Published in Biochem J on July 01, 2004
Cellular function and molecular structure of ecto-nucleotidases. Purinergic Signal (2012) 2.13
Crystal structure of autotaxin and insight into GPCR activation by lipid mediators. Nat Struct Mol Biol (2011) 1.87
Structural basis of substrate discrimination and integrin binding by autotaxin. Nat Struct Mol Biol (2011) 1.81
Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis. J Biol Chem (2009) 1.78
Specificity of the ecto-ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases. Br J Pharmacol (2007) 1.55
Therapeutic potential of autotaxin/lysophospholipase d inhibitors. Curr Drug Targets (2008) 1.27
Physiologic and pathologic functions of the NPP nucleotide pyrophosphatase/phosphodiesterase family focusing on NPP1 in calcification. Purinergic Signal (2006) 1.12
Lysophospholipid interactions with protein targets. Biochim Biophys Acta (2008) 1.08
Modulation of purinergic signaling by NPP-type ectophosphodiesterases. Purinergic Signal (2006) 1.07
Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling. Proc Natl Acad Sci U S A (2012) 1.05
Autotaxin (ATX): a multi-functional and multi-modular protein possessing enzymatic lysoPLD activity and matricellular properties. Biochim Biophys Acta (2008) 1.04
Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity. Biochem J (2006) 0.95
Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin. J Biol Chem (2009) 0.93
Functional studies of human intestinal alkaline sphingomyelinase by deglycosylation and mutagenesis. Biochem J (2005) 0.89
Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression. J Lipid Res (2015) 0.80
ENPP1 processes protein ADP-ribosylation in vitro. FEBS J (2016) 0.77
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Novel point mutations attenuate autotaxin activity. Lipids Health Dis (2009) 0.75
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J Cell Biol (2002) 5.52
Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J Biol Chem (2002) 3.53
Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet (1998) 2.77
Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/phosphodiesterase family. Biochim Biophys Acta (2003) 2.00
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Autotaxin (NPP-2), a metastasis-enhancing motogen, is an angiogenic factor. Cancer Res (2001) 1.73
Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases. J Biol Chem (2001) 1.67
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Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity. J Biol Chem (2003) 1.39
The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site. FEBS Lett (2003) 1.38
Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family. J Biol Chem (2003) 1.28
Lysophospholipids in the limelight: autotaxin takes center stage. J Cell Biol (2002) 1.17
Site-directed mutations in the tumor-associated cytokine, autotaxin, eliminate nucleotide phosphodiesterase, lysophospholipase D, and motogenic activities. Cancer Res (2003) 1.03
Functional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/phosphodiesterase NPP1. Biochem J (2003) 0.95
Threonine autophosphorylation and nucleotidylation of the hepatic membrane protein PC-1. Eur J Biochem (1996) 0.91
Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain. Biochem Biophys Res Commun (2003) 0.88
The Polycomb group protein EZH2 directly controls DNA methylation. Nature (2005) 13.67
Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol Rev (2004) 3.82
Transportin-SR2 imports HIV into the nucleus. Curr Biol (2008) 2.35
Docking motif-guided mapping of the interactome of protein phosphatase-1. Chem Biol (2009) 2.17
Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus. J Virol (2006) 2.09
NPP-type ectophosphodiesterases: unity in diversity. Trends Biochem Sci (2005) 2.08
False-positive detection of recombinant human erythropoietin in urine following strenuous physical exercise. Blood (2006) 2.06
Long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy. J Gene Med (2013) 2.02
Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication. J Virol (2006) 1.82
Structural basis of substrate discrimination and integrin binding by autotaxin. Nat Struct Mol Biol (2011) 1.81
Degeneracy and function of the ubiquitous RVXF motif that mediates binding to protein phosphatase-1. J Biol Chem (2003) 1.72
PP1/Repo-man dephosphorylates mitotic histone H3 at T3 and regulates chromosomal aurora B targeting. Curr Biol (2011) 1.63
Highly efficient multicistronic lentiviral vectors with peptide 2A sequences. Hum Gene Ther (2009) 1.54
Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. J Biol Chem (2003) 1.46
Protein phosphatase 1 regulates the histone code for long-term memory. J Neurosci (2009) 1.44
Substrate specificity and activity regulation of protein kinase MELK. J Biol Chem (2005) 1.43
Comparison of lentiviral vector titration methods. BMC Biotechnol (2006) 1.42
Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV. PLoS Pathog (2007) 1.41
Testing for recombinant erythropoietin. Am J Hematol (2008) 1.39
Upscaling of lentiviral vector production by tangential flow filtration. J Gene Med (2005) 1.38
The PP1 binding code: a molecular-lego strategy that governs specificity. FEBS J (2012) 1.38
The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site. FEBS Lett (2003) 1.38
Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing. Hum Mol Genet (2007) 1.33
Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ. J Biol Chem (2009) 1.30
Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D. J Cell Sci (2005) 1.28
The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites. Cell Rep (2013) 1.26
Interactor-mediated nuclear translocation and retention of protein phosphatase-1. J Biol Chem (2004) 1.25
LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs. PLoS Pathog (2012) 1.25
Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. Bioessays (2002) 1.22
LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions. Retrovirology (2013) 1.17
Interplay between HIV entry and transportin-SR2 dependency. Retrovirology (2011) 1.17
Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75. J Mol Biol (2007) 1.14
Protein phosphatase-1 dephosphorylates the C-terminal domain of RNA polymerase-II. J Biol Chem (2002) 1.14
Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts. PLoS One (2010) 1.12
Nuclear protein phosphatase-1 regulates HIV-1 transcription. J Biol Chem (2003) 1.12
Noninvasive monitoring of long-term lentiviral vector-mediated gene expression in rodent brain with bioluminescence imaging. Mol Ther (2006) 1.11
Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. J Biol Chem (2002) 1.11
Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein. J Biol Chem (2005) 1.10
Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 affects its binding activity and deregulates pre-mRNA splicing. J Biol Chem (2010) 1.09
High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region. Nucleic Acids Res (2010) 1.08
The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering. Nucleic Acids Res (2010) 1.08
Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells. Endocrinology (2006) 1.07
Modulation of purinergic signaling by NPP-type ectophosphodiesterases. Purinergic Signal (2006) 1.07
Spindle checkpoint silencing: PP1 tips the balance. Curr Biol (2011) 1.07
Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). J Biol Chem (2009) 1.07
Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175. PLoS One (2011) 1.06
Protein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor. Biochem J (2007) 1.05
Retracted Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells. J Biol Chem (2013) 1.04
Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75. Mol Cancer Res (2008) 1.04
A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3. Biochemistry (2007) 1.04
An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D. J Biol Chem (2007) 1.04
Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1. J Biol Chem (2002) 1.03
Clinical impact of trabectedin (ecteinascidin-743) in advanced/metastatic soft tissue sarcoma. Expert Opin Pharmacother (2008) 1.02
Aurora B defines its own chromosomal targeting by opposing the recruitment of the phosphatase scaffold Repo-Man. Curr Biol (2013) 1.02
High efficacy of panobinostat towards human gastrointestinal stromal tumors in a xenograft mouse model. Clin Cancer Res (2009) 1.02
Expression of a protein phosphatase 1 inhibitor, cdNIPP1, increases CDK9 threonine 186 phosphorylation and inhibits HIV-1 transcription. J Biol Chem (2010) 1.02
A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents. FEBS J (2005) 1.01
Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells. Cancer Lett (2009) 1.00
State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations. Curr Gene Ther (2009) 1.00
Noninvasive and quantitative monitoring of adult neuronal stem cell migration in mouse brain using bioluminescence imaging. Stem Cells (2008) 0.99
Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease. Mol Ther (2006) 0.99
miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors. J Cell Biol (2011) 0.99
Single-cell imaging of HIV-1 provirus (SCIP). Proc Natl Acad Sci U S A (2013) 0.98
Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression. AIDS (2011) 0.97
PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner. Biochem J (2005) 0.96
SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. Biochem J (2004) 0.95
CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90. Retrovirology (2012) 0.95
Functional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/phosphodiesterase NPP1. Biochem J (2003) 0.95
4D-networking by mitotic phosphatases. Curr Opin Cell Biol (2013) 0.95
YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7. J Biol Chem (2006) 0.94
The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. Structure (2012) 0.94
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle. Biochem J (2013) 0.94
HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells. Retrovirology (2012) 0.94
Immunohistochemical detection of transgene expression in the brain using small epitope tags. BMC Biotechnol (2010) 0.93
Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin. J Biol Chem (2009) 0.93
Sperm PP1gamma2 is regulated by a homologue of the yeast protein phosphatase binding protein sds22. Biol Reprod (2002) 0.93
The heat shock protein 90 inhibitor IPI-504 induces KIT degradation, tumor shrinkage, and cell proliferation arrest in xenograft models of gastrointestinal stromal tumors. Mol Cancer Ther (2011) 0.92
Challenges and opportunities in the development of protein phosphatase-directed therapeutics. ACS Chem Biol (2012) 0.91
PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway. Blood (2013) 0.90
The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly. J Biol Chem (2002) 0.90
Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells. Prostate (2011) 0.89
Trabectedin (ET-743): evaluation of its use in advanced soft-tissue sarcoma. Future Oncol (2007) 0.89
Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication. Mol Ther (2012) 0.89
Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA. J Biol Chem (2011) 0.89
The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets. Nucleic Acids Res (2010) 0.89
C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1. Nucleic Acids Res (2011) 0.88
Lens epithelium-derived growth factor/p75 qualifies as a target for HIV gene therapy in the NSG mouse model. Mol Ther (2012) 0.88
The KH-Tudor domain of a-kinase anchoring protein 149 mediates RNA-dependent self-association. Biochemistry (2006) 0.88
The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α. Biochem J (2012) 0.87
Nucleocytoplasmic shuttling of the splicing factor SIPP1. J Biol Chem (2005) 0.87