Published in Science on July 25, 2003
Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature (2005) 6.67
The PAR proteins: fundamental players in animal cell polarization. Dev Cell (2007) 4.92
Spindle orientation during asymmetric cell division. Nat Cell Biol (2009) 4.08
The physics of cancer: the role of physical interactions and mechanical forces in metastasis. Nat Rev Cancer (2011) 3.42
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Int J Biol Sci (2005) 2.76
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. Genes Dev (2009) 2.76
Organelle transport along microtubules in Xenopus melanophores: evidence for cooperation between multiple motors. Biophys J (2005) 2.55
Influence of cell geometry on division-plane positioning. Cell (2011) 2.53
Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows. Nature (2010) 2.39
G-protein signaling: back to the future. Cell Mol Life Sci (2005) 2.38
Force and length in the mitotic spindle. Curr Biol (2009) 2.11
Nuclear positioning. Cell (2013) 2.01
LGN regulates mitotic spindle orientation during epithelial morphogenesis. J Cell Biol (2010) 1.95
A role for the centrosome and PAR-3 in the hand-off of MTOC function during epithelial polarization. Curr Biol (2012) 1.72
A model for cleavage plane determination in early amphibian and fish embryos. Curr Biol (2010) 1.72
Probing single-cell micromechanics in vivo: the microrheology of C. elegans developing embryos. Biophys J (2006) 1.66
NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Nat Cell Biol (2009) 1.60
Spindle position in symmetric cell divisions during epiboly is controlled by opposing and dynamic apicobasal forces. Dev Cell (2012) 1.59
Mitotic functions of kinesin-5. Semin Cell Dev Biol (2010) 1.56
Functional analysis of cytoplasmic dynein heavy chain in Caenorhabditis elegans with fast-acting temperature-sensitive mutations. Mol Biol Cell (2004) 1.52
Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans. J Cell Biol (2007) 1.50
How does a millimeter-sized cell find its center? Cell Cycle (2009) 1.48
Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts. Dev Biol (2008) 1.43
The Fz-Dsh planar cell polarity pathway induces oriented cell division via Mud/NuMA in Drosophila and zebrafish. Dev Cell (2010) 1.42
MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis. Nat Cell Biol (2011) 1.36
The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly. Cell (2007) 1.34
Codon adaptation-based control of protein expression in C. elegans. Nat Methods (2011) 1.32
Control of microtubule organization and dynamics: two ends in the limelight. Nat Rev Mol Cell Biol (2015) 1.31
Mechanisms of spindle positioning. J Cell Biol (2013) 1.27
Coordinating mitosis with cell polarity: Molecular motors at the cell cortex. Semin Cell Dev Biol (2010) 1.27
Dynamic localization of LIN-5 and GPR-1/2 to cortical force generation domains during spindle positioning. Dev Biol (2007) 1.24
Multiple mechanisms contribute to centriole separation in C. elegans. Curr Biol (2013) 1.23
Centrosome fragments and microtubules are transported asymmetrically away from division plane in anaphase. J Cell Biol (2005) 1.22
Cell cycle-regulated cortical dynein/dynactin promotes symmetric cell division by differential pole motion in anaphase. Mol Biol Cell (2012) 1.21
The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly. J Cell Biol (2004) 1.17
A cell cycle timer for asymmetric spindle positioning. PLoS Biol (2009) 1.16
Dlg1 binds GKAP to control dynein association with microtubules, centrosome positioning, and cell polarity. J Cell Biol (2010) 1.14
A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning. Dev Cell (2008) 1.13
Epithelial homeostasis. Curr Biol (2014) 1.12
RAB-11 permissively regulates spindle alignment by modulating metaphase microtubule dynamics in Caenorhabditis elegans early embryos. Mol Biol Cell (2008) 1.10
Local cortical pulling-force repression switches centrosomal centration and posterior displacement in C. elegans. J Cell Biol (2007) 1.07
Membrane invaginations reveal cortical sites that pull on mitotic spindles in one-cell C. elegans embryos. PLoS One (2010) 1.05
Epithelial polarity and spindle orientation: intersecting pathways. Philos Trans R Soc Lond B Biol Sci (2013) 1.03
Early spindle assembly in Drosophila embryos: role of a force balance involving cytoskeletal dynamics and nuclear mechanics. Mol Biol Cell (2005) 1.03
Visualization of dynein-dependent microtubule gliding at the cell cortex: implications for spindle positioning. J Cell Biol (2011) 1.02
Caenorhabditis elegans EFA-6 limits microtubule growth at the cell cortex. Nat Cell Biol (2010) 1.02
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression. J Cell Biol (2013) 1.02
Memory of cell shape biases stochastic fate decision-making despite mitotic rounding. Nat Commun (2016) 1.02
