PubRank

Thomas S Scanlan

Author PubWeight™ 86.08‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein kinase C. J Neurosci 2003 2.73
2 A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis. J Neurosci 2006 2.40
3 Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest 2007 2.20
4 Thyronamines inhibit plasma membrane and vesicular monoamine transport. ACS Chem Biol 2007 1.91
5 Rapid nongenomic actions of thyroid hormone. Proc Natl Acad Sci U S A 2006 1.79
6 Polybrominated diphenyl ethers induce developmental neurotoxicity in a human in vitro model: evidence for endocrine disruption. Environ Health Perspect 2010 1.75
7 Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc Natl Acad Sci U S A 2005 1.52
8 Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J Med Chem 2006 1.52
9 Amphioxus postembryonic development reveals the homology of chordate metamorphosis. Curr Biol 2008 1.51
10 In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23 on rat liver, heart, and brain. Endocrinology 2011 1.50
11 Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine. Endocrinology 2003 1.42
12 Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res 2009 1.39
13 Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev 2006 1.34
14 Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function. FASEB J 2007 1.34
15 Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem 2002 1.28
16 Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury. Stroke 2007 1.23
17 Tissue distribution and cardiac metabolism of 3-iodothyronamine. Endocrinology 2010 1.22
18 Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc Natl Acad Sci U S A 2003 1.17
19 Toward deciphering the code to aminergic G protein-coupled receptor drug design. Chem Biol 2008 1.16
20 Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol 2007 1.08
21 Quantitative proteomics of the thyroid hormone receptor-coregulator interactions. J Biol Chem 2004 1.06
22 A thyroid hormone antagonist that inhibits thyroid hormone action in vivo. J Biol Chem 2002 1.05
23 Thyroid hormone receptor subtype specificity for hormone-dependent neurogenesis in Xenopus laevis. Dev Biol 2008 1.05
24 Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates. Rapid Commun Mass Spectrom 2008 1.05
25 Cardiac effects of trace amines: pharmacological characterization of trace amine-associated receptors. Eur J Pharmacol 2008 1.04
26 Differential effects of triiodothyronine and the thyroid hormone receptor beta-specific agonist GC-1 on thyroid hormone target genes in the b ain. Endocrinology 2003 1.04
27 Contribution of a membrane estrogen receptor to the estrogenic regulation of body temperature and energy homeostasis. Endocrinology 2010 1.04
28 Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology 2006 1.04
29 Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors. Environ Health Perspect 2005 1.04
30 Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1. J Med Chem 2007 1.03
31 Synthesis and biological evaluation of SERMs with potent nongenomic estrogenic activity. ChemMedChem 2006 1.03
32 Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice. J Neurosci Res 2010 1.03
33 Design and characterization of a thyroid hormone receptor alpha (TRalpha)-specific agonist. ACS Chem Biol 2006 1.01
34 Quantification of ligand-regulated nuclear receptor corepressor and coactivator binding, key interactions determining ligand potency and efficacy for the thyroid hormone receptor. Biochemistry 2008 0.98
35 Detection of 3-iodothyronamine in human patients: a preliminary study. J Clin Endocrinol Metab 2011 0.95
36 The proangiogenic action of thyroid hormone analogue GC-1 is initiated at an integrin. J Cardiovasc Pharmacol 2005 0.94
37 Validation of a liquid chromatography-tandem mass spectrometry method to enable quantification of 3-iodothyronamine from serum. J Chromatogr A 2008 0.94
38 Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist. Endocrinology 2002 0.93
39 Identification and characterization of 3-iodothyronamine intracellular transport. Endocrinology 2008 0.93
40 The T3 receptor beta1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes. Endocrinology 2010 0.92
41 Thyroid hormone reduces cholesterol via a non-LDL receptor-mediated pathway. Endocrinology 2012 0.92
42 Central effects of thyronamines on glucose metabolism in rats. J Endocrinol 2009 0.92
43 The thyroid hormone receptor beta-specific agonist GC-1 selectively affects the bone development of hypothyroid rats. J Bone Miner Res 2004 0.92
44 Iodothyronamines are oxidatively deaminated to iodothyroacetic acids in vivo. Chembiochem 2009 0.92
45 Thyroid hormone receptor-beta-selective agonist GC-24 spares skeletal muscle type I to II fiber shift. Cell Tissue Res 2005 0.92
46 Unliganded thyroid hormone receptor is essential for Xenopus laevis eye development. EMBO J 2006 0.92
47 Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1. Am J Physiol Endocrinol Metab 2003 0.92
