Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes.

PubWeight™: 1.57‹?› | Rank: Top 4%

🔗 View Article (PMC 3355073)

Published in PLoS Genet on May 17, 2012

Authors

Geraldine Aubert1, Gabriela M Baerlocher, Irma Vulto, Steven S Poon, Peter M Lansdorp

Author Affiliations

1: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

Articles citing this

Telomeres shorten at equivalent rates in somatic tissues of adults. Nat Commun (2013) 2.56

Association between donor leukocyte telomere length and survival after unrelated allogeneic hematopoietic cell transplantation for severe aplastic anemia. JAMA (2015) 2.20

Gender and telomere length: systematic review and meta-analysis. Exp Gerontol (2013) 1.62

Telomeres and age-related disease: how telomere biology informs clinical paradigms. J Clin Invest (2013) 1.58

The telomere lengthening conundrum--artifact or biology? Nucleic Acids Res (2013) 1.38

Do leukocyte telomere length dynamics depend on baseline telomere length? An analysis that corrects for 'regression to the mean'. Eur J Epidemiol (2013) 1.28

Cancer-associated TERT promoter mutations abrogate telomerase silencing. Elife (2015) 1.28

Early life stress and telomere length: investigating the connection and possible mechanisms: a critical survey of the evidence base, research methodology and basic biology. Bioessays (2012) 1.23

Tracking and fixed ranking of leukocyte telomere length across the adult life course. Aging Cell (2013) 1.17

Poly(A)-specific ribonuclease (PARN) mediates 3'-end maturation of the telomerase RNA component. Nat Genet (2015) 1.06

Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions. Clin Sci (Lond) (2015) 0.95

Telomeres, atherosclerosis, and human longevity: a causal hypothesis. Epidemiology (2015) 0.93

Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease. Pediatrics (2016) 0.93

Leukocyte telomere dynamics in the elderly. Eur J Epidemiol (2013) 0.92

The molecular genetics of the telomere biology disorders. RNA Biol (2015) 0.91

Short telomeres, telomeropathy, and subclinical extrapulmonary organ damage in patients with interstitial lung disease. Chest (2015) 0.89

Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions. Elife (2015) 0.88

The heritability of leucocyte telomere length dynamics. J Med Genet (2015) 0.87

Telomere length and common disease: study design and analytical challenges. Hum Genet (2015) 0.87

Age-related declines and disease-associated variation in immune cell telomere length in a wild mammal. PLoS One (2014) 0.84

Leukocyte telomere length dynamics in women and men: menopause vs age effects. Int J Epidemiol (2015) 0.83

A Rationale for Age-Adapted Immunosuppression in Organ Transplantation. Transplantation (2015) 0.81

Paternal age and telomere length in twins: the germ stem cell selection paradigm. Aging Cell (2015) 0.80

Telomere length in relation to immunological parameters in patients with renal cell carcinoma. PLoS One (2013) 0.80

Shorter Ends, Faster End? Leukocyte Telomere Length and Mortality Among Older Taiwanese. J Gerontol A Biol Sci Med Sci (2014) 0.79

Women and Lung Disease. Sex Differences and Global Health Disparities. Am J Respir Crit Care Med (2015) 0.78

A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition. Aging (Albany NY) (2015) 0.77

Predicting Survival from Telomere Length versus Conventional Predictors: A Multinational Population-Based Cohort Study. PLoS One (2016) 0.76

Telomere length change plateaus at 4 years of age in Latino children: associations with baseline length and maternal change. Mol Genet Genomics (2016) 0.76

Genomic instability in newborn with short telomeres. PLoS One (2014) 0.76

Telomeres in aging and disease: lessons from zebrafish. Dis Model Mech (2016) 0.75

Longitudinal Telomere Erosion in Lymphocyte Subsets of Patients with Atherosclerotic Peripheral Arterial Disease (PAD). J Clin Diagn Res (2015) 0.75

Telomere attrition in beta and alpha cells with age. Age (Dordr) (2016) 0.75

DNA methylation in PRDM8 is indicative for dyskeratosis congenita. Oncotarget (2016) 0.75

