Published in Biotechnology (N Y) on December 01, 1990
HIV-1 activates macrophages independent of Toll-like receptors. PLoS One (2008) 1.26
Preclinical evaluation of a replication-deficient intranasal DeltaNS1 H5N1 influenza vaccine. PLoS One (2009) 1.04
Induced expression of trimerized intracellular domains of the human tumor necrosis factor (TNF) p55 receptor elicits TNF effects. J Cell Biol (1997) 1.03
Species-independent bioassay for sensitive quantification of antiviral type I interferons. Virol J (2010) 0.93
Bioactivity determination of native and variant forms of therapeutic interferons. J Biomed Biotechnol (2011) 0.92
A rapid, sensitive, and specific method for the determination of protein in dilute solution. Anal Biochem (1973) 31.32
Mapping of RNA by a modification of the Berk-Sharp procedure: the 5' termini of 15 S beta-globin mRNA precursor and mature 10 s beta-globin mRNA have identical map coordinates. Nucleic Acids Res (1979) 31.23
Mice devoid of PrP are resistant to scrapie. Cell (1993) 11.46
Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit beta-globin gene in mouse 3T6 cells. Cell (1983) 9.51
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature (1992) 9.01
Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence. Science (1979) 6.94
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J (1996) 6.66
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proc Natl Acad Sci U S A (1978) 6.20
Hybrid plasmids containing an active thymidine kinase gene of Herpes simplex virus 1. Nucleic Acids Res (1979) 5.55
Nucleotide sequence heterogeneity of an RNA phage population. Cell (1978) 5.55
A minimal intron length but no specific internal sequence is required for splicing the large rabbit beta-globin intron. Cell (1984) 5.37
DNA sequences preceding the rabbit beta-globin gene are required for formation in mouse L cells of beta-globin RNA with the correct 5' terminus. Proc Natl Acad Sci U S A (1981) 5.26
Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell (1986) 4.92
The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha. Nature (1980) 4.82
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell (1986) 4.82
Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA. Cell (1986) 4.40
Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit beta-globin gene. Nature (1983) 4.38
Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature (1996) 4.25
Mapping of biological functions on RNA of avian tumor viruses: location of regions required for transformation and determination of host range. Proc Natl Acad Sci U S A (1975) 4.01
A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc Natl Acad Sci U S A (1997) 3.88
Rabbit beta-globin mRNA production in mouse L cells transformed with cloned rabbit beta-globin chromosomal DNA. Nature (1979) 3.88
Comparison of cloned rabbit and mouse beta-globin genes showing strong evolutionary divergence of two homologous pairs of introns. Nature (1978) 3.86
Specific excision of the inserted DNA segment from hybrid plasmids constructed by the poly(dA). poly (dT) method. Biochim Biophys Acta (1976) 3.79
Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes. J Immunol (1987) 3.78
Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. Nature (1980) 3.78
Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell (1998) 3.59
Human leukocyte and fibroblast interferons are structurally related. Nature (1980) 3.57
Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB. EMBO J (1997) 3.34
Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter. Mol Cell Biol (1988) 3.19
QB DNA-containing hybrid plasmids giving rise to QB phage formation in the bacterial host. Nature (1978) 3.11
The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei. Gene (1980) 2.99
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions. Proc Natl Acad Sci U S A (2003) 2.94
Infectivity in mouse fibroblasts of polyoma DNA integrated into plasmid pBR322 or lambdoid phage DNA. Nature (1979) 2.92
Localization of Q-beta maturation cistron ribosome binding site. Nat New Biol (1971) 2.91
The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate. Gene (1976) 2.77
5' cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5' splice region, not by the conserved 5' GU. Cell (1987) 2.69
A 46-nucleotide promoter segment from an IFN-alpha gene renders an unrelated promoter inducible by virus. Cell (1985) 2.65
Avian myeloblastosis virus RNA is terminally redundant: implications for the mechanism of retrovirus replication. Cell (1977) 2.55
Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody. Proc Natl Acad Sci U S A (2001) 2.53
The nucleotide sequence of a cloned human leukocyte interferon cDNA. Gene (1980) 2.51
Structure and function of phage RNA. Annu Rev Biochem (1973) 2.50
Replication of viral ribonucleic acid. IX. Properties of double-stranded RNA from Escherichia coli infected with bacteriophage MS2. J Mol Biol (1966) 2.45
Quantitative determination and location of newly synthesized virus-specific ribonucleic acid in chicken cells infected with Rous sarcoma virus. J Virol (1973) 2.45
PrP expression in B lymphocytes is not required for prion neuroinvasion. Nat Med (1998) 2.40
At least three human type alpha interferons: structure of alpha 2. Science (1980) 2.38
Structure and expression of cloned murine IFN-alpha genes. Nucleic Acids Res (1983) 2.35
Subunit structure of Q-beta replicase. Nature (1970) 2.30