48 Cardioprotective effect of 3-iodothyronamine in perfused rat heart subjected to ischemia and reperfusion. Cardiovasc Drugs Ther 2011 0.90
49 Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites. Bioorg Med Chem Lett 2008 0.90
50 Identification and quantification of 3-iodothyronamine metabolites in mouse serum using liquid chromatography-tandem mass spectrometry. J Chromatogr A 2012 0.89
51 Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone. Endocrinology 2004 0.88
52 Structural determinants of selective thyromimetics. J Med Chem 2003 0.88
53 Complex actions of thyroid hormone receptor antagonist NH-3 on gene promoters in different cell lines. Mol Cell Endocrinol 2008 0.87
54 Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared with prednisolone. J Pharmacol Exp Ther 2010 0.87
55 Induction of larval tissue resorption in Xenopus laevis tadpoles by the thyroid hormone receptor agonist GC-1. J Biol Chem 2004 0.87
56 The molecular basis of species-specific ligand activation of trace amine-associated receptor 1 (TAAR(1)). ACS Chem Biol 2009 0.86
57 Design of thyroid hormone receptor antagonists from first principles. J Steroid Biochem Mol Biol 2002 0.86
58 Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands. Bioorg Med Chem Lett 2004 0.85
59 Characterization of thyroid hormone receptor alpha (TRalpha)-specific analogs with varying inner- and outer-ring substituents. Bioorg Med Chem 2007 0.85
60 Endogenous 3-iodothyronamine (T1AM): more than we bargained for. J Clin Endocrinol Metab 2011 0.84
61 Modulation of cardiac ionic homeostasis by 3-iodothyronamine. J Cell Mol Med 2009 0.83
62 3-Iodothyronamine metabolism and functional effects in FRTL5 thyroid cells. J Mol Endocrinol 2011 0.82
63 Does the aromatic L-amino acid decarboxylase contribute to thyronamine biosynthesis? Mol Cell Endocrinol 2011 0.82
64 Differential response of estrogen receptor subtypes to 1,3-diarylindene and 2,3-diarylindene ligands. J Med Chem 2005 0.82
65 Analysis of thyroid hormone receptor betaA mRNA expression in Xenopus laevis tadpoles as a means to detect agonism and antagonism of thyroid hormone action. Toxicol Appl Pharmacol 2005 0.82
66 Aberrant maturation of astrocytes in thyroid hormone receptor alpha 1 knockout mice reveals an interplay between thyroid hormone receptor isoforms. Endocrinology 2003 0.82
67 The thyroid hormone receptor-beta agonist GC-1 induces cell proliferation in rat liver and pancreas. Endocrinology 2006 0.81
68 3-Iodothyronamine (T(1)AM): a new chapter of thyroid hormone endocrinology? Mol Biosyst 2010 0.81
69 Hammett analysis of selective thyroid hormone receptor modulators reveals structural and electronic requirements for hormone antagonists. J Am Chem Soc 2005 0.81
70 Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine. Mol Biosyst 2010 0.81
71 Few things in life are "free": cellular uptake of steroid hormones by an active transport mechanism. Mol Interv 2005 0.81
72 Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives. Bioorg Med Chem 2002 0.80
73 Biosynthesis of 3-iodothyronamine (T1AM) is dependent on the sodium-iodide symporter and thyroperoxidase but does not involve extrathyroidal metabolism of T4. Endocrinology 2012 0.80
74 Pharmacological profile of the thyroid hormone receptor antagonist NH3 in rats. J Pharmacol Exp Ther 2007 0.80
75 ApoB-100-containing lipoproteins are major carriers of 3-iodothyronamine in circulation. J Biol Chem 2011 0.80
76 Selective thyroid hormone receptor modulators. Curr Top Med Chem 2003 0.79
77 The thyroid hormone receptor (TR) beta-selective agonist GC-1 inhibits proliferation but induces differentiation and TR beta mRNA expression in mouse and rat osteoblast-like cells. Calcif Tissue Int 2009 0.78
78 Binding and catalysis: a thermodynamic study on a catalytic antibody system. Chembiochem 2003 0.77
79 Direct hydroxide attack is a plausible mechanism for amidase antibody 43C9. J Comput Chem 2003 0.76
80 Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size. Endocrinology 2014 0.76
81 Effects of acute microinjections of the thyroid hormone derivative 3-iodothyronamine to the preoptic region of adult male rats on sleep, thermoregulation and motor activity. Horm Behav 2013 0.76
82 Differential effects of TR ligands on hormone dissociation rates: evidence for multiple ligand entry/exit pathways. J Steroid Biochem Mol Biol 2009 0.75
83 Albumin Regulates Induction of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) by 15-Deoxy-Δ12-14-Prostaglandin J2 in Vitro and May Be an Important Regulator of PPARγ Function in Vivo**This work was supported by grants from the NSF (MCB-9513300; to E.C.P. and T.S.S.), the NIH [HD-08567 (to L.L.W.) and HD-30367 (to R.N.T.)], and the Sandler Foundation. Endocrinology 2001 0.75
84 Design and synthesis of receptor ligands. Methods Enzymol 2003 0.75
85 The Thyroid Hormone Receptor-β-Selective Agonist GC-1 Differentially Affects Plasma Lipids and Cardiac Activity. Endocrinology 2000 0.75