Published in Mol Cell Biol on October 01, 1992
Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. Mol Cell Biol (1997) 2.04
Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc Natl Acad Sci U S A (1994) 1.67
Transcriptional and posttranscriptional silencing of rodent alpha1(I) collagen by a homologous transcriptionally self-silenced transgene. Mol Cell Biol (1999) 1.20
The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts. J Invest Dermatol (1999) 1.06
Enhanced prolidase activity and decreased collagen content in breast cancer tissue. Int J Exp Pathol (2006) 1.04
The 5' stem-loop regulates expression of collagen alpha1(I) mRNA in mouse fibroblasts cultured in a three-dimensional matrix. Nucleic Acids Res (2000) 0.98
Collagen metabolism disturbances are accompanied by an increase in prolidase activity in lung carcinoma planoepitheliale. Int J Exp Pathol (2000) 0.89
A novel mechanism of Ha-ras oncogene action: regulation of fibronectin mRNA levels by a nuclear posttranscriptional event. Mol Cell Biol (1994) 0.85
Regulation of type I collagen mRNA in lung fibroblasts by cystine availability. Biochem J (1998) 0.82
Ha-Ras stabilization mediates pro-fibrotic signals in dermal fibroblasts. Fibrogenesis Tissue Repair (2011) 0.80
Overexpressed vs mutated Kras in murine fibroblasts: a molecular phenotyping study. Br J Cancer (2009) 0.79
RNA protein interactions governing expression of the most abundant protein in human body, type I collagen. Wiley Interdiscip Rev RNA (2013) 0.77
Involvement of 90-kuD ribosomal S6 kinase in collagen type I expression in rat hepatic fibrosis. World J Gastroenterol (2009) 0.77
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
ras genes. Annu Rev Biochem (1987) 22.59
ras oncogenes in human cancer: a review. Cancer Res (1989) 22.03
Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. Nature (1983) 10.64
The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes Dev (1989) 7.03
Molecular themes in oncogenesis. Cell (1991) 6.73
Structurally distinct collagen types. Annu Rev Biochem (1980) 6.43
Requirement for c-ras proteins during viral oncogene transformation. Nature (1986) 5.24
Enhanced transcription of c-myc in bursal lymphoma cells requires continuous protein synthesis. Science (1985) 5.08
Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell (1992) 4.50
A stem-loop in the 3' untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm. Cell (1988) 4.34
Cell surface proteins and malignant transformation. Biochim Biophys Acta (1976) 4.33
Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts. Proc Natl Acad Sci U S A (1976) 4.32
Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature (1991) 4.17
Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters. Cell (1988) 4.13
Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science (1987) 3.44
Cloning and characterization of five overlapping cDNAs specific for the human pro alpha 1(I) collagen chain. Nucleic Acids Res (1982) 3.40
Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein. Cell (1977) 3.36
The protein-coding region of c-myc mRNA contains a sequence that specifies rapid mRNA turnover and induction by protein synthesis inhibitors. Genes Dev (1991) 3.33
Changes in integrin receptors on oncogenically transformed cells. Cell (1989) 3.09
Construction of DNA sequences complementary to rat alpha 1 and alpha 2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D. Biochemistry (1984) 2.49
Perinatal lethal osteogenesis imperfecta in transgenic mice bearing an engineered mutant pro-alpha 1(I) collagen gene. Nature (1988) 2.49
Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells. Mol Cell Biol (1990) 2.46
Microinjection of transforming ras protein induces c-fos expression. Mol Cell Biol (1987) 1.91
Regulation of a collagen gene promoter by the product of viral mos oncogene. Nature (1985) 1.85
Regulation of collagen gene expression. Prog Nucleic Acid Res Mol Biol (1989) 1.75
Coordinate regulation of the levels of type III and type I collagen mRNA in most but not all mouse fibroblasts. J Biol Chem (1985) 1.71
