Published in J Biol Chem on June 26, 2003
A census of membrane-bound and intracellular signal transduction proteins in bacteria: bacterial IQ, extroverts and introverts. BMC Microbiol (2005) 3.38
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. Nat Struct Mol Biol (2004) 2.52
Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence. Curr Biol (2005) 2.42
Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol (2006) 2.05
Characterization of Mycobacterium tuberculosis Rv3676 (CRPMt), a cyclic AMP receptor protein-like DNA binding protein. J Bacteriol (2005) 1.57
Intracellular cAMP signaling by soluble adenylyl cyclase. Kidney Int (2011) 1.40
The Pseudomonas aeruginosa Chp chemosensory system regulates intracellular cAMP levels by modulating adenylate cyclase activity. Mol Microbiol (2010) 1.18
Reversible acetylation and inactivation of Mycobacterium tuberculosis acetyl-CoA synthetase is dependent on cAMP. Biochemistry (2011) 1.17
Regulation of prokaryotic adenylyl cyclases by CO2. Biochem J (2006) 1.16
Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice. PLoS One (2008) 1.15
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans. PLoS Pathog (2010) 1.15
Identification of cyclic AMP-regulated genes in Mycobacterium tuberculosis complex bacteria under low-oxygen conditions. J Bacteriol (2005) 1.12
Involvement of a membrane-bound class III adenylate cyclase in regulation of anaerobic respiration in Shewanella oneidensis MR-1. J Bacteriol (2009) 1.08
Acylation of Biomolecules in Prokaryotes: a Widespread Strategy for the Control of Biological Function and Metabolic Stress. Microbiol Mol Biol Rev (2015) 0.99
Conservation of functional domain structure in bicarbonate-regulated "soluble" adenylyl cyclases in bacteria and eukaryotes. Dev Genes Evol (2004) 0.96
Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate. Proc Natl Acad Sci U S A (2014) 0.96
Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator-dependent anion and fluid secretion in airway epithelia. J Physiol (2015) 0.95
Pharmacological profiling of the Dictyostelium adenylate cyclases ACA, ACB and ACG. Biochem J (2007) 0.94
The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes. PLoS Pathog (2014) 0.92
An adenylyl cyclase, CyaB, acts as an osmosensor in Myxococcus xanthus. J Bacteriol (2005) 0.92
Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide. J Biol Chem (2008) 0.88
Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa. J Mol Biol (2011) 0.88
Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling. Sensors (Basel) (2011) 0.87
Regulation of CO2 Concentrating Mechanism in Cyanobacteria. Life (Basel) (2015) 0.86
Adenylyl cyclase activity of Cya1 from the cyanobacterium Synechocystis sp. strain PCC 6803 is inhibited by bicarbonate. J Bacteriol (2005) 0.86
Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. ChemMedChem (2014) 0.82
Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites. PLoS One (2012) 0.80
CO(2)-cAMP-responsive cis-elements targeted by a transcription factor with CREB/ATF-like basic zipper domain in the marine diatom Phaeodactylum tricornutum. Plant Physiol (2011) 0.80
Lineage-specific domain fusion in the evolution of purine nucleotide cyclases in cyanobacteria. J Mol Evol (2008) 0.79
Bicarbonate disruption of the pulmonary endothelial barrier via activation of endogenous soluble adenylyl cyclase, isoform 10. Am J Physiol Lung Cell Mol Physiol (2013) 0.78
Acetate regulation of spore formation is under the control of the Ras/cyclic AMP/protein kinase A pathway and carbon dioxide in Saccharomyces cerevisiae. Eukaryot Cell (2012) 0.78
The role of transcriptional regulation in maintaining the availability of mycobacterial adenylate cyclases. PeerJ (2014) 0.75
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A (2007) 4.62
Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature (2009) 4.49
A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet (2009) 4.28
The protein kinase IKKepsilon regulates energy balance in obese mice. Cell (2009) 3.93
TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing. Brain (2010) 3.66
Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. J Exp Med (2004) 3.43
Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature (2008) 3.06
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle (2010) 2.80
IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections. Hepatology (2015) 2.76
Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A (2007) 2.67
Crystal structure and association behaviour of the GluR2 amino-terminal domain. EMBO J (2009) 2.19
Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases. Mol Biol Cell (2003) 2.11
microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc Natl Acad Sci U S A (2010) 1.97
Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance. Nat Genet (2013) 1.95
Study design for genetic analysis in the Jackson Heart Study. Ethn Dis (2005) 1.93
p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo. Proc Natl Acad Sci U S A (2009) 1.89
RNA-seq differential expression studies: more sequence or more replication? Bioinformatics (2013) 1.87
Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. Am J Pathol (2009) 1.87
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82
OsPTF1, a novel transcription factor involved in tolerance to phosphate starvation in rice. Plant Physiol (2005) 1.76
Transferability and fine-mapping of genome-wide associated loci for adult height across human populations. PLoS One (2009) 1.68
Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering. Biomaterials (2003) 1.67
A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma. Cancer Res (2004) 1.65
Botulinum neurotoxin is shielded by NTNHA in an interlocked complex. Science (2012) 1.62
DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Vaccine (2008) 1.60
Identification and subcellular localization of the RP1 protein in human and mouse photoreceptors. Invest Ophthalmol Vis Sci (2002) 1.58
Polarized type 1 cytokine response and cell-mediated immunity determine genetic resistance to mousepox. Proc Natl Acad Sci U S A (2004) 1.56
Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis. Chem Soc Rev (2012) 1.53
Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest (2012) 1.52
Distribution and characterization of over 1000 T-DNA tags in rice genome. Plant J (2003) 1.50
Biliary tract injury caused by different relative warm ischemia time in liver transplantation in rats. Hepatobiliary Pancreat Dis Int (2009) 1.50
Facile synthesis of spiroisoquinolines based on photocycloaddition of isoquinoline-1,3,4-trione with oxazoles. Org Biomol Chem (2011) 1.49
Automatic image analysis for gene expression patterns of fly embryos. BMC Cell Biol (2007) 1.47
Microsurgical anatomy of the greater superficial petrosal nerve. World Neurosurg (2011) 1.45
A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. J Pharmacol Exp Ther (2002) 1.43
Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease. Diabetes (2008) 1.42
Reconstructing orientation field from fingerprint minutiae to improve minutiae-matching accuracy. IEEE Trans Image Process (2009) 1.42
Intraventricular craniopharyngioma: morphological analysis and outcome evaluation of 17 cases. Acta Neurochir (Wien) (2011) 1.40
Metabolic changes in schizophrenia and human brain evolution. Genome Biol (2008) 1.39
SARS-related virus predating SARS outbreak, Hong Kong. Emerg Infect Dis (2004) 1.38
Origin of mitochondrial DNA diversity of domestic yaks. BMC Evol Biol (2006) 1.35
A genome-wide search for type 2 diabetes susceptibility genes in West Africans: the Africa America Diabetes Mellitus (AADM) Study. Diabetes (2004) 1.34
Low HDL-Cholesterol with Normal Triglyceride Levels is the Most Common Lipid Pattern in West Africans and African Americans with Metabolic Syndrome: Implications for Cardiovascular Disease Prevention. CVD Prev Control (2010) 1.34
Voluntary participation and informed consent to international genetic research. Am J Public Health (2006) 1.32
Expansion of monocytic myeloid-derived suppressor cells dampens T cell function in HIV-1-seropositive individuals. J Virol (2012) 1.32
Metformin is associated with survival benefit in cancer patients with concurrent type 2 diabetes: a systematic review and meta-analysis. Oncologist (2013) 1.32
Re: Intracaval migration: an uncommon complication of ureteral double-J stent placement. (From: Falahatkar S, Hemmati H, Gholamjani Moghaddam K. J Endourol 2012;26:119-121). J Endourol (2012) 1.32
Structural and functional analysis of VQ motif-containing proteins in Arabidopsis as interacting proteins of WRKY transcription factors. Plant Physiol (2012) 1.32
Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association. Int J Nephrol (2012) 1.31
A genome-wide association study of serum uric acid in African Americans. BMC Med Genomics (2011) 1.28
The Dachshund gene in development and hormone-responsive tumorigenesis. Trends Endocrinol Metab (2009) 1.28
Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor. Mol Endocrinol (2007) 1.28
Protein-protein interactions in the regulation of WRKY transcription factors. Mol Plant (2013) 1.26
Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet (2013) 1.24
The prevalence of PALB2 germline mutations in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives. Breast Cancer Res Treat (2008) 1.23
