PubRank

Jürg Tschopp

Author PubWeight™ 329.43‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006 24.43
2 The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002 20.11
3 Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 2005 17.47
4 Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008 16.54
5 NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 2004 13.55
6 A role for mitochondria in NLRP3 inflammasome activation. Nature 2010 13.21
7 The inflammasomes: guardians of the body. Annu Rev Immunol 2009 12.89
8 Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003 11.07
9 Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol 2009 9.24
10 Intracellular pattern recognition receptors in the host response. Nature 2006 8.04
11 The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol 2007 6.81
12 Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med 2009 6.73
13 Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004 6.06
14 RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol 2004 5.74
15 Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 2009 5.00
16 Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol 2004 4.89
17 A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res Ther 2007 4.65
18 The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 2004 4.17
19 NLRs join TLRs as innate sensors of pathogens. Trends Immunol 2005 4.12
20 Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 2011 3.97
21 Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J Immunol 2008 3.66
22 Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity 2012 3.51
23 PIDD mediates NF-kappaB activation in response to DNA damage. Cell 2005 3.48
24 The molecular architecture of the TNF superfamily. Trends Biochem Sci 2002 3.39
25 Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med 2003 3.24
26 Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol Cell 2006 3.23
27 Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem 2006 3.20
28 CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation. Nat Immunol 2002 3.16
29 The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem 2002 2.75
30 Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J Biol Chem 2006 2.75
31 Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol 2007 2.73
32 A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat Immunol 2007 2.68
33 T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature 2009 2.59
34 Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum 2002 2.58
35 The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci 2005 2.56
36 cFLIP regulation of lymphocyte activation and development. Nat Rev Immunol 2006 2.53
37 Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex. Mol Cell Biol 2003 2.50
38 Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med 2009 2.45
39 Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity 2003 2.41
40 TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity 2008 2.37
41 Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity 2004 2.36
42 Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome. Curr Biol 2009 2.34
43 Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol Cell Biol 2006 2.33
44 Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol 2008 2.32
45 Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome. PLoS Pathog 2009 2.24
46 NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. Structure 2003 2.15
47 N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway. Mol Cell Biol 2004 2.11
48 Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β. Proc Natl Acad Sci U S A 2010 2.09
49 Identification of proteoglycans as the APRIL-specific binding partners. J Exp Med 2005 2.03
50 Caspase-independent cell death in T lymphocytes. Nat Immunol 2003 1.99
51 NALP inflammasomes: a central role in innate immunity. Semin Immunopathol 2007 1.91
52 Type I IFN controls chikungunya virus via its action on nonhematopoietic cells. J Exp Med 2010 1.86
53 TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. Blood 2007 1.85
54 Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol 2009 1.74
55 Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. EMBO J 2006 1.74
56 DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep 2009 1.72
57 NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells. Nat Immunol 2012 1.62
58 Differential expression of NLRP3 among hematopoietic cells. J Immunol 2011 1.60
59 The inflammasome. Curr Biol 2005 1.58
60 New insights into the mechanism of IL-1beta maturation. Curr Opin Immunol 2003 1.54
61 The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia. J Immunol 2011 1.54
62 Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation. Curr Biol 2002 1.50
63 Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses. Proc Natl Acad Sci U S A 2010 1.50
64 Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling. J Immunol 2010 1.43
65 The role of interleukin-1 and the inflammasome in gout: implications for therapy. Arthritis Rheum 2007 1.39
66 The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes. Mol Cell Biol 2002 1.36
67 Structure of the PRYSPRY-domain: implications for autoinflammatory diseases. FEBS Lett 2005 1.36
68 TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1. Trends Immunol 2003 1.32
69 BAFF is a survival and maturation factor for mouse B cells. Eur J Immunol 2002 1.31
70 BAFF production by antigen-presenting cells provides T cell co-stimulation. Int Immunol 2004 1.29
71 The role of potassium in inflammasome activation by bacteria. J Biol Chem 2010 1.29
72 RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis. EMBO Rep 2002 1.23
73 From inflammasomes to fevers, crystals and hypertension: how basic research explains inflammatory diseases. Trends Mol Med 2007 1.20
74 The role of the inflammasome in nonmyeloid cells. J Clin Immunol 2010 1.18
75 Intracellular trafficking of interleukin-1 receptor I requires Tollip. Curr Biol 2006 1.18
76 BAFF and the regulation of B cell survival. Immunol Lett 2003 1.18
77 Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis. Eur J Immunol 2011 1.18
78 Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes. Mol Cell 2012 1.17
79 Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system. Hepatology 2010 1.15
80 NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells. J Immunol 2012 1.14
81 The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF. Eur J Immunol 2004 1.08
82 Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization. J Immunol 2008 1.08
83 Protein-based therapeutic approaches targeting death receptors. Cell Death Differ 2003 1.08
84 Defective death receptor signaling as a cause of tumor immune escape. Semin Cancer Biol 2002 1.04
85 Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages. Eur J Immunol 2010 1.02
86 Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8. J Immunol 2005 1.01
87 The mycobacterial cord factor adjuvant analogue trehalose-6,6'-dibehenate (TDB) activates the Nlrp3 inflammasome. Immunobiology 2012 0.96
88 NALP3 is not necessary for early protection against experimental tuberculosis. Immunobiology 2010 0.94
89 Intracellular localization of keratinocyte Fas ligand explains lack of cytolytic activity under physiological conditions. J Biol Chem 2002 0.94
90 Cellular FLIP long form-transgenic mice manifest a Th2 cytokine bias and enhanced allergic airway inflammation. J Immunol 2004 0.93
91 Intracellular pattern-recognition receptors. Adv Drug Deliv Rev 2007 0.92
92 NLRP3 suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases. Cancer Res 2012 0.92
93 NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma. Immunol Cell Biol 2012 0.91
94 Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling. FEBS Lett 2002 0.89
95 Expression level of c-FLIP versus Fas determines susceptibility to Fas ligand-induced cell death in murine thymoma EL-4 cells. Exp Cell Res 2002 0.87
96 Ubiquitination of the Epstein-Barr virus-encoded latent membrane protein 1 depends on the integrity of the TRAF binding site. Oncogene 2003 0.86
97 DEteCTINg fungal pathogens. Nat Immunol 2007 0.84
98 IRAK2 takes its place in TLR signaling. Nat Immunol 2008 0.84
99 The combination of chemotherapy and intraperitoneal MegaFas Ligand improves treatment of ovarian carcinoma. Gynecol Oncol 2007 0.81
100 Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells. J Virol 2010 0.79
101 NLRX1: friend or foe? EMBO Rep 2008 0.78
102 Bcl10. Curr Biol 2002 0.77
103 Viruses under the control of RIP kinases. Cell Cycle 2010 0.75
104 Innate immunity. Curr Opin Immunol 2010 0.75