Published in ACS Chem Biol on December 20, 2012
Signalling scaffolds and local organization of cellular behaviour. Nat Rev Mol Cell Biol (2015) 1.35
Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation. Cell Host Microbe (2014) 0.98
Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration. J Biol Chem (2014) 0.84
The Basic Biology of PP2A in Hematologic Cells and Malignancies. Front Oncol (2014) 0.83
Viewing serine/threonine protein phosphatases through the eyes of drug designers. FEBS J (2013) 0.81
Hydroxyindole carboxylic acid-based inhibitors for receptor-type protein tyrosine protein phosphatase beta. Antioxid Redox Signal (2014) 0.78
Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor. Org Biomol Chem (2016) 0.75
Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays. PLoS One (2015) 0.75
Harnessing the Electric Spark of Life to Cure Skin Wounds. Adv Wound Care (New Rochelle) (2014) 0.75
Moving Beyond Active-Site Detection: MixMD Applied to Allosteric Systems. J Phys Chem B (2016) 0.75
Bacterial-like PPP protein phosphatases: novel sequence alterations in pathogenic eukaryotes and peculiar features of bacterial sequence similarity. Plant Signal Behav (2013) 0.75
Modulation of VEGF receptor 2 signaling by protein phosphatases. Pharmacol Res (2016) 0.75
Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases. Front Pharmacol (2015) 0.75
The Polycomb group protein EZH2 directly controls DNA methylation. Nature (2005) 13.67
Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol Rev (2004) 3.82
Docking motif-guided mapping of the interactome of protein phosphatase-1. Chem Biol (2009) 2.17
NPP-type ectophosphodiesterases: unity in diversity. Trends Biochem Sci (2005) 2.08
False-positive detection of recombinant human erythropoietin in urine following strenuous physical exercise. Blood (2006) 2.06
Structural basis of substrate discrimination and integrin binding by autotaxin. Nat Struct Mol Biol (2011) 1.81
Degeneracy and function of the ubiquitous RVXF motif that mediates binding to protein phosphatase-1. J Biol Chem (2003) 1.72
PP1/Repo-man dephosphorylates mitotic histone H3 at T3 and regulates chromosomal aurora B targeting. Curr Biol (2011) 1.63
Azide-alkyne coupling: a powerful reaction for bioconjugate chemistry. Chembiochem (2003) 1.46
Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. J Biol Chem (2003) 1.46
Protein phosphatase 1 regulates the histone code for long-term memory. J Neurosci (2009) 1.44
Substrate specificity and activity regulation of protein kinase MELK. J Biol Chem (2005) 1.43
Testing for recombinant erythropoietin. Am J Hematol (2008) 1.39
The PP1 binding code: a molecular-lego strategy that governs specificity. FEBS J (2012) 1.38
The hydrolysis of lysophospholipids and nucleotides by autotaxin (NPP2) involves a single catalytic site. FEBS Lett (2003) 1.38
Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B. ACS Chem Biol (2009) 1.33
Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing. Hum Mol Genet (2007) 1.33
Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D. J Cell Sci (2005) 1.28
Interactor-mediated nuclear translocation and retention of protein phosphatase-1. J Biol Chem (2004) 1.25
Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. Bioessays (2002) 1.22
Protein phosphatase-1 dephosphorylates the C-terminal domain of RNA polymerase-II. J Biol Chem (2002) 1.14
Nuclear protein phosphatase-1 regulates HIV-1 transcription. J Biol Chem (2003) 1.12
Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts. PLoS One (2010) 1.12
Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. J Biol Chem (2002) 1.11
Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein. J Biol Chem (2005) 1.10
Diels-Alder ligation and surface immobilization of proteins. Angew Chem Int Ed Engl (2005) 1.10
Molecular mechanisms of the PRL phosphatases. FEBS J (2012) 1.09
Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 affects its binding activity and deregulates pre-mRNA splicing. J Biol Chem (2010) 1.09
Substrate-specifying determinants of the nucleotide pyrophosphatases/phosphodiesterases NPP1 and NPP2. Biochem J (2004) 1.08
Modulation of purinergic signaling by NPP-type ectophosphodiesterases. Purinergic Signal (2006) 1.07
Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells. Endocrinology (2006) 1.07
Spindle checkpoint silencing: PP1 tips the balance. Curr Biol (2011) 1.07
Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). J Biol Chem (2009) 1.07
Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175. PLoS One (2011) 1.06
Protein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor. Biochem J (2007) 1.05
Retracted Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells. J Biol Chem (2013) 1.04
A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3. Biochemistry (2007) 1.04
An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D. J Biol Chem (2007) 1.04
Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1. J Biol Chem (2002) 1.03
Aurora B defines its own chromosomal targeting by opposing the recruitment of the phosphatase scaffold Repo-Man. Curr Biol (2013) 1.02
Expression of a protein phosphatase 1 inhibitor, cdNIPP1, increases CDK9 threonine 186 phosphorylation and inhibits HIV-1 transcription. J Biol Chem (2010) 1.02
A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents. FEBS J (2005) 1.01
The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides. Biochemistry (2011) 1.00
