Published in EMBO J on January 01, 1983
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Effect of 5' splice site mutations on splicing of the preceding intron. Mol Cell Biol (1990) 2.75
Factors influencing alternative splice site utilization in vivo. Mol Cell Biol (1987) 2.39
Nuclear pre-mRNA processing in plants: distinct modes of 3'-splice-site selection in plants and animals. Mol Cell Biol (1988) 2.32
Role of intron-contained sequences in formation of moloney murine leukemia virus env mRNA. Mol Cell Biol (1984) 2.21
Spontaneous splicing mutations at the dihydrofolate reductase locus in Chinese hamster ovary cells. Mol Cell Biol (1986) 2.19
The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor. EMBO J (1986) 1.98
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Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA. Mol Cell Biol (1993) 1.85
Nucleotide substitutions within the cardiac troponin T alternative exon disrupt pre-mRNA alternative splicing. Nucleic Acids Res (1989) 1.81
Short artificial hairpins sequester splicing signals and inhibit yeast pre-mRNA splicing. Mol Cell Biol (1993) 1.73
The length of the downstream exon and the substitution of specific sequences affect pre-mRNA splicing in vitro. Mol Cell Biol (1988) 1.69
In vivo recognition of a vertebrate mini-exon as an exon-intron-exon unit. Mol Cell Biol (1993) 1.60
Splicing mutants and their second-site suppressors at the dihydrofolate reductase locus in Chinese hamster ovary cells. Mol Cell Biol (1993) 1.58
Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin. Proc Natl Acad Sci U S A (1987) 1.58
Size and position of intervening sequences are critical for the splicing efficiency of pre-mRNA in the yeast Saccharomyces cerevisiae. Nucleic Acids Res (1985) 1.54
Specific accessory sequences in Saccharomyces cerevisiae introns control assembly of pre-mRNAs into spliceosomes. EMBO J (1987) 1.53
Aberrant splicing events that are induced by proviral integration: implications for myb oncogene activation. Proc Natl Acad Sci U S A (1987) 1.52
In vitro splicing of simian virus 40 early pre mRNA. Nucleic Acids Res (1986) 1.40
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Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma. EMBO J (1985) 1.39
Synthesis of predominantly unspliced cytoplasmic RNAs by chimeric herpes simplex virus type 1 thymidine kinase-human beta-globin genes. Mol Cell Biol (1985) 1.24
A comparison between mammalian and avian fast skeletal muscle alkali myosin light chain genes: regulatory implications. Nucleic Acids Res (1985) 1.23
The length but not the sequence of the polyoma virus late leader exon is important for both late RNA splicing and stability. Nucleic Acids Res (1987) 1.21
In vitro splicing of adenovirus E1A transcripts: characterization of novel reactions and of multiple branch points abnormally far from the 3' splice site. Nucleic Acids Res (1988) 1.19
Short donor site sequences inserted within the intron of beta-globin pre-mRNA serve for splicing in vitro. Mol Cell Biol (1988) 1.17
In vitro splicing pathways of pre-mRNAs containing multiple intervening sequences? Mol Cell Biol (1987) 1.14
Novel deletion mutants that enhance a distant upstream 5' splice in the E3 transcription unit of adenovirus 2. Nucleic Acids Res (1985) 1.11
U1 RNA-protein complex preferentially binds to both 5' and 3' splice junction sequences in RNA or single-stranded DNA. Proc Natl Acad Sci U S A (1984) 1.03
Virus deletion mutants that affect a 3' splice site in the E3 transcription unit of adenovirus 2. Mol Cell Biol (1985) 1.01
Accurate 5' splice-site selection in mouse kappa immunoglobulin light chain premessenger RNAs is not cell-type-specific. Proc Natl Acad Sci U S A (1987) 1.00
In vitro splicing of kappa immunoglobulin precursor mRNA. Mol Cell Biol (1987) 0.97
Beta zero thalassemia caused by a base substitution that creates an alternative splice acceptor site in an intron. EMBO J (1986) 0.97
Structure of a pre-mRNA branch point/3' splice site region. Proc Natl Acad Sci U S A (1988) 0.96
Secondary structure of splice sites in adenovirus mRNA precursors. Nucleic Acids Res (1984) 0.96
Comparison of in vitro and in vivo splice site selection in kappa-immunoglobulin precursor mRNA. Mol Cell Biol (1988) 0.94
A large inverted repeat sequence overlaps two acceptor splice sites in adenovirus. Nucleic Acids Res (1983) 0.92
The secondary structure of a messenger RNA precursor probed with psoralen is melted in an in vitro splicing reaction. Nucleic Acids Res (1987) 0.91
The 5' and 3' splice sites come together via a three dimensional diffusion mechanism. Nucleic Acids Res (1996) 0.90
