Published in Cell on January 12, 2007
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Munc18a scaffolds SNARE assembly to promote membrane fusion. Mol Biol Cell (2008) 1.36
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The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organelles. Mol Biol Cell (2009) 1.27
CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactions. Proc Natl Acad Sci U S A (2009) 1.26
Munc18-1 is critical for plasma membrane localization of syntaxin1 but not of SNAP-25 in PC12 cells. Mol Biol Cell (2007) 1.26
The SM protein Vps33 and the t-SNARE H(abc) domain promote fusion pore opening. Nat Struct Mol Biol (2010) 1.26
Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells. Mol Biol Cell (2009) 1.24
VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis. J Clin Invest (2008) 1.23
Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. EMBO J (2009) 1.23
Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion. EMBO J (2012) 1.22
Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proc Natl Acad Sci U S A (2010) 1.22
Sec1/Munc18 protein Vps33 binds to SNARE domains and the quaternary SNARE complex. Mol Biol Cell (2012) 1.20
Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c in vitro. PLoS One (2008) 1.20
A single-vesicle content mixing assay for SNARE-mediated membrane fusion. Nat Commun (2010) 1.20
NMR analysis of the closed conformation of syntaxin-1. J Biomol NMR (2008) 1.19
A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly. Science (2015) 1.18
Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1. Mol Biol Cell (2011) 1.16
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ. Proc Natl Acad Sci U S A (2013) 1.16
Single-Vesicle Fusion Assay Reveals Munc18-1 Binding to the SNARE Core Is Sufficient for Stimulating Membrane Fusion. ACS Chem Neurosci (2010) 1.16
UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin. Mol Biol Cell (2008) 1.16
Variable cooperativity in SNARE-mediated membrane fusion. Proc Natl Acad Sci U S A (2014) 1.15
Munc13-4 reconstitutes calcium-dependent SNARE-mediated membrane fusion. J Cell Biol (2012) 1.14
The N-terminal peptide of the syntaxin Tlg2p modulates binding of its closed conformation to Vps45p. Proc Natl Acad Sci U S A (2009) 1.12
Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission. EMBO J (2012) 1.11
Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins. Proc Natl Acad Sci U S A (2013) 1.10
Mechanism of arachidonic acid action on syntaxin-Munc18. EMBO Rep (2007) 1.09
Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the Syntaxin N-peptide. Proc Natl Acad Sci U S A (2012) 1.08
Docking, not fusion, as the rate-limiting step in a SNARE-driven vesicle fusion assay. Biophys J (2011) 1.06
Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis. J Cell Biol (2011) 1.05
Common intermediates and kinetics, but different energetics, in the assembly of SNARE proteins. Elife (2014) 1.05
SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18. Elife (2014) 1.05
Protein determinants of SNARE-mediated lipid mixing. Biophys J (2010) 1.05
Nitric oxide regulation of protein trafficking in the cardiovascular system. Cardiovasc Res (2007) 1.04
Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis. Proc Natl Acad Sci U S A (2011) 1.04
Reluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formation. Proc Natl Acad Sci U S A (2011) 1.04
Abrogating Munc18-1-SNARE complex interaction has limited impact on exocytosis in PC12 cells. J Biol Chem (2009) 1.03
Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming. Nat Struct Mol Biol (2015) 1.02
Friends and foes in synaptic transmission: the role of tomosyn in vesicle priming. Trends Neurosci (2009) 1.02
Resolving the function of distinct Munc18-1/SNARE protein interaction modes in a reconstituted membrane fusion assay. J Biol Chem (2011) 1.02
Syntaxin binding mechanism and disease-causing mutations in Munc18-2. Proc Natl Acad Sci U S A (2013) 1.01
The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation. Nat Struct Mol Biol (2012) 1.01
A half-zippered SNARE complex represents a functional intermediate in membrane fusion. J Am Chem Soc (2014) 1.00
Novel interactions of CAPS (Ca2+-dependent activator protein for secretion) with the three neuronal SNARE proteins required for vesicle fusion. J Biol Chem (2010) 1.00
Munc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membrane. Mol Biol Cell (2011) 1.00
Crystal Structures of the Sec1/Munc18 (SM) Protein Vps33, Alone and Bound to the Homotypic Fusion and Vacuolar Protein Sorting (HOPS) Subunit Vps16*. PLoS One (2013) 0.99
The SNARE Machinery in Mast Cell Secretion. Front Immunol (2012) 0.98
The tyrosine phosphorylation of Munc18c induces a switch in binding specificity from syntaxin 4 to Doc2beta. J Biol Chem (2008) 0.98
The specificity of SNARE pairing in biological membranes is mediated by both proof-reading and spatial segregation. EMBO J (2007) 0.98
Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. Mol Biol Cell (2011) 0.97
Yeast Sec1p functions before and after vesicle docking. Mol Biol Cell (2009) 0.97
UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans. Mol Biol Cell (2008) 0.96
Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter release. Elife (2014) 0.96
Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis. Elife (2015) 0.96
Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms. J Biol Chem (2012) 0.95
Munc18/Syntaxin interaction kinetics control secretory vesicle dynamics. J Biol Chem (2009) 0.94
AQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18b. J Cell Sci (2008) 0.94
An extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly. J Biol Chem (2014) 0.93