Rapid clearance of the circulating metastatic factor autotaxin by the scavenger receptors of liver sinusoidal endothelial cells. Cancer Lett (2009) 1.00
Site-selective protein immobilization by Staudinger ligation. Angew Chem Int Ed Engl (2006) 1.00
PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner. Biochem J (2005) 0.96
SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1. Biochem J (2004) 0.95
CDK2 regulates HIV-1 transcription by phosphorylation of CDK9 on serine 90. Retrovirology (2012) 0.95
Functional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/phosphodiesterase NPP1. Biochem J (2003) 0.95
4D-networking by mitotic phosphatases. Curr Opin Cell Biol (2013) 0.95
Photochemical surface patterning by the thiol-ene reaction. Angew Chem Int Ed Engl (2008) 0.94
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle. Biochem J (2013) 0.94
YPI1 and SDS22 proteins regulate the nuclear localization and function of yeast type 1 phosphatase Glc7. J Biol Chem (2006) 0.94
The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme. Structure (2012) 0.94
Sperm PP1gamma2 is regulated by a homologue of the yeast protein phosphatase binding protein sds22. Biol Reprod (2002) 0.93
Elucidating human phosphatase-substrate networks. Sci Signal (2013) 0.93
Domain interplay mediated by an essential disulfide linkage is critical for the activity and secretion of the metastasis-promoting enzyme autotaxin. J Biol Chem (2009) 0.93
The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly. J Biol Chem (2002) 0.90
Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA. J Biol Chem (2011) 0.89
The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets. Nucleic Acids Res (2010) 0.89
Dual-specificity phosphatases as molecular targets for inhibition in human disease. Antioxid Redox Signal (2014) 0.88
C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1. Nucleic Acids Res (2011) 0.88
The KH-Tudor domain of a-kinase anchoring protein 149 mediates RNA-dependent self-association. Biochemistry (2006) 0.88
A generic building block for C- and N-terminal protein-labeling and protein-immobilization. Bioorg Med Chem (2006) 0.88
Nucleocytoplasmic shuttling of the splicing factor SIPP1. J Biol Chem (2005) 0.87
Structure of NPP1, an ectonucleotide pyrophosphatase/phosphodiesterase involved in tissue calcification. Structure (2012) 0.87
The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α. Biochem J (2012) 0.87
The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation. Mol Cell Biol (2004) 0.87
AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase. J Cell Sci (2003) 0.86
Characterization of the condensin component Cnap1 and protein kinase Melk as novel E2F target genes down-regulated by 1,25-dihydroxyvitamin D3. J Biol Chem (2005) 0.86
The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor. J Biol Chem (2003) 0.86
Regulation of protein phosphatase 1gamma activity in hypoxia through increased interaction with NIPP1: implications for cellular metabolism. J Cell Physiol (2006) 0.85
Growth inhibition properties of the putative prostate cancer biomarkers PSP94 and CRISP-3. Asian J Androl (2010) 0.85
Glucose-dependent regulation of AMP-activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway. FEBS Lett (2012) 0.84
A role for PP1/NIPP1 in steering migration of human cancer cells. PLoS One (2012) 0.84
Methylation of PITX2, HOXD3, RASSF1 and TDRD1 predicts biochemical recurrence in high-risk prostate cancer. J Cancer Res Clin Oncol (2014) 0.84
NIPP1 maintains EZH2 phosphorylation and promoter occupancy at proliferation-related target genes. Nucleic Acids Res (2012) 0.83
The translation initiation factor eIF2beta is an interactor of protein phosphatase-1. Biochem J (2006) 0.82
Development of a peptide that selectively activates protein phosphatase-1 in living cells. Angew Chem Int Ed Engl (2012) 0.82
Determinants of the nucleolar targeting of protein phosphatase-1. FEBS Lett (2005) 0.82
Targeting the untargetable: recent advances in the selective chemical modulation of protein phosphatase-1 activity. Curr Opin Chem Biol (2013) 0.81
Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells. ACS Chem Biol (2014) 0.81
Preparation of biomolecule microstructures and microarrays by thiol-ene photoimmobilization. Chembiochem (2010) 0.80
The transcriptional repression by NIPP1 is mediated by Polycomb group proteins. Biochim Biophys Acta (2007) 0.79
Interactor-guided dephosphorylation by protein phosphatase-1. Methods Mol Biol (2013) 0.78
Chemical activators of protein phosphatase-1 induce calcium release inside intact cells. Chem Biol (2013) 0.78
Nature of the nuclear inclusions formed by PQBP1, a protein linked to neurodegenerative polyglutamine diseases. Eur J Cell Biol (2008) 0.78
Endogenous regulators of protein phosphatase-1 during mouse oocyte development and meiosis. Reproduction (2004) 0.77
Approaches to defining the ancestral eukaryotic protein complexome. Bioessays (2006) 0.77
A tighter RVxF motif makes a finer Sift. Chem Biol (2006) 0.76
Simultaneous protein tagging in two colors. Chem Biol (2008) 0.75
Unnatural amino acid mutagenesis reveals dimerization as a negative regulatory mechanism of VHR's phosphatase activity. ACS Chem Biol (2014) 0.75
Validation of interactions with protein phosphatase-1. Methods Enzymol (2003) 0.75
Correction: Biogenesis and activity regulation of protein phosphatase 1. Biochem Soc Trans (2017) 0.75
Chemical biology techniques unlock the secrets of casein kinase 2 regulation by phosphorylation and glycosylation. Chembiochem (2012) 0.75