Published in Physiol Rev on January 01, 2004
Alternative splicing and disease. Biochim Biophys Acta (2008) 3.47
The extended PP1 toolkit: designed to create specificity. Trends Biochem Sci (2010) 2.51
Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature (2013) 2.33
Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. J Cell Biol (2006) 2.33
Genome-wide functional analysis of human cell-cycle regulators. Proc Natl Acad Sci U S A (2006) 2.31
Glycogen and its metabolism: some new developments and old themes. Biochem J (2012) 2.24
PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation. Nat Cell Biol (2009) 2.20
Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome. Circ Res (2012) 2.06
Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates. J Biol Chem (2006) 2.04
Gene therapy in heart failure. Circ Res (2008) 1.79
Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients. J Am Coll Cardiol (2015) 1.57
Spinophilin facilitates dephosphorylation of doublecortin by PP1 to mediate microtubule bundling at the axonal wrist. Cell (2007) 1.56
Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites. Nat Struct Mol Biol (2010) 1.56
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J (2007) 1.55
Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7. Mol Cell Biol (2006) 1.50
Tumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinus squamous cell carcinoma. Br J Cancer (2011) 1.45
Regulation of cellular protein phosphatase-1 (PP1) by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors. J Biol Chem (2009) 1.45
Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions. Thromb Haemost (2012) 1.44
Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1. J Biol Chem (2009) 1.43
Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiology. J Mol Cell Cardiol (2009) 1.42
Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton. EMBO Rep (2005) 1.41
A dual role for PP1 in shaping the Msn2-dependent transcriptional response to glucose starvation. EMBO J (2005) 1.41
Beta-adrenergic stimulation and myocardial function in the failing heart. Heart Fail Rev (2009) 1.40
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. Dev Cell (2008) 1.38
PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora disease. PLoS Genet (2011) 1.35
Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1). Genes Dev (2007) 1.33
Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits. Proc Natl Acad Sci U S A (2004) 1.30
Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes. Genes Dev (2007) 1.29
Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover. Mol Cell (2008) 1.27
Targeting protein serine/threonine phosphatases for drug development. Mol Pharmacol (2009) 1.25
Characterization of Staufen 1 ribonucleoprotein complexes. Biochem J (2004) 1.24
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5. Heart Fail Rev (2010) 1.24
Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration. Biochem J (2005) 1.23
Transcriptome analysis of functional differentiation between haploid and diploid cells of Emiliania huxleyi, a globally significant photosynthetic calcifying cell. Genome Biol (2009) 1.22
Displacement affinity chromatography of protein phosphatase one (PP1) complexes. BMC Biochem (2008) 1.21
Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism. J Biol Chem (2010) 1.20
Protein phosphatases and their regulation in the control of mitosis. EMBO Rep (2012) 1.20
Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1. J Biol Chem (2009) 1.19
Target gene approaches: Gene expression in Daphnia magna exposed to predator-borne kairomones or to microcystin-producing and microcystin-free Microcystis aeruginosa. BMC Genomics (2009) 1.19
KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1. J Biol Chem (2011) 1.14
Mengovirus-induced rearrangement of the nuclear pore complex: hijacking cellular phosphorylation machinery. J Virol (2009) 1.13
Identification and characterization of a novel human PP1 phosphatase complex. J Biol Chem (2010) 1.09
Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells. Cell Signal (2010) 1.08
Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma. Proc Natl Acad Sci U S A (2007) 1.07
Darpp-32 and its truncated variant t-Darpp have antagonistic effects on breast cancer cell growth and herceptin resistance. PLoS One (2009) 1.04
Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast. Cell Res (2012) 1.04
SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. Sci Signal (2010) 1.03
Intermolecular autophosphorylation regulates myosin IIIa activity and localization in parallel actin bundles. J Biol Chem (2010) 1.03
The TriTryp phosphatome: analysis of the protein phosphatase catalytic domains. BMC Genomics (2007) 1.03
