Published in Mol Cell Biol on August 01, 1989
Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA. EMBO J (1989) 4.69
Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA. Proc Natl Acad Sci U S A (1990) 2.76
Dynamic localization of RNase MRP RNA in the nucleolus observed by fluorescent RNA cytochemistry in living cells. J Cell Biol (1995) 1.77
Electron microscopy of small nuclear ribonucleoprotein (snRNP) particles U2 and U5: evidence for a common structure-determining principle in the major U snRNP family. Proc Natl Acad Sci U S A (1990) 1.65
Multiple domains of U1 snRNA, including U1 specific protein binding sites, are required for splicing. EMBO J (1990) 1.60
Structure-probing of U1 snRNPs gradually depleted of the U1-specific proteins A, C and 70k. Evidence that A interacts differentially with developmentally regulated mouse U1 snRNA variants. Nucleic Acids Res (1990) 1.51
Site-specific excision from RNA by RNase H and mixed-phosphate-backbone oligodeoxynucleotides. Proc Natl Acad Sci U S A (1990) 1.50
The PRP4 (RNA4) protein of Saccharomyces cerevisiae is associated with the 5' portion of the U4 small nuclear RNA. Mol Cell Biol (1990) 1.42
Pseudouridine modification of U5 RNA in ribonucleoprotein particles assembled in vitro. Mol Cell Biol (1991) 1.36
Assembly, nuclear import and function of U7 snRNPs studied by microinjection of synthetic U7 RNA into Xenopus oocytes. Nucleic Acids Res (1995) 1.33
Structure of the small nuclear RNP particle U1: identification of the two structural protuberances with RNP-antigens A and 70K. J Cell Biol (1992) 1.28
Multiple pseudouridine synthase activities for small nuclear RNAs. Biochem J (1993) 1.26
Pseudouridine formation in U2 small nuclear RNA. Proc Natl Acad Sci U S A (1994) 1.24
Analysis of in vitro binding of U1-A protein mutants to U1 snRNA. Nucleic Acids Res (1991) 1.17
Anti-(U1) small nuclear RNA antibodies in anti-small nuclear ribonucleoprotein sera from patients with connective tissue diseases. J Clin Invest (1990) 1.11
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A pre-export U1 snRNP in Xenopus laevis oocyte nuclei. Nucleic Acids Res (1993) 0.89
U1 small nuclear RNA chimeric ribozymes with substrate specificity for the Rev pre-mRNA of human immunodeficiency virus. Proc Natl Acad Sci U S A (1996) 0.87
Purification of Drosophila snRNPs and characterization of two populations of functional U1 particles. RNA (2001) 0.82
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus. Proc Natl Acad Sci U S A (1979) 14.61
Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease. Proc Natl Acad Sci U S A (1981) 10.72
Use of in vitro 32P labeling in the sequence analysis of nonradioactive tRNAs. Methods Enzymol (1979) 9.54
The U1 small nuclear RNA-protein complex selectively binds a 5' splice site in vitro. Cell (1983) 9.00
U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing. Cell (1985) 8.85
The 5' terminus of the RNA moiety of U1 small nuclear ribonucleoprotein particles is required for the splicing of messenger RNA precursors. Cell (1984) 6.25
Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding. Cell (1986) 5.59
Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins. Cell (1985) 4.98
The structure of mammalian small nuclear ribonucleoproteins. Identification of multiple protein components reactive with anti-(U1)ribonucleoprotein and anti-Sm autoantibodies. J Biol Chem (1984) 4.68
Cloning of the human cDNA for the U1 RNA-associated 70K protein. EMBO J (1986) 4.43
Isolation of small nuclear ribonucleoproteins containing U1, U2, U4, U5, and U6 RNAs. J Biol Chem (1983) 3.65
Structural organization of ribonucleoproteins containing small nuclear RNAs from HeLa cells. Proteins interact closely with a similar structural domain of U1, U2, U4 and U5 small nuclear RNAs. J Mol Biol (1982) 3.51
cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins. EMBO J (1987) 3.47
Anti-RNP monoclonal antibodies derived from a mouse strain with lupus-like autoimmunity. J Immunol (1982) 3.29
In vitro assembly of U1 snRNPs. EMBO J (1987) 3.18
Purification of the individual snRNPs U1, U2, U5 and U4/U6 from HeLa cells and characterization of their protein constituents. EMBO J (1986) 2.79
