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Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library. Proc Natl Acad Sci U S A (1987) 5.80

GTP-binding domain: three consensus sequence elements with distinct spacing. Proc Natl Acad Sci U S A (1987) 5.16

Microinjection of recombinant p21rho induces rapid changes in cell morphology. J Cell Biol (1990) 4.83

A novel GTP-binding protein, Sar1p, is involved in transport from the endoplasmic reticulum to the Golgi apparatus. J Cell Biol (1989) 4.29

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells. EMBO J (1989) 4.21

The ral gene: a new ras related gene isolated by the use of a synthetic probe. EMBO J (1986) 3.50

Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1987) 3.50

Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line. Mol Cell Biol (1990) 3.31

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Intracellular localization of the P21rho proteins. J Cell Biol (1992) 3.21

rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles. Proc Natl Acad Sci U S A (1990) 3.13

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum. Mol Cell Biol (1988) 3.11

Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21. Proc Natl Acad Sci U S A (1986) 3.11

Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae. Mol Cell Biol (1989) 2.57

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rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo. EMBO J (1993) 2.31

Rho GTPases have diverse effects on the organization of the actin filament system. Biochem J (2004) 2.23

Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42. Proc Natl Acad Sci U S A (1990) 2.22

PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. Biochem J (2005) 2.19

The ras-related ypt protein is an ubiquitous eukaryotic protein: isolation and sequence analysis of mouse cDNA clones highly homologous to the yeast YPT1 gene. EMBO J (1987) 2.14

Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. Gut (2005) 2.13

Mutations in a gene encoding the alpha subunit of a Saccharomyces cerevisiae G protein indicate a role in mating pheromone signaling. Mol Cell Biol (1988) 1.98

Evolution of the Rho family of ras-like GTPases in eukaryotes. Mol Biol Evol (2006) 1.96

Nucleotide sequence of human rho cDNA clone 12. Nucleic Acids Res (1987) 1.94

The erg gene: a human gene related to the ets oncogene. Proc Natl Acad Sci U S A (1987) 1.90

The ras oncogene--an important regulatory element in lower eucaryotic organisms. Microbiol Rev (1989) 1.79

Mutations of the ras gene product p21 that abolish guanine nucleotide binding. Proc Natl Acad Sci U S A (1986) 1.71

Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis. J Cell Biol (1996) 1.63

ADP-ribosylation of p21ras and related proteins by Pseudomonas aeruginosa exoenzyme S. Infect Immun (1991) 1.61

Detection and identification of activated oncogenes in spontaneously occurring benign and malignant hepatocellular tumors of the B6C3F1 mouse. Proc Natl Acad Sci U S A (1986) 1.60

Association of the GTP-binding protein Rab3A with bovine adrenal chromaffin granules. Proc Natl Acad Sci U S A (1990) 1.58

Growth-regulated expression of rhoG, a new member of the ras homolog gene family. Mol Cell Biol (1992) 1.58

The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts. Mol Cell Biol (1991) 1.54

Characterization and expression of the human rhoH12 gene product. Mol Cell Biol (1989) 1.43

Involvement of the GTP binding protein Rho in constitutive endocytosis in Xenopus laevis oocytes. J Cell Biol (1995) 1.36

A chimeric toxin to study the role of the 21 kDa GTP binding protein rho in the control of actin microfilament assembly. EMBO J (1993) 1.31

Coding sequence of human rho cDNAs clone 6 and clone 9. Nucleic Acids Res (1988) 1.30

Heterologous expression and characterization of the human R-ras gene product. Mol Cell Biol (1987) 1.27

Genetic structure and evolution of RAC-GTPases in Arabidopsis thaliana. Genetics (2000) 1.27

Identification of ras-related, YPT family genes in Schizosaccharomyces pombe. EMBO J (1990) 1.26

The small GTP-binding protein Rho1p is localized on the Golgi apparatus and post-Golgi vesicles in Saccharomyces cerevisiae. J Cell Biol (1991) 1.26

Role of Dictyostelium racE in cytokinesis: mutational analysis and localization studies by use of green fluorescent protein. Mol Biol Cell (1997) 1.23

Primary, nonsyndromic vesicoureteric reflux and its nephropathy is genetically heterogeneous, with a locus on chromosome 1. Am J Hum Genet (2000) 1.18

Rho GTPases in platelet function. J Thromb Haemost (2013) 1.15

Yeast RNC1 encodes a chimeric protein, RhoNUC, with a human rho motif and deoxyribonuclease activity. Nucleic Acids Res (1992) 1.14