Circulating cell-free DNA, telomere length and bilirubin in the Vienna Active Ageing Study: exploratory analysis of a randomized, controlled trial. Sci Rep (2016) 0.75

Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish. PLoS Genet (2016) 0.75

Flow Cytometry, a Versatile Tool for Diagnosis and Monitoring of Primary Immunodeficiencies. Clin Vaccine Immunol (2016) 0.75

The limitations of qPCR telomere length measurement in diagnosing dyskeratosis congenita. Mol Genet Genomic Med (2016) 0.75

A retrospective examination of mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study. Oncol Rep (2014) 0.75

Childhood adversity, social support, and telomere length among perinatal women. Psychoneuroendocrinology (2017) 0.75

The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation. Sci Rep (2017) 0.75

Leukocyte telomere length, T cell composition and DNA methylation age. Aging (Albany NY) (2017) 0.75

Articles cited by this

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell (1985) 24.17

Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97

Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A (2004) 12.89

A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55

Telomere reduction in human colorectal carcinoma and with ageing. Nature (1990) 11.24

Association between telomere length in blood and mortality in people aged 60 years or older. Lancet (2003) 10.56

DNA damage foci at dysfunctional telomeres. Curr Biol (2003) 9.08

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature (2011) 8.45

Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med (2007) 8.23

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med (2005) 7.09

Genetic determination of telomere size in humans: a twin study of three age groups. Am J Hum Genet (1994) 7.04

Heterogeneity in telomere length of human chromosomes. Hum Mol Genet (1996) 6.55

Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36

The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell (2001) 5.98

Telomere diseases. N Engl J Med (2009) 5.68

Telomeres and aging. Physiol Rev (2008) 4.79

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci U S A (1994) 4.57

Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J Exp Med (1999) 4.27

Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell (2007) 4.18

The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci U S A (1998) 4.17

Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension (2001) 4.07

Flow cytometry and FISH to measure the average length of telomeres (flow FISH). Nat Protoc (2006) 4.00

Telomerase modulates Wnt signalling by association with target gene chromatin. Nature (2009) 3.96

Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci U S A (2008) 3.86

Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita. Blood (2007) 3.86

Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci U S A (1995) 3.79

CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset. Blood (2010) 3.32

Different telomere damage signaling pathways in human and mouse cells. EMBO J (2002) 2.87

Short telomeres on human chromosome 17p. Nat Genet (1998) 2.81

Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood (2003) 2.73

Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci U S A (2009) 2.44

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med (2007) 2.41

Telomere length and replicative aging in human vascular tissues. Proc Natl Acad Sci U S A (1995) 2.40

Dyskeratosis congenita: a genetic disorder of many faces. Clin Genet (2007) 2.23

Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging. Immunol Rev (1997) 2.13

Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells. Blood (2009) 2.12

Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow. Stem Cells (1996) 1.97

Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. J Gerontol A Biol Sci Med Sci (2009) 1.90

Telomere length measurement-caveats and a critical assessment of the available technologies and tools. Mutat Res (2011) 1.79

Dyskeratosis congenita: the diverse clinical presentation of mutations in the telomerase complex. Biochimie (2007) 1.72

Telomerase regulation during entry into the cell cycle in normal human T cells. Mol Biol Cell (1996) 1.71

Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties. Proc Natl Acad Sci U S A (2007) 1.68

Ontogeny-related changes in proliferative potential of human hematopoietic cells. J Exp Med (1993) 1.64

Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. Mol Cell (2007) 1.56

Aging in the lympho-hematopoietic stem cell compartment. Trends Immunol (2009) 1.47

Telomeres and disease. EMBO J (2009) 1.41

Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita. Blood (2005) 1.37

Telomere length measurements in leukocyte subsets by automated multicolor flow-FISH. Cytometry A (2003) 1.36

Estimating human hematopoietic stem cell kinetics using granulocyte telomere lengths. Exp Hematol (2004) 1.33

Association of immune abnormalities with telomere shortening in autosomal-dominant dyskeratosis congenita. Blood (2004) 1.33

