Published in Science on February 24, 2012
Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity. PLoS Pathog (2013) 1.22
Crystal structure of Clostridium botulinum whole hemagglutinin reveals a huge triskelion-shaped molecular complex. J Biol Chem (2013) 1.05
Molecular assembly of botulinum neurotoxin progenitor complexes. Proc Natl Acad Sci U S A (2013) 1.03
Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex. Science (2014) 1.03
Assembly and function of the botulinum neurotoxin progenitor complex. Curr Top Microbiol Immunol (2013) 1.00
Immunogenicity of botulinum toxins. J Neural Transm (Vienna) (2012) 0.99
Isolation and functional characterization of the novel Clostridium botulinum neurotoxin A8 subtype. PLoS One (2015) 0.91
Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A. FEBS Lett (2014) 0.90
Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology. Pharmacol Rev (2017) 0.87
Positive regulation of botulinum neurotoxin gene expression by CodY in Clostridium botulinum ATCC 3502. Appl Environ Microbiol (2014) 0.87
Two-component signal transduction system CBO0787/CBO0786 represses transcription from botulinum neurotoxin promoters in Clostridium botulinum ATCC 3502. PLoS Pathog (2013) 0.87
On botulinum neurotoxin variability. MBio (2015) 0.87
Holotoxin Activity of Botulinum Neurotoxin Subtype A4 Originating from a Nontoxigenic Clostridium botulinum Expression System. Appl Environ Microbiol (2014) 0.86
Botulinum Neurotoxins: Qualitative and Quantitative Analysis Using the Mouse Phrenic Nerve Hemidiaphragm Assay (MPN). Toxins (Basel) (2015) 0.86
High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex. Biochem Biophys Res Commun (2014) 0.86
Botulinum Neurotoxin Subtype A4 Originating from Nontoxigenic Clostridium botulinum. Appl Environ Microbiol (2014) 0.85
Structural basis of the pH-dependent assembly of a botulinum neurotoxin complex. J Mol Biol (2014) 0.85
Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test. Toxins (Basel) (2015) 0.85
Botulinum Toxin as a Pain Killer: Players and Actions in Antinociception. Toxins (Basel) (2015) 0.84
Pharmaceutical, biological, and clinical properties of botulinum neurotoxin type A products. Drugs R D (2015) 0.84
Botulinum neurotoxin A complex recognizes host carbohydrates through its hemagglutinin component. Toxins (Basel) (2014) 0.84
Diverse binding modes, same goal: The receptor recognition mechanism of botulinum neurotoxin. Prog Biophys Mol Biol (2015) 0.83
A comparative assessment of three formulations of botulinum toxin A for facial rhytides: a systematic review and meta-analyses. Syst Rev (2013) 0.83
Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity. Nat Commun (2015) 0.82
You are lost without a map: Navigating the sea of protein structures. Biochim Biophys Acta (2014) 0.82
Qualitative and Quantitative Detection of Botulinum Neurotoxins from Complex Matrices: Results of the First International Proficiency Test. Toxins (Basel) (2015) 0.82
Immunoprecipitation of native botulinum neurotoxin complexes from Clostridium botulinum subtype A strains. Appl Environ Microbiol (2014) 0.80
Architecture of the botulinum neurotoxin complex: a molecular machine for protection and delivery. Curr Opin Struct Biol (2015) 0.80
Structural biology. How a neurotoxin survives. Science (2012) 0.79
Detection of botulinum neurotoxin serotype A, B, and F proteolytic activity in complex matrices with picomolar to femtomolar sensitivity. Appl Environ Microbiol (2012) 0.79
Translocation of botulinum neurotoxin serotype A and associated proteins across the intestinal epithelia. Cell Microbiol (2015) 0.79
"Non-Toxic" Proteins of the Botulinum Toxin Complex Exert In-vivo Toxicity. Sci Rep (2016) 0.78
Random phage display-based screening of peptides that bind to botulinum neurotoxin binding protein, nontoxic nonhemagglutinin. Curr Microbiol (2013) 0.77
New Elements To Consider When Modeling the Hazards Associated with Botulinum Neurotoxin in Food. J Bacteriol (2015) 0.77
The C-terminal heavy-chain domain of botulinum neurotoxin a is not the only site that binds neurons, as the N-terminal heavy-chain domain also plays a very active role in toxin-cell binding and interactions. Infect Immun (2015) 0.77
Recommended Immunological Strategies to Screen for Botulinum Neurotoxin-Containing Samples. Toxins (Basel) (2015) 0.77
Identification and characterization of a novel botulinum neurotoxin. Nat Commun (2017) 0.77
Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics. Toxicon (2015) 0.76
Regulation of Botulinum Neurotoxin Synthesis and Toxin Complex Formation by Arginine and Glucose in Clostridium botulinum ATCC 3502. Appl Environ Microbiol (2017) 0.75
Molecular Assembly of Clostridium botulinum progenitor M complex of type E. Sci Rep (2015) 0.75
Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H. Toxins (Basel) (2017) 0.75
An Integrative Approach to Computational Modelling of the Gene Regulatory Network Controlling Clostridium botulinum Type A1 Toxin Production. PLoS Comput Biol (2016) 0.75
