. Stem Cells (2003) 1.28
RTEL1 contributes to DNA replication and repair and telomere maintenance. Mol Biol Cell (2012) 1.28
Longitudinal data on telomere length in leukocytes from newborn baboons support a marked drop in stem cell turnover around 1 year of age. Aging Cell (2006) 1.28
Genes and pathways downstream of telomerase in melanoma metastasis. Proc Natl Acad Sci U S A (2006) 1.27
Hematopoietic stem-cell behavior in nonhuman primates. Blood (2007) 1.27
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2002) 1.27
RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination. Nucleic Acids Res (2010) 1.27
Shorter leukocyte telomere length in midlife women with poor sleep quality. J Aging Res (2011) 1.26
Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA. J Biol Chem (2005) 1.25
Telomere length in human natural killer cell subsets. Ann N Y Acad Sci (2007) 1.25
A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity. RNA (2003) 1.24
Is human immunosenescence clinically relevant? Looking for 'immunological risk phenotypes'. Trends Immunol (2002) 1.24
Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length. Brain Behav Immun (2012) 1.22
Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives. Diabetes (2006) 1.21