The different intron 2 species excised in vivo from the E2A premRNA of adenovirus-2: an approach to analyse alternative splicing. Nucleic Acids Res (1986) 0.83
Splice site selection in polyomavirus late pre-mRNA processing. J Virol (1994) 0.83
Expression of MDR1/P glycoprotein in human sarcomas. Br J Cancer (1993) 0.82
Oriented scanning is the leading mechanism underlying 5' splice site selection in mammals. PLoS Genet (2006) 0.79
A new method for sequencing DNA. Proc Natl Acad Sci U S A (1977) 250.51
Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. Cell (1977) 61.24
A catalogue of splice junction sequences. Nucleic Acids Res (1982) 39.41
Mapping of RNA by a modification of the Berk-Sharp procedure: the 5' termini of 15 S beta-globin mRNA precursor and mature 10 s beta-globin mRNA have identical map coordinates. Nucleic Acids Res (1979) 31.23
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur J Biochem (1980) 26.55
Transcription maps of polyoma virus-specific RNA: analysis by two-dimensional nuclease S1 gel mapping. Methods Enzymol (1980) 24.43
Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences. Cell (1981) 20.72
Are snRNPs involved in splicing? Nature (1980) 15.47
The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants. Nucleic Acids Res (1981) 15.12
Construction and characterization of new cloning vehicles. IV. Deletion derivatives of pBR322 and pBR325. Gene (1980) 12.14
Speculations on RNA splicing. Cell (1981) 8.28
A mechanism for RNA splicing. Proc Natl Acad Sci U S A (1980) 7.76
Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence. Science (1979) 6.94
Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature (1982) 6.56
A simple method to recover intact high molecular weight RNA and DNA after electrophoretic separation in low gelling temperature agarose gels. Anal Biochem (1979) 5.98
The enzymatic preparation of [alpha-32P]ATP, [alpha-32P]GTP, [32P]cAMP, and [32P]cGMP, and their use in the assay of adenylate and guanylate cyclases and cyclic nucleotide phosphodiesterases. Adv Cyclic Nucleotide Res (1979) 5.93
Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences. Proc Natl Acad Sci U S A (1977) 5.28
Making ends meet: a model for RNA splicing in fungal mitochondria. Nature (1982) 5.27
DNA sequences preceding the rabbit beta-globin gene are required for formation in mouse L cells of beta-globin RNA with the correct 5' terminus. Proc Natl Acad Sci U S A (1981) 5.26
Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit beta-globin gene. Nature (1983) 4.38
A single-base change at a splice site in a beta 0-thalassemic gene causes abnormal RNA splicing. Cell (1982) 4.22
A subcloning strategy for DNA sequence analysis. Nucleic Acids Res (1980) 4.06
Human growth hormone DNA sequence and mRNA structure: possible alternative splicing. Nucleic Acids Res (1981) 4.03
Beta + thalassemia: aberrant splicing results from a single point mutation in an intron. Cell (1981) 3.51
Processing and expression of early SV40 mRNA: a role for RNA conformation in splicing. Cell (1979) 2.80
Alternatives for splicing: recognizing the ends of introns. Cell (1980) 2.59
Cloning DNA restriction endonuclease fragments with protruding single-stranded ends. Gene (1980) 2.39
Specific labeling of 3' termini with T4 DNA polymerase. Methods Enzymol (1980) 2.30
Abnormal RNA processing due to the exon mutation of beta E-globin gene. Nature (1982) 1.98
Deletions at intervening sequence splice sites in the alcohol dehydrogenase gene of Drosophila. Nucleic Acids Res (1982) 1.72
Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms. Proc Natl Acad Sci U S A (1981) 1.48
A rapid, sensitive, and specific method for the determination of protein in dilute solution. Anal Biochem (1973) 31.32
Mapping of RNA by a modification of the Berk-Sharp procedure: the 5' termini of 15 S beta-globin mRNA precursor and mature 10 s beta-globin mRNA have identical map coordinates. Nucleic Acids Res (1979) 31.23
Detection of specific RNAs or specific fragments of DNA by fractionation in gels and transfer to diazobenzyloxymethyl paper. Methods Enzymol (1979) 18.24
Transfer of small DNA fragments from polyacrylamide gels to diazobenzyloxymethyl-paper and detection by hybridization with DNA probes. Biochem Biophys Res Commun (1978) 12.71
Mice devoid of PrP are resistant to scrapie. Cell (1993) 11.46
Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit beta-globin gene in mouse 3T6 cells. Cell (1983) 9.51
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature (1992) 9.01
Comparison of relative susceptibilities of Candida species to three antifungal agents as determined by unstandardized methods. Antimicrob Agents Chemother (1987) 7.33
Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence. Science (1979) 6.94