Drosophila Uri, a PP1alpha binding protein, is essential for viability, maintenance of DNA integrity and normal transcriptional activity. BMC Mol Biol (2008) 1.02
Ypi1, a positive regulator of nuclear protein phosphatase type 1 activity in Saccharomyces cerevisiae. Mol Biol Cell (2008) 1.02
Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis. Diabetes (2011) 1.00
Mass spectrometry and biochemical analysis of RNA polymerase II: targeting by protein phosphatase-1. Mol Cell Biochem (2010) 1.00
Protein phosphatase 1 positively regulates stomatal opening in response to blue light in Vicia faba. Proc Natl Acad Sci U S A (2006) 1.00
Protein phosphatase 1 regulates the stability of the circadian protein PER2. Biochem J (2006) 0.99
Spatial targeting of type II protein kinase A to filopodia mediates the regulation of growth cone guidance by cAMP. J Cell Biol (2007) 0.99
Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb. Cancer Cell Int (2006) 0.96
Rb1 gene inactivation expands satellite cell and postnatal myoblast pools. J Biol Chem (2011) 0.96
PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner. Biochem J (2005) 0.96
RSS1 regulates the cell cycle and maintains meristematic activity under stress conditions in rice. Nat Commun (2011) 0.95
The Hsp70 homolog Ssb is essential for glucose sensing via the SNF1 kinase network. Genes Dev (2009) 0.95
Scapinin, the protein phosphatase 1 binding protein, enhances cell spreading and motility by interacting with the actin cytoskeleton. PLoS One (2009) 0.95
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle. Biochem J (2013) 0.94
MiR-125b promotes cell migration and invasion by targeting PPP1CA-Rb signal pathways in gastric cancer, resulting in a poor prognosis. Gastric Cancer (2014) 0.93
Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases. Br J Pharmacol (2008) 0.92
Selective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin. FASEB J (2008) 0.92
Glycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapy. J Mol Med (Berl) (2016) 0.91
Increased laforin and laforin binding to glycogen underlie Lafora body formation in malin-deficient Lafora disease. J Biol Chem (2012) 0.91
Protein phosphatases decrease their activity during capacitation: a new requirement for this event. PLoS One (2013) 0.91
Par-4: a new activator of myosin phosphatase. Mol Biol Cell (2010) 0.91
MicroRNA overexpression increases cortical neuronal vulnerability to injury. Brain Res (2013) 0.90
Molecular investigations of the structure and function of the protein phosphatase 1-spinophilin-inhibitor 2 heterotrimeric complex. Biochemistry (2011) 0.90
Essential, overlapping and redundant roles of the Drosophila protein phosphatase 1 alpha and 1 beta genes. Genetics (2007) 0.90
The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels. Exp Cell Res (2006) 0.89
Unlocking repression of the human luteinizing hormone receptor gene by trichostatin A-induced cell-specific phosphatase release. J Biol Chem (2008) 0.89
Identification of a novel Leucine-rich repeat protein and candidate PP1 regulatory subunit expressed in developing spermatids. BMC Cell Biol (2008) 0.89
Physiological performance, secondary metabolite and expression profiling of genes associated with drought tolerance in Withania somnifera. Protoplasma (2015) 0.88
Identification and functional characterization of inhibitor-3, a regulatory subunit of protein phosphatase 1 in plants. Plant Physiol (2009) 0.88
Avicin D: a protein reactive plant isoprenoid dephosphorylates Stat 3 by regulating both kinase and phosphatase activities. PLoS One (2009) 0.88
Applying a targeted label-free approach using LC-MS AMT tags to evaluate changes in protein phosphorylation following phosphatase inhibition. J Proteome Res (2007) 0.88
A dopaminergic gene cluster in the prefrontal cortex predicts performance indicative of general intelligence in genetically heterogeneous mice. PLoS One (2010) 0.88
Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations. J Mol Cell Cardiol (2015) 0.87
Direct interaction between myocyte enhancer factor 2 (MEF2) and protein phosphatase 1alpha represses MEF2-dependent gene expression. Mol Cell Biol (2009) 0.87
The IKAROS interaction with a complex including chromatin remodeling and transcription elongation activities is required for hematopoiesis. PLoS Genet (2014) 0.87
The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation. Mol Cell Biol (2004) 0.87
Calyculin A, an enhancer of myosin, speeds up anaphase chromosome movement. Cell Chromosome (2007) 0.87
Differential localization of protein phosphatase-1alpha, beta and gamma1 isoforms in primate prefrontal cortex. Cereb Cortex (2005) 0.86