The structure of the tetanus toxin reveals pH-mediated domain dynamics. EMBO Rep (2017) 0.75
Vaccines against Botulism. Toxins (Basel) (2017) 0.75
Differentiating botulinum-neurotoxin-producing clostridia with a simple, multiplex PCR assay. Appl Environ Microbiol (2017) 0.75
Construction of "Toxin Complex" in a Mutant Serotype C Strain of Clostridium botulinum Harboring a Defective Neurotoxin Gene. Curr Microbiol (2016) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2009) 53.36
Electrostatics of nanosystems: application to microtubules and the ribosome. Proc Natl Acad Sci U S A (2001) 42.14
Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. Nature (1992) 36.50
ESPript: analysis of multiple sequence alignments in PostScript. Bioinformatics (1999) 21.85
iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM. Acta Crystallogr D Biol Crystallogr (2011) 18.13
A graphical user interface to the CCP4 program suite. Acta Crystallogr D Biol Crystallogr (2003) 13.43
Botulinum toxin as a biological weapon: medical and public health management. JAMA (2001) 9.18
Very fast empirical prediction and rationalization of protein pKa values. Proteins (2005) 8.61
Systematic analysis of domain motions in proteins from conformational change: new results on citrate synthase and T4 lysozyme. Proteins (1998) 5.91
Crystal structure of botulinum neurotoxin type A and implications for toxicity. Nat Struct Biol (1998) 4.21
Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery. Anal Biochem (2004) 3.73
Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B. Nat Struct Biol (2000) 3.31
PROMALS: towards accurate multiple sequence alignments of distantly related proteins. Bioinformatics (2007) 3.26
Phylogeny and taxonomy of the food-borne pathogen Clostridium botulinum and its neurotoxins. J Appl Microbiol (1998) 2.86
Substrate recognition strategy for botulinum neurotoxin serotype A. Nature (2004) 2.81
Structure and function of tetanus and botulinum neurotoxins. Q Rev Biophys (1995) 2.57
Botulinum neurotoxin: a marvel of protein design. Annu Rev Biochem (2010) 2.54
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity. Nature (2006) 2.20
The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves. FEBS Lett (2006) 2.04
Structural basis of cell surface receptor recognition by botulinum neurotoxin B. Nature (2006) 1.97
Protein ionizable groups: pK values and their contribution to protein stability and solubility. J Biol Chem (2009) 1.85
Oral toxicities of Clostridium botulinum toxins in response to molecular size. Infect Immun (1977) 1.75
The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction. Mol Microbiol (2004) 1.73
A novel subunit structure of Clostridium botulinum serotype D toxin complex with three extended arms. J Biol Chem (2007) 1.59
Crystal structure of botulinum neurotoxin type A in complex with the cell surface co-receptor GT1b-insight into the toxin-neuron interaction. PLoS Pathog (2008) 1.54
Inactivation of Clostridium botulinum type A neurotoxin by trypsin and purification of two tryptic fragments. Proteolytic action near the COOH-terminus of the heavy subunit destroys toxin-binding activity. Eur J Biochem (1985) 1.41
Studies on the dissociation of botulinum neurotoxin type A complexes. Toxicon (2010) 1.36
Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation. J Mol Biol (2008) 1.35
Arg(362) and Tyr(365) of the botulinum neurotoxin type a light chain are involved in transition state stabilization. Biochemistry (2002) 1.16
Effects of purification on the bioavailability of botulinum neurotoxin type A. Toxicology (2008) 1.16
Antibody mapping to domains of botulinum neurotoxin serotype A in the complexed and uncomplexed forms. Infect Immun (1997) 1.15
A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region. J Mol Biol (2010) 1.10
Probing the mechanistic role of glutamate residue in the zinc-binding motif of type A botulinum neurotoxin light chain. Biochemistry (2000) 1.10
Expression of the Clostridium botulinum A2 neurotoxin gene cluster proteins and characterization of the A2 complex. Appl Environ Microbiol (2009) 1.09
Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristics. J Biol Chem (2008) 1.08
In vitro reconstitution of the Clostridium botulinum type D progenitor toxin. J Biol Chem (2001) 1.06
Molecular characterization of two forms of nontoxic-nonhemagglutinin components of Clostridium botulinum type A progenitor toxins. FEBS Lett (1995) 1.05
Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate. Biochemistry (2006) 1.04
Role of metals in the biological activity of Clostridium botulinum neurotoxins. Biochemistry (2004) 0.98
Botulinum neurotoxin B-host receptor recognition: it takes two receptors to tango. Nat Struct Mol Biol (2007) 0.93
The complete nucleotide sequence of the gene encoding the nontoxic component of Clostridium botulinum type E progenitor toxin. J Gen Microbiol (1993) 0.93