Dynein-mediated pulling forces drive rapid mitotic spindle elongation in Ustilago maydis. EMBO J (2006) 0.98
Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cells. Mol Biol Cell (2013) 0.98
Aster migration determines the length scale of nuclear separation in the Drosophila syncytial embryo. J Cell Biol (2012) 0.96
The elegans of spindle assembly. Cell Mol Life Sci (2010) 0.96
LET-99 inhibits lateral posterior pulling forces during asymmetric spindle elongation in C. elegans embryos. J Cell Biol (2010) 0.94
How signaling between cells can orient a mitotic spindle. Semin Cell Dev Biol (2011) 0.93
Dynamic localization of C. elegans TPR-GoLoco proteins mediates mitotic spindle orientation by extrinsic signaling. Development (2011) 0.92
Cell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation. Mol Biol Cell (2013) 0.92
Emergent complexity of the cytoskeleton: from single filaments to tissue. Adv Phys (2013) 0.92
Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle. Nat Commun (2015) 0.90
A novel mechanism of microtubule length-dependent force to pull centrosomes toward the cell center. Bioarchitecture (2011) 0.90
Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance. Cell Cycle (2013) 0.90
PAR-3 and PAR-1 inhibit LET-99 localization to generate a cortical band important for spindle positioning in Caenorhabditis elegans embryos. Mol Biol Cell (2007) 0.89
Mechanical and biochemical modeling of cortical oscillations in spreading cells. Biophys J (2008) 0.88
Polarity mediates asymmetric trafficking of the Gbeta heterotrimeric G-protein subunit GPB-1 in C. elegans embryos. Development (2011) 0.88
End-on microtubule-dynein interactions and pulling-based positioning of microtubule organizing centers. Cell Cycle (2012) 0.86
Galpha/LGN-mediated asymmetric spindle positioning does not lead to unequal cleavage of the mother cell in 3-D cultured MDCK cells. Biochem Biophys Res Commun (2012) 0.86
Microneedle-based analysis of the micromechanics of the metaphase spindle assembled in Xenopus laevis egg extracts. Nat Protoc (2012) 0.85
Functional characterization of the Saccharomyces cerevisiae protein Chl1 reveals the role of sister chromatid cohesion in the maintenance of spindle length during S-phase arrest. BMC Genet (2011) 0.85
An improved optical tweezers assay for measuring the force generation of single kinesin molecules. Methods Mol Biol (2014) 0.83
Study on multicellular systems using a phase field model. PLoS One (2012) 0.82
Eg5 restricts anaphase B spindle elongation in mammalian cells. Cytoskeleton (Hoboken) (2013) 0.82
Crosstalk of cell polarity signaling pathways. Protoplasma (2017) 0.81
Active chiral fluids. Eur Phys J E Soft Matter (2012) 0.81
Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation. Mol Biol Cell (2017) 0.80
Micromechanics of the vertebrate meiotic spindle examined by stretching along the pole-to-pole axis. Biophys J (2014) 0.80
Astral microtubules control redistribution of dynein at the cell cortex to facilitate spindle positioning. Cell Cycle (2014) 0.80
Chromatids segregate without centrosomes during Caenorhabditis elegans mitosis in a Ran- and CLASP-dependent manner. Mol Biol Cell (2015) 0.79
Swinging a sword: how microtubules search for their targets. Syst Synth Biol (2014) 0.79
The KLP-7 Residue S546 Is a Putative Aurora Kinase Site Required for Microtubule Regulation at the Centrosome in C. elegans. PLoS One (2015) 0.78
Characterization of ring-like F-actin structure as a mechanical partner for spindle positioning in mitosis. PLoS One (2014) 0.78
Mitotic spindle orients perpendicular to the forces imposed by dynamic shear. PLoS One (2011) 0.78
On-chip open microfluidic devices for chemotaxis studies. Microsc Microanal (2012) 0.78
Oriented cell division: new roles in guiding skin wound repair and regeneration. Biosci Rep (2015) 0.77
Automated high-throughput quantification of mitotic spindle positioning from DIC movies of Caenorhabditis embryos. PLoS One (2014) 0.77
The mechanics of microtubule networks in cell division. J Cell Biol (2017) 0.77
Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans. PLoS Genet (2016) 0.75
Understanding force-generating microtubule systems through in vitro reconstitution. Cell Adh Migr (2016) 0.75
Modeling of Noisy Spindle Dynamics Reveals Separable Contributions to Achieving Correct Orientation. Biophys J (2015) 0.75
Anaphase B. Biology (Basel) (2016) 0.75
Systems biomechanics of centrosome positioning: A conserved complexity. Commun Integr Biol (2011) 0.75
Boveri revisited. EMBO J (2005) 0.75
The Mitotic Spindle in the One-Cell C. elegans Embryo Is Positioned with High Precision and Stability. Biophys J (2016) 0.75
Stronger net posterior cortical forces and asymmetric microtubule arrays produce simultaneous centration and rotation of the pronuclear complex in the early Caenorhabditis elegans embryo. Mol Biol Cell (2016) 0.75