Role of PP1 in the regulation of Ca cycling in cardiac physiology and pathophysiology. Front Biosci (Landmark Ed) (2009) 0.86
Exercise training-induced adaptations associated with increases in skeletal muscle glycogen content. FEBS J (2013) 0.86
Multiple glycogen-binding sites in eukaryotic glycogen synthase are required for high catalytic efficiency toward glycogen. J Biol Chem (2011) 0.86
Myosin phosphatase isoforms as determinants of smooth muscle contractile function and calcium sensitivity of force production. Microcirculation (2014) 0.85
Identification and functional characterization of a PP1-binding site in BRCA1. Biochem Biophys Res Commun (2007) 0.85
Maternal phosphatase inhibitor-2 is required for proper chromosome segregation and mitotic synchrony during Drosophila embryogenesis. Genetics (2008) 0.85
A new fluorescence-based method identifies protein phosphatases regulating lipid droplet metabolism. PLoS One (2010) 0.85
An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. J Neurosci (2013) 0.85
Protein phosphatase 1α interacting proteins in the human brain. OMICS (2012) 0.85
The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function. PLoS One (2009) 0.85
Physiological performance and differential expression profiling of genes associated with drought tolerance in contrasting varieties of two Gossypium species. Protoplasma (2014) 0.85
Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. PLoS One (2011) 0.84
Complex phosphatase regulation of Ca2+-activated Cl- currents in pulmonary arterial smooth muscle cells. J Biol Chem (2009) 0.84
The Polycomb group protein EZH2 directly controls DNA methylation. Nature (2005) 13.67
Docking motif-guided mapping of the interactome of protein phosphatase-1. Chem Biol (2009) 2.17
NPP-type ectophosphodiesterases: unity in diversity. Trends Biochem Sci (2005) 2.08
False-positive detection of recombinant human erythropoietin in urine following strenuous physical exercise. Blood (2006) 2.06
Structural basis of substrate discrimination and integrin binding by autotaxin. Nat Struct Mol Biol (2011) 1.81
Degeneracy and function of the ubiquitous RVXF motif that mediates binding to protein phosphatase-1. J Biol Chem (2003) 1.72
PP1/Repo-man dephosphorylates mitotic histone H3 at T3 and regulates chromosomal aurora B targeting. Curr Biol (2011) 1.63
Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. J Biol Chem (2003) 1.46
Protein phosphatase 1 regulates the histone code for long-term memory. J Neurosci (2009) 1.44
Substrate specificity and activity regulation of protein kinase MELK. J Biol Chem (2005) 1.43
Testing for recombinant erythropoietin. Am J Hematol (2008) 1.39
The PP1 binding code: a molecular-lego strategy that governs specificity. FEBS J (2012) 1.38
The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site. FEBS Lett (2003) 1.38
Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing. Hum Mol Genet (2007) 1.33
Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D. J Cell Sci (2005) 1.28
Interactor-mediated nuclear translocation and retention of protein phosphatase-1. J Biol Chem (2004) 1.25
Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. Bioessays (2002) 1.22
Protein phosphatase-1 dephosphorylates the C-terminal domain of RNA polymerase-II. J Biol Chem (2002) 1.14
Nuclear protein phosphatase-1 regulates HIV-1 transcription. J Biol Chem (2003) 1.12
Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts. PLoS One (2010) 1.12
Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. J Biol Chem (2002) 1.11
Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein. J Biol Chem (2005) 1.10
Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 affects its binding activity and deregulates pre-mRNA splicing. J Biol Chem (2010) 1.09
Substrate-specifying determinants of the nucleotide pyrophosphatases/phosphodiesterases NPP1 and NPP2. Biochem J (2004) 1.08
Modulation of purinergic signaling by NPP-type ectophosphodiesterases. Purinergic Signal (2006) 1.07
Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells. Endocrinology (2006) 1.07
Spindle checkpoint silencing: PP1 tips the balance. Curr Biol (2011) 1.07
Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). J Biol Chem (2009) 1.07
Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175. PLoS One (2011) 1.06
Protein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor. Biochem J (2007) 1.05
Retracted Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells. J Biol Chem (2013) 1.04
An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D. J Biol Chem (2007) 1.04
A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3. Biochemistry (2007) 1.04
Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1. J Biol Chem (2002) 1.03
