Published in Science on June 13, 2003
Synaptic vesicle fusion. Nat Struct Mol Biol (2008) 4.22
The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell (2005) 3.05
The energetics of membrane fusion from binding, through hemifusion, pore formation, and pore enlargement. J Membr Biol (2004) 2.59
Alternative zippering as an on-off switch for SNARE-mediated fusion. Science (2009) 2.30
In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release. Proc Natl Acad Sci U S A (2011) 2.27
Imaging single membrane fusion events mediated by SNARE proteins. Proc Natl Acad Sci U S A (2004) 1.99
SNARE-mediated lipid mixing depends on the physical state of the vesicles. Biophys J (2005) 1.91
SNARE proteins: one to fuse and three to keep the nascent fusion pore open. Science (2012) 1.89
Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol (2011) 1.81
SNAREs can promote complete fusion and hemifusion as alternative outcomes. J Cell Biol (2005) 1.78
A fast, single-vesicle fusion assay mimics physiological SNARE requirements. Proc Natl Acad Sci U S A (2010) 1.68
Single-molecule studies of synaptotagmin and complexin binding to the SNARE complex. Biophys J (2005) 1.60
Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. J Biol Chem (2008) 1.59
Time scales of membrane fusion revealed by direct imaging of vesicle fusion with high temporal resolution. Proc Natl Acad Sci U S A (2006) 1.50
SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes. Proc Natl Acad Sci U S A (2008) 1.48
Gene replacement reveals that p115/SNARE interactions are essential for Golgi biogenesis. Proc Natl Acad Sci U S A (2004) 1.47
Selective mobility and sensitivity to SNAREs is exhibited by the Arabidopsis KAT1 K+ channel at the plasma membrane. Plant Cell (2006) 1.43
SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion. J Cell Biol (2010) 1.43
Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack. Mol Biol Cell (2004) 1.39
A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion. Nat Struct Mol Biol (2011) 1.37
Viral and developmental cell fusion mechanisms: conservation and divergence. Dev Cell (2008) 1.32
Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release. EMBO J (2012) 1.31
A role of complexin-lipid interactions in membrane fusion. FEBS Lett (2009) 1.30
Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation. Proc Natl Acad Sci U S A (2004) 1.28
Two synaptobrevin molecules are sufficient for vesicle fusion in central nervous system synapses. Proc Natl Acad Sci U S A (2011) 1.27
Silencing of VAMP3 inhibits cell migration and integrin-mediated adhesion. Biochem Biophys Res Commun (2009) 1.22
A tripartite SNARE-K+ channel complex mediates in channel-dependent K+ nutrition in Arabidopsis. Plant Cell (2009) 1.18
i-SNAREs: inhibitory SNAREs that fine-tune the specificity of membrane fusion. J Cell Biol (2003) 1.14
Prophylactic, therapeutic and neutralizing effects of zinc oxide tetrapod structures against herpes simplex virus type-2 infection. Antiviral Res (2012) 1.14
Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells. Mol Biol Cell (2007) 1.10
Legionella pneumophila promotes functional interactions between plasma membrane syntaxins and Sec22b. Traffic (2010) 1.08
SNAREs: cogs and coordinators in signaling and development. Plant Physiol (2008) 1.08
Single Molecule Measurements of Interaction Free Energies Between the Proteins Within Binary and Ternary SNARE Complexes. J Nanoneurosci (2009) 1.06
Leaky synapses: regulation of spontaneous neurotransmission in central synapses. Neuroscience (2008) 1.05
A novel motif essential for SNARE interaction with the K(+) channel KC1 and channel gating in Arabidopsis. Plant Cell (2010) 1.05
Interactive, computer-assisted tracking of speckle trajectories in fluorescence microscopy: application to actin polymerization and membrane fusion. Biophys J (2011) 1.04
Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta-cells. Mol Biol Cell (2004) 1.03
A novel function of heparan sulfate in the regulation of cell-cell fusion. J Biol Chem (2009) 1.02
