Published in Blood on September 21, 2006
Principles of adoptive T cell cancer therapy. J Clin Invest (2007) 2.65
Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10. Hum Mol Genet (2007) 2.61
Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci U S A (2009) 2.44
Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita. Proc Natl Acad Sci U S A (2008) 2.37
Human diseases of telomerase dysfunction: insights into tissue aging. Nucleic Acids Res (2007) 2.34
Telomere maintenance and human bone marrow failure. Blood (2008) 2.09
Telomerase reverse-transcriptase homozygous mutations in autosomal recessive dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome. Blood (2007) 1.93
Architecture of human telomerase RNA. Proc Natl Acad Sci U S A (2011) 1.93
Dyskeratosis congenita, stem cells and telomeres. Biochim Biophys Acta (2009) 1.62
Mutations in the SBDS gene in acquired aplastic anemia. Blood (2007) 1.62
Effects of age and heart failure on human cardiac stem cell function. Am J Pathol (2011) 1.57
A spectrum of severe familial liver disorders associate with telomerase mutations. PLoS One (2009) 1.57
InTERTpreting telomerase structure and function. Nucleic Acids Res (2010) 1.47
It all comes together at the ends: telomerase structure, function, and biogenesis. Mutat Res (2011) 1.36
Dyskeratosis congenita as a disorder of telomere maintenance. Mutat Res (2011) 1.35
Telomeres, stem cells, and hematology. Blood (2008) 1.34
Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology. J Transl Med (2009) 1.31
Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts. Aging Cell (2007) 1.20
Investigation of human telomerase holoenzyme assembly, activity, and processivity using disease-linked subunit variants. J Biol Chem (2009) 1.17
Differences in disease severity but similar telomere lengths in genetic subgroups of patients with telomerase and shelterin mutations. PLoS One (2011) 1.16
Telomere length is inherited with resetting of the telomere set-point. Proc Natl Acad Sci U S A (2010) 1.15
Telomerase reverse transcriptase haploinsufficiency and telomere length in individuals with 5p- syndrome. Aging Cell (2007) 1.05
Many disease-associated variants of hTERT retain high telomerase enzymatic activity. Nucleic Acids Res (2013) 1.04
Telomere and adaptive immunity. Mech Ageing Dev (2007) 1.02
Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder. Br J Haematol (2015) 1.01
Disease-associated human telomerase RNA variants show loss of function for telomere synthesis without dominant-negative interference. Mol Cell Biol (2008) 0.98
Molecular basis of telomere dysfunction in human genetic diseases. Nat Struct Mol Biol (2015) 0.97
Identification and functional characterization of novel telomerase variant alleles in Japanese patients with bone-marrow failure syndromes. Blood Cells Mol Dis (2007) 0.92
Telomere dysfunction in human diseases: the long and short of it! Int J Clin Exp Pathol (2009) 0.89
The role of telomeres in the ageing of human skin. Exp Dermatol (2011) 0.87
Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes. Dis Model Mech (2009) 0.84
No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells. DNA Repair (Amst) (2008) 0.84
Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia. Leukemia (2013) 0.83
A homozygous telomerase T-motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome. Blood (2013) 0.83
Telomere dysfunction in human bone marrow failure syndromes. Nucleus (2011) 0.82
Medical genetics and epigenetics of telomerase. J Cell Mol Med (2011) 0.82
Triallelic and epigenetic-like inheritance in human disorders of telomerase. Blood (2015) 0.81
Genetic and environmental factors influencing human diseases with telomere dysfunction. Int J Clin Exp Med (2009) 0.80
In silico discrimination of nsSNPs in hTERT gene by means of local DNA sequence context and regularity. J Mol Model (2013) 0.76
Somatic mutations in telomerase promoter counterbalance germline loss-of-function mutations. J Clin Invest (2017) 0.75
Expression of Shelterin component POT1 is associated with decreased telomere length and immunity condition in humans with severe aplastic anemia. J Immunol Res (2014) 0.75
Multiple Mechanisms Contribute to the Cell Growth Defects Imparted by Human Telomerase Insertion in Fingers Domain Mutations Associated with Premature Aging Diseases. J Biol Chem (2016) 0.75
Telomere biology and telomerase mutations in cirrhotic patients with hepatocellular carcinoma. PLoS One (2017) 0.75
Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med (2004) 12.20
Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med (2007) 8.23
Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med (2005) 7.09
The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med (2006) 6.90
Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. J Clin Invest (2008) 6.15
Telomere diseases. N Engl J Med (2009) 5.68
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
Current concepts in the pathophysiology and treatment of aplastic anemia. Blood (2006) 5.20
Telomeres and aging. Physiol Rev (2008) 4.79
TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. Am J Hum Genet (2008) 4.12
Flow cytometry and FISH to measure the average length of telomeres (flow FISH). Nat Protoc (2006) 4.00
Hematopoietic-specific microRNA expression in human cells. Leuk Res (2005) 3.95
Eltrombopag and improved hematopoiesis in refractory aplastic anemia. N Engl J Med (2012) 3.93
Antithymocyte globulin and cyclosporine for severe aplastic anemia: association between hematologic response and long-term outcome. JAMA (2003) 3.90
Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci U S A (2008) 3.86
Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita. Blood (2007) 3.86
Horse versus rabbit antithymocyte globulin in acquired aplastic anemia. N Engl J Med (2011) 3.82
Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA. Nat Genet (2002) 3.50
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia. N Engl J Med (2015) 3.42
Hybrid DNA virus in Chinese patients with seronegative hepatitis discovered by deep sequencing. Proc Natl Acad Sci U S A (2013) 3.35
Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein. Cell (2004) 2.91