Thrombolamban, the 22-kDa platelet substrate of cyclic AMP-dependent protein kinase, is immunologically homologous with the Ras family of GTP-binding proteins. Proc Natl Acad Sci U S A (1990) 1.14

Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins. Mol Cell Biol (1990) 1.13

Growing and developing Dictyostelium cells express different ras genes. Proc Natl Acad Sci U S A (1989) 1.12

Transient expression of RhoA, -B, and -C GTPases in HeLa cells potentiates resistance to Clostridium difficile toxins A and B but not to Clostridium sordellii lethal toxin. Infect Immun (1995) 1.11

Rho GTPases in animal cell cytokinesis: an occupation by the one percent. Cytoskeleton (Hoboken) (2012) 1.11

Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production. Mol Biol Cell (2000) 1.10

Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins. Mol Cell Biol (1989) 1.09

Cloning of the RHO1 gene from Candida albicans and its regulation of beta-1,3-glucan synthesis. J Bacteriol (1997) 1.09

The biochemistry of ras p21. Biochem J (1991) 1.08

Polylysine-containing peptides, including the carboxyl-terminal segment of the human c-Ki-ras 2 protein, affect the activity of some key membrane enzymes. Proc Natl Acad Sci U S A (1987) 1.03

A new member of the ras gene superfamily identified in a rat liver cell line. Nucleic Acids Res (1988) 1.01

Rho GTPase isoforms in cell motility: Don't fret, we have FRET. Cell Adh Migr (2014) 0.98

A processed chicken pseudogene (CPS1) related to the ras oncogene superfamily. Nucleic Acids Res (1986) 0.96

Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer. Pharmacol Rev (2014) 0.96

Rho/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damage. Int J Ophthalmol (2011) 0.94

Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking. Small GTPases (2014) 0.93

Synergism between a novel amphibian oocyte ribonuclease and lovastatin in inducing cytostatic and cytotoxic effects in human lung and pancreatic carcinoma cell lines. Br J Cancer (1992) 0.91

Expression of the Aplysia californica rho gene in Escherichia coli: purification and characterization of its encoded p21 product. Mol Cell Biol (1987) 0.90

Rho/ROCK signaling in motility and metastasis of gastric cancer. World J Gastroenterol (2014) 0.90

Toward understanding RhoGTPase specificity: structure, function and local activation. Small GTPases (2014) 0.89

Role of G-proteins in T cell activation: non-hydrolysable GTP analogues induce early ornithine decarboxylase activity in human T lymphocytes. EMBO J (1986) 0.87

p21 ras proteins and guanine nucleotides modulate the phosphorylation of 36- and 17-kilodalton mitochondria-associated proteins. Proc Natl Acad Sci U S A (1986) 0.86

Expression of G3BP and RhoC in esophageal squamous carcinoma and their effect on prognosis. World J Gastroenterol (2007) 0.85

Redistribution of 23 kDa tubulovesicle-associated GTP-binding proteins during parietal cell stimulation. Biochem J (1991) 0.85

Guanine nucleotide binding properties of rap1 purified from human neutrophils. Biochem J (1990) 0.84

The small GTPase RhoH is an atypical regulator of haematopoietic cells. Cell Commun Signal (2008) 0.84

Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells. Immunol Rev (2013) 0.83

The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression. Mol Cancer (2010) 0.83

Multiple GTP-binding proteins from cholinergic synaptic vesicles. J Neurosci (1990) 0.82

Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion. Oncotarget (2016) 0.81

SAS1 and SAS2, GTP-binding protein genes in Dictyostelium discoideum with sequence similarities to essential genes in Saccharomyces cerevisiae. Mol Cell Biol (1990) 0.81

Systemic Sclerosis is a Complex Disease Associated Mainly with Immune Regulatory and Inflammatory Genes. Open Rheumatol J (2014) 0.80

Rho GTPases as pathogen targets: Focus on curable sexually transmitted infections. Small GTPases (2015) 0.78

Calycosin-7-O-β-D-glucoside promotes oxidative stress-induced cytoskeleton reorganization through integrin-linked kinase signaling pathway in vascular endothelial cells. BMC Complement Altern Med (2015) 0.78

Immunochemical analysis of protein expression in breast epithelial cells transformed by estrogens and high linear energy transfer (LET) radiation. Histochem Cell Biol (2005) 0.77

Pathophysiological Functions of Rnd3/RhoE. Compr Physiol (2015) 0.77

Gene and protein expressions induced by 17beta-estradiol and parathion in cultured breast epithelial cells. Mol Med (2007) 0.76