Conserved structure of genes encoding components of botulinum neurotoxin complex M and the sequence of the gene coding for the nontoxic component in nonproteolytic Clostridium botulinum type F. Curr Microbiol (1994) 0.88
Spontaneous nicking in the nontoxic-nonhemagglutinin component of the Clostridium botulinum toxin complex. Biochem Biophys Res Commun (2002) 0.88
Electron density projection map of the botulinum neurotoxin 900-kilodalton complex by electron crystallography. J Struct Biol (1997) 0.84
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A (2007) 4.62
Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature (2009) 4.49
A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet (2009) 4.28
The protein kinase IKKepsilon regulates energy balance in obese mice. Cell (2009) 3.93
TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing. Brain (2010) 3.66
Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. J Exp Med (2004) 3.43
Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature (2008) 3.06
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle (2010) 2.80
IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections. Hepatology (2015) 2.76
Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A (2007) 2.67
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity. Nature (2006) 2.20
Crystal structure and association behaviour of the GluR2 amino-terminal domain. EMBO J (2009) 2.19
Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases. Mol Biol Cell (2003) 2.11
The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves. FEBS Lett (2006) 2.04
microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc Natl Acad Sci U S A (2010) 1.97
Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance. Nat Genet (2013) 1.95
Study design for genetic analysis in the Jackson Heart Study. Ethn Dis (2005) 1.93
p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo. Proc Natl Acad Sci U S A (2009) 1.89
RNA-seq differential expression studies: more sequence or more replication? Bioinformatics (2013) 1.87
Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. Am J Pathol (2009) 1.87
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82
OsPTF1, a novel transcription factor involved in tolerance to phosphate starvation in rice. Plant Physiol (2005) 1.76
The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction. Mol Microbiol (2004) 1.73
The N-terminal domain of GluR6-subtype glutamate receptor ion channels. Nat Struct Mol Biol (2009) 1.73
Transferability and fine-mapping of genome-wide associated loci for adult height across human populations. PLoS One (2009) 1.68
Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering. Biomaterials (2003) 1.67
Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G. J Biol Chem (2004) 1.67
A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma. Cancer Res (2004) 1.65
DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo. Vaccine (2008) 1.60
Identification and subcellular localization of the RP1 protein in human and mouse photoreceptors. Invest Ophthalmol Vis Sci (2002) 1.58
Polarized type 1 cytokine response and cell-mediated immunity determine genetic resistance to mousepox. Proc Natl Acad Sci U S A (2004) 1.56
Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis. Chem Soc Rev (2012) 1.53
Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest (2012) 1.52
Biliary tract injury caused by different relative warm ischemia time in liver transplantation in rats. Hepatobiliary Pancreat Dis Int (2009) 1.50
Distribution and characterization of over 1000 T-DNA tags in rice genome. Plant J (2003) 1.50
Facile synthesis of spiroisoquinolines based on photocycloaddition of isoquinoline-1,3,4-trione with oxazoles. Org Biomol Chem (2011) 1.49
Automatic image analysis for gene expression patterns of fly embryos. BMC Cell Biol (2007) 1.47
Optimizing gene suppression in schistosomes using RNA interference. Mol Biochem Parasitol (2007) 1.47
Microsurgical anatomy of the greater superficial petrosal nerve. World Neurosurg (2011) 1.45
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor. J Neurochem (2009) 1.44
A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. J Pharmacol Exp Ther (2002) 1.43
Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease. Diabetes (2008) 1.42
Reconstructing orientation field from fingerprint minutiae to improve minutiae-matching accuracy. IEEE Trans Image Process (2009) 1.42
A defined subset of adenylyl cyclases is regulated by bicarbonate ion. J Biol Chem (2003) 1.42
Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept. Proc Natl Acad Sci U S A (2006) 1.41
Intraventricular craniopharyngioma: morphological analysis and outcome evaluation of 17 cases. Acta Neurochir (Wien) (2011) 1.40
Metabolic changes in schizophrenia and human brain evolution. Genome Biol (2008) 1.39
SARS-related virus predating SARS outbreak, Hong Kong. Emerg Infect Dis (2004) 1.38
Alpaca (Lama pacos) as a convenient source of recombinant camelid heavy chain antibodies (VHHs). J Immunol Methods (2007) 1.36