Cap binding and immune evasion revealed by Lassa nucleoprotein structure. Nature (2010) 2.87
Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria. Blood (2007) 2.76
Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet (2003) 2.76
Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood (2003) 2.73
Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia. Blood (2006) 2.69
Host range of Kaposi's sarcoma-associated herpesvirus in cultured cells. J Virol (2003) 2.60
XMRV infection in patients with prostate cancer: novel serologic assay and correlation with PCR and FISH. Urology (2010) 2.55
In-vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing. Lancet (2004) 2.47
How I treat acquired aplastic anemia. Blood (2012) 2.44
Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci U S A (2009) 2.44
Effect of the complement inhibitor eculizumab on thromboembolism in patients with paroxysmal nocturnal hemoglobinuria. Blood (2007) 2.36
Viral RNA is required for the association of APOBEC3G with human immunodeficiency virus type 1 nucleoprotein complexes. J Virol (2005) 2.29
Aplastic anemia. Curr Opin Hematol (2008) 2.17
Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells. Blood (2009) 2.12
Distinct clinical outcomes for cytogenetic abnormalities evolving from aplastic anemia. Blood (2002) 2.10
Telomere maintenance and human bone marrow failure. Blood (2008) 2.09
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci U S A (2005) 2.01
Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug. Blood (2013) 1.97
Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro. Blood (2008) 1.95
CD27 expression promotes long-term survival of functional effector-memory CD8+ cytotoxic T lymphocytes in HIV-infected patients. J Exp Med (2004) 1.92
Th17 immune responses contribute to the pathophysiology of aplastic anemia. Blood (2010) 1.91
Overcoming graft rejection in heavily transfused and allo-immunised patients with bone marrow failure syndromes using fludarabine-based haematopoietic cell transplantation. Br J Haematol (2006) 1.88
DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution. Nat Methods (2012) 1.85
A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein. Proc Natl Acad Sci U S A (2004) 1.83
Treatment of severe aplastic anaemia with combined immunosuppression: anti-thymocyte globulin, ciclosporin and mycophenolate mofetil. Br J Haematol (2006) 1.82
Alemtuzumab treatment of intermediate-1 myelodysplasia patients is associated with sustained improvement in blood counts and cytogenetic remissions. J Clin Oncol (2010) 1.79
Telomere length measurement-caveats and a critical assessment of the available technologies and tools. Mutat Res (2011) 1.79
Constitutional telomerase mutations are genetic risk factors for cirrhosis. Hepatology (2011) 1.77
Treatment of severe aplastic anemia with a combination of horse antithymocyte globulin and cyclosporine, with or without sirolimus: a prospective randomized study. Haematologica (2009) 1.73
Mutational analyses of packaging signals in influenza virus PA, PB1, and PB2 genomic RNA segments. J Virol (2007) 1.72
Telomere length is associated with disease severity and declines with age in dyskeratosis congenita. Haematologica (2011) 1.71
Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities. Blood (2004) 1.70
Retreatment with rabbit anti-thymocyte globulin and ciclosporin for patients with relapsed or refractory severe aplastic anaemia. Br J Haematol (2006) 1.68
Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na. Leuk Res (2012) 1.65
Robust expansion of viral antigen-specific CD4+ and CD8+ T cells for adoptive T cell therapy using gene-modified activated T cells as antigen presenting cells. J Immunother (2006) 1.65
T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia. Blood (2006) 1.64
Synchrony of telomere length among hematopoietic cells. Exp Hematol (2010) 1.63
Mutations in the SBDS gene in acquired aplastic anemia. Blood (2007) 1.62
Telomerase levels control the lifespan of human T lymphocytes. Blood (2003) 1.59
A spectrum of severe familial liver disorders associate with telomerase mutations. PLoS One (2009) 1.57
Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes. PLoS Genet (2012) 1.57
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol (2006) 1.54
Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res (2013) 1.53
Identification of sister chromatids by DNA template strand sequences. Nature (2009) 1.53
Predicting response to immunosuppressive therapy and survival in severe aplastic anaemia. Br J Haematol (2008) 1.49
Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia. Hum Mol Genet (2003) 1.48
Analysis of T-cell repertoire in hepatitis-associated aplastic anemia. Blood (2004) 1.46
Defective assembly of influenza A virus due to a mutation in the polymerase subunit PA. J Virol (2006) 1.45
Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia. Blood (2007) 1.44
Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls. Cytometry (2002) 1.43
A mouse model of lymphocyte infusion-induced bone marrow failure. Exp Hematol (2004) 1.42
Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice. Exp Hematol (2008) 1.41
Transcript profile of CD4+ and CD8+ T cells from the bone marrow of acquired aplastic anemia patients. Exp Hematol (2004) 1.40
Ex vivo-generated CD36+ erythroid progenitors are highly permissive to human parvovirus B19 replication. J Virol (2007) 1.40
Myelodysplastic syndromes. Hematology Am Soc Hematol Educ Program (2002) 1.39
The epidemiology of aplastic anemia in Thailand. Blood (2005) 1.38
NF-kappaB signaling differentially regulates influenza virus RNA synthesis. J Virol (2008) 1.38
Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita. Blood (2005) 1.37
Telomere length measurements in leukocyte subsets by automated multicolor flow-FISH. Cytometry A (2003) 1.36
Granulocyte colony-stimulating factor preferentially stimulates proliferation of monosomy 7 cells bearing the isoform IV receptor. Proc Natl Acad Sci U S A (2006) 1.36
Estimating human hematopoietic stem cell kinetics using granulocyte telomere lengths. Exp Hematol (2004) 1.33