Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells.

PubWeight™: 8.33‹?› | Rank: Top 0.1%

🔗 View Article (PMC 2731699)

Published in Cell on August 07, 2009

Authors

Yohei Shimono1, Maider Zabala, Robert W Cho, Neethan Lobo, Piero Dalerba, Dalong Qian, Maximilian Diehn, Huiping Liu, Sarita P Panula, Eric Chiao, Frederick M Dirbas, George Somlo, Renee A Reijo Pera, Kaiqin Lao, Michael F Clarke

Author Affiliations

1: Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304, USA.

Articles citing this

(truncated to the top 100)

Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol (2009) 8.63

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med (2011) 6.85

Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer (2013) 6.13

Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77

Self-renewal as a therapeutic target in human colorectal cancer. Nat Med (2013) 4.20

Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell (2010) 4.18

The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer? EMBO Rep (2010) 4.05

p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol (2011) 3.85

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med (2011) 3.82

To differentiate or not--routes towards metastasis. Nat Rev Cancer (2012) 3.59

Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell (2010) 3.53

Selective release of microRNA species from normal and malignant mammary epithelial cells. PLoS One (2010) 3.50

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci U S A (2011) 3.42

Non-coding RNAs as regulators of embryogenesis. Nat Rev Genet (2011) 3.36

Unravelling cancer stem cell potential. Nat Rev Cancer (2013) 3.06

microRNA involvement in human cancer. Carcinogenesis (2012) 2.98

MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell (2013) 2.92

Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A (2010) 2.89

MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression. J Biol Chem (2010) 2.85

The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell (2012) 2.84

MicroRNAs and their target gene networks in breast cancer. Breast Cancer Res (2010) 2.83

MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat Rev Cancer (2012) 2.78

Reprogramming of miRNA networks in cancer and leukemia. Genome Res (2010) 2.65

Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells. PLoS One (2010) 2.63

Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells. PLoS One (2010) 2.55

Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res (2011) 2.53

An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol Biol Cell (2011) 2.49

The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. EMBO J (2011) 2.29

Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A (2011) 2.01

miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells. J Biol Chem (2011) 1.98

Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance. Drug Resist Updat (2010) 1.98

MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways. Oncogene (2010) 1.97

Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression. Breast Cancer Res (2011) 1.96

miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response. Nat Med (2011) 1.94

Manifestations and mechanisms of stem cell aging. J Cell Biol (2011) 1.93

Tumour angiogenesis regulation by the miR-200 family. Nat Commun (2013) 1.90

Coordinated regulation of polycomb group complexes through microRNAs in cancer. Cancer Cell (2011) 1.86

MicroRNA regulation of cancer stem cells. Cancer Res (2011) 1.84

Mechanisms governing metastatic dormancy and reactivation. Cell (2013) 1.81

Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Int J Cancer (2011) 1.79

Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited. Stem Cells (2010) 1.78

Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2. Immunity (2013) 1.77

The evolving concept of cancer and metastasis stem cells. J Cell Biol (2012) 1.76

Targets of miR-200c mediate suppression of cell motility and anoikis resistance. Breast Cancer Res (2011) 1.74

Targeting breast cancer stem cells. Mol Oncol (2010) 1.72

Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers. EMBO Mol Med (2011) 1.68

Epithelial-mesenchymal transition, cancer stem cells and treatment resistance. Breast Cancer Res (2012) 1.68

Circulating MiR-125b as a marker predicting chemoresistance in breast cancer. PLoS One (2012) 1.67

MicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation. Mol Cancer (2010) 1.66

The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex. PLoS One (2010) 1.63

MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer. Theranostics (2015) 1.62

Implication of microRNAs in drug resistance for designing novel cancer therapy. Drug Resist Updat (2010) 1.61

The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells. Gut (2015) 1.60

IL6-mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis. Mol Cell (2012) 1.59

Metastamirs: a stepping stone towards improved cancer management. Nat Rev Clin Oncol (2010) 1.58

Distinct microRNA expression profiles in prostate cancer stem/progenitor cells and tumor-suppressive functions of let-7. Cancer Res (2012) 1.55

miR-200b targets Ets-1 and is down-regulated by hypoxia to induce angiogenic response of endothelial cells. J Biol Chem (2010) 1.53