The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding. Nucleic Acids Res (1987) 2.57
Fractionation and characterization of human small nuclear ribonucleoproteins containing U1 and U2 RNAs. J Biol Chem (1983) 2.45
Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals. Nucleic Acids Res (1988) 2.02
The Mr 70,000 protein of the U1 small nuclear ribonucleoprotein particle binds to the 5' stem-loop of U1 RNA and interacts with Sm domain proteins. Proc Natl Acad Sci U S A (1988) 1.98
Reconstitution of the U1 small nuclear ribonucleoprotein particle. Mol Cell Biol (1987) 1.94
Antibodies against distinct nuclear matrix proteins are characteristic for mixed connective tissue disease. Clin Exp Immunol (1983) 1.92
Characterization of the SS-B (La) antigen in adenovirus-infected and uninfected HeLa cells. EMBO J (1983) 1.83
Characterization of U small nuclear RNA-associated proteins. J Biol Chem (1984) 1.81
Nuclear ribonucleoprotein particles probed in living cells. Proc Natl Acad Sci U S A (1981) 1.79
Loop I of U1 small nuclear RNA is the only essential RNA sequence for binding of specific U1 small nuclear ribonucleoprotein particle proteins. Mol Cell Biol (1988) 1.77
Small nuclear ribonucleoproteins of Drosophila: identification of U1 RNA-associated proteins and their behavior during heat shock. Mol Cell Biol (1982) 1.70
Antibody-antigen complexes. J Biol Chem (1988) 1.69
Protein binding sites are conserved in U1 small nuclear RNA from insects and mammals. Proc Natl Acad Sci U S A (1983) 1.63
Electron microscopy of U1 small nuclear ribonucleoprotein particles: shape of the particle and position of the 5' RNA terminus. EMBO J (1989) 1.41
Mg2+ induces a sharp and reversible transition in U1 and U2 small nuclear ribonucleoprotein configurations. Mol Cell Biol (1984) 1.21
U1 small nuclear ribonucleoprotein studied by in vitro assembly. J Cell Biol (1983) 1.16
Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiation in situ. Nucleic Acids Res (1988) 1.08
Ribonucleoprotein organization of eukaryotic RNA. XXXI. Structure of the U1 small nuclear ribonucleoprotein. J Mol Biol (1984) 0.99
Characterization of the autoimmune antigenic determinant for ribonucleoprotein (RNP) antibody. Immunol Commun (1984) 0.84
The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum (2000) 8.64
Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest (1998) 6.92
Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA. EMBO J (1989) 4.69
Major determinants of the specificity of interaction between small nuclear ribonucleoproteins U1A and U2B'' and their cognate RNAs. Nature (1990) 4.67
Polymyositis: an overdiagnosed entity. Neurology (2003) 4.36
The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis. Arthritis Rheum (2000) 4.10
cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins. EMBO J (1987) 3.47
Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study. Arthritis Rheum (2004) 3.38
Intranuclear diffusion and hybridization state of oligonucleotides measured by fluorescence correlation spectroscopy in living cells. Proc Natl Acad Sci U S A (1998) 3.36
U6 small nuclear RNA is transcribed by RNA polymerase III. Proc Natl Acad Sci U S A (1986) 3.14
Proteins associated with heterogeneous nuclear RNA in eukaryotic cells. J Mol Biol (1974) 3.13
hnRNA and its attachment to a nuclear protein matrix. J Cell Biol (1981) 2.88
Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages. Ann Rheum Dis (2004) 2.82
Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen. Proc Natl Acad Sci U S A (1987) 2.75
The human U1 snRNP-specific U1A protein inhibits polyadenylation of its own pre-mRNA. Cell (1993) 2.58
Upstream elements required for efficient transcription of a human U6 RNA gene resemble those of U1 and U2 genes even though a different polymerase is used. Genes Dev (1988) 2.55
Base-pairing interactions between small nuclear RNAs and nuclear RNA precursors as revealed by psoralen cross-linking in vivo. Cell (1981) 2.49
Structure of nuclear ribonucleoprotein: identification of proteins in contact with poly(A)+ heterogeneous nuclear RNA in living HeLa cells. J Cell Biol (1981) 2.42
