PubRank

A R Krainer

Author PubWeight™ 185.90‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell 1984 12.30
2 Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell 1984 9.13
3 Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell 1992 7.90
4 Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science 1994 7.09
5 Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell 1985 6.85
6 Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors. Nucleic Acids Res 1993 6.15
7 Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev 1998 5.79
8 A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes. Nat Genet 2001 5.02
9 AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes. Mol Cell Biol 1999 4.87
10 Pre-mRNA splicing in the new millennium. Curr Opin Cell Biol 2001 4.64
11 General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes Dev 1993 4.40
12 A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. Genes Dev 1998 4.19
13 Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors. RNA 1998 4.05
14 General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proc Natl Acad Sci U S A 1992 3.97
15 Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. J Cell Biol 1997 3.95
16 Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J 1995 3.56
17 Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains. EMBO J 1993 3.51
18 Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. EMBO J 1994 3.35
19 The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. J Cell Biol 2000 3.34
20 Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins. Mol Cell 2001 3.34
21 Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Mol Cell Biol 1993 3.16
22 Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF. EMBO J 1993 3.11
23 Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA. Genes Dev 1999 3.08
24 hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing. EMBO J 1999 3.04
25 Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Mol Cell Biol 2000 3.01
26 Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing. Proc Natl Acad Sci U S A 1992 2.66
27 Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. J Cell Biol 1998 2.60
28 Mechanisms for selecting 5' splice sites in mammalian pre-mRNA splicing. Trends Genet 1994 2.54
29 Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1. Mol Cell Biol 2000 2.22
30 Purification and characterization of human RNPS1: a general activator of pre-mRNA splicing. EMBO J 1999 2.20
31 Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors. J Cell Biol 1994 2.12
32 Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elements. Mol Cell Biol 1999 2.05
33 Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing. Methods Mol Biol 1999 2.02
34 The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). J Biol Chem 1999 1.90
35 Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein. Proc Natl Acad Sci U S A 1999 1.86
36 atSRp30, one of two SF2/ASF-like proteins from Arabidopsis thaliana, regulates splicing of specific plant genes. Genes Dev 1999 1.82
37 U1-mediated exon definition interactions between AT-AC and GT-AG introns. Science 1996 1.74
38 RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins. Proc Natl Acad Sci U S A 1997 1.72
39 Pre-mRNA splicing in the absence of an SR protein RS domain. Genes Dev 2000 1.58
40 Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. Nucleic Acids Res 1993 1.57
41 Mammalian in vitro splicing assays. Methods Mol Biol 1999 1.57
42 The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor. Genes Dev 1999 1.49
43 A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. RNA 1997 1.43
44 Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway. RNA 2001 1.42
45 RNA splicing at human immunodeficiency virus type 1 3' splice site A2 is regulated by binding of hnRNP A/B proteins to an exonic splicing silencer element. J Virol 2001 1.41
46 The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA- and DNA-binding protein p54nrb/NonO. Mol Cell Biol 1997 1.41
47 Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs. Structure 1997 1.40
48 Independent deposition of heterogeneous nuclear ribonucleoproteins and small nuclear ribonucleoprotein particles at sites of transcription. Proc Natl Acad Sci U S A 1992 1.40
49 A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. Genes Dev 1997 1.36
50 The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins. EMBO J 2001 1.36
51 Splicing of a divergent subclass of AT-AC introns requires the major spliceosomal snRNAs. RNA 1997 1.27
52 Pre-mRNA splicing in plants: characterization of Ser/Arg splicing factors. Proc Natl Acad Sci U S A 1996 1.26
53 The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles. Mol Cell Biol 1994 1.25
54 Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing. Proc Natl Acad Sci U S A 1999 1.23
55 Distinct functions of the closely related tandem RNA-recognition motifs of hnRNP A1. RNA 1998 1.18
56 Extensive in silico analysis of NF1 splicing defects uncovers determinants for splicing outcome upon 5' splice-site disruption. Hum Mutat 2007 1.17
57 NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry. J Biol Chem 2000 1.15
58 Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing. Proc Natl Acad Sci U S A 1999 1.14
59 The U6 small nuclear RNA from Trypanosoma brucei. Nucleic Acids Res 1988 1.14
60 Human p32: a coactivator for Epstein-Barr virus nuclear antigen-1-mediated transcriptional activation and possible role in viral latent cycle DNA replication. Virology 2000 1.10
61 Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP. RNA 1998 1.05
62 Characterization of a SR protein from Trypanosoma brucei with homology to RNA-binding cis-splicing proteins. Mol Biochem Parasitol 1999 0.95
63 Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing. Mol Cell Biol 1989 0.94
64 Spatio-temporal expression of the trans-acting splicing factors SF2/ASF and heterogeneous ribonuclear proteins A1/A1B in the myometrium of the pregnant human uterus: a molecular mechanism for regulating regional protein isoform expression in vivo. J Clin Endocrinol Metab 2000 0.89
65 A putative homolog of U2AF65 in S. cerevisiae. Nucleic Acids Res 1992 0.88
66 Mapping the SF2/ASF binding sites in the bovine growth hormone exonic splicing enhancer. J Biol Chem 2000 0.84
67 Crystallization and preliminary X-ray diffraction studies of UP1, the two-RRM domain of hnRNP A1. Acta Crystallogr D Biol Crystallogr 1997 0.81
68 RCC1 and nuclear organization. Mol Biol Cell 1997 0.79
69 Non-radioactive detection of m3G capped RNAs by immunoblotting. Nucleic Acids Res 1994 0.75
70 Long-term storage of concentrated tris-borate-EDTA electrophoresis buffers without precipitation. Biotechniques 1991 0.75
71 A putative homology of U2AF65 in S. cerevisiae. Nucleic Acids Res 1993 0.75