Published in Cell on June 25, 2004
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell (2009) 5.74
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility. Nat Genet (2009) 5.13
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
RTEL1 maintains genomic stability by suppressing homologous recombination. Cell (2008) 3.84
Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev (2006) 3.14
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability. Mol Cell Biol (2008) 2.88
Zscan4 regulates telomere elongation and genomic stability in ES cells. Nature (2010) 2.46
Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet (2006) 2.36
The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo. PLoS Genet (2009) 2.32
Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita. Hum Genet (2013) 2.10
Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions. Nat Struct Mol Biol (2009) 2.08
Genomic distribution and functional analyses of potential G-quadruplex-forming sequences in Saccharomyces cerevisiae. Nucleic Acids Res (2007) 1.98
FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts. J Biol Chem (2008) 1.93
The G4 genome. PLoS Genet (2013) 1.83
Telomere length measurement-caveats and a critical assessment of the available technologies and tools. Mutat Res (2011) 1.79
Constitutional mutations in RTEL1 cause severe dyskeratosis congenita. Am J Hum Genet (2013) 1.71
G-quadruplex nucleic acids and human disease. FEBS J (2010) 1.58
Maintaining the end: roles of telomere proteins in end-protection, telomere replication and length regulation. Mutat Res (2011) 1.56
Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins. Cell Mol Life Sci (2009) 1.54
Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res (2013) 1.53
Identification of sister chromatids by DNA template strand sequences. Nature (2009) 1.53
Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans. Genetics (2006) 1.47
G-quadruplexes and their regulatory roles in biology. Nucleic Acids Res (2015) 1.43
Replication fork regression in repetitive DNAs. Nucleic Acids Res (2006) 1.35
Telomeres, stem cells, and hematology. Blood (2008) 1.34
G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates. J Biol Chem (2008) 1.32
RTEL1 contributes to DNA replication and repair and telomere maintenance. Mol Biol Cell (2012) 1.28
RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination. Nucleic Acids Res (2010) 1.27
Telomeres: structures in need of unwinding. FEBS Lett (2010) 1.21
DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster. Nucleic Acids Res (2012) 1.20
Biochemical characterization of Warsaw breakage syndrome helicase. J Biol Chem (2011) 1.19
Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo. Mol Cell Biol (2006) 1.16
Telomere length is inherited with resetting of the telomere set-point. Proc Natl Acad Sci U S A (2010) 1.15
Rare variants in RTEL1 are associated with familial interstitial pneumonia. Am J Respir Crit Care Med (2015) 1.15
Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae. Nat Struct Mol Biol (2011) 1.14
Genetic advances in glioma: susceptibility genes and networks. Curr Opin Genet Dev (2010) 1.14
Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome. Proc Natl Acad Sci U S A (2013) 1.13
TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes Dev (2014) 1.07
A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome. PLoS Genet (2013) 1.05
Human POT1 is required for efficient telomere C-rich strand replication in the absence of WRN. Genes Dev (2009) 1.05
G-quadruplex preferentially forms at the very 3' end of vertebrate telomeric DNA. Nucleic Acids Res (2007) 1.05
TeloTool: a new tool for telomere length measurement from terminal restriction fragment analysis with improved probe intensity correction. Nucleic Acids Res (2013) 1.04
TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding. Mol Cell (2015) 1.03
From yeast to mammals: recent advances in genetic control of homologous recombination. DNA Repair (Amst) (2012) 1.02
Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder. Br J Haematol (2015) 1.01
DNA and RNA quadruplex-binding proteins. Int J Mol Sci (2014) 1.01
FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress. Curr Mol Med (2009) 1.00
Molecular basis of telomere dysfunction in human genetic diseases. Nat Struct Mol Biol (2015) 0.97
In vivo veritas: using yeast to probe the biological functions of G-quadruplexes. Biochimie (2008) 0.97
Human TEN1 maintains telomere integrity and functions in genome-wide replication restart. J Biol Chem (2013) 0.95
Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome. Cell Mol Life Sci (2014) 0.95
Distinct activities of exonuclease 1 and flap endonuclease 1 at telomeric g4 DNA. PLoS One (2010) 0.92
Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases. J Nucleic Acids (2011) 0.90
Identification and biochemical characterization of a novel mutation in DDX11 causing Warsaw breakage syndrome. Hum Mutat (2012) 0.90
G-quadruplexes and helicases. Nucleic Acids Res (2016) 0.90
DNA repair at telomeres: keeping the ends intact. Cold Spring Harb Perspect Biol (2013) 0.89
Loss of HLTF function promotes intestinal carcinogenesis. Mol Cancer (2012) 0.88
Cerebellar telomere length and psychiatric disorders. Behav Genet (2010) 0.88
Guanine quadruplex structures localize to heterochromatin. Nucleic Acids Res (2015) 0.87
Mechanisms of telomere loss and their consequences for chromosome instability. Front Oncol (2012) 0.87
Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells. Proc Natl Acad Sci U S A (2014) 0.87
Structure and Mechanisms of SF1 DNA Helicases. Adv Exp Med Biol (2013) 0.86
Regulation of DNA pairing in homologous recombination. Cold Spring Harb Perspect Biol (2014) 0.86