Divergence of Rho residue 43 impacts GEF activity. Small GTPases (2012) 0.76

Structural Mechanisms and Drug Discovery Prospects of Rho GTPases. Cells (2016) 0.76

Rho GTPases at the crossroad of signaling networks in mammals. Small GTPases (2015) 0.76

The Rho GTPase Family Genes in Bivalvia Genomes: Sequence, Evolution and Expression Analysis. PLoS One (2015) 0.75

Rho GTPases in ameloblast differentiation. Jpn Dent Sci Rev (2015) 0.75

Hypoxic Pulmonary Vasoconstriction in Humans: Tale or Myth. Open Cardiovasc Med J (2017) 0.75

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell (1986) 22.26

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc Natl Acad Sci U S A (1979) 21.22

Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell (1978) 19.44

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell (1977) 18.95

A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell (1991) 18.19

Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. Cell (1981) 12.73

Intragenic DNA spacers interrupt the ovalbumin gene. Proc Natl Acad Sci U S A (1978) 11.03

Visualizing an olfactory sensory map. Cell (1996) 8.79

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Cell (1985) 7.16

A spatial map of olfactory receptor expression in the Drosophila antenna. Cell (1999) 6.42

A soluble form of CD4 (T4) protein inhibits AIDS virus infection. Nature (1988) 6.39

The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell (1978) 6.38

Allelic inactivation regulates olfactory receptor gene expression. Cell (1994) 5.93

An olfactory sensory map in the fly brain. Cell (2000) 5.29

Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei. Proc Natl Acad Sci U S A (1976) 5.27

Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell (1984) 5.12

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J (1997) 5.03

A novel family of genes encoding putative pheromone receptors in mammals. Cell (1995) 4.88

Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature (1990) 4.81

Topographic organization of sensory projections to the olfactory bulb. Cell (1994) 4.74

A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. Cell (2001) 4.64

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells. EMBO J (1989) 4.21

Transforming DNA integrates into the host chromosome. Cell (1981) 3.98

Synthesis of globin ribonucleic acid from duck-reticulocyte chromatin in vitro. Proc Natl Acad Sci U S A (1973) 3.93

The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes. Cell (1985) 3.91

Altering genotype and phenotype by DNA-mediated gene transfer. Science (1980) 3.82

Integration, transcription, and control of a Drosophila heat shock gene in mouse cells. Proc Natl Acad Sci U S A (1981) 3.70

Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proc Natl Acad Sci U S A (1979) 3.53

Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell (1993) 3.53

Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1987) 3.50

Transformation of mammalian cells with an amplifiable dominant-acting gene. Proc Natl Acad Sci U S A (1980) 3.39

Specific sites of interaction between histones and DNA in chromatin. Proc Natl Acad Sci U S A (1974) 3.25

Cleavage of DNA in nuclei and chromatin with staphylococcal nuclease. Biochemistry (1975) 3.20

Analysis of DNA of isolated chromatin subunits. Proc Natl Acad Sci U S A (1975) 3.17

Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science (1988) 3.02

Mice deficient in G(olf) are anosmic. Neuron (1998) 3.00

Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho. Science (1996) 2.99

Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. J Biol Chem (1996) 2.92

Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen. Nature (1987) 2.89

HIV infection does not require endocytosis of its receptor, CD4. Cell (1988) 2.88

The regulated expression of beta-globin genes introduced into mouse erythroleukemia cells. Cell (1983) 2.75

Isolation of transforming DNA: cloning the hamster aprt gene. Cell (1980) 2.73

Odorant receptors govern the formation of a precise topographic map. Cell (1998) 2.60

Regulated expression of human growth hormone genes in mouse cells. Cell (1982) 2.58

Gene amplification and gene correction in somatic cells. Cell (1982) 2.46

An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development (1994) 2.46

Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc Natl Acad Sci U S A (1999) 2.39

Genes expressed in neurons of adult male Drosophila. Cell (1997) 2.31

Presence in human breast cancer of RNA homologous to mouse mammary tumour virus RNA. Nature (1972) 2.31

Molecular cloning and nucleotide sequence of the streptavidin gene. Nucleic Acids Res (1986) 2.30

Regulation of dimorphism in Saccharomyces cerevisiae: involvement of the novel protein kinase homolog Elm1p and protein phosphatase 2A. Mol Cell Biol (1993) 2.19

Genes transcribed at diverse rates have a similar conformation in chromatin. Proc Natl Acad Sci U S A (1977) 2.17

