Published in Proc Natl Acad Sci U S A on September 15, 1992
iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution. Nat Struct Mol Biol (2010) 5.98
A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export. J Cell Biol (1996) 2.84
NAB2: a yeast nuclear polyadenylated RNA-binding protein essential for cell viability. Mol Cell Biol (1993) 2.76
Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. J Cell Biol (1994) 2.37
Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization. EMBO J (1999) 2.34
Ultrastructural analysis of transcription and splicing in the cell nucleus after bromo-UTP microinjection. Mol Biol Cell (1999) 2.08
Association of individual hnRNP proteins and snRNPs with nascent transcripts. J Cell Biol (1993) 1.95
Potential RNA binding proteins in Saccharomyces cerevisiae identified as suppressors of temperature-sensitive mutations in NPL3. Genetics (1996) 1.76
Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles. RNA (2010) 1.74
RNA binding by Sxl proteins in vitro and in vivo. Mol Cell Biol (1994) 1.63
Arginine methylation and binding of Hrp1p to the efficiency element for mRNA 3'-end formation. RNA (1999) 1.53
Assembly and disassembly of spliceosomes along a specific pre-messenger RNP fiber. EMBO J (1994) 1.42
Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila. PLoS Genet (2009) 1.30
Altered levels of the Drosophila HRB87F/hrp36 hnRNP protein have limited effects on alternative splicing in vivo. Mol Biol Cell (1996) 1.26
The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles. Mol Cell Biol (1994) 1.25
Sex-lethal interacts with splicing factors in vitro and in vivo. Mol Cell Biol (1996) 1.12
Specific combinations of SR proteins associate with single pre-messenger RNAs in vivo and contribute different functions. J Cell Biol (2009) 1.01
Separable roles in vivo for the two RNA binding domains of Drosophila A1-hnRNP homolog. RNA (1998) 0.97
Analysis of the functional specificity of RS domains in vivo. EMBO J (1998) 0.94
A unique ribonucleoprotein complex assembles preferentially on ecdysone-responsive sites in Drosophila melanogaster. Mol Cell Biol (1993) 0.87
A discrete 3' region of U6 small nuclear RNA modulates the phosphorylation cycle of the C1 heterogeneous nuclear ribonucleoprotein particle protein. Mol Cell Biol (1996) 0.86
Arginine methylation of hnRNP A2 does not directly govern its subcellular localization. PLoS One (2013) 0.76
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell (1992) 7.90
Splice site selection, rate of splicing, and alternative splicing on nascent transcripts. Genes Dev (1988) 5.97
Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene. Mol Cell Biol (1986) 5.77
Heterogeneous nuclear ribonucleoproteins: role in RNA splicing. Science (1986) 5.52
RNA binding specificity of hnRNP proteins: a subset bind to the 3' end of introns. EMBO J (1988) 4.26
Transcripts from both strands of a satellite DNA occur on lampbrush chromosome loops of the newt Notophthalmus. Cell (1981) 3.92
Determinants of heat shock-induced chromosome puffing. Cell (1985) 3.91
Sequence of U1 RNA from Drosophila melanogaster: implications for U1 secondary structure and possible involvement in splicing. Nucleic Acids Res (1981) 3.65
Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery. EMBO J (1991) 3.49
cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins. EMBO J (1987) 3.47
Effects of RNA secondary structure on alternative splicing of pre-mRNA: is folding limited to a region behind the transcribing RNA polymerase? Cell (1988) 3.41
Mapping of B cell epitopes on small nuclear ribonucleoproteins that react with human autoantibodies as well as with experimentally-induced mouse monoclonal antibodies. J Immunol (1989) 3.13
Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles. Proc Natl Acad Sci U S A (1990) 2.96
Mammalian heterogeneous nuclear ribonucleoprotein complex protein A1. Large-scale overproduction in Escherichia coli and cooperative binding to single-stranded nucleic acids. J Biol Chem (1988) 2.88
Small nuclear ribonucleoproteins and heterogeneous nuclear ribonucleoproteins in the amphibian germinal vesicle: loops, spheres, and snurposomes. J Cell Biol (1991) 2.86
Pre-mRNA splicing by complementation with purified human U1, U2, U4/U6 and U5 snRNPs. Nucleic Acids Res (1988) 2.86
RNP particles at splice junction sequences on Drosophila chorion transcripts. Cell (1985) 2.69
Protein composition of mammalian spliceosomes assembled in vitro. Proc Natl Acad Sci U S A (1990) 2.58
Antibodies to hnRNP core proteins inhibit in vitro splicing of human beta-globin pre-mRNA. Nucleic Acids Res (1986) 2.28
Set of novel, conserved proteins fold pre-messenger RNA into ribonucleosomes. Proteins (1986) 2.28
Autoantibodies to ribonucleoprotein particles containing U2 small nuclear RNA. EMBO J (1985) 2.04
Splicing precedes polyadenylation during Drosophila E74A transcription. Mol Cell Biol (1990) 1.99
Recombinant hnRNP protein A1 and its N-terminal domain show preferential affinity for oligodeoxynucleotides homologous to intron/exon acceptor sites. Nucleic Acids Res (1990) 1.72
Crosslinking of hnRNP proteins to pre-mRNA requires U1 and U2 snRNPs. Nucleic Acids Res (1990) 1.68