Coordinate transcriptional regulation of type I procollagen genes by Rous sarcoma virus. J Biol Chem (1981) 1.68
Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras. Mol Cell Biol (1991) 1.62
ras-induced neuronal differentiation of PC12 cells: possible involvement of fos and jun. Mol Cell Biol (1989) 1.59
Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene. Proc Natl Acad Sci U S A (1990) 1.57
The first intron of the alpha 1(I) collagen gene contains several transcriptional regulatory elements. J Biol Chem (1988) 1.57
Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080. EMBO J (1984) 1.56
Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Mol Cell Biol (1989) 1.55
Differential utilization of regulatory domains within the alpha 1(I) collagen promoter in osseous and fibroblastic cells. J Cell Biol (1992) 1.48
Transformation and stimulation of DNA synthesis in NIH-3T3 cells are a titratable function of normal p21N-ras expression. EMBO J (1986) 1.46
Regulation or procollagen messenger ribonucleic acid levels in Rous sarcoma virus transformed chick embryo fibroblasts. Biochemistry (1981) 1.46
Inhibition of v-src-induced transformation by a GTPase-activating protein. Mol Cell Biol (1991) 1.46
An upstream regulatory region mediates high-level, tissue-specific expression of the human alpha 1(I) collagen gene in transgenic mice. Mol Cell Biol (1991) 1.36
The cellular response to induction of the p21 c-Ha-ras oncoprotein includes stimulation of jun gene expression. EMBO J (1989) 1.35
Introduction of the human pro alpha 1(I) collagen gene into pro alpha 1(I)-deficient Mov-13 mouse cells leads to formation of functional mouse-human hybrid type I collagen. Proc Natl Acad Sci U S A (1987) 1.30
Expression of H-ras correlates with metastatic potential: evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells. Mol Cell Biol (1987) 1.24
Organization of the human pro-alpha 2(I) collagen gene. J Biol Chem (1987) 1.24
Isolation and characterization of the rat alpha 1(I) collagen promoter. Regulation by 1,25-dihydroxyvitamin D. J Biol Chem (1989) 1.21
Declining procollagen mRNA sequences in chick embryo fibroblasts infected with rous sarcoma virus. Correlation with procollagen synthesis. J Biol Chem (1979) 1.18
Transcriptional suppression of cellular gene expression by c-Myc. Mol Cell Biol (1991) 1.14
Antisense-fos RNA causes partial reversion of the transformed phenotypes induced by the c-Ha-ras oncogene. Mol Cell Biol (1990) 1.13
Correlation of collagen synthesis and procollagen messenger RNA levels with transformation in rat embryo fibroblasts. Cancer Res (1981) 1.09
'Nuclear' oncogenes convert extracellular stimuli into changes in the genetic program. Trends Genet (1989) 1.07
Depletion of c-myc with specific antisense sequences reverses the transformed phenotype in ras oncogene-transformed NIH 3T3 cells. Mol Cell Biol (1991) 1.01
Protein synthesis inhibition stabilizes urokinase-type plasminogen activator mRNA. Studies in vivo and in cell-free decay reactions. J Biol Chem (1991) 0.98
Regulation of insulin-like growth factor I gene expression in the human macrophage-like cell line U937. J Clin Invest (1990) 0.92
Absence of alpha 2(1) procollagen synthesis in a clone of SV40-transformed WI-38 human fibroblasts. J Biol Chem (1989) 0.87
Regulation of collagen gene expression by transformed human fibroblasts: decreased type I and type III collagen RNA transcription. J Invest Dermatol (1991) 0.84
The effect of antisense RNA to fibronectin on the malignancy of hybrids between melanoma cells and normal fibroblasts. J Cell Sci (1989) 0.83
Use of revertant cell lines to identify targets of v-fos transformation-specific alterations in gene expression. Cell Growth Differ (1990) 0.79
Reduced levels of alpha 1 (I) collagen mRNA in cells immortalized by mutant p53 or transformed by ras. Biochim Biophys Acta (1991) 0.78
The extracellular matrix of hybrids between melanoma cells and normal fibroblasts. J Cell Sci (1988) 0.78