Mice devoid of interferon regulatory factor 1 (IRF-1) show normal expression of type I interferon genes. EMBO J (1994) 2.27
High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene. Mol Med (1994) 2.18
Site-directed mutagenesis in DNA: generation of point mutations in cloned beta globin complementary dna at the positions corresponding to amino acids 121 to 123. J Mol Biol (1978) 2.17
Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science (2000) 2.15
Prion research: the next frontiers. Nature (1997) 2.13
Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice. Neuron (2000) 2.13
Effect of mutations at the lariat branch acceptor site on beta-globin pre-mRNA splicing in vitro. Nature (1987) 2.11
Possible origin of a minor virus specific protein (A1) in Q-beta particles. Nat New Biol (1971) 2.09
Characterization and kinetics of synthesis of 15S beta-globin RNA, a putative precursor of beta-globin mRNA. Cold Spring Harb Symp Quant Biol (1978) 2.08
PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature (1997) 2.08
No propagation of prions in mice devoid of PrP. Cell (1994) 2.02
Evidence against a scanning model of RNA splicing. EMBO J (1983) 2.01
Purification of globin messenger RNA from dimethylsulfoxide-induced Friend cells and detection of a putative globin messenger RNA precursor. J Mol Biol (1976) 1.92
Different pathways mediate virus inducibility of the human IFN-alpha 1 and IFN-beta genes. Cell (1990) 1.91
Target cell specificity of two species of human interferon-alpha produced in Escherichia coli and of hybrid molecules derived from them. Proc Natl Acad Sci U S A (1981) 1.89
Reconstitution of Q replicase lacking subunit with protein-synthesis-interference factor i. Eur J Biochem (1972) 1.88
Reversible silencing of enhancers by sequences derived from the human IFN-alpha promoter. Cell (1987) 1.87
The interferon genes. Prog Nucleic Acid Res Mol Biol (1986) 1.85
Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain. EMBO J (2001) 1.85
Sequence of the first 175 nucleotides from the 5' terminus of Qbeta RNA synthesized in vitro. Nature (1969) 1.84
Abnormal expression of chromosomal rabbit beta-globin gene in Saccharomyces cerevisiae. Nature (1980) 1.84
Differential expression of human interferon genes. Nucleic Acids Res (1984) 1.82
Nonconsensus branch-site sequences in the in vitro splicing of transcripts of mutant rabbit beta-globin genes. Proc Natl Acad Sci U S A (1985) 1.82
Inhibition of Qbeta RNA 70S ribosome initiation complex formation by an oligonucleotide complementary to the 3' terminal region of E. coli 16S ribosomal RNA. Nature (1978) 1.81
Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication. Proc Natl Acad Sci U S A (1999) 1.81
Studies on the structure and synthesis of Rous sarcoma virus RNA. Cold Spring Harb Symp Quant Biol (1975) 1.80
Initiation sites of Rous sarcoma virus RNA-directed DNA synthesis in vitro. Nature (1976) 1.77
Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex. Mol Cell Biol (1999) 1.73
In vitro site-directed mutagenesis: generation and properties of an infectious extracistronic mutant of bacteriophage Qbeta. Gene (1976) 1.72
Secretion of interferon by Bacillus subtilis. Gene (1983) 1.70
Interactions of Q beta replicase with Q beta RNA. J Mol Biol (1981) 1.68
Web-based access to mouse models of human cancers: the Mouse Tumor Biology (MTB) Database. Nucleic Acids Res (2001) 1.68
Replication of viral RNA, 8. Studies on the enzymatic mechanism of replication of MS2 RNA. Proc Natl Acad Sci U S A (1965) 1.65
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Cell (1994) 1.64
Transmission of scrapie by steel-surface-bound prions. Mol Med (2001) 1.63
Spongiform encephalopathies. The prion's progress. Nature (1991) 1.62
Transport of the murine Mx protein into the nucleus is dependent on a basic carboxy-terminal sequence. J Interferon Res (1987) 1.62
Replication of viral RNA. XI. Synthesis of viral "minus" strands in vitro. Proc Natl Acad Sci U S A (1966) 1.60
Normal host prion protein (PrPC) is required for scrapie spread within the central nervous system. Proc Natl Acad Sci U S A (1996) 1.60
Infectivity of scrapie prions bound to a stainless steel surface. Mol Med (1999) 1.59
Induction of type I interferon genes and interferon-inducible genes in embryonal stem cells devoid of interferon regulatory factor 1. Proc Natl Acad Sci U S A (1993) 1.58
Controlled transcription of a human alpha-interferon gene introduced into mouse L cells. Nature (1982) 1.58
In vitro synthesis of Rous sarcoma virus-specific RNA is catalyzed by a DNA-dependent RNA polymerase. Proc Natl Acad Sci U S A (1974) 1.53
Site-directed mutagenesis: generation of an extracistronic mutation in bacteriophage Q beta RNA. J Mol Biol (1974) 1.53
Replication of viral RNA. 13. The early product of phage RNA synthesis in vitro. Proc Natl Acad Sci U S A (1967) 1.49
Molecular basis for repressor activity of Q replicase. Nat New Biol (1972) 1.49
Presence of a putative 15S precursor to beta-globin mRNA but not to alpha-globin mRNA in Friend cells. Proc Natl Acad Sci U S A (1977) 1.45
Molecular analysis of the human interferon-alpha gene family. Gene (1981) 1.44
Replication of viral RNA, VII. Further studies on the enzymatic replication of MS2 RNA. Proc Natl Acad Sci U S A (1965) 1.42
Single amino acid changes that render human IFN-alpha 2 biologically active on mouse cells. EMBO J (1987) 1.37