Isolation of hnRNP complexes from Drosophila melanogaster. J Cell Biol (1992) 1.66
Transcription-dependent localization of U1 and U2 small nuclear ribonucleoproteins at major sites of gene activity in polytene chromosomes. J Mol Biol (1984) 1.66
Immunoelectron microscope visualization of nuclear ribonucleoprotein antigens within spread transcription complexes. J Cell Biol (1986) 1.62
The Drosophila Hrb87F gene encodes a new member of the A and B hnRNP protein group. Nucleic Acids Res (1991) 1.55
The Drosophila Hrb98DE locus encodes four protein isoforms homologous to the A1 protein of mammalian heterogeneous nuclear ribonucleoprotein complexes. Mol Cell Biol (1990) 1.54
Compilation of small RNA sequences. Nucleic Acids Res (1988) 1.53
Ribonucleoproteins package 700 nucleotides of pre-mRNA into a repeating array of regular particles. Mol Cell Biol (1988) 1.53
Spliceosomes and snurposomes. Science (1991) 1.36
Heterogeneous nuclear ribonucleoprotein complexes and proteins in Drosophila melanogaster. Mol Cell Biol (1992) 1.02
The Balbiani ring 3 gene in Chironomus tentans has a diverged repetitive structure split by many introns. J Mol Biol (1990) 1.01
A unique zinc finger protein is associated preferentially with active ecdysone-responsive loci in Drosophila. Genes Dev (1991) 0.98
Terminal repeats in long repeat arrays are likely to reflect the early evolution of Balbiani ring genes. J Mol Biol (1988) 0.93
Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell (1984) 12.30
Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell (1984) 9.13
The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum (2000) 8.64
Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell (1992) 7.90
Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science (1994) 7.09
Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest (1998) 6.92
Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell (1985) 6.85
Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res (1993) 6.15
Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev (1998) 5.79
Identification and characterization of the packaging proteins of core 40S hnRNP particles. Cell (1977) 5.50
A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes. Nat Genet (2001) 5.02
AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes. Mol Cell Biol (1999) 4.87
Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA. EMBO J (1989) 4.69
Major determinants of the specificity of interaction between small nuclear ribonucleoproteins U1A and U2B'' and their cognate RNAs. Nature (1990) 4.67
Pre-mRNA splicing in the new millennium. Curr Opin Cell Biol (2001) 4.64
General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes Dev (1993) 4.40
Polymyositis: an overdiagnosed entity. Neurology (2003) 4.36
A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes Dev (1998) 4.19
The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis. Arthritis Rheum (2000) 4.10
Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA (1998) 4.05
General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proc Natl Acad Sci U S A (1992) 3.97
Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. J Cell Biol (1997) 3.95
Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J (1995) 3.56
Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains. EMBO J (1993) 3.51
cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins. EMBO J (1987) 3.47
Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study. Arthritis Rheum (2004) 3.38
Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. EMBO J (1994) 3.35
The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. J Cell Biol (2000) 3.34
Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins. Mol Cell (2001) 3.34
Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Mol Cell Biol (1993) 3.16
Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF. EMBO J (1993) 3.11
Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA. Genes Dev (1999) 3.08
hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing. EMBO J (1999) 3.04
Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Mol Cell Biol (2000) 3.01
hnRNA and its attachment to a nuclear protein matrix. J Cell Biol (1981) 2.88
Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages. Ann Rheum Dis (2004) 2.82
Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen. Proc Natl Acad Sci U S A (1987) 2.75
RNP particles at splice junction sequences on Drosophila chorion transcripts. Cell (1985) 2.69
Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing. Proc Natl Acad Sci U S A (1992) 2.66
Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. J Cell Biol (1998) 2.60
The human U1 snRNP-specific U1A protein inhibits polyadenylation of its own pre-mRNA. Cell (1993) 2.58
Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing. Trends Genet (1994) 2.54
Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1. Mol Cell Biol (2000) 2.22
Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. EMBO J (1999) 2.20
The U2B'' RNP motif as a site of protein-protein interaction. EMBO J (1990) 2.12
Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors. J Cell Biol (1994) 2.12