Transient alterations in the expression of protease and extracellular matrix genes during metastatic lung colonization by H-ras-transformed 10T1/2 fibroblasts. Cancer Res (1990) 0.76
Structurally distinct collagen types. Annu Rev Biochem (1980) 6.43
The elastic fiber. I. The separation and partial characterization of its macromolecular components. J Cell Biol (1969) 4.51
The nature of the intramolecular cross-links in collagen. The separation and characterization of peptides from the cross-link region of rat skin collagen. Biochemistry (1966) 4.04
Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis. J Cell Biol (1998) 3.27
Evidence for procollagen, a biosynthetic precursors of collagen. Proc Natl Acad Sci U S A (1971) 2.96
Correlation of procollagen mRNA levels in normal and transformed chick embryo fibroblasts with different rates of procollagen synthesis. Biochemistry (1978) 2.85
Cleavage at Asn-Gly bonds with hydroxylamine. Methods Enzymol (1977) 2.80
Transforming growth factor beta increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability. Proc Natl Acad Sci U S A (1988) 2.73
The biosynthesis of collagen. Annu Rev Biochem (1974) 2.50
Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin. J Biol Chem (1991) 2.47
Thrombospondin: synthesis and secretion by cells in culture. J Cell Biol (1982) 2.33
Isolation and characterization of a glycoprotein secreted by aortic endothelial cells in culture. Apparent identity with platelet thrombospondin. J Biol Chem (1981) 2.25
Regional chromosome mapping of human collagen genes alpha 2(I) and alpha 1(I) (COLIA2 and COLIA1). Hum Genet (1985) 2.24
Light microscopic immunolocation of thrombospondin in human tissues. J Histochem Cytochem (1985) 2.20
Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2. J Biol Chem (2000) 2.18
Control of smooth muscle cell growth by components of the extracellular matrix: autocrine role for thrombospondin. Proc Natl Acad Sci U S A (1986) 2.10
Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Dev Dyn (1997) 2.05
Platelet-derived growth factor and heparin-like glycosaminoglycans regulate thrombospondin synthesis and deposition in the matrix by smooth muscle cells. J Cell Biol (1985) 2.05
Characterization of a novel serum albumin-binding glycoprotein secreted by endothelial cells in culture. J Biol Chem (1984) 2.01
Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis. Proc Natl Acad Sci U S A (1999) 2.01
Cell surface-associated structural proteins in connective tissue cells. Proc Natl Acad Sci U S A (1977) 1.99
Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn. J Biol Chem (1981) 1.95
Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro. Proc Natl Acad Sci U S A (1991) 1.94
Effects of antimicrotubular agents on the secretion of collagen. A biochemical and morphological study. J Cell Biol (1974) 1.93
Differential expression of thrombospondin 1, 2, and 3 during murine development. Dev Dyn (1993) 1.92
Matricellular proteins as modulators of cell-matrix interactions: adhesive defect in thrombospondin 2-null fibroblasts is a consequence of increased levels of matrix metalloproteinase-2. Mol Biol Cell (2000) 1.85
Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen. J Cell Biol (1984) 1.85
Isolation of a collagen-binding fragment from fibronectin and cold-insoluble globulin. J Biol Chem (1979) 1.80
Accelerated wound healing in mice with a disruption of the thrombospondin 2 gene. J Invest Dermatol (1999) 1.79
Characterization of the pro- 1 chain of procollagen. J Biol Chem (1972) 1.78
Isolation and characterization of the cyanogen bromide peptides from the alpha-1 chain of rat skin collagen. Biochemistry (1967) 1.77
Structural studies on human type IV collagen. J Biol Chem (1979) 1.77
Regulation of collagen gene expression. Prog Nucleic Acid Res Mol Biol (1989) 1.75
The low density lipoprotein receptor-related protein modulates levels of matrix metalloproteinase 9 (MMP-9) by mediating its cellular catabolism. J Biol Chem (2001) 1.72
Coordinate transcriptional regulation of type I procollagen genes by Rous sarcoma virus. J Biol Chem (1981) 1.68