Resolving the function of distinct Munc18-1/SNARE protein interaction modes in a reconstituted membrane fusion assay. J Biol Chem (2011) 1.02
Conserved eukaryotic fusogens can fuse viral envelopes to cells. Science (2011) 1.01
A half-zippered SNARE complex represents a functional intermediate in membrane fusion. J Am Chem Soc (2014) 1.00
Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. Mol Biol Cell (2011) 0.97
New putative chloroplast vesicle transport components and cargo proteins revealed using a bioinformatics approach: an Arabidopsis model. PLoS One (2013) 0.97
A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins. J Virol (2005) 0.97
Vacuolar H(+)-ATPase subunits Voa1 and Voa2 cooperatively regulate secretory vesicle acidification, transmitter uptake, and storage. Mol Biol Cell (2011) 0.97
Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat. Biol Psychiatry (2005) 0.94
SNAP-23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane. Blood (2007) 0.94
Microarray analysis of fiber cell maturation in the lens. FEBS Lett (2005) 0.93
Genetic control of fusion pore expansion in the epidermis of Caenorhabditis elegans. Mol Biol Cell (2007) 0.91
SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1. J Biol Chem (2012) 0.90
Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin. Biophys J (2013) 0.89
Organization of SNAREs within the Golgi stack. Cold Spring Harb Perspect Biol (2011) 0.88
Towards reconstitution of membrane fusion mediated by SNAREs and other synaptic proteins. Crit Rev Biochem Mol Biol (2015) 0.88
SNARE motif: a common motif used by pathogens to manipulate membrane fusion. Virulence (2010) 0.88
Re-visiting the trans insertion model for complexin clamping. Elife (2015) 0.87
Membrane fusion by VAMP3 and plasma membrane t-SNAREs. Exp Cell Res (2007) 0.87
A novel di-acidic motif facilitates ER export of the syntaxin SYP31. J Exp Bot (2009) 0.87
A common mechanism for the regulation of vesicular SNAREs on phospholipid membranes. Biochem J (2004) 0.86
Tag team action at the synapse. EMBO Rep (2007) 0.84
Fusogenic pairings of vesicle-associated membrane proteins (VAMPs) and plasma membrane t-SNAREs--VAMP5 as the exception. PLoS One (2010) 0.84
A role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex dimerization during neurosecretion. Mol Biol Cell (2008) 0.83
Binary polypeptide system for permanent and oriented protein immobilization. J Nanobiotechnology (2010) 0.83
Sorting of GLUT4 into its insulin-sensitive store requires the Sec1/Munc18 protein mVps45. Mol Biol Cell (2013) 0.83
Association among SNAP-25 gene DdeI and MnlI polymorphisms and hemodynamic changes during methylphenidate use: a functional near-infrared spectroscopy study. J Atten Disord (2010) 0.82
An important role for syndecan-1 in herpes simplex virus type-1 induced cell-to-cell fusion and virus spread. PLoS One (2011) 0.82
Extracellular localization of epimorphin/syntaxin-2. Blood (2007) 0.80
Tethering membrane fusion: common and different players in myoblasts and at the synapse. J Neurogenet (2014) 0.80
Role of VAMP-2, VAMP-7, and VAMP-8 in constitutive exocytosis from HSY cells. Histochem Cell Biol (2005) 0.80
In vitro assay using engineered yeast vacuoles for neuronal SNARE-mediated membrane fusion. Proc Natl Acad Sci U S A (2014) 0.79
Synaptosomal-associated protein 25 gene polymorphisms and antisocial personality disorder: association with temperament and psychopathy. Can J Psychiatry (2011) 0.79
Synaptosomal-associated protein 25 (Snap-25) gene polymorphism frequency in fibromyalgia syndrome and relationship with clinical symptoms. BMC Musculoskelet Disord (2014) 0.78
The Dark Side of Cell Fusion. Int J Mol Sci (2016) 0.78
Nanodisc-cell fusion: control of fusion pore nucleation and lifetimes by SNARE protein transmembrane domains. Sci Rep (2016) 0.78
Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens. J Cell Biol (2017) 0.76
Analysis of SNARE-mediated membrane fusion using an enzymatic cell fusion assay. J Vis Exp (2012) 0.75
SM protein Munc18-2 facilitates transition of Syntaxin 11-mediated lipid mixing to complete fusion for T-lymphocyte cytotoxicity. Proc Natl Acad Sci U S A (2017) 0.75