Structural stability and chromosome-specific telomere length is governed by cis-acting determinants in humans. Hum Mol Genet (2006) 1.30

Longitudinal data on telomere length in leukocytes from newborn baboons support a marked drop in stem cell turnover around 1 year of age. Aging Cell (2006) 1.28

Telomere length in atherosclerosis and diabetes. Atherosclerosis (2009) 1.24

Major cutbacks at chromosome ends. Trends Biochem Sci (2005) 1.20

Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1. DNA Repair (Amst) (2010) 1.17

NK and NKT cell functions in immunosenescence. Aging Cell (2004) 1.16

Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita. Blood (2008) 1.04

Telomere elongation involves intra-molecular DNA replication in cells utilizing alternative lengthening of telomeres. Hum Mol Genet (2008) 1.01

Telomere shortening in leukocyte subpopulations from baboons. J Leukoc Biol (2003) 0.98

Repair of telomeric DNA prior to replicative senescence. Mech Ageing Dev (2000) 0.98

Probing the mitotic history and developmental stage of hematopoietic cells using single telomere length analysis (STELA). Blood (2009) 0.95

Erosion of telomeric single-stranded overhang in patients with aplastic anaemia carrying telomerase complex mutations. Eur J Clin Invest (2009) 0.80

Multicolor fluorescence in situ hybridization with peptide nucleic acid probes for enumeration of specific chromosomes in human cells. Genes Chromosomes Cancer (2001) 0.78

Articles by these authors

Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med (2004) 12.20

Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med (2007) 8.23

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med (2005) 7.09

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. J Clin Invest (2008) 6.15

The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38

Telomeres and aging. Physiol Rev (2008) 4.79

Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-study IV. J Clin Oncol (2013) 4.50

TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. Am J Hum Genet (2008) 4.12

Flow cytometry and FISH to measure the average length of telomeres (flow FISH). Nat Protoc (2006) 4.00

Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci U S A (2008) 3.86

Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita. Blood (2007) 3.86

Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA. Nat Genet (2002) 3.50

Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein. Cell (2004) 2.91

Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet (2003) 2.76

Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood (2003) 2.73

Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci U S A (2009) 2.44

The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci U S A (2005) 2.01

CD27 expression promotes long-term survival of functional effector-memory CD8+ cytotoxic T lymphocytes in HIV-infected patients. J Exp Med (2004) 1.92

DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution. Nat Methods (2012) 1.85

Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus. Nat Genet (2012) 1.82

Telomere length measurement-caveats and a critical assessment of the available technologies and tools. Mutat Res (2011) 1.79

Telomere length is associated with disease severity and declines with age in dyskeratosis congenita. Haematologica (2011) 1.71

Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV. Blood (2011) 1.65

Synchrony of telomere length among hematopoietic cells. Exp Hematol (2010) 1.63

Mutations in the SBDS gene in acquired aplastic anemia. Blood (2007) 1.62

Telomerase levels control the lifespan of human T lymphocytes. Blood (2003) 1.59

A spectrum of severe familial liver disorders associate with telomerase mutations. PLoS One (2009) 1.57

Functional characterization of natural telomerase mutations found in patients with hematologic disorders. Blood (2006) 1.57

RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol (2006) 1.54

Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res (2013) 1.53

Identification of sister chromatids by DNA template strand sequences. Nature (2009) 1.53

Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia. Hum Mol Genet (2003) 1.48

Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls. Cytometry (2002) 1.43

Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita. Blood (2005) 1.37

Telomere length measurements in leukocyte subsets by automated multicolor flow-FISH. Cytometry A (2003) 1.36

Estimating human hematopoietic stem cell kinetics using granulocyte telomere lengths. Exp Hematol (2004) 1.33

Functional characterization of telomerase RNA variants found in patients with hematologic disorders. Blood (2004) 1.33

Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. PLoS Genet (2011) 1.29

RTEL1 contributes to DNA replication and repair and telomere maintenance. Mol Biol Cell (2012) 1.28

Telomere length in subpopulations of human hematopoietic cells. Stem Cells (2003) 1.28