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Transfer of proteins from gels to diazobenzyloxymethyl-paper and detection with antisera: a method for studying antibody specificity and antigen structure. Proc Natl Acad Sci U S A (1979) 6.93
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J (1996) 6.66
Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res (1997) 6.24
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proc Natl Acad Sci U S A (1978) 6.20
Hybrid plasmids containing an active thymidine kinase gene of Herpes simplex virus 1. Nucleic Acids Res (1979) 5.55
Nucleotide sequence heterogeneity of an RNA phage population. Cell (1978) 5.55
A minimal intron length but no specific internal sequence is required for splicing the large rabbit beta-globin intron. Cell (1984) 5.37
DNA sequences preceding the rabbit beta-globin gene are required for formation in mouse L cells of beta-globin RNA with the correct 5' terminus. Proc Natl Acad Sci U S A (1981) 5.26
Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. J Bacteriol (1994) 5.03
Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (1995) 5.03
Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell (1986) 4.92
The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha. Nature (1980) 4.82
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell (1986) 4.82
Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol (1997) 4.43
Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA. Cell (1986) 4.40
Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit beta-globin gene. Nature (1983) 4.38
Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine. Science (1994) 4.27
Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature (1996) 4.25
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A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc Natl Acad Sci U S A (1997) 3.88
Rabbit beta-globin mRNA production in mouse L cells transformed with cloned rabbit beta-globin chromosomal DNA. Nature (1979) 3.88
Comparison of cloned rabbit and mouse beta-globin genes showing strong evolutionary divergence of two homologous pairs of introns. Nature (1978) 3.86
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Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes. J Immunol (1987) 3.78
Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. Nature (1980) 3.78
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Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell (1998) 3.59
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Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB. EMBO J (1997) 3.34
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Cloning of a gene that is rearranged in patients with choroideraemia. Nature (1990) 3.21
Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter. Mol Cell Biol (1988) 3.19
QB DNA-containing hybrid plasmids giving rise to QB phage formation in the bacterial host. Nature (1978) 3.11
The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei. Gene (1980) 2.99
Isolation, characterization, and expression in Escherichia coli of the Pseudomonas aeruginosa rhlAB genes encoding a rhamnosyltransferase involved in rhamnolipid biosurfactant synthesis. J Biol Chem (1994) 2.96
A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions. Proc Natl Acad Sci U S A (2003) 2.94
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Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody. Proc Natl Acad Sci U S A (2001) 2.53
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High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene. Mol Med (1994) 2.18
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Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science (2000) 2.15
Prion research: the next frontiers. Nature (1997) 2.13
Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice. Neuron (2000) 2.13
A physical map of 4 million bp around the Duchenne muscular dystrophy gene on the human X-chromosome. Cell (1986) 2.12
Effect of mutations at the lariat branch acceptor site on beta-globin pre-mRNA splicing in vitro. Nature (1987) 2.11
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Adenylate kinase phosphotransfer communicates cellular energetic signals to ATP-sensitive potassium channels. Proc Natl Acad Sci U S A (2001) 2.08
PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain. Nature (1997) 2.08
Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity. Cell (1993) 2.04
No propagation of prions in mice devoid of PrP. Cell (1994) 2.02
Purified donor NK-lymphocyte infusion to consolidate engraftment after haploidentical stem cell transplantation. Leukemia (2004) 1.97
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