X-linked cutis laxa: defective cross-link formation in collagen due to decreased lysyl oxidase activity. N Engl J Med (1980) 1.62
The nature and location of intramolecular cross-links in collagen. Proc Natl Acad Sci U S A (1966) 1.60
Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization. J Histochem Cytochem (1993) 1.56
Sulfated proteoglycans synthesized by vascular endothelial cells in culture. J Biol Chem (1983) 1.55
The amino acid sequence of peptides from the cross-linking region of rat skin collagen. Biochemistry (1967) 1.54
Microtubules in transcellular movement of procollagen. Nat New Biol (1972) 1.53
Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism. EMBO J (2001) 1.51
Secretory phenotypes of endothelial cells in culture: comparison of aortic, venous, capillary, and corneal endothelium. Arteriosclerosis (1982) 1.49
TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax. Cell Death Differ (2006) 1.47
Altered secretion of type III procollagen in a form of type IV Ehlers-Danlos syndrome. Biochemical studies in cultured fibroblasts. Lab Invest (1981) 1.46
Comparative sequence studies of rat skin and tendon collagen. I. Evidence for incomplete hydroxylation of individual prolyl residues in the normal proteins. Biochemistry (1967) 1.46
Altered extracellular matrix remodeling and angiogenesis in sponge granulomas of thrombospondin 2-null mice. Am J Pathol (2001) 1.45
Synthesis of types I and III procollagen and collagen by monkey aortic smooth muscle cells in vitro. Biochemistry (1977) 1.44
Mice that lack the angiogenesis inhibitor, thrombospondin 2, mount an altered foreign body reaction characterized by increased vascularity. Proc Natl Acad Sci U S A (1999) 1.42
Biochemical and ultrastructural studies of proteoheparan sulfates synthesized by PYS-2, a basement membrane-producing cell line. J Cell Biol (1982) 1.41
Collagen synthesis by bovine aortic endothelial cells in culture. Biochemistry (1979) 1.40
Structure of alpha-1-CB8, a large cyanogen bromide produced fragment from the alpha-1 chain of rat collagen. The nature of a hydroxylamine-sensitive bond and composition of tryptic peptides. Biochemistry (1970) 1.39
Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes. Proc Natl Acad Sci U S A (1982) 1.39
An upstream regulatory region mediates high-level, tissue-specific expression of the human alpha 1(I) collagen gene in transgenic mice. Mol Cell Biol (1991) 1.36
A presumptive subunit of elastic fiber microfibrils secreted by arterial smooth-muscle cells in culture. Eur J Biochem (1976) 1.36
The distribution of antigenic determinants in rat skin collagen. J Exp Med (1971) 1.35
Increased marrow-derived osteoprogenitor cells and endosteal bone formation in mice lacking thrombospondin 2. J Bone Miner Res (2000) 1.35
Isolation and characterization of the cyanogen bromide peptides from the alpha 1 and alpha 2 chains of human skin collagen. Biochemistry (1970) 1.34
NH2-terminal sequence of the chick proalpha1(I) chain synthesized in the reticulocyte lysate system. Evidence for a transient hydrophobic leader sequence. J Biol Chem (1979) 1.34
Transforming growth factor and epidermal growth factor stimulate the phosphorylation of a synthetic, tyrosine-containing peptide in a similar manner. J Biol Chem (1982) 1.34
Biosynthetic and structural properties of endothelial cell type VIII collagen. J Biol Chem (1983) 1.34
Metaxin is a component of a preprotein import complex in the outer membrane of the mammalian mitochondrion. J Biol Chem (1997) 1.32
Changes in surface properties of normal and transformed cells caused by tunicamycin, an inhibitor of protein glycosylation. Proc Natl Acad Sci U S A (1977) 1.32
Regulation of thrombospondin secretion by cells in culture. J Cell Physiol (1984) 1.32
Location of a collagen-binding domain in fibronectin. J Biol Chem (1980) 1.31
Cell-specific expression of alpha 1(I) collagen-hGH minigenes in transgenic mice. J Cell Biol (1994) 1.28
Characterization of a novel collagen chain in human placenta and its relation to AB collagen. Biochemistry (1979) 1.28
