Published in J Immunol on July 01, 2005
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Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature (2006) 24.43
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Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature (2005) 17.47
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science (2008) 16.54
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity (2004) 13.55
A role for mitochondria in NLRP3 inflammasome activation. Nature (2010) 13.21
The inflammasomes: guardians of the body. Annu Rev Immunol (2009) 12.89
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell (2003) 11.07
Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol (2009) 9.24
Intracellular pattern recognition receptors in the host response. Nature (2006) 8.04
The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol (2007) 6.81
Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73
Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell (2004) 6.06
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol (2004) 5.74
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature (2009) 5.00
Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol (2004) 4.89
A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res Ther (2007) 4.65
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science (2004) 4.17
NLRs join TLRs as innate sensors of pathogens. Trends Immunol (2005) 4.12
Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity (2011) 3.97
Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J Immunol (2008) 3.66
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity (2012) 3.51
PIDD mediates NF-kappaB activation in response to DNA damage. Cell (2005) 3.48
The molecular architecture of the TNF superfamily. Trends Biochem Sci (2002) 3.39
Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med (2003) 3.24
Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol Cell (2006) 3.23
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem (2006) 3.20
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation. Nat Immunol (2002) 3.16
The CD95 receptor: apoptosis revisited. Cell (2007) 3.13
The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem (2002) 2.75
Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J Biol Chem (2006) 2.75
Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol (2007) 2.73
A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat Immunol (2007) 2.68
Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity. Immunity (2008) 2.62
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature (2009) 2.59
Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum (2002) 2.58
The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci (2005) 2.56
cFLIP regulation of lymphocyte activation and development. Nat Rev Immunol (2006) 2.53
Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex. Mol Cell Biol (2003) 2.50
Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell (2007) 2.48
Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med (2009) 2.45
Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity (2003) 2.41
TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity (2008) 2.37
Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity (2004) 2.36
Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome. Curr Biol (2009) 2.34
Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol Cell Biol (2006) 2.33
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol (2008) 2.32
Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome. PLoS Pathog (2009) 2.24
NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. Structure (2003) 2.15
N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway. Mol Cell Biol (2004) 2.11
Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β. Proc Natl Acad Sci U S A (2010) 2.09
Identification of proteoglycans as the APRIL-specific binding partners. J Exp Med (2005) 2.03
Caspase-independent cell death in T lymphocytes. Nat Immunol (2003) 1.99
NALP inflammasomes: a central role in innate immunity. Semin Immunopathol (2007) 1.91
Type I IFN controls chikungunya virus via its action on nonhematopoietic cells. J Exp Med (2010) 1.86
TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts. Blood (2007) 1.85
Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol (2009) 1.74
Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. EMBO J (2006) 1.74
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep (2009) 1.72
NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells. Nat Immunol (2012) 1.62
Differential expression of NLRP3 among hematopoietic cells. J Immunol (2011) 1.60
The inflammasome. Curr Biol (2005) 1.58
New insights into the mechanism of IL-1beta maturation. Curr Opin Immunol (2003) 1.54
The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia. J Immunol (2011) 1.54
Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation. J Immunol (2005) 1.51
Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation. Curr Biol (2002) 1.50
Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses. Proc Natl Acad Sci U S A (2010) 1.50
Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling. J Immunol (2010) 1.43
Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas. J Cell Biol (2009) 1.42
Morphological and cytochemical determination of cell death by apoptosis. Histochem Cell Biol (2007) 1.42
The role of interleukin-1 and the inflammasome in gout: implications for therapy. Arthritis Rheum (2007) 1.39
The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes. Mol Cell Biol (2002) 1.36
Structure of the PRYSPRY-domain: implications for autoinflammatory diseases. FEBS Lett (2005) 1.36
TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1. Trends Immunol (2003) 1.32
Inhibition of apoptosis and caspase-3 in vascular smooth muscle cells by plasminogen activator inhibitor type-1. J Cell Biochem (2004) 1.31
BAFF is a survival and maturation factor for mouse B cells. Eur J Immunol (2002) 1.31
BAFF production by antigen-presenting cells provides T cell co-stimulation. Int Immunol (2004) 1.29
The role of potassium in inflammasome activation by bacteria. J Biol Chem (2010) 1.29
RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis. EMBO Rep (2002) 1.23
Gammadelta T cells promote a Th1 response during coxsackievirus B3 infection in vivo: role of Fas and Fas ligand. J Virol (2002) 1.22
From inflammasomes to fevers, crystals and hypertension: how basic research explains inflammatory diseases. Trends Mol Med (2007) 1.20
The role of the inflammasome in nonmyeloid cells. J Clin Immunol (2010) 1.18
Intracellular trafficking of interleukin-1 receptor I requires Tollip. Curr Biol (2006) 1.18
BAFF and the regulation of B cell survival. Immunol Lett (2003) 1.18
Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis. Eur J Immunol (2011) 1.18
Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes. Mol Cell (2012) 1.17
Augmentation of proliferation of vascular smooth muscle cells by plasminogen activator inhibitor type 1. Arterioscler Thromb Vasc Biol (2006) 1.15
Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system. Hepatology (2010) 1.15
NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells. J Immunol (2012) 1.14
Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells. Proc Natl Acad Sci U S A (2007) 1.12
Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation. J Biol Chem (2007) 1.12
The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF. Eur J Immunol (2004) 1.08
Danger signaling through the inflammasome acts as a master switch between tolerance and sensitization. J Immunol (2008) 1.08
Protein-based therapeutic approaches targeting death receptors. Cell Death Differ (2003) 1.08