A family of glutamate receptor genes: evidence for the formation of heteromultimeric receptors with distinct channel properties. Neuron (1990) 2.10

The gene encoding the T-cell surface protein T4 is located on human chromosome 12. Proc Natl Acad Sci U S A (1986) 2.08

Molecular cloning and single-channel properties of the cyclic nucleotide-gated channel from catfish olfactory neurons. Neuron (1992) 2.04

The structure of the globin genes in chromatin. Biochemistry (1975) 2.02

Particles containing RNA-instructed DNA polymerase and virus-related RNA in human breast cancers. Proc Natl Acad Sci U S A (1972) 2.02

The family of genes encoding odorant receptors in the channel catfish. Cell (1993) 2.02

Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin. Cell (1985) 1.99

Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation. Science (1989) 1.97

Nucleotide sequence of human rho cDNA clone 12. Nucleic Acids Res (1987) 1.94

Analysis of the complexity and diversity of mRNA from chicken liver and oviduct. Cell (1976) 1.92

A structure for amplified DNA. Cell (1983) 1.88

Structure and expression of the human and mouse T4 genes. Proc Natl Acad Sci U S A (1987) 1.77

Glucocorticoids enhance stability of human growth hormone mRNA. Mol Cell Biol (1987) 1.77

A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons. Proc Natl Acad Sci U S A (1995) 1.77

Evidence for translation of viral-specific RNA in cells of a mouse mammary carcinoma. Proc Natl Acad Sci U S A (1972) 1.76

An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron (1998) 1.76

A single gene encodes multiple neuropeptides mediating a stereotyped behavior. Cell (1983) 1.75

Detection of RNA-instructed DNA polymerase and high molecular weight RNA in malignant tissue. Proc Natl Acad Sci U S A (1972) 1.73

Nucleosomes are phased along the mouse beta-major globin gene in erythroid and nonerythroid cells. Cell (1986) 1.70

Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution. Cell (1992) 1.70

Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine. Nature (1995) 1.68

Odorant receptors on axon termini in the brain. Science (2004) 1.67

CD4: collaborator in immune recognition and HIV infection. Cell (1990) 1.59

Introduction of a viral thymidine kinase gene and the human beta-globin gene into developmentally multipotential mouse teratocarcinoma cells. Proc Natl Acad Sci U S A (1980) 1.58

The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors. Proc Natl Acad Sci U S A (1990) 1.58

Mutational analysis of morphologic differentiation in Saccharomyces cerevisiae. Genetics (1995) 1.56

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell (1991) 1.54

Molecular probes for the development and plasticity of neural crest derivatives. Cell (1985) 1.53

A bipotential neuroendocrine precursor whose choice of cell fate is determined by NGF and glucocorticoids. Cell (1986) 1.53

The level of CD8 expression can determine the outcome of thymic selection. Cell (1992) 1.53

Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity. Neuron (2000) 1.52

Rho-dependent transfer of Citron-kinase to the cleavage furrow of dividing cells. J Cell Sci (2001) 1.50

Coding of olfactory information: topography of odorant receptor expression in the catfish olfactory epithelium. Cell (1993) 1.49

A map of pheromone receptor activation in the mammalian brain. Cell (1999) 1.43

5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system. Proc Natl Acad Sci U S A (1989) 1.39

Genomic analysis of orthologous mouse and human olfactory receptor loci. Proc Natl Acad Sci U S A (2001) 1.39

Virus-related RNA in human and mouse mammary tumors. J Natl Cancer Inst (1972) 1.34

Genetic ablation and restoration of the olfactory topographic map. Cell (2000) 1.34

A family of genes that codes for ELH, a neuropeptide eliciting a stereotyped pattern of behavior in Aplysia. Cell (1982) 1.30

Coding sequence of human rho cDNAs clone 6 and clone 9. Nucleic Acids Res (1988) 1.30

The structure of the thymidine kinase gene promoter: nuclease hypersensitivity correlates with expression. Cell (1982) 1.30

Patterns of transfer RNA in normal rat liver and during hepatic carcinogenesis. Proc Natl Acad Sci U S A (1967) 1.27

The small GTP-binding protein Rho1p is localized on the Golgi apparatus and post-Golgi vesicles in Saccharomyces cerevisiae. J Cell Biol (1991) 1.26

Restriction endonuclease cleavage of satellite DNA in intact bovine nuclei. Cell (1976) 1.23

Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules. J Biol Chem (1998) 1.21

Identification of a neutralizing domain in the external envelope glycoprotein of simian immunodeficiency virus. AIDS Res Hum Retroviruses (1992) 1.19