HIF-1 and p53: communication of transcription factors under hypoxia. J Cell Mol Med (2004) 1.20
Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology (2007) 1.20
Dephosphorylation of D-peptide derivatives to form biofunctional, supramolecular nanofibers/hydrogels and their potential applications for intracellular imaging and intratumoral chemotherapy. J Am Chem Soc (2013) 1.20
D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice. Exp Biol Med (Maywood) (2010) 1.19
p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1). Biochem J (2004) 1.19
Prevalence, intensity and associated morbidity of Schistosoma japonicum infection in the Dongting Lake region, China. Bull World Health Organ (2007) 1.19
Altered expression of DACH1 and cyclin D1 in endometrial cancer. Cancer Biol Ther (2009) 1.18
The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1alpha (HIF-1alpha). Curr Med Chem (2003) 1.18
HIF-1 alpha protein as a target for S-nitrosation. FEBS Lett (2003) 1.17
PlantQTL-GE: a database system for identifying candidate genes in rice and Arabidopsis by gene expression and QTL information. Nucleic Acids Res (2006) 1.17
Prevalence and determinants of diabetic retinopathy and cataracts in West African type 2 diabetes patients. Ethn Dis (2003) 1.17
A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes. Am J Kidney Dis (2007) 1.16
Nanomolar fluorescent detection of c-di-GMP using a modular aptamer strategy. Chem Commun (Camb) (2012) 1.16
Genetic linkage study of high-grade myopia in a Hutterite population from South Dakota. Mol Vis (2007) 1.16
Isothermal amplified detection of DNA and RNA. Mol Biosyst (2014) 1.16
Structural basis of agrin-LRP4-MuSK signaling. Genes Dev (2012) 1.15
Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms. Blood (2003) 1.15
The cell fate determination factor DACH1 is expressed in estrogen receptor-alpha-positive breast cancer and represses estrogen receptor-alpha signaling. Cancer Res (2009) 1.14
Solution structure of Urm1 and its implications for the origin of protein modifiers. Proc Natl Acad Sci U S A (2006) 1.14
D-amino acids modulate the cellular response of enzymatic-instructed supramolecular nanofibers of small peptides. Biomacromolecules (2014) 1.14
UGT1A1 is a major locus influencing bilirubin levels in African Americans. Eur J Hum Genet (2011) 1.14
Hypoxia enhances sphingosine kinase 2 activity and provokes sphingosine-1-phosphate-mediated chemoresistance in A549 lung cancer cells. Mol Cancer Res (2009) 1.13
Nitric oxide and superoxide: interference with hypoxic signaling. Cardiovasc Res (2007) 1.12
The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain. J Cell Biochem (2006) 1.11
Structural basis for the function of DCN-1 in protein Neddylation. J Biol Chem (2007) 1.11
The prevalence of BRCA1 and BRCA2 germline mutations in high-risk breast cancer patients of Chinese Han nationality: two recurrent mutations were identified. Breast Cancer Res Treat (2007) 1.10
Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner. Biochem J (2010) 1.10
A comprehensive nuclear receptor network for breast cancer cells. Cell Rep (2013) 1.09
FTO genetic variation and association with obesity in West Africans and African Americans. Diabetes (2010) 1.09
Matrix metalloproteinase-9 expression correlates with prognosis and involved in ovarian cancer cell invasion. Arch Gynecol Obstet (2012) 1.09
Human adenovirus infection in children with acute respiratory tract disease in Guangzhou, China. APMIS (2012) 1.08
5-Phenyl-3,4,4a,5,6,12c-hexa-hydro-2H-benzo[f]pyrano[3,2-c]quinoline. Acta Crystallogr Sect E Struct Rep Online (2010) 1.08
A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses. PLoS One (2011) 1.08
Circulating levels of periostin may help identify patients with more aggressive colorectal cancer. Int J Oncol (2009) 1.08
Dachshund binds p53 to block the growth of lung adenocarcinoma cells. Cancer Res (2013) 1.07
Genomewide scan and fine mapping of quantitative trait loci for intraocular pressure on 5q and 14q in West Africans. Invest Ophthalmol Vis Sci (2006) 1.07
Reactive oxygen species attenuate nitric-oxide-mediated hypoxia-inducible factor-1alpha stabilization. Free Radic Biol Med (2006) 1.07
Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells. Carcinogenesis (2004) 1.07
PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice. Nucleic Acids Res (2007) 1.07
Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature. Am J Pathol (2009) 1.06
Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions. Am J Pathol (2009) 1.05
Development of admixture mapping panels for African Americans from commercial high-density SNP arrays. BMC Genomics (2010) 1.05