Published in J Immunol on June 15, 2004
STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells. Blood (2010) 2.48
CCAAT/enhancer-binding protein δ is a critical mediator of lipopolysaccharide-induced acute lung injury. Am J Pathol (2012) 2.12
Regulators of endothelial and epithelial barrier integrity and function in acute lung injury. Biochem Pharmacol (2009) 1.85
Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus. Immunology (2006) 1.28
Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis. Am J Respir Crit Care Med (2007) 1.24
Molecular mechanisms of inflammation and tissue injury after major trauma--is complement the "bad guy"? J Biomed Sci (2011) 1.04
MicroRNA-127 inhibits lung inflammation by targeting IgG Fcγ receptor I. J Immunol (2012) 1.03
Critical analysis of the potential for targeting STAT3 in human malignancy. Onco Targets Ther (2013) 0.99
Pulmonary inflammation after ethanol exposure and burn injury is attenuated in the absence of IL-6. Alcohol (2013) 0.92
Critical role for CCAAT/enhancer-binding protein β in immune complex-induced acute lung injury. J Immunol (2012) 0.89
Cr(VI)-stimulated STAT3 tyrosine phosphorylation and nuclear translocation in human airway epithelial cells requires Lck. Biochem J (2007) 0.89
An essential role for Stat3 in regulating IgG immune complex-induced pulmonary inflammation. FASEB J (2011) 0.88
Role of p38 MAPK and STAT3 in lipopolysaccharide-stimulated mouse alveolar macrophages. Exp Ther Med (2014) 0.84
Vagus nerve through α7 nAChR modulates lung infection and inflammation: models, cells, and signals. Biomed Res Int (2014) 0.82
Sex differences in the expression of lung inflammatory mediators in response to ozone. Am J Physiol Lung Cell Mol Physiol (2015) 0.80
STAT3 single-nucleotide polymorphisms and STAT3 mutations associated with hyper-IgE syndrome are not responsible for increased serum IgE serum levels in asthma families. Eur J Hum Genet (2008) 0.80
Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-κb, STAT3 and pro-inflammatory mediators and enhancement of IκBα and anti-inflammatory cytokines. Inflammation (2015) 0.80
Functional genomic assessment of phosgene-induced acute lung injury in mice. Am J Respir Cell Mol Biol (2013) 0.79
Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol (2016) 0.79
Loss of phosphatase and tensin homolog (PTEN) induces leptin-mediated leptin gene expression: feed-forward loop operating in the lung. J Biol Chem (2013) 0.78
Genetics of asthma susceptibility and severity. Clin Chest Med (2012) 0.78
Nitric oxide and Brazilian propolis combined accelerates tissue repair by modulating cell migration, cytokine production and collagen deposition in experimental leishmaniasis. PLoS One (2015) 0.77
Sex-specific IL-6-associated signaling activation in ozone-induced lung inflammation. Biol Sex Differ (2016) 0.76
Analysis of mechanical ventilation and lipopolysaccharide‑induced acute lung injury using DNA microarray analysis. Mol Med Rep (2015) 0.75
Protective Role of Rho Guanosine Diphosphate Dissociation Inhibitor, Ly-GDI, in Pulmonary Alveolitis. PLoS One (2015) 0.75
Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol (2004) 8.65
Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc (2009) 6.71
Harmful molecular mechanisms in sepsis. Nat Rev Immunol (2008) 6.03
Perioperative fluid therapy with tetrastarch and gelatin in cardiac surgery--a prospective sequential analysis*. Crit Care Med (2013) 5.88
Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature (2007) 5.82
Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med (2006) 5.26
Novel strategies for the treatment of sepsis. Nat Med (2003) 5.14
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell (2007) 4.56
Role of C5a in inflammatory responses. Annu Rev Immunol (2005) 4.38
The enigma of sepsis. J Clin Invest (2003) 4.32
Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nat Med (2006) 4.16
Control of TH17 cells occurs in the small intestine. Nature (2011) 4.03
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med (2012) 3.96
Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest (2005) 3.77
Functional roles for C5a receptors in sepsis. Nat Med (2008) 3.33
Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A (2006) 3.25
The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol (2006) 3.11
Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis. J Exp Med (2008) 3.08
Mucosal damage and neutropenia are required for Candida albicans dissemination. PLoS Pathog (2008) 2.80
An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection. Nat Med (2012) 2.60
Adverse functions of IL-17A in experimental sepsis. FASEB J (2008) 2.60
Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature (2007) 2.56
Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs. J Exp Med (2008) 2.55
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol (2009) 2.47
Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability. J Cereb Blood Flow Metab (2005) 2.45
Renal effects of synthetic colloids and crystalloids in patients with severe sepsis: a prospective sequential comparison. Crit Care Med (2011) 2.30
Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood (2011) 2.24
Mouse and human neutrophils induce anaphylaxis. J Clin Invest (2011) 2.21
The Ly-6Chigh monocyte subpopulation transports Listeria monocytogenes into the brain during systemic infection of mice. J Immunol (2004) 2.07
New approaches to sepsis: molecular diagnostics and biomarkers. Clin Microbiol Rev (2012) 2.01
Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. J Immunol (2003) 2.00
Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study. Am J Physiol Regul Integr Comp Physiol (2006) 1.94
Roles of macrophages and neutrophils in the early host response to Bacillus anthracis spores in a mouse model of infection. Infect Immun (2006) 1.93
Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia. Nat Med (2013) 1.89
Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. J Clin Invest (2009) 1.87
The complement system. Cell Tissue Res (2010) 1.86
Increased C5a receptor expression in sepsis. J Clin Invest (2002) 1.79
Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection. J Immunol (2010) 1.79
The late phase of sepsis is characterized by an increased microbiological burden and death rate. Crit Care (2011) 1.77
Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways. J Infect Dis (2002) 1.77
Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo. J Immunol (2008) 1.76
Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. J Bone Miner Res (2011) 1.76
Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA. J Biol Chem (2006) 1.75
Generation of C5a by phagocytic cells. Am J Pathol (2002) 1.72
Role of oxidants in lung injury during sepsis. Antioxid Redox Signal (2007) 1.71
WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. J Clin Invest (2015) 1.68
In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice. Gastroenterology (2010) 1.61
Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation. J Clin Invest (2006) 1.58
Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells. Proc Natl Acad Sci U S A (2007) 1.58
C5a initiates the inflammatory cascade in immune complex peritonitis. J Immunol (2004) 1.57
Changes and regulation of the C5a receptor on neutrophils during septic shock in humans. J Immunol (2013) 1.57
Complement activation and the resulting placental vascular insufficiency drives fetal growth restriction associated with placental malaria. Cell Host Microbe (2013) 1.57
Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection. J Infect Dis (2005) 1.56
The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12. Cancer Res (2009) 1.56
Regulation by C5a of neutrophil activation during sepsis. Immunity (2003) 1.54
Evidence for a functional role of the second C5a receptor C5L2. FASEB J (2005) 1.53
Expression and function of C5a receptor in mouse microvascular endothelial cells. J Immunol (2002) 1.53
Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia. Infect Immun (2009) 1.52
IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection. J Exp Med (2010) 1.52
Role of nitric oxide in acute lung inflammation: lessons learned from the inducible nitric oxide synthase knockout mouse. Crit Care Med (2002) 1.51