Movement of nuclear poly(A) RNA throughout the interchromatin space in living cells. Curr Biol (1999) 2.20
Structure of nuclear ribonucleoprotein: heterogeneous nuclear RNA is complexed with a major sextet of proteins in vivo. Proc Natl Acad Sci U S A (1983) 2.19
The U2B'' RNP motif as a site of protein-protein interaction. EMBO J (1990) 2.12
Autoantibodies to ribonucleoprotein particles containing U2 small nuclear RNA. EMBO J (1985) 2.04
Cross-linking of mRNA to proteins by irradiation of intact cells with ultraviolet light. Eur J Biochem (1980) 2.04
Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals. Nucleic Acids Res (1988) 2.02
Comparison of proteins bound to heterogeneous nuclear RNA and messenger RNA in HeLa cells. J Mol Biol (1975) 2.00
The association of the U1-specific 70K and C proteins with U1 snRNPs is mediated in part by common U snRNP proteins. EMBO J (1994) 2.00
Nuclear domains of the RNA subunit of RNase P. J Cell Sci (1997) 1.99
The Mr 70,000 protein of the U1 small nuclear ribonucleoprotein particle binds to the 5' stem-loop of U1 RNA and interacts with Sm domain proteins. Proc Natl Acad Sci U S A (1988) 1.98
Generation and application of type-specific anti-heparan sulfate antibodies using phage display technology. Further evidence for heparan sulfate heterogeneity in the kidney. J Biol Chem (1998) 1.97
Monospecific antibodies reveal details of U2 snRNP structure and interaction between U1 and U2 snRNPs. EMBO J (1986) 1.96
Signal recognition particle components in the nucleolus. Proc Natl Acad Sci U S A (2000) 1.95
Regulated transcription of the genes for actin and heat-shock proteins in cultured Drosophila cells. J Cell Biol (1981) 1.95
Reconstitution of the U1 small nuclear ribonucleoprotein particle. Mol Cell Biol (1987) 1.94
Antibodies against distinct nuclear matrix proteins are characteristic for mixed connective tissue disease. Clin Exp Immunol (1983) 1.92
Chromatin structure and the cell cycle. Proc Natl Acad Sci U S A (1972) 1.91
Localization of signal recognition particle RNA in the nucleolus of mammalian cells. Proc Natl Acad Sci U S A (1998) 1.89
hPop1: an autoantigenic protein subunit shared by the human RNase P and RNase MRP ribonucleoproteins. EMBO J (1996) 1.87
A critical evaluation of enzyme immunoassays for detection of antinuclear autoantibodies of defined specificities. I. Precision, sensitivity, and specificity. Arthritis Rheum (1999) 1.85
Characterization of the SS-B (La) antigen in adenovirus-infected and uninfected HeLa cells. EMBO J (1983) 1.83
Intracellular site of U1 small nuclear RNA processing and ribonucleoprotein assembly. J Cell Biol (1984) 1.81
Nuclear ribonucleoprotein particles probed in living cells. Proc Natl Acad Sci U S A (1981) 1.79
Dynamic localization of RNase MRP RNA in the nucleolus observed by fluorescent RNA cytochemistry in living cells. J Cell Biol (1995) 1.77
Analysis of protein--RNA interactions within Ro ribonucleoprotein complexes. Nucleic Acids Res (1991) 1.76
Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire. J Mol Biol (1999) 1.75
Localization of pre-messenger RNA at discrete nuclear sites. Proc Natl Acad Sci U S A (1991) 1.74
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Three novel components of the human exosome. J Biol Chem (2000) 1.72
Small nuclear ribonucleoproteins of Drosophila: identification of U1 RNA-associated proteins and their behavior during heat shock. Mol Cell Biol (1982) 1.70
Crosslinking of hnRNP proteins to pre-mRNA requires U1 and U2 snRNPs. Nucleic Acids Res (1990) 1.68
Antiperinuclear factor, a marker autoantibody for rheumatoid arthritis: colocalisation of the perinuclear factor and profilaggrin. Ann Rheum Dis (1991) 1.68
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Transcription-dependent localization of U1 and U2 small nuclear ribonucleoproteins at major sites of gene activity in polytene chromosomes. J Mol Biol (1984) 1.66
Protein binding sites are conserved in U1 small nuclear RNA from insects and mammals. Proc Natl Acad Sci U S A (1983) 1.63
In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes. Nucleic Acids Res (1996) 1.62