TMPRSS2-ERG gene fusions induce prostate tumorigenesis by modulating microRNA miR-200c. Oncogene (2013) 1.51

Breast cancer epithelial-to-mesenchymal transition: examining the functional consequences of plasticity. Breast Cancer Res (2011) 1.50

MiR-200, a new star miRNA in human cancer. Cancer Lett (2013) 1.50

A putative role for microRNA-205 in mammary epithelial cell progenitors. J Cell Sci (2010) 1.47

Downregulation of miR-140 promotes cancer stem cell formation in basal-like early stage breast cancer. Oncogene (2013) 1.41

Regulation of microRNAs by natural agents: an emerging field in chemoprevention and chemotherapy research. Pharm Res (2010) 1.40

A Quiescent Bcl11b High Stem Cell Population Is Required for Maintenance of the Mammary Gland. Cell Stem Cell (2016) 1.38

MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells. PLoS Genet (2012) 1.38

Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. EMBO J (2011) 1.36

Cancer stem cells. Int J Biochem Cell Biol (2012) 1.35

MicroRNA control of epithelial-mesenchymal transition and metastasis. Cancer Metastasis Rev (2012) 1.34

Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells. BMC Res Notes (2010) 1.32

CAMTA1 is a novel tumour suppressor regulated by miR-9/9* in glioblastoma stem cells. EMBO J (2011) 1.32

Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression. J Surg Res (2011) 1.31

Oncogenes and tumor suppressor genes. Cold Spring Harb Perspect Biol (2010) 1.31

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. J Clin Invest (2012) 1.29

Non-coding RNAs: a key to future personalized molecular therapy? Genome Med (2010) 1.29

MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition. Oncogene (2013) 1.29

DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs. PLoS One (2011) 1.27

Expanding roles of ZEB factors in tumorigenesis and tumor progression. Am J Cancer Res (2011) 1.26

Identification of a stem-like cell population by exposing metastatic breast cancer cell lines to repetitive cycles of hypoxia and reoxygenation. Breast Cancer Res (2010) 1.26

The miR-200 and miR-221/222 microRNA families: opposing effects on epithelial identity. J Mammary Gland Biol Neoplasia (2012) 1.25

Role of microRNAs in the regulation of breast cancer stem cells. J Mammary Gland Biol Neoplasia (2012) 1.25

Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression. Breast Cancer Res (2010) 1.24

The role of microRNAs in breast cancer migration, invasion and metastasis. Int J Mol Sci (2012) 1.24

Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis. Mol Cancer (2011) 1.23

MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells. J Biol Chem (2011) 1.23

MicroRNA alterations and associated aberrant DNA methylation patterns across multiple sample types in oral squamous cell carcinoma. PLoS One (2011) 1.23

The role of epithelial-mesenchymal transition programming in invasion and metastasis: a clinical perspective. Cancer Manag Res (2013) 1.22

Retracted MicroRNA miR-214 regulates ovarian cancer cell stemness by targeting p53/Nanog. J Biol Chem (2012) 1.22

An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state. Proc Natl Acad Sci U S A (2012) 1.22

Leptin-STAT3-G9a Signaling Promotes Obesity-Mediated Breast Cancer Progression. Cancer Res (2015) 1.21

Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation. Proc Natl Acad Sci U S A (2013) 1.21

MicroRNA-125b induces metastasis by targeting STARD13 in MCF-7 and MDA-MB-231 breast cancer cells. PLoS One (2012) 1.19

The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy. Oncotarget (2015) 1.18

The microRNA-302-367 cluster suppresses the proliferation of cervical carcinoma cells through the novel target AKT1. RNA (2012) 1.18

miRNA Biomarkers in Breast Cancer Detection and Management. J Cancer (2011) 1.18

MicroRNAs in breast cancer initiation and progression. Cell Mol Life Sci (2012) 1.17

The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors. Cell Cycle (2010) 1.17

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER. Nat Commun (2014) 1.17

Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications. J Hepatol (2010) 1.16

Ablation of breast cancer stem cells with radiation. Transl Oncol (2011) 1.15

Articles cited by this

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87

Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17

Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer (2006) 46.47

The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08

A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature (2000) 39.31

Identification of human brain tumour initiating cells. Nature (2004) 38.87

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet (2008) 32.08

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A (2004) 28.29

MicroRNA gene expression deregulation in human breast cancer. Cancer Res (2005) 27.56