Generation of a mouse model for studying the role of upregulated RTEL1 activity in tumorigenesis. Transgenic Res (2012) 0.86
Telomerase-independent paths to immortality in predictable cancer subtypes. J Cancer (2012) 0.84
Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links. Plant Cell (2015) 0.84
Analysis of repetitive DNA in chromosomes by flow cytometry. Nat Methods (2011) 0.83
Genome-wide study of DNA methylation alterations in response to diazinon exposure in vitro. Environ Toxicol Pharmacol (2012) 0.83
Substitution mapping in dahl rats identifies two distinct blood pressure quantitative trait loci within 1.12- and 1.25-mb intervals on chromosome 3. Genetics (2006) 0.83
Genetic architecture of natural variation of telomere length in Arabidopsis thaliana. Genetics (2014) 0.82
Association between RTEL1, PHLDB1, and TREH Polymorphisms and Glioblastoma Risk: A Case-Control Study. Med Sci Monit (2015) 0.82
Telomeres do the (un)twist: helicase actions at chromosome termini. Biochim Biophys Acta (2009) 0.82
Portrait of replication stress viewed from telomeres. Cancer Sci (2013) 0.81
How homologous recombination maintains telomere integrity. Chromosoma (2014) 0.81
A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation. Cell Death Dis (2015) 0.81
The Arabidopsis thaliana homolog of the helicase RTEL1 plays multiple roles in preserving genome stability. Plant Cell (2014) 0.80
Put on your thinking cap: G-quadruplexes, helicases, and telomeres. Aging (Albany NY) (2011) 0.80
EMG1 is essential for mouse pre-implantation embryo development. BMC Dev Biol (2010) 0.79
Roles of DNA helicases in the mediation and regulation of homologous recombination. Adv Exp Med Biol (2013) 0.79
Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. PLoS One (2012) 0.79
Resolution of telomere associations by TRF1 cleavage in mouse embryonic stem cells. Mol Biol Cell (2014) 0.79
The role of the RTEL1 rs2297440 polymorphism in the risk of glioma development: a meta-analysis. Neurol Sci (2016) 0.78
p53 downregulates the Fanconi anaemia DNA repair pathway. Nat Commun (2016) 0.77
Identification and characterization of bovine regulator of telomere length elongation helicase gene (RTEL): molecular cloning, expression distribution, splice variants and DNA methylation profile. BMC Mol Biol (2007) 0.77
What the genetics "RTEL"ing us about telomeres and pulmonary fibrosis. Am J Respir Crit Care Med (2015) 0.77
Human regulator of telomere elongation helicase 1 (RTEL1) is required for the nuclear and cytoplasmic trafficking of pre-U2 RNA. Nucleic Acids Res (2015) 0.76
Human Cell Assays for Synthesis-Dependent Strand Annealing and Crossing over During Double-Strand Break Repair. G3 (Bethesda) (2017) 0.76
The N-terminal domain of human DNA helicase Rtel1 contains a redox active iron-sulfur cluster. Biomed Res Int (2014) 0.75
Polymorphisms in Telomere Length Associated TERC and TERT predispose for Ischemic Stroke in a Chinese Han population. Sci Rep (2017) 0.75
Clinical and Molecular Heterogeneity of RTEL1 Deficiency. Front Immunol (2017) 0.75
Recurrent amplification of RTEL1 and ABCA13 and its synergistic effect associated with clinicopathological data of gastric adenocarcinoma. Mol Cytogenet (2016) 0.75
Modeling the study of DNA damage responses in mice. Methods Mol Biol (2015) 0.75
Remodeling and Control of Homologous Recombination by DNA Helicases and Translocases that Target Recombinases and Synapsis. Genes (Basel) (2016) 0.75
The RTR Complex Partner RMI2 and the DNA Helicase RTEL1 Are Both Independently Involved in Preserving the Stability of 45S rDNA Repeats in Arabidopsis thaliana. PLoS Genet (2016) 0.75
DNA Replication Origins and Fork Progression at Mammalian Telomeres. Genes (Basel) (2017) 0.75
Concise Review: Getting to the Core of Inherited Bone Marrow Failures. Stem Cells (2016) 0.75
RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population. Oncotarget (2016) 0.75
Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles. Genes (Basel) (2016) 0.75
Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population. Int J Chron Obstruct Pulmon Dis (2017) 0.75
Association between genetic risk score for telomere length and risk of breast cancer. Cancer Causes Control (2016) 0.75
The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A (2004) 26.56
Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med (2004) 12.20
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature (2009) 11.27
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol (2007) 9.36
Copy number variation and selection during reprogramming to pluripotency. Nature (2011) 8.24
Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med (2007) 8.23
The knockout mouse project. Nat Genet (2004) 7.80
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell (2010) 7.51
Autocrine VEGF signaling is required for vascular homeostasis. Cell (2007) 7.37
Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med (2005) 7.09
Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. J Clin Invest (2008) 6.15
Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis (2002) 6.11
Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene. Hum Genet (2010) 5.68
Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A (2002) 5.54
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
Telomeres and aging. Physiol Rev (2008) 4.79
Depletion of definitive gut endoderm in Sox17-null mutant mice. Development (2002) 4.13
TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. Am J Hum Genet (2008) 4.12
Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res (2005) 4.08
Flow cytometry and FISH to measure the average length of telomeres (flow FISH). Nat Protoc (2006) 4.00
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci U S A (2008) 3.86
Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita. Blood (2007) 3.86