Bundling, sliding, and pulling microtubules in cells and in silico. HFSP J (2007) 0.75
Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast. Sci Adv (2017) 0.75
Local 3D matrix confinement determines division axis through cell shape. Oncotarget (2016) 0.75
A Motor-Gradient and Clustering Model of the Centripetal Motility of MTOCs in Meiosis I of Mouse Oocytes. PLoS Comput Biol (2016) 0.75
Two populations of cytoplasmic dynein contribute to spindle positioning in C. elegans embryos. J Cell Biol (2017) 0.75
Optical sectioning deep inside live embryos by selective plane illumination microscopy. Science (2004) 13.77
Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy. Science (2008) 11.23
Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature (2010) 9.95
The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol (2007) 7.38
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Methods (2008) 6.51
Germline P granules are liquid droplets that localize by controlled dissolution/condensation. Science (2009) 5.55
Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (2010) 4.69
Dynamics and mechanics of the microtubule plus end. Nature (2003) 4.68
A standardized kinesin nomenclature. J Cell Biol (2004) 4.43
Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers. Cell (2010) 4.31
Fast, high-contrast imaging of animal development with scanned light sheet-based structured-illumination microscopy. Nat Methods (2010) 4.14
Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner. Nat Cell Biol (2006) 4.13
The kinesin-related protein MCAK is a microtubule depolymerase that forms an ATP-hydrolyzing complex at microtubule ends. Mol Cell (2003) 4.03
Genome-scale RNAi profiling of cell division in human tissue culture cells. Nat Cell Biol (2007) 3.91
The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends. Nature (2006) 3.89
Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis. Nature (2005) 3.62
High-resolution three-dimensional imaging of large specimens with light sheet-based microscopy. Nat Methods (2007) 3.62
Centriole assembly in Caenorhabditis elegans. Nature (2006) 3.58
A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell (2013) 3.53
XMAP215 is a processive microtubule polymerase. Cell (2008) 3.33
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nat Struct Mol Biol (2009) 3.26
SAS-4 is a C. elegans centriolar protein that controls centrosome size. Cell (2003) 3.19
Multi-view image fusion improves resolution in three-dimensional microscopy. Opt Express (2007) 3.09
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00
HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Curr Biol (2009) 2.98
Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells. Nat Cell Biol (2010) 2.91
Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding. Nature (2011) 2.68
Spindle oscillations during asymmetric cell division require a threshold number of active cortical force generators. Curr Biol (2006) 2.67
A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell (2011) 2.64
Microtubule polymerases and depolymerases. Curr Opin Cell Biol (2006) 2.64
RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells. Proc Natl Acad Sci U S A (2005) 2.59
Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis. J Cell Biol (2005) 2.57
Protein friction limits diffusive and directed movements of kinesin motors on microtubules. Science (2009) 2.54
Genome-wide identification of binding sites defines distinct functions for Caenorhabditis elegans PHA-4/FOXA in development and environmental response. PLoS Genet (2010) 2.46
Katanin disrupts the microtubule lattice and increases polymer number in C. elegans meiosis. Curr Biol (2006) 2.45
The Caenorhabditis elegans centrosomal protein SPD-2 is required for both pericentriolar material recruitment and centriole duplication. Curr Biol (2004) 2.44
Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes. Proc Natl Acad Sci U S A (2011) 2.44
A spatial accommodation by neighboring cells is required for organ initiation in Arabidopsis. Science (2014) 2.36
Hierarchical structure formation and pattern replication induced by an electric field. Nat Mater (2003) 2.34
Depolymerizing kinesins Kip3 and MCAK shape cellular microtubule architecture by differential control of catastrophe. Cell (2011) 2.31
Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegans. Genome Res (2010) 2.30
How molecular motors shape the flagellar beat. HFSP J (2007) 2.27
Limiting amounts of centrosome material set centrosome size in C. elegans embryos. Curr Biol (2011) 2.25
A protein domain-based interactome network for C. elegans early embryogenesis. Cell (2008) 2.23
Centrosome size sets mitotic spindle length in Caenorhabditis elegans embryos. Curr Biol (2010) 2.23
