Published in J Immunol on April 15, 2006
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A (2009) 2.83
CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms. Nat Immunol (2009) 1.70
The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation. J Exp Med (2008) 1.34
Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation. Nat Immunol (2012) 1.28
Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice. J Clin Invest (2007) 1.23
T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity. J Biol Chem (2009) 1.04
Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation. Blood (2011) 1.03
Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes. J Exp Med (2010) 0.97
The emerging role of p38 mitogen-activated protein kinase in multiple sclerosis and its models. Mol Cell Biol (2013) 0.94
Elevating calcium in Th2 cells activates multiple pathways to induce IL-4 transcription and mRNA stabilization. J Immunol (2008) 0.93
Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production. Blood (2008) 0.93
The regulation of Th1 responses by the p38 MAPK. J Immunol (2010) 0.91
Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling. BMC Genomics (2010) 0.91
Control of Borrelia burgdorferi-specific CD4+-T-cell effector function by interleukin-12- and T-cell receptor-induced p38 mitogen-activated protein kinase activity. Infect Immun (2006) 0.90
A major population of mucosal memory CD4+ T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality. Mucosal Immunol (2014) 0.83
Phosphorylation of mitogen-activated protein kinases contributes to interferon γ production in response to Mycobacterium tuberculosis. J Infect Dis (2012) 0.81
p38α protein negatively regulates T helper type 2 responses by orchestrating multiple T cell receptor-associated signals. J Biol Chem (2012) 0.79
Diverse inflammatory cytokines induce selectin ligand expression on murine CD4 T cells via p38α MAPK. J Immunol (2015) 0.78
TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma. J Clin Cell Immunol (2012) 0.77
Loss of functionally redundant p38 isoforms in T cells enhances regulatory T cell induction. J Biol Chem (2016) 0.75
p38α regulates cytokine-induced IFNγ secretion via the Mnk1/eIF4E pathway in Th1 cells. Immunol Cell Biol (2017) 0.75
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol (2005) 30.22
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature (2008) 10.84
Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity (2006) 10.53
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34
Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science (2008) 7.87
T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells. Nat Immunol (2002) 7.28
A validated regulatory network for Th17 cell specification. Cell (2012) 4.82
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. J Exp Med (2010) 4.56
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol (2003) 4.56
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8{alpha}+ dendritic cells. J Exp Med (2011) 4.02
Type I interferon is selectively required by dendritic cells for immune rejection of tumors. J Exp Med (2011) 3.85
The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature (2009) 3.75
B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat Immunol (2004) 3.49
53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature (2008) 3.47
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination. Nature (2006) 3.35
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol (2011) 3.21
Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity (2012) 3.18
A distal conserved sequence element controls Ifng gene expression by T cells and NK cells. Immunity (2006) 3.16
Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature (2003) 2.83
Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development (2006) 2.82
ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell (2007) 2.78
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J Exp Med (2012) 2.74
Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity (2009) 2.61
ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature (2005) 2.58
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol (2002) 2.54
CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity (2011) 2.50
Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs. Cell Stem Cell (2008) 2.46
A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science (2012) 2.30
Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature (2012) 2.25
Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis. Nature (2008) 2.18
Re(de)fining the dendritic cell lineage. Nat Immunol (2012) 2.17
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol Cell (2009) 2.08
Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells. Eur J Immunol (2008) 2.05
53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell (2013) 2.05
BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature (2012) 2.00
CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes. Immunity (2011) 1.99
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci. Nat Immunol (2009) 1.98
CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2010) 1.94
DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature (2008) 1.88
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol (2013) 1.87
Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J (2009) 1.83
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers. Nat Immunol (2012) 1.82
Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells. Immunity (2013) 1.81
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature (2010) 1.78
B and T lymphocyte attenuator exhibits structural and expression polymorphisms and is highly Induced in anergic CD4+ T cells. J Immunol (2005) 1.78
Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. Proc Natl Acad Sci U S A (2005) 1.76
Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG. Cell Cycle (2009) 1.75
Slow down and survive: Enigmatic immunoregulation by BTLA and HVEM. Annu Rev Immunol (2010) 1.73
Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host Microbe (2007) 1.71
CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms. Nat Immunol (2009) 1.70
Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells. J Exp Med (2009) 1.67
A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med (2008) 1.67
The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol (2012) 1.64
From IL-10 to IL-12: how pathogens and their products stimulate APCs to induce T(H)1 development. Nat Immunol (2009) 1.61
Cross-presenting CD103+ dendritic cells are protected from influenza virus infection. J Clin Invest (2012) 1.57
DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues. Blood (2012) 1.56
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS One (2008) 1.56
Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts. J Immunol (2005) 1.55
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat Med (2003) 1.55
Batf3-dependent dendritic cells in the renal lymph node induce tolerance against circulating antigens. J Am Soc Nephrol (2013) 1.54
BTLA targeting modulates lymphocyte phenotype, function, and numbers and attenuates disease in nonobese diabetic mice. J Leukoc Biol (2009) 1.53
N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation. Nat Immunol (2004) 1.51
Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat Immunol (2008) 1.51
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J Exp Med (2009) 1.50
Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc. Proc Natl Acad Sci U S A (2009) 1.50
Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks. Nat Rev Immunol (2013) 1.50
Unconventional ligand activation of herpesvirus entry mediator signals cell survival. Proc Natl Acad Sci U S A (2009) 1.49
Dynamic regulation of c-Myc proto-oncogene expression during lymphocyte development revealed by a GFP-c-Myc knock-in mouse. Eur J Immunol (2008) 1.48
Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human. J Immunol (2002) 1.40
Thymocyte apoptosis induced by T cell activation is mediated by glucocorticoids in vivo. J Immunol (2002) 1.39
Proteasome activator PA200 is required for normal spermatogenesis. Mol Cell Biol (2006) 1.38
Evidence for carbohydrate recognition and homotypic and heterotypic binding by the TIM family. Int Immunol (2007) 1.37