Tyrosine phosphorylation of Munc18c on residue 521 abrogates binding to Syntaxin 4. BMC Biochem (2011) 0.93
Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis. J Cell Sci (2011) 0.93
Arabidopsis Sec1/Munc18 protein SEC11 is a competitive and dynamic modulator of SNARE binding and SYP121-dependent vesicle traffic. Plant Cell (2013) 0.93
Opposing functions of two sub-domains of the SNARE-complex in neurotransmission. EMBO J (2010) 0.92
Secretory vesicles are preferentially targeted to areas of low molecular SNARE density. PLoS One (2012) 0.92
Dissection of SNARE-driven membrane fusion and neuroexocytosis by wedging small hydrophobic molecules into the SNARE zipper. Proc Natl Acad Sci U S A (2010) 0.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Membrane fusion: grappling with SNARE and SM proteins. Science (2009) 8.98
A clamping mechanism involved in SNARE-dependent exocytosis. Science (2006) 3.74
Energetics and dynamics of SNAREpin folding across lipid bilayers. Nat Struct Mol Biol (2007) 3.39
SNARE proteins are required for macroautophagy. Cell (2011) 2.99
Single reconstituted neuronal SNARE complexes zipper in three distinct stages. Science (2012) 2.98
Fusion of cells by flipped SNAREs. Science (2003) 2.60
Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell (2009) 2.57
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J Cell Biol (2006) 2.45
Journeys through the Golgi--taking stock in a new era. J Cell Biol (2009) 2.30
Alternative zippering as an on-off switch for SNARE-mediated fusion. Science (2009) 2.30
Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins. J Cell Biol (2002) 2.13
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell (2010) 2.12
Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity. Proc Natl Acad Sci U S A (2002) 2.07
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Imaging single membrane fusion events mediated by SNARE proteins. Proc Natl Acad Sci U S A (2004) 1.99
SNARE proteins: one to fuse and three to keep the nascent fusion pore open. Science (2012) 1.89
The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science (2012) 1.82
Complexin cross-links prefusion SNAREs into a zigzag array. Nat Struct Mol Biol (2011) 1.81
SNAREs can promote complete fusion and hemifusion as alternative outcomes. J Cell Biol (2005) 1.78
A fast, single-vesicle fusion assay mimics physiological SNARE requirements. Proc Natl Acad Sci U S A (2010) 1.68
Sequence characteristics of functional siRNAs. RNA (2005) 1.59
Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. J Biol Chem (2008) 1.59
SNARE protein mimicry by an intracellular bacterium. PLoS Pathog (2008) 1.52
Liposome fusion assay to monitor intracellular membrane fusion machines. Methods Enzymol (2003) 1.49
SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes. Proc Natl Acad Sci U S A (2008) 1.48
Stapled Golgi cisternae remain in place as cargo passes through the stack. Elife (2013) 1.47
SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion. J Cell Biol (2010) 1.43
Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat Neurosci (2011) 1.41
Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack. Mol Biol Cell (2004) 1.39
A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion. Nat Struct Mol Biol (2011) 1.37
A SNARE required for retrograde transport to the endoplasmic reticulum. Proc Natl Acad Sci U S A (2003) 1.31
Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation. Proc Natl Acad Sci U S A (2004) 1.28
Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state. Nat Struct Mol Biol (2011) 1.26
The specificity of SNARE-dependent fusion is encoded in the SNARE motif. Proc Natl Acad Sci U S A (2004) 1.23
Two-color STED microscopy in living cells. Biomed Opt Express (2011) 1.19
i-SNAREs: inhibitory SNAREs that fine-tune the specificity of membrane fusion. J Cell Biol (2003) 1.14
A resident Golgi protein is excluded from peri-Golgi vesicles in NRK cells. Proc Natl Acad Sci U S A (2002) 1.14
Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages. Proc Natl Acad Sci U S A (2005) 1.12
Intracellular bacteria encode inhibitory SNARE-like proteins. PLoS One (2009) 1.10
COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function. Proc Natl Acad Sci U S A (2013) 1.08
Lipidic antagonists to SNARE-mediated fusion. J Biol Chem (2006) 1.05
Protein determinants of SNARE-mediated lipid mixing. Biophys J (2010) 1.05
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Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. Mol Biol Cell (2011) 0.97
Fusion of single proteoliposomes with planar, cushioned bilayers in microfluidic flow cells. Nat Protoc (2012) 0.92
Preparation and characterization of SNARE-containing nanodiscs and direct study of cargo release through fusion pores. Nat Protoc (2013) 0.90
Dynamic transport of SNARE proteins in the Golgi apparatus. Proc Natl Acad Sci U S A (2005) 0.89
Two coiled-coil domains of Chlamydia trachomatis IncA affect membrane fusion events during infection. PLoS One (2013) 0.89
Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin. Biophys J (2013) 0.89
Functional mapping of disease susceptibility loci using cell biology. Proc Natl Acad Sci U S A (2006) 0.89
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Membrane adhesion dictates Golgi stacking and cisternal morphology. Proc Natl Acad Sci U S A (2014) 0.86
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The impact of bacterial infection on mast cell degranulation. Immunol Res (2011) 0.84
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Cell-based assays using primary endothelial cells to study multiple steps in inflammation. Methods Enzymol (2006) 0.79
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