Correlation of hnRNP structure and nascent transcript cleavage. Cell (1981) 2.06
Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements. Mol Cell Biol (1999) 2.05
Cross-linking of mRNA to proteins by irradiation of intact cells with ultraviolet light. Eur J Biochem (1980) 2.04
Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing. Methods Mol Biol (1999) 2.02
Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals. Nucleic Acids Res (1988) 2.02
The association of the U1-specific 70K and C proteins with U1 snRNPs is mediated in part by common U snRNP proteins. EMBO J (1994) 2.00
Generation and application of type-specific anti-heparan sulfate antibodies using phage display technology. Further evidence for heparan sulfate heterogeneity in the kidney. J Biol Chem (1998) 1.97
Monospecific antibodies reveal details of U2 snRNP structure and interaction between U1 and U2 snRNPs. EMBO J (1986) 1.96
Ribonucleoprotein structure in nascent hnRNA is nonrandom and sequence-dependent. Cell (1980) 1.93
Antibodies against distinct nuclear matrix proteins are characteristic for mixed connective tissue disease. Clin Exp Immunol (1983) 1.92
The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). J Biol Chem (1999) 1.90
hPop1: an autoantigenic protein subunit shared by the human RNase P and RNase MRP ribonucleoproteins. EMBO J (1996) 1.87
Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein. Proc Natl Acad Sci U S A (1999) 1.86
A critical evaluation of enzyme immunoassays for detection of antinuclear autoantibodies of defined specificities. I. Precision, sensitivity, and specificity. Arthritis Rheum (1999) 1.85
Characterization of the SS-B (La) antigen in adenovirus-infected and uninfected HeLa cells. EMBO J (1983) 1.83
atSRp30, one of two SF2/ASF-like proteins from Arabidopsis thaliana, regulates splicing of specific plant genes. Genes Dev (1999) 1.82
Analysis of protein--RNA interactions within Ro ribonucleoprotein complexes. Nucleic Acids Res (1991) 1.76
Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire. J Mol Biol (1999) 1.75
U1-mediated exon definition interactions between AT-AC and GT-AG introns. Science (1996) 1.74
RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins. Proc Natl Acad Sci U S A (1997) 1.72
Three novel components of the human exosome. J Biol Chem (2000) 1.72
The packaging proteins of core hnRNP particles and the maintenance of proliferative cell states. Cold Spring Harb Symp Quant Biol (1978) 1.68
Antiperinuclear factor, a marker autoantibody for rheumatoid arthritis: colocalisation of the perinuclear factor and profilaggrin. Ann Rheum Dis (1991) 1.68
In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes. Nucleic Acids Res (1996) 1.62
A complex secondary structure in U1A pre-mRNA that binds two molecules of U1A protein is required for regulation of polyadenylation. EMBO J (1993) 1.62
Quantitation of anti-RNP and anti-Sm antibodies in MCTD and SLE patients by immunoblotting. Clin Exp Immunol (1985) 1.62
The prognostic value of the antiperinuclear factor, anti-citrullinated peptide antibodies and rheumatoid factor in early rheumatoid arthritis. Clin Exp Rheumatol (2000) 1.61
Adenoviral heterogeneous nuclear RNA is associated with the host nuclear matrix during splicing. J Mol Biol (1982) 1.60
Pre-mRNA splicing in the absence of an SR protein RS domain. Genes Dev (2000) 1.58
Mammalian in vitro splicing assays. Methods Mol Biol (1999) 1.57
Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. Nucleic Acids Res (1993) 1.57
U1 small nuclear ribonucleoprotein particle-specific proteins interact with the first and second stem-loops of U1 RNA, with the A protein binding directly to the RNA independently of the 70K and Sm proteins. Mol Cell Biol (1989) 1.56
The Drosophila Hrb87F gene encodes a new member of the A and B hnRNP protein group. Nucleic Acids Res (1991) 1.55
The Drosophila Hrb98DE locus encodes four protein isoforms homologous to the A1 protein of mammalian heterogeneous nuclear ribonucleoprotein complexes. Mol Cell Biol (1990) 1.54
Anti-signal recognition particle autoantibodies: marker of a necrotising myopathy. Ann Rheum Dis (2006) 1.54
The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor. Genes Dev (1999) 1.49
On the association of mRNA with the cytoskeleton in uninfected and adenovirus-infected human KB cells. Exp Cell Res (1981) 1.48
Identification of NG, NG-dimethylarginine in a nuclear protein from the lower eukaryote physarum polycephalum homologous to the major proteins of mammalian 40S ribonucleoprotein particles. Biochem Biophys Res Commun (1977) 1.48
EM visualization of transcription by RNA polymerase II: downstream termination requires a poly(A) signal but not transcript cleavage. Mol Cell (1999) 1.47
Further characterization and subcellular localization of Sm and U1 ribonucleoprotein antigens. Eur J Immunol (1985) 1.44
Scl-86, a marker antigen for diffuse scleroderma. J Clin Invest (1985) 1.43
A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. RNA (1997) 1.43
Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. RNA (2001) 1.42
Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis. Arthritis Rheum (2001) 1.42