Kinesin-8 motors act cooperatively to mediate length-dependent microtubule depolymerization. Cell (2009) 2.22
Asymmetric cell division in C. elegans: cortical polarity and spindle positioning. Annu Rev Cell Dev Biol (2004) 2.22
A cytokinesis furrow is positioned by two consecutive signals. Nature (2005) 2.21
GTP binding induces filament assembly of a recombinant septin. Curr Biol (2002) 2.16
Spindle positioning by cortical pulling forces. Dev Cell (2005) 2.14
Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization. J Cell Sci (2009) 2.14
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J (2011) 2.14
The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent. J Cell Biol (2002) 2.13
Sororin mediates sister chromatid cohesion by antagonizing Wapl. Cell (2010) 2.12
A self-organized vortex array of hydrodynamically entrained sperm cells. Science (2005) 2.09
A genome-scale resource for in vivo tag-based protein function exploration in C. elegans. Cell (2012) 2.07
Identification and characterization of factors required for microtubule growth and nucleation in the early C. elegans embryo. Dev Cell (2005) 2.02
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Nature (2005) 2.01
Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons. Mol Biol Cell (2002) 1.97
Drosophila auditory organ genes and genetic hearing defects. Cell (2012) 1.94
Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A. J Cell Biol (2008) 1.92
LET-99, GOA-1/GPA-16, and GPR-1/2 are required for aster-positioned cytokinesis. Curr Biol (2006) 1.91
Trapping forces, force constants, and potential depths for dielectric spheres in the presence of spherical aberrations. Appl Opt (2002) 1.89
The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis. Curr Biol (2008) 1.88
Polarization of PAR proteins by advective triggering of a pattern-forming system. Science (2011) 1.88
Quantitative in vivo imaging of entire embryos with Digital Scanned Laser Light Sheet Fluorescence Microscopy. Curr Opin Neurobiol (2009) 1.88
XMAP215: a key component of the dynamic microtubule cytoskeleton. Trends Cell Biol (2002) 1.87
Centrosomes direct cell polarity independently of microtubule assembly in C. elegans embryos. Nature (2004) 1.85
Molecular profiling reveals synaptic release machinery in Merkel cells. Proc Natl Acad Sci U S A (2004) 1.77
Microtubule dynamics reconstituted in vitro and imaged by single-molecule fluorescence microscopy. Methods Cell Biol (2010) 1.76
CDC-42 and RHO-1 coordinate acto-myosin contractility and PAR protein localization during polarity establishment in C. elegans embryos. Development (2006) 1.74
Filopodia act as phagocytic tentacles and pull with discrete steps and a load-dependent velocity. Proc Natl Acad Sci U S A (2007) 1.72
Organelle growth control through limiting pools of cytoplasmic components. Curr Biol (2012) 1.71
Aurora A activates D-TACC-Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules. J Cell Biol (2005) 1.70
Caenorhabditis elegans TAC-1 and ZYG-9 form a complex that is essential for long astral and spindle microtubules. Curr Biol (2003) 1.67
Rapid microtubule self-assembly kinetics. Cell (2011) 1.65
Beyond the diffraction limit? Nature (2002) 1.65
Detection of fractional steps in cargo movement by the collective operation of kinesin-1 motors. Proc Natl Acad Sci U S A (2007) 1.64
Cell division. WormBook (2006) 1.63
Growth, fluctuation and switching at microtubule plus ends. Nat Rev Mol Cell Biol (2009) 1.62
Straight GDP-tubulin protofilaments form in the presence of taxol. Curr Biol (2007) 1.59
Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast. J Cell Biol (2005) 1.57
XMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region. Proc Natl Acad Sci U S A (2011) 1.56
Light sheet-based fluorescence microscopy: more dimensions, more photons, and less photodamage. HFSP J (2008) 1.54
Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding. Structure (2007) 1.54
Reconstitution and characterization of budding yeast gamma-tubulin complex. Mol Biol Cell (2002) 1.53
Stable chromosomal units determine the spatial and temporal organization of DNA replication. J Cell Sci (2004) 1.53
Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division. EMBO J (2009) 1.51
Lateral modulation boosts image quality in single plane illumination fluorescence microscopy. Opt Lett (2007) 1.49
EB1 recognizes the nucleotide state of tubulin in the microtubule lattice. PLoS One (2009) 1.45
BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures. Mol Biol Cell (2012) 1.44
Stoichiometry of chromatin-associated protein complexes revealed by label-free quantitative mass spectrometry-based proteomics. Nucleic Acids Res (2012) 1.43
Morphologically distinct microtubule ends in the mitotic centrosome of Caenorhabditis elegans. J Cell Biol (2003) 1.42