Published in Am J Clin Nutr on August 01, 2008
The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome. Nat Rev Gastroenterol Hepatol (2010) 2.50
Alterations in ventricular structure and function in obese adolescents with nonalcoholic fatty liver disease. J Pediatr (2012) 2.23
Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology (2009) 2.19
Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes (2010) 2.10
Insulin resistance in children: consensus, perspective, and future directions. J Clin Endocrinol Metab (2010) 1.73
Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents. Diabetes Care (2010) 1.55
Relationships of circulating sex hormone-binding globulin with metabolic traits in humans. Diabetes (2010) 1.43
Intracellular lipid accumulation in liver and muscle and the insulin resistance syndrome. Endocrinol Metab Clin North Am (2008) 1.38
Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content. Obesity (Silver Spring) (2008) 1.27
Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance. Diabetes (2009) 1.24
Hepatic steatosis does not cause insulin resistance in people with familial hypobetalipoproteinaemia. Diabetologia (2011) 1.17
Metabolically normal obese people are protected from adverse effects following weight gain. J Clin Invest (2015) 1.17
Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction. Obesity (Silver Spring) (2010) 1.14
Weight loss reduces liver fat and improves hepatic and skeletal muscle insulin sensitivity in obese adolescents. Obesity (Silver Spring) (2009) 1.14
Inhibitory cross-talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle. Br J Pharmacol (2013) 0.94
Metabolic consequences of hepatic steatosis in overweight and obese adolescents. Diabetes Care (2012) 0.94
Origins of metabolic complications in obesity: adipose tissue and free fatty acid trafficking. Curr Opin Clin Nutr Metab Care (2011) 0.92
Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates. PLoS One (2011) 0.87
Dissociation of hepatic insulin resistance from susceptibility of nonalcoholic fatty liver disease induced by a high-fat and high-carbohydrate diet in mice. Am J Physiol Gastrointest Liver Physiol (2014) 0.84
Continuous parenteral and enteral nutrition induces metabolic dysfunction in neonatal pigs. JPEN J Parenter Enteral Nutr (2012) 0.84
Metabolic inflexibility and insulin resistance in obese adolescents with non-alcoholic fatty liver disease. Pediatr Diabetes (2014) 0.84
Intravenous niacin acutely improves the efficiency of dietary fat storage in lean and obese humans. Diabetes (2012) 0.81
Predictors of impaired glucose regulation in patients with non-alcoholic fatty liver disease. Exp Diabetes Res (2011) 0.77
Effect of Alkaloids from Nelumbinis Plumula against Insulin Resistance of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice. J Diabetes Res (2016) 0.75
Hepatic glucose utilisation in hepatic steatosis and obesity. Biosci Rep (2016) 0.75
Positive effects of voluntary running on metabolic syndrome-related disorders in non-obese hereditary hypertriacylglycerolemic rats. PLoS One (2015) 0.75
Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans. Cell Rep (2017) 0.75
Pediatric Non-Alcoholic Fatty Liver Disease. Children (Basel) (2017) 0.75
Upper Normal Alanine Aminotransferase Range and Insulin Resistance in Korean Adolescents: Korean National Health and Nutrition Examination Survey, 2009-2010. Dig Dis Sci (2015) 0.75
Fructose Consumption, Lipogenesis, and Non-Alcoholic Fatty Liver Disease. Nutrients (2017) 0.75
Prevalence of overweight and obesity in the United States, 1999-2004. JAMA (2006) 72.59
Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002. JAMA (2004) 25.36
The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology (2005) 15.74
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med (2006) 10.97
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology (2003) 9.36
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest (2005) 9.09
Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest (2007) 8.71
Influences of glucose loading and of injected insulin on hepatic glucose output. Ann N Y Acad Sci (1959) 8.62
Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab (2004) 8.36
Prevalence of fatty liver in children and adolescents. Pediatrics (2006) 7.00
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab (2002) 6.79
Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med (1999) 5.65
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes (1997) 5.61
Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol (1999) 5.38
Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology (2003) 4.95
Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes (2007) 4.28
Splanchnic lipolysis in human obesity. J Clin Invest (2004) 3.94
Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology (2008) 3.04
Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes (1987) 2.95
Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease. J Pediatr (2003) 2.77
High visceral and low abdominal subcutaneous fat stores in the obese adolescent: a determinant of an adverse metabolic phenotype. Diabetes (2007) 2.59
Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat. J Clin Endocrinol Metab (2006) 2.34
Regulation of plasma triglycerides in insulin resistance and diabetes. Arch Med Res (2005) 2.31
Women and men have similar amounts of liver and intra-abdominal fat, despite more subcutaneous fat in women: implications for sex differences in markers of cardiovascular risk. Diabetologia (2004) 2.12
Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies. Am J Physiol Endocrinol Metab (2007) 1.80
Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity. J Clin Endocrinol Metab (2005) 1.73
Elevated serum alanine aminotransferase activity and calculated risk of coronary heart disease in the United States. Hepatology (2006) 1.65
Measurement of very low stable isotope enrichments by gas chromatography/mass spectrometry: application to measurement of muscle protein synthesis. Metabolism (1997) 1.61
Update on non-alcoholic fatty liver disease in children. Clin Nutr (2007) 1.43
Insulin resistance and whole body energy homeostasis in obese adolescents with fatty liver disease. Am J Physiol Endocrinol Metab (2006) 1.32
Dual-energy X-ray absorptiometry and body composition: differences between devices and comparison with reference methods. Nutrition (2002) 1.28
Decreased prevalence of nonalcoholic fatty liver disease in black obese children. J Pediatr Gastroenterol Nutr (2005) 1.22
Separate contribution of diabetes, total fat mass, and fat topography to glucose production, gluconeogenesis, and glycogenolysis. J Clin Endocrinol Metab (2004) 1.16
The association between non-alcoholic fatty liver disease and insulin resistance in 20 obese children and adolescents. Acta Paediatr (2007) 1.08
Lipoprotein physiology. Endocrinol Metab Clin North Am (1998) 1.01
Fatty liver in obese children: prevalence and correlation with anthropometric measurements and hyperlipidemia. Turk J Pediatr (2005) 0.94
The variation of integrated backscatter in human hearts in differing ultrasonic transthoracic views. J Am Soc Echocardiogr (1996) 0.87
Noninvasive assessment of hepatic triglyceride content in humans with 13C nuclear magnetic resonance spectroscopy. Hepatology (1996) 0.81
Microbial ecology: human gut microbes associated with obesity. Nature (2006) 36.98
A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med (2003) 9.23
Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. N Engl J Med (2004) 6.12
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci U S A (2009) 5.64
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology (2010) 5.35
Physical frailty and body composition in obese elderly men and women. Obes Res (2004) 4.61
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci U S A (2004) 4.60
Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes (2007) 4.28
Aging, adiposity, and calorie restriction. JAMA (2007) 3.95
Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: a randomized trial. Ann Intern Med (2010) 3.73
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes (2008) 3.47
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature (2012) 3.35
Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Am J Clin Nutr (2005) 3.33
Long-term caloric restriction ameliorates the decline in diastolic function in humans. J Am Coll Cardiol (2006) 3.29
Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology (2008) 3.04
Metabolic and structural effects of phosphatidylcholine and deoxycholate injections on subcutaneous fat: a randomized, controlled trial. Aesthet Surg J (2013) 3.02
Assessing adiposity: a scientific statement from the American Heart Association. Circulation (2011) 3.00
Effect of weight loss and exercise on frailty in obese older adults. Arch Intern Med (2006) 2.94
Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell (2008) 2.87
Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Am J Clin Nutr (2006) 2.76
Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women. Circulation (2004) 2.73
Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Obes Res (2005) 2.72
Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am J Clin Nutr (2006) 2.57
Energy balance and its components: implications for body weight regulation. Am J Clin Nutr (2012) 2.51
Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial. Arch Intern Med (2006) 2.37
One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue. J Gerontol A Biol Sci Med Sci (2006) 2.31
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology (2007) 2.29
Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Diabetes (2013) 2.25
Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial. Obesity (Silver Spring) (2010) 2.25
Alterations in ventricular structure and function in obese adolescents with nonalcoholic fatty liver disease. J Pediatr (2012) 2.23
Gastric bypass and banding equally improve insulin sensitivity and β cell function. J Clin Invest (2012) 2.19
Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology (2009) 2.19
Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes (2010) 2.10
Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol. Hum Mol Genet (2008) 1.98