Longitudinal data on telomere length in leukocytes from newborn baboons support a marked drop in stem cell turnover around 1 year of age. Aging Cell (2006) 1.28

Hematopoietic stem-cell behavior in nonhuman primates. Blood (2007) 1.27

RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination. Nucleic Acids Res (2010) 1.27

Telomere length in human natural killer cell subsets. Ann N Y Acad Sci (2007) 1.25

Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation. Cancer Res (2002) 1.20

Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts. Aging Cell (2007) 1.20

Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance. J Clin Invest (2014) 1.16

Telomere length is inherited with resetting of the telomere set-point. Proc Natl Acad Sci U S A (2010) 1.15

Stem cells: hype and reality. Hematology Am Soc Hematol Educ Program (2002) 1.14

Telomeres, telomerase, and hematopoietic stem cell biology. Arch Med Res (2004) 1.10

Telomere length in Hutchinson-Gilford progeria syndrome. Mech Ageing Dev (2009) 1.10

Mutations in the reverse transcriptase component of telomerase (TERT) in patients with bone marrow failure. Blood Cells Mol Dis (2006) 1.09

Telomere maintenance in human B lymphocytes. Br J Haematol (2002) 1.08

Imetelstat (GRN163L)--telomerase-based cancer therapy. Recent Results Cancer Res (2010) 1.07

Restoration of the CD4 T cell compartment after long-term highly active antiretroviral therapy without phenotypical signs of accelerated immunological aging. J Immunol (2008) 1.07

Proliferative defects in dyskeratosis congenita skin keratinocytes are corrected by expression of the telomerase reverse transcriptase, TERT, or by activation of endogenous telomerase through expression of papillomavirus E6/E7 or the telomerase RNA component, TERC. Exp Dermatol (2009) 1.06

Short telomeres resulting from heritable mutations in the telomerase reverse transcriptase gene predispose for a variety of malignancies. Ann N Y Acad Sci (2009) 1.05

Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita. Blood (2008) 1.04

Telomere length measurements using fluorescence in situ hybridization and flow cytometry. Methods Cell Biol (2004) 1.00

Longitudinal studies of telomere length in feline blood cells: implications for hematopoietic stem cell turnover in vivo. Exp Hematol (2002) 0.99

Telomere shortening in leukocyte subpopulations from baboons. J Leukoc Biol (2003) 0.98

Deregulated expression of Kruppel-like factors in acute myeloid leukemia. Leuk Res (2011) 0.97

Reduced telomere length variation in healthy oldest old. Mech Ageing Dev (2008) 0.97

NDRG1/2 expression is inhibited in primary acute myeloid leukemia. Leuk Res (2009) 0.95

Telomere elongation followed by telomere length reduction, in leukocytes from divers exposed to intense oxidative stress--implications for tissue and organismal aging. Mech Ageing Dev (2011) 0.95

Probing the mitotic history and developmental stage of hematopoietic cells using single telomere length analysis (STELA). Blood (2009) 0.95

Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERT. Blood (2005) 0.94

How to count chromosomes in a cell: An overview of current and novel technologies. Bioessays (2015) 0.92

Telomere length and the expression of natural telomeric genes in human fibroblasts. Hum Mol Genet (2003) 0.92

High incidence of rapid telomere loss in telomerase-deficient Caenorhabditis elegans. Nucleic Acids Res (2006) 0.90

Telomere shortening in hematopoietic stem cell transplantation: a potential mechanism for late graft failure? Biol Blood Marrow Transplant (2002) 0.90

The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. J Biol Chem (2012) 0.89

Functional characterization of multiple domains involved in the subcellular localization of the hematopoietic Pbx interacting protein (HPIP). Oncogene (2002) 0.89

IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. J Clin Invest (2015) 0.89

Telomeres and prognosis in patients with chronic lymphocytic leukaemia. Int J Hematol (2011) 0.88

Telomere lengths in the oral epithelia with and without carcinoma. Eur J Cancer (2009) 0.88

Strain-specific telomere length revealed by single telomere length analysis in Caenorhabditis elegans. Nucleic Acids Res (2004) 0.88