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med (2005) 26.02

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature (2006) 24.52

Identification and expansion of human colon-cancer-initiating cells. Nature (2006) 24.44

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol (2008) 24.27

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature (1994) 21.59

Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res (2004) 18.86

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet (2008) 17.67

Efficient tumour formation by single human melanoma cells. Nature (2008) 16.35

Purification and unique properties of mammary epithelial stem cells. Nature (2006) 15.98

Dicer is essential for mouse development. Nat Genet (2003) 15.87

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev (2008) 15.01

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35

let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell (2007) 13.69

Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A (2007) 13.58

The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med (2007) 13.39

Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A (2007) 11.94

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature (2003) 11.23

Tumor growth need not be driven by rare cancer stem cells. Science (2007) 10.34

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25

Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell (2008) 7.69

The biology of cancer stem cells. Annu Rev Cell Dev Biol (2007) 6.23

Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev (2005) 5.78

A skin microRNA promotes differentiation by repressing 'stemness'. Nature (2008) 5.66

Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell (2008) 5.53

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature (2008) 4.60

Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis. Nat Rev Cancer (2007) 4.06

Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A (2008) 4.00

Cytological evidence for a relationship between normal hemotopoietic colony-forming cells and cells of the lymphoid system. J Exp Med (1968) 3.97

A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med (2008) 3.64

Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells (2007) 3.60

A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro. Cancer Res (2009) 3.38

Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci (2008) 3.33

Clonal origin of human tumors. Biochim Biophys Acta (1976) 3.07

Hirschsprung disease is linked to defects in neural crest stem cell function. Science (2003) 2.98

Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors. Nature (2008) 2.82

miR-200b mediates post-transcriptional repression of ZFHX1B. RNA (2007) 2.67

Human tumors studied with genetic markers. Birth Defects Orig Artic Ser (1976) 2.52

A QUANTITATIVE ASSAY FOR THE NUMBER OF MURINE LYMPHOMA CELLS CAPABLE OF PROLIFERATION IN VIVO. Nature (1963) 1.96

220-plex microRNA expression profile of a single cell. Nat Protoc (2006) 1.88

Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium. Curr Biol (2008) 1.45

A genetic determinant that specifically regulates the frequency of hematopoietic stem cells. J Immunol (2002) 1.41

Stem cell origin of human myeloid blood cell neoplasms. Verh Dtsch Ges Pathol (1990) 0.94

Articles by these authors

Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev (2003) 20.77

Identification of pancreatic cancer stem cells. Cancer Res (2007) 18.36

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35

Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A (2007) 13.58

The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med (2007) 13.39

mRNA-Seq whole-transcriptome analysis of a single cell. Nat Methods (2009) 11.71

2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. J Clin Oncol (2006) 11.26

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature (2003) 11.23

Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31

Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol (2007) 9.36

Applying the principles of stem-cell biology to cancer. Nat Rev Cancer (2003) 8.95

CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer. N Engl J Med (2016) 8.53

Cancer stem cells: models and concepts. Annu Rev Med (2007) 8.06

Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol (2011) 7.84

Probing gene expression in live cells, one protein molecule at a time. Science (2006) 7.21

Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proc Natl Acad Sci U S A (2005) 6.54

Individuality and variation in gene expression patterns in human blood. Proc Natl Acad Sci U S A (2003) 6.49

The biology of cancer stem cells. Annu Rev Cell Dev Biol (2007) 6.23

A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma. Blood (2012) 5.11

Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-Seq analysis. Cell Stem Cell (2010) 4.97

Self-renewal and solid tumor stem cells. Oncogene (2004) 4.60

Stem cells in normal breast development and breast cancer. Cell Prolif (2003) 4.47

RNA-Seq analysis to capture the transcriptome landscape of a single cell. Nat Protoc (2010) 4.35

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20

Maternal microRNAs are essential for mouse zygotic development. Genes Dev (2007) 4.16

Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. Genome Res (2009) 4.11

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nat Struct Mol Biol (2013) 4.04

Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One (2008) 3.97

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97

Stereotyped and specific gene expression programs in human innate immune responses to bacteria. Proc Natl Acad Sci U S A (2002) 3.85