Mouse in red: red fluorescent protein expression in mouse ES cells, embryos, and adult animals. Genesis (2004) 3.80
Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA. Nat Genet (2002) 3.50
Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development (2009) 3.25
Embryonic stem cells and mice expressing different GFP variants for multiple non-invasive reporter usage within a single animal. BMC Biotechnol (2002) 2.97
Niche-mediated control of human embryonic stem cell self-renewal and differentiation. EMBO J (2007) 2.91
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell (2011) 2.89
Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet (2003) 2.76
Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood (2003) 2.73
The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome (2012) 2.65
Developmental and adult phenotyping directly from mutant embryonic stem cells. Proc Natl Acad Sci U S A (2007) 2.61
Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Mol Cell Biol (2006) 2.58
IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Dev Cell (2005) 2.57
Oct4 is required for primordial germ cell survival. EMBO Rep (2004) 2.56
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature (2013) 2.49
Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci U S A (2009) 2.44
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood (2012) 2.43
Extrinsic regulation of pluripotent stem cells. Nature (2010) 2.39
Early response to highly active antiretroviral therapy in HIV-1-infected Kenyan children. J Acquir Immune Defic Syndr (2007) 2.34
Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells. Cell Stem Cell (2008) 2.31
Site-specific cassette exchange and germline transmission with mouse ES cells expressing phiC31 integrase. Nat Biotechnol (2003) 2.28
Lineage choice and differentiation in mouse embryos and embryonic stem cells. Dev Biol (2003) 2.27
Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling. Dev Biol (2003) 2.24
Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell Metab (2013) 2.21
Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism. Cell Metab (2007) 2.12
African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans. Hum Mol Genet (2010) 2.11
Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival. J Am Soc Nephrol (2006) 2.10
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci U S A (2005) 2.01
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96
Transposon-mediated genome manipulation in vertebrates. Nat Methods (2009) 1.96
CD27 expression promotes long-term survival of functional effector-memory CD8+ cytotoxic T lymphocytes in HIV-infected patients. J Exp Med (2004) 1.92
Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain (2006) 1.88
Mutations of CDKL5 cause a severe neurodevelopmental disorder with infantile spasms and mental retardation. Am J Hum Genet (2004) 1.88
A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet (2004) 1.87
DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution. Nat Methods (2012) 1.85
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc Natl Acad Sci U S A (2008) 1.84
Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development (2005) 1.82
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development (2003) 1.80
Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function. Cell (2012) 1.79
Telomere length measurement-caveats and a critical assessment of the available technologies and tools. Mutat Res (2011) 1.79
Telomere length is associated with disease severity and declines with age in dyskeratosis congenita. Haematologica (2011) 1.71
Alkaline phosphatase-positive colony formation is a sensitive, specific, and quantitative indicator of undifferentiated human embryonic stem cells. Stem Cells (2008) 1.69
Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J (2009) 1.68
Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions. Hum Mol Genet (2008) 1.67
Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve. Genes Dev (2004) 1.65
The increasing use of intravesical therapies for stage T1 bladder cancer coincides with decreasing survival after cystectomy. BJU Int (2007) 1.65
Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation. Development (2002) 1.63
Synchrony of telomere length among hematopoietic cells. Exp Hematol (2010) 1.63
Mutations in the SBDS gene in acquired aplastic anemia. Blood (2007) 1.62
Elevated coding mutation rate during the reprogramming of human somatic cells into induced pluripotent stem cells. Stem Cells (2012) 1.62
Telomerase levels control the lifespan of human T lymphocytes. Blood (2003) 1.59
Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo. Development (2002) 1.59
A spectrum of severe familial liver disorders associate with telomerase mutations. PLoS One (2009) 1.57
Functional characterization of natural telomerase mutations found in patients with hematologic disorders. Blood (2006) 1.57
Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes. PLoS Genet (2012) 1.57
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol (2006) 1.54
Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res (2013) 1.53
Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins. Blood (2009) 1.53
Identification of sister chromatids by DNA template strand sequences. Nature (2009) 1.53
Functional immobilization of signaling proteins enables control of stem cell fate. Nat Methods (2008) 1.52
Emerging asymmetry and embryonic patterning in early mouse development. Dev Cell (2004) 1.49
Missed opportunities for appropriate anticoagulation among emergency department patients with uncomplicated atrial fibrillation or flutter. Ann Emerg Med (2013) 1.48
Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia. Hum Mol Genet (2003) 1.48