Are there too many or too few SNAREs in proteoliposomes? Biophys J (2006) 0.75
Dilation of fusion pores by crowding of SNARE proteins. Elife (2017) 0.75
Fusoselect: cell-cell fusion activity engineered by directed evolution of a retroviral glycoprotein. Nucleic Acids Res (2006) 0.75
Lipid Regulated Intramolecular Conformational Dynamics of SNARE-Protein Ykt6. Sci Rep (2016) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Membrane fusion: grappling with SNARE and SM proteins. Science (2009) 8.98
Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell (2007) 4.26
A clamping mechanism involved in SNARE-dependent exocytosis. Science (2006) 3.74
Energetics and dynamics of SNAREpin folding across lipid bilayers. Nat Struct Mol Biol (2007) 3.39
SNARE proteins are required for macroautophagy. Cell (2011) 2.99
Single reconstituted neuronal SNARE complexes zipper in three distinct stages. Science (2012) 2.98
Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell (2009) 2.57
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J Cell Biol (2006) 2.45
Journeys through the Golgi--taking stock in a new era. J Cell Biol (2009) 2.30
Alternative zippering as an on-off switch for SNARE-mediated fusion. Science (2009) 2.30
FKBP12 binds to acylated H-ras and promotes depalmitoylation. Mol Cell (2011) 2.17
Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins. J Cell Biol (2002) 2.13
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell (2010) 2.12
Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity. Proc Natl Acad Sci U S A (2002) 2.07
A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (2011) 2.02
Imaging single membrane fusion events mediated by SNARE proteins. Proc Natl Acad Sci U S A (2004) 1.99
SNARE proteins: one to fuse and three to keep the nascent fusion pore open. Science (2012) 1.89
Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42. Biochemistry (2006) 1.88
The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science (2012) 1.82
Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol (2011) 1.81
SNAREs can promote complete fusion and hemifusion as alternative outcomes. J Cell Biol (2005) 1.78
First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients. J Am Soc Nephrol (2002) 1.71
A fast, single-vesicle fusion assay mimics physiological SNARE requirements. Proc Natl Acad Sci U S A (2010) 1.68
Sequence characteristics of functional siRNAs. RNA (2005) 1.59
Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. J Biol Chem (2008) 1.59
High-resolution atomic force microscopy of soluble Abeta42 oligomers. J Mol Biol (2006) 1.55
The carboxy-terminal domain of complexin I stimulates liposome fusion. Proc Natl Acad Sci U S A (2009) 1.51
Liposome fusion assay to monitor intracellular membrane fusion machines. Methods Enzymol (2003) 1.49
SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes. Proc Natl Acad Sci U S A (2008) 1.48
Stapled Golgi cisternae remain in place as cargo passes through the stack. Elife (2013) 1.47
SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion. J Cell Biol (2010) 1.43
Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat Neurosci (2011) 1.41
Macrocephalic mental retardation associated with a novel C-terminal MECP2 frameshift deletion. Eur J Pediatr (2004) 1.39
Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack. Mol Biol Cell (2004) 1.39
A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion. Nat Struct Mol Biol (2011) 1.37
Calcium-independent stimulation of membrane fusion and SNAREpin formation by synaptotagmin I. J Cell Biol (2002) 1.33
Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release. EMBO J (2012) 1.31
A SNARE required for retrograde transport to the endoplasmic reticulum. Proc Natl Acad Sci U S A (2003) 1.31
A role of complexin-lipid interactions in membrane fusion. FEBS Lett (2009) 1.30
Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation. Proc Natl Acad Sci U S A (2004) 1.28
Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. Nat Struct Mol Biol (2011) 1.26