Bmi1, stem cells, and senescence regulation. J Clin Invest (2004) 3.80

Unique gene expression signatures of independently-derived human embryonic stem cell lines. Hum Mol Genet (2004) 3.77

Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells (2007) 3.60

DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. Cell Stem Cell (2009) 3.48

MicroRNA expression profiling of single whole embryonic stem cells. Nucleic Acids Res (2006) 3.36

Cell-type specific gene expression profiles of leukocytes in human peripheral blood. BMC Genomics (2006) 3.27

Breast cancer. Clinical practice guidelines in oncology. J Natl Compr Canc Netw (2009) 3.17

Therapeutic implications of cancer stem cells. Curr Opin Genet Dev (2004) 3.04

Stereotactic ablative radiotherapy should be combined with a hypoxic cell radiosensitizer. Int J Radiat Oncol Biol Phys (2010) 2.97

Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A (2010) 2.89

Transcriptional programs activated by exposure of human prostate cancer cells to androgen. Genome Biol (2002) 2.87

Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors. Nature (2008) 2.82

MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS One (2008) 2.82

Autologous haemopoietic stem-cell transplantation followed by allogeneic or autologous haemopoietic stem-cell transplantation in patients with multiple myeloma (BMT CTN 0102): a phase 3 biological assignment trial. Lancet Oncol (2011) 2.78

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci U S A (2009) 2.76

Development and applications of single-cell transcriptome analysis. Nat Methods (2011) 2.62

Gene expression patterns in ovarian carcinomas. Mol Biol Cell (2003) 2.55

CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res (2012) 2.50

Heterogeneous dysregulation of microRNAs across the autism spectrum. Neurogenetics (2008) 2.50

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors. Nat Med (2010) 2.41

Spontaneous differentiation of germ cells from human embryonic stem cells in vitro. Hum Mol Genet (2004) 2.35

Allografting with nonmyeloablative conditioning following cytoreductive autografts for the treatment of patients with multiple myeloma. Blood (2003) 2.33

Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. Nat Med (2006) 2.23

Recent advances in cancer stem cells. Curr Opin Genet Dev (2008) 2.17

HER2 testing in breast cancer: NCCN Task Force report and recommendations. J Natl Compr Canc Netw (2006) 2.15

The unique transcriptome through day 3 of human preimplantation development. Hum Mol Genet (2004) 2.15

Cancer stem cells and radiotherapy: new insights into tumor radioresistance. J Natl Cancer Inst (2006) 2.10

Somatodendritic microRNAs identified by laser capture and multiplex RT-PCR. RNA (2007) 2.01

Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer. J Clin Invest (2012) 1.92

NCCN Task Force Report: Adjuvant Therapy for Breast Cancer. J Natl Compr Canc Netw (2006) 1.88

220-plex microRNA expression profile of a single cell. Nat Protoc (2006) 1.88

Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. Proc Natl Acad Sci U S A (2003) 1.85

Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One (2011) 1.82

Breast cancer, version 3.2013: featured updates to the NCCN guidelines. J Natl Compr Canc Netw (2013) 1.79

Sperm-borne microRNA-34c is required for the first cleavage division in mouse. Proc Natl Acad Sci U S A (2011) 1.74

Bone morphogenetic proteins induce germ cell differentiation from human embryonic stem cells. Stem Cells Dev (2006) 1.73

Differential gene expression profiling of adult murine hematopoietic stem cells. Blood (2002) 1.69

Immunity to cancer: attack and escape in T lymphocyte-tumor cell interaction. Immunol Rev (2002) 1.66

Impaired interferon signaling is a common immune defect in human cancer. Proc Natl Acad Sci U S A (2009) 1.66

Breast cancer version 3.2014. J Natl Compr Canc Netw (2014) 1.63

A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a California Cancer Consortium study. Clin Cancer Res (2008) 1.60

Breast Cancer Version 2.2015. J Natl Compr Canc Netw (2015) 1.59

Radiation modulation of microRNA in prostate cancer cell lines. Prostate (2008) 1.58

Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells. Stem Cells (2007) 1.57

Cancer immunotherapy with peptide-based vaccines: what have we achieved? Where are we going? J Natl Cancer Inst (2002) 1.56

Therapeutic implications of the cancer stem cell hypothesis. Semin Radiat Oncol (2009) 1.53