The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake. Cell Metab (2008) 1.94
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab (2012) 1.93
Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial. Am J Physiol Endocrinol Metab (2007) 1.85
Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk. Am J Clin Nutr (2006) 1.75
Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss. J Appl Physiol (1985) (2006) 1.68
Use of stable isotopically labeled tracers to measure very low density lipoprotein-triglyceride turnover. J Lipid Res (2002) 1.67
Extreme obesity: a new medical crisis in the United States. Mayo Clin Proc (2006) 1.66
Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones. J Clin Endocrinol Metab (2006) 1.64
Metabolic effects of treatment with atypical antipsychotics. J Clin Psychiatry (2004) 1.63
Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial. Am J Clin Nutr (2010) 1.63
Sucralose affects glycemic and hormonal responses to an oral glucose load. Diabetes Care (2013) 1.63
Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults. Gastroenterology (2010) 1.62
Energy expenditure, sex, and endogenous fuel availability in humans. J Clin Invest (2003) 1.62
The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects. J Lipid Res (2011) 1.60
Bariatric surgery and cardiovascular risk factors: a scientific statement from the American Heart Association. Circulation (2011) 1.59
Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production. Age (Dordr) (2009) 1.57
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals. Gastroenterology (2013) 1.57
What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean? Diabetes (2003) 1.56
Assessment of intrahepatic triglyceride content using magnetic resonance spectroscopy. J Cardiometab Syndr (2007) 1.55
A 6-month randomized, placebo-controlled, dose-ranging trial of topiramate for weight loss in obesity. Obes Res (2003) 1.48
Effect of sex and obesity on basal VLDL-triacylglycerol kinetics. Am J Clin Nutr (2003) 1.48
Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss. Diabetes (2007) 1.47
Weight loss induced by Roux-en-Y gastric bypass but not laparoscopic adjustable gastric banding increases circulating bile acids. J Clin Endocrinol Metab (2013) 1.45
Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial. J Clin Endocrinol Metab (2008) 1.41
Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile. Hum Mol Genet (2010) 1.40
Celiac disease unmasked after pancreaticoduodenectomy. JPEN J Parenter Enteral Nutr (2005) 1.39
Relationship between body fat mass and free fatty acid kinetics in men and women. Obesity (Silver Spring) (2009) 1.37
Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes: A 1-year randomized controlled trial. Diabetes Care (2002) 1.35
Lipid metabolism response to a single, prolonged bout of endurance exercise in healthy young men. Am J Physiol Endocrinol Metab (2005) 1.34
Effect of weight loss on VLDL-triglyceride and apoB-100 kinetics in women with abdominal obesity. Am J Physiol Endocrinol Metab (2002) 1.34
Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults. Obesity (Silver Spring) (2009) 1.33
Effects of bariatric surgery on glucose homeostasis and type 2 diabetes. Gastroenterology (2012) 1.33
Women produce fewer but triglyceride-richer very low-density lipoproteins than men. J Clin Endocrinol Metab (2007) 1.31
Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology (2012) 1.27
Dissociation between intrahepatic triglyceride content and insulin resistance in familial hypobetalipoproteinemia. Gastroenterology (2010) 1.27
Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content. Obesity (Silver Spring) (2008) 1.27
Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes. Diabetes (2006) 1.25
Impact of gender on the myocardial metabolic response to obesity. JACC Cardiovasc Imaging (2008) 1.22
Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease. J Clin Endocrinol Metab (2010) 1.21
Multiorgan insulin sensitivity in lean and obese subjects. Diabetes Care (2012) 1.20
Weight loss therapy improves pancreatic endocrine function in obese older adults. Obesity (Silver Spring) (2008) 1.18
Effect of orlistat in overweight and obese patients with type 2 diabetes treated with metformin. Diabetes Care (2002) 1.18
Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease. Hepatology (2012) 1.18
Effect of gender on lipid kinetics during endurance exercise of moderate intensity in untrained subjects. Am J Physiol Endocrinol Metab (2002) 1.18
Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia-hyperaminoacidaemia in healthy young and middle-aged men and women. Clin Sci (Lond) (2011) 1.17
Effect of moderate diet-induced weight loss and weight regain on cardiovascular structure and function. J Am Coll Cardiol (2009) 1.17
Metabolically normal obese people are protected from adverse effects following weight gain. J Clin Invest (2015) 1.17
Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of insulin sensitization therapy. Diabetes (2003) 1.15
VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of sex and obesity. Am J Physiol Endocrinol Metab (2002) 1.15