The distribution of the matricellular protein thrombospondin 2 in tissues of embryonic and adult mice. J Histochem Cytochem (1998) 1.27
Structural basis for apparent heterogeneity of collagens in human basement membranes: type IV procollagen contains two distinct chains. Proc Natl Acad Sci U S A (1980) 1.25
Impaired conversion of procollagen to collagen by fibroblasts and bone treated with tunicamycin, an inhibitor of protein glycosylation. J Biol Chem (1977) 1.24
A unique, pepsin-sensitive collagen synthesized by aortic endothelial cells in culture. Biochemistry (1980) 1.23
Expression of thrombospondins by endothelial cells. Injury is correlated with TSP-1. Am J Pathol (1995) 1.23
Characterization of a type IV procollagen synthesized by human amniotic fluid cells in culture. J Biol Chem (1979) 1.23
Studies of morphologically atypical ("sprouting") cultures of bovine aortic endothelial cells. Growth characteristics and connective tissue protein synthesis. J Cell Physiol (1980) 1.21
Structure of rat skin collagen 1-CB8. Amino acid sequence of the hydroxylamine-produced fragment HA1. Biochemistry (1971) 1.21
Structural analysis and expression of the human thrombospondin gene promoter. J Biol Chem (1988) 1.21
Characterization of the precursor form of type VI collagen. J Biol Chem (1984) 1.20
Procollagen: conversion of the precursor to collagen by a neutral protease. Science (1972) 1.20
Declining procollagen mRNA sequences in chick embryo fibroblasts infected with rous sarcoma virus. Correlation with procollagen synthesis. J Biol Chem (1979) 1.18
Metaxin 1 interacts with metaxin 2, a novel related protein associated with the mammalian mitochondrial outer membrane. J Cell Biochem (1999) 1.18
The specific nonenzymatic cleavage of bovine ribonuclease with hydroxylamine. J Biol Chem (1970) 1.17
Structure and organization of the human metaxin gene (MTX) and pseudogene. Genomics (1996) 1.16
Interchain disulfide bonds in procollagen are located in a large nontriple-helical COOH-terminal domain. Proc Natl Acad Sci U S A (1975) 1.14
A serum response element and a binding site for NF-Y mediate the serum response of the human thrombospondin 1 gene. J Biol Chem (1993) 1.13
The cross-linking of collagen and elastin and its inhibition in osteolathyrism. Is there a relation to the aging process? Am J Med (1970) 1.13
Amniotic fluid fibronectin. Characterization and synthesis by cells in culture. J Cell Biol (1978) 1.12
Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family. J Biol Chem (1992) 1.12
Tyrosylprotein kinase and phosphatase activities in membrane vesicles from normal and Rous sarcoma virus-transformed rat cells. Proc Natl Acad Sci U S A (1981) 1.11
Heparin and related glycosaminoglycans modulate the secretory phenotype of vascular smooth muscle cells. J Cell Biol (1984) 1.11
Regulation of protein synthesis: translational control by procollagen-derived fragments. Proc Natl Acad Sci U S A (1981) 1.11
Regulation of expression of the type I collagen genes. Am J Med Genet (1993) 1.10
Biosynthesis of an unusual collagen type by human astrocytoma cells in vitro. J Biol Chem (1983) 1.10
Partial amino acid sequence of human thrombospondin as determined by analysis of cDNA clones: homology to malarial circumsporozoite proteins. Biochemistry (1986) 1.10
Endothelial cells from umbilical vein and a hemangioendothelioma secrete basement membrane largely to the exclusion of interstitial procollagens. Arteriosclerosis (1982) 1.10
Correlation of collagen synthesis and procollagen messenger RNA levels with transformation in rat embryo fibroblasts. Cancer Res (1981) 1.09
Human papillomavirus associated with oesophageal cancer. J Clin Pathol (2002) 1.09
Biosynthesis of type V procollagen by A204, a human rhabdomyosarcoma cell line. J Biol Chem (1982) 1.09
Collagen synthesis by human amniotic fluid cells in culture: characterization of a procollagen with three identical proalpha1(I) chains. Biochemistry (1978) 1.09
Mapping of the thrombospondin gene to human chromosome 15 and mouse chromosome 2 by in situ hybridization. Genomics (1990) 1.08