A complex secondary structure in U1A pre-mRNA that binds two molecules of U1A protein is required for regulation of polyadenylation. EMBO J (1993) 1.62
Quantitation of anti-RNP and anti-Sm antibodies in MCTD and SLE patients by immunoblotting. Clin Exp Immunol (1985) 1.62
The prognostic value of the antiperinuclear factor, anti-citrullinated peptide antibodies and rheumatoid factor in early rheumatoid arthritis. Clin Exp Rheumatol (2000) 1.61
Adenoviral heterogeneous nuclear RNA is associated with the host nuclear matrix during splicing. J Mol Biol (1982) 1.60
cDNA cloning of a human autoimmune nuclear ribonucleoprotein antigen. Proc Natl Acad Sci U S A (1985) 1.59
Anti-signal recognition particle autoantibodies: marker of a necrotising myopathy. Ann Rheum Dis (2006) 1.54
Heat shock alters nuclear ribonucleoprotein assembly in Drosophila cells. Mol Cell Biol (1983) 1.54
Chromatin: its isolation from cultured mammalian cells with particular reference to contamination by nuclear ribnucleoprotein particles. Biochemistry (1973) 1.54
Small nuclear RNA U2 is base-paired to heterogeneous nuclear RNA. Science (1982) 1.53
Site-specific excision from RNA by RNase H and mixed-phosphate-backbone oligodeoxynucleotides. Proc Natl Acad Sci U S A (1990) 1.50
On the association of mRNA with the cytoskeleton in uninfected and adenovirus-infected human KB cells. Exp Cell Res (1981) 1.48
Eukaryotic small ribonucleoproteins. Anti-La human autoantibodies react with U1 RNA-protein complexes. J Biol Chem (1984) 1.46
Scl-86, a marker antigen for diffuse scleroderma. J Clin Invest (1985) 1.43
Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis. Arthritis Rheum (2001) 1.42
Specificity in the interaction of hnRNA and mRNA with proteins as revealed by in vivo cross linking. FEBS Lett (1981) 1.42
RNA-protein interactions in the human RNase MRP ribonucleoprotein complex. RNA (1999) 1.41
Conserved amino acid residues within and outside of the N-terminal ribonucleoprotein motif of U1A small nuclear ribonucleoprotein involved in U1 RNA binding. J Mol Biol (1991) 1.40
Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription. Proc Natl Acad Sci U S A (1992) 1.40
[The anti-synthetase syndrome: muscle disease and multisystem disorder at the same time]. Ned Tijdschr Geneeskd (2003) 1.38
Comparison of mitotic phenomena and effects induced by hypertonic solutions in HeLa cells. J Cell Biol (1970) 1.37
Precursors of U4 small nuclear RNA. J Cell Biol (1984) 1.36
Transcription of a human U6 small nuclear RNA gene in vivo withstands deletion of intragenic sequences but not of an upstream TATATA box. Nucleic Acids Res (1989) 1.36
Transcription boundaries of U1 small nuclear RNA. Mol Cell Biol (1985) 1.36
Review: movement of mRNA from transcription site to nuclear pores. J Struct Biol (2000) 1.35
Messenger RNA processing and nuclear structure: isolation of nuclear ribonucleoprotein particles containing beta-globin messenger RNA precursors. J Cell Biol (1980) 1.35
Use and significance of anti-CCP autoantibodies in rheumatoid arthritis. Rheumatology (Oxford) (2005) 1.34
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Ro ribonucleoprotein assembly in vitro. Identification of RNA-protein and protein-protein interactions. J Mol Biol (1992) 1.31
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Somatic insertions and deletions shape the human antibody repertoire. J Mol Biol (1999) 1.28
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Ribonucleoprotein particles containing heterogeneous nuclear RNA in the cellular slime mold Dictyostelium discoideum. Proc Natl Acad Sci U S A (1975) 1.25
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Long-term outcome in polymyositis and dermatomyositis. Ann Rheum Dis (2006) 1.22
Zinc finger-like structure in U1-specific protein C is essential for specific binding to U1 snRNP. Nucleic Acids Res (1991) 1.22
The interactions with Ro60 and La differentially affect nuclear export of hY1 RNA. RNA (1996) 1.21
A weak interaction between the U2A' protein and U2 snRNA helps to stabilize their complex with the U2B" protein. Nucleic Acids Res (1991) 1.21