Origin of mitochondrial DNA diversity of domestic yaks. BMC Evol Biol (2006) 1.35
A genome-wide search for type 2 diabetes susceptibility genes in West Africans: the Africa America Diabetes Mellitus (AADM) Study. Diabetes (2004) 1.34
Low HDL-Cholesterol with Normal Triglyceride Levels is the Most Common Lipid Pattern in West Africans and African Americans with Metabolic Syndrome: Implications for Cardiovascular Disease Prevention. CVD Prev Control (2010) 1.34
Voluntary participation and informed consent to international genetic research. Am J Public Health (2006) 1.32
Metformin is associated with survival benefit in cancer patients with concurrent type 2 diabetes: a systematic review and meta-analysis. Oncologist (2013) 1.32
Expansion of monocytic myeloid-derived suppressor cells dampens T cell function in HIV-1-seropositive individuals. J Virol (2012) 1.32
Re: Intracaval migration: an uncommon complication of ureteral double-J stent placement. (From: Falahatkar S, Hemmati H, Gholamjani Moghaddam K. J Endourol 2012;26:119-121). J Endourol (2012) 1.32
Structural and functional analysis of VQ motif-containing proteins in Arabidopsis as interacting proteins of WRKY transcription factors. Plant Physiol (2012) 1.32
Variation in APOL1 Contributes to Ancestry-Level Differences in HDLc-Kidney Function Association. Int J Nephrol (2012) 1.31
Functions of the tegument of schistosomes: clues from the proteome and lipidome. Int J Parasitol (2006) 1.30
Cell entry strategy of clostridial neurotoxins. J Neurochem (2009) 1.29
Botulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chain. PLoS Pathog (2007) 1.28
A genome-wide association study of serum uric acid in African Americans. BMC Med Genomics (2011) 1.28
The Dachshund gene in development and hormone-responsive tumorigenesis. Trends Endocrinol Metab (2009) 1.28
Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor. Mol Endocrinol (2007) 1.28
Protein-protein interactions in the regulation of WRKY transcription factors. Mol Plant (2013) 1.26
Genome-wide association of body fat distribution in African ancestry populations suggests new loci. PLoS Genet (2013) 1.24
A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model. PLoS One (2012) 1.24
The prevalence of PALB2 germline mutations in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives. Breast Cancer Res Treat (2008) 1.23
Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity. PLoS Pathog (2013) 1.22
HIF-1 and p53: communication of transcription factors under hypoxia. J Cell Mol Med (2004) 1.20
Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology (2007) 1.20
Dephosphorylation of D-peptide derivatives to form biofunctional, supramolecular nanofibers/hydrogels and their potential applications for intracellular imaging and intratumoral chemotherapy. J Am Chem Soc (2013) 1.20
D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice. Exp Biol Med (Maywood) (2010) 1.19
p300 relieves p53-evoked transcriptional repression of hypoxia-inducible factor-1 (HIF-1). Biochem J (2004) 1.19
Prevalence, intensity and associated morbidity of Schistosoma japonicum infection in the Dongting Lake region, China. Bull World Health Organ (2007) 1.19
The role of nitric oxide (NO) in stability regulation of hypoxia inducible factor-1alpha (HIF-1alpha). Curr Med Chem (2003) 1.18
Altered expression of DACH1 and cyclin D1 in endometrial cancer. Cancer Biol Ther (2009) 1.18
Two carbohydrate binding sites in the H(CC)-domain of tetanus neurotoxin are required for toxicity. J Mol Biol (2003) 1.18
HIF-1 alpha protein as a target for S-nitrosation. FEBS Lett (2003) 1.17
Suppressing glucose transporter gene expression in schistosomes impairs parasite feeding and decreases survival in the mammalian host. PLoS Pathog (2010) 1.17
PlantQTL-GE: a database system for identifying candidate genes in rice and Arabidopsis by gene expression and QTL information. Nucleic Acids Res (2006) 1.17
Prevalence and determinants of diabetic retinopathy and cataracts in West African type 2 diabetes patients. Ethn Dis (2003) 1.17
Arg(362) and Tyr(365) of the botulinum neurotoxin type a light chain are involved in transition state stabilization. Biochemistry (2002) 1.16
Nanomolar fluorescent detection of c-di-GMP using a modular aptamer strategy. Chem Commun (Camb) (2012) 1.16
Genetic linkage study of high-grade myopia in a Hutterite population from South Dakota. Mol Vis (2007) 1.16
A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes. Am J Kidney Dis (2007) 1.16
Isothermal amplified detection of DNA and RNA. Mol Biosyst (2014) 1.16
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Eur J Immunol (2008) 1.15
Structural basis of agrin-LRP4-MuSK signaling. Genes Dev (2012) 1.15
Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms. Blood (2003) 1.15
Calcitonin gene-related peptide inhibits local acute inflammation and protects mice against lethal endotoxemia. Shock (2005) 1.14