Aurora B defines its own chromosomal targeting by opposing the recruitment of the phosphatase scaffold Repo-Man. Curr Biol (2013) 1.02
Expression of a protein phosphatase 1 inhibitor, cdNIPP1, increases CDK9 threonine 186 phosphorylation and inhibits HIV-1 transcription. J Biol Chem (2010) 1.02
A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents. FEBS J (2005) 1.01
Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells. Cancer Lett (2009) 1.00
PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner. Biochem J (2005) 0.96
SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. Biochem J (2004) 0.95
Functional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/phosphodiesterase NPP1. Biochem J (2003) 0.95
4D-networking by mitotic phosphatases. Curr Opin Cell Biol (2013) 0.95
CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90. Retrovirology (2012) 0.95
The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. Structure (2012) 0.94
YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7. J Biol Chem (2006) 0.94
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle. Biochem J (2013) 0.94
Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin. J Biol Chem (2009) 0.93
Sperm PP1gamma2 is regulated by a homologue of the yeast protein phosphatase binding protein sds22. Biol Reprod (2002) 0.93
Challenges and opportunities in the development of protein phosphatase-directed therapeutics. ACS Chem Biol (2012) 0.91
The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly. J Biol Chem (2002) 0.90
The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets. Nucleic Acids Res (2010) 0.89
Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA. J Biol Chem (2011) 0.89
The KH-Tudor domain of a-kinase anchoring protein 149 mediates RNA-dependent self-association. Biochemistry (2006) 0.88
C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1. Nucleic Acids Res (2011) 0.88
Nucleocytoplasmic shuttling of the splicing factor SIPP1. J Biol Chem (2005) 0.87
Structure of NPP1, an ectonucleotide pyrophosphatase/phosphodiesterase involved in tissue calcification. Structure (2012) 0.87
The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α. Biochem J (2012) 0.87
The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation. Mol Cell Biol (2004) 0.87
AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase. J Cell Sci (2003) 0.86
Characterization of the condensin component Cnap1 and protein kinase Melk as novel E2F target genes down-regulated by 1,25-dihydroxyvitamin D3. J Biol Chem (2005) 0.86
The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor. J Biol Chem (2003) 0.86
Regulation of protein phosphatase 1gamma activity in hypoxia through increased interaction with NIPP1: implications for cellular metabolism. J Cell Physiol (2006) 0.85
Growth inhibition properties of the putative prostate cancer biomarkers PSP94 and CRISP-3. Asian J Androl (2010) 0.85
Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway. FEBS Lett (2012) 0.84
A role for PP1/NIPP1 in steering migration of human cancer cells. PLoS One (2012) 0.84
Methylation of PITX2, HOXD3, RASSF1 and TDRD1 predicts biochemical recurrence in high-risk prostate cancer. J Cancer Res Clin Oncol (2014) 0.84
NIPP1 maintains EZH2 phosphorylation and promoter occupancy at proliferation-related target genes. Nucleic Acids Res (2012) 0.83
Development of a peptide that selectively activates protein phosphatase-1 in living cells. Angew Chem Int Ed Engl (2012) 0.82
The translation initiation factor eIF2beta is an interactor of protein phosphatase-1. Biochem J (2006) 0.82
Determinants of the nucleolar targeting of protein phosphatase-1. FEBS Lett (2005) 0.82
The transcriptional repression by NIPP1 is mediated by Polycomb group proteins. Biochim Biophys Acta (2007) 0.79
Interactor-guided dephosphorylation by protein phosphatase-1. Methods Mol Biol (2013) 0.78
Chemical activators of protein phosphatase-1 induce calcium release inside intact cells. Chem Biol (2013) 0.78
Nature of the nuclear inclusions formed by PQBP1, a protein linked to neurodegenerative polyglutamine diseases. Eur J Cell Biol (2008) 0.78
Approaches to defining the ancestral eukaryotic protein complexome. Bioessays (2006) 0.77
Endogenous regulators of protein phosphatase-1 during mouse oocyte development and meiosis. Reproduction (2004) 0.77
A tighter RVxF motif makes a finer Sift. Chem Biol (2006) 0.76
Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells. J Biol Chem (2017) 0.75
Correction: Biogenesis and activity regulation of protein phosphatase 1. Biochem Soc Trans (2017) 0.75
Validation of interactions with protein phosphatase-1. Methods Enzymol (2003) 0.75