The specificity of SNARE-dependent fusion is encoded in the SNARE motif. Proc Natl Acad Sci U S A (2004) 1.23
Two-color STED microscopy in living cells. Biomed Opt Express (2011) 1.19
Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain. Protein Sci (2004) 1.17
i-SNAREs: inhibitory SNAREs that fine-tune the specificity of membrane fusion. J Cell Biol (2003) 1.14
A resident Golgi protein is excluded from peri-Golgi vesicles in NRK cells. Proc Natl Acad Sci U S A (2002) 1.14
Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages. Proc Natl Acad Sci U S A (2005) 1.12
Imaging seizure activity: a combined EEG/EMG-fMRI study in reading epilepsy. Epilepsia (2008) 1.12
Intracellular bacteria encode inhibitory SNARE-like proteins. PLoS One (2009) 1.10
COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function. Proc Natl Acad Sci U S A (2013) 1.08
Lipidic antagonists to SNARE-mediated fusion. J Biol Chem (2006) 1.05
Synthesis and target identification of hymenialdisine analogs. Chem Biol (2004) 1.05
Protein determinants of SNARE-mediated lipid mixing. Biophys J (2010) 1.05
Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes. Proc Natl Acad Sci U S A (2010) 1.04
Pharmacodynamics of single doses of the novel immunosuppressant FTY720 in stable renal transplant patients. Am J Transplant (2003) 1.04
Nuclear matrix protein-22: a prospective evaluation in a population at risk for bladder cancer. Results from the UroScreen study. BJU Int (2012) 1.04
Resolving the function of distinct Munc18-1/SNARE protein interaction modes in a reconstituted membrane fusion assay. J Biol Chem (2011) 1.02
A half-zippered SNARE complex represents a functional intermediate in membrane fusion. J Am Chem Soc (2014) 1.00
Degradation of amyloid beta protein by purified myelin basic protein. J Biol Chem (2009) 1.00
Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage. RNA (2007) 0.98
Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. Mol Biol Cell (2011) 0.97
Seizure anticipation by patients with focal and generalized epilepsy: a multicentre assessment of premonitory symptoms. Epilepsy Res (2006) 0.95
Restless legs syndrome: epidemiological and clinicogenetic study in a South Tyrolean population isolate. Mov Disord (2006) 0.94
An extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly. J Biol Chem (2014) 0.93
SNARE and regulatory proteins induce local membrane protrusions to prime docked vesicles for fast calcium-triggered fusion. EMBO Rep (2014) 0.93
Fusion of single proteoliposomes with planar, cushioned bilayers in microfluidic flow cells. Nat Protoc (2012) 0.92
Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro. Biochemistry (2009) 0.91
SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1. J Biol Chem (2012) 0.90
«Interventional Neuroradiology: a neuroscience sub-specialty?». Interv Neuroradiol (2013) 0.90
Preparation and characterization of SNARE-containing nanodiscs and direct study of cargo release through fusion pores. Nat Protoc (2013) 0.90
Dynamic transport of SNARE proteins in the Golgi apparatus. Proc Natl Acad Sci U S A (2005) 0.89
Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin. Biophys J (2013) 0.89
Editorial: «Interventional Neuroradiology: a Neuroscience sub-specialty?». Interv Neuroradiol (2013) 0.89
Functional mapping of disease susceptibility loci using cell biology. Proc Natl Acad Sci U S A (2006) 0.89
N-terminal domain of myelin basic protein inhibits amyloid beta-protein fibril assembly. J Biol Chem (2010) 0.88
Organization of SNAREs within the Golgi stack. Cold Spring Harb Perspect Biol (2011) 0.88
Inter-Golgi transport mediated by COPI-containing vesicles carrying small cargoes. Elife (2013) 0.88
Temporary aneurysm orifice balloon occlusion as an alternative to retrograde suction decompression for giant paraclinoid internal carotid artery aneurysms: technical note. Neurosurgery (2005) 0.88
Distinct roles of myosin Va in membrane remodeling and exocytosis of secretory granules. Traffic (2010) 0.88
How a G protein binds a membrane. J Biol Chem (2004) 0.87
Concerted auto-regulation in yeast endosomal t-SNAREs. J Biol Chem (2005) 0.87