Published in Chem Biol on July 01, 2004
Telavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2005) 4.22
Genetic changes that correlate with reduced susceptibility to daptomycin in Staphylococcus aureus. Antimicrob Agents Chemother (2006) 4.19
Failures in clinical treatment of Staphylococcus aureus Infection with daptomycin are associated with alterations in surface charge, membrane phospholipid asymmetry, and drug binding. Antimicrob Agents Chemother (2007) 3.54
Transcriptional profiling reveals that daptomycin induces the Staphylococcus aureus cell wall stress stimulon and genes responsive to membrane depolarization. Antimicrob Agents Chemother (2007) 2.27
Bactericidal action of daptomycin against stationary-phase and nondividing Staphylococcus aureus cells. Antimicrob Agents Chemother (2007) 1.99
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Daptomycin nonsusceptibility in Staphylococcus aureus with reduced vancomycin susceptibility is independent of alterations in MprF. Antimicrob Agents Chemother (2007) 1.68
Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype. Antimicrob Agents Chemother (2008) 1.63
Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides. Microbiol Mol Biol Rev (2006) 1.41
The lipopeptide antibiotic Friulimicin B inhibits cell wall biosynthesis through complex formation with bactoprenol phosphate. Antimicrob Agents Chemother (2009) 1.38
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Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. Antimicrob Agents Chemother (2007) 1.25
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Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains. Proc Natl Acad Sci U S A (2016) 1.19
Effect of divalent cations on the structure of the antibiotic daptomycin. Eur Biophys J (2007) 1.17
How nature morphs peptide scaffolds into antibiotics. Chembiochem (2009) 1.14
Ubiquitous detection of gram-positive bacteria with bioorthogonal magnetofluorescent nanoparticles. ACS Nano (2011) 1.13
Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery. J Biol Chem (2010) 1.11
Reversible daptomycin tolerance of adherent staphylococci in an implant infection model. Antimicrob Agents Chemother (2011) 1.10
The target of daptomycin is absent from Escherichia coli and other gram-negative pathogens. Antimicrob Agents Chemother (2012) 1.06
Mechanisms of resistance to daptomycin in Enterococcus faecium. Antimicrob Agents Chemother (2008) 1.05
The potential of antimicrobial peptides as biocides. Int J Mol Sci (2011) 0.99
Heterologous production of daptomycin in Streptomyces lividans. J Ind Microbiol Biotechnol (2005) 0.91
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The lipid-modifying multiple peptide resistance factor is an oligomer consisting of distinct interacting synthase and flippase subunits. MBio (2015) 0.86
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Antimicrobial properties of MX-2401, an expanded-spectrum lipopeptide active in the presence of lung surfactant. Antimicrob Agents Chemother (2011) 0.83
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Cyclic lipodepsipeptides: a new class of antibacterial agents in the battle against resistant bacteria. Future Med Chem (2013) 0.82
Daptomycin structure and mechanism of action revealed. Chem Biol (2004) 0.82
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Influence of Ca(2+) ions on the activity of lantibiotics containing a mersacidin-like lipid II binding motif. Appl Environ Microbiol (2009) 0.80
Interaction of daptomycin with lipid bilayers: a lipid extracting effect. Biochemistry (2014) 0.79
Exogenous Fatty Acids Protect Enterococcus faecalis from Daptomycin-Induced Membrane Stress Independently of the Response Regulator LiaR. Appl Environ Microbiol (2016) 0.78
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Effect of ester to amide or N-methylamide substitution on bacterial membrane depolarization and antibacterial activity of novel cyclic lipopeptides. ChemMedChem (2013) 0.77
Binding of Daptomycin to Anionic Lipid Vesicles Is Reduced in the Presence of Lysyl-Phosphatidylglycerol. Antimicrob Agents Chemother (2016) 0.76
Membrane Binding and Oligomerization of the Lipopeptide A54145 Studied by Pyrene Fluorescence. Biophys J (2016) 0.75
Comparative Genome Analysis of the Daptomycin Resistant Streptococcus anginosus strain J4206 associated with Breakthrough Bacteremia. Genome Biol Evol (2016) 0.75
A Novel Phosphodiesterase of the GdpP Family Modulates Cyclic di-AMP Levels in Response to Cell Membrane Stress in Daptomycin-Resistant Enterococci. Antimicrob Agents Chemother (2017) 0.75
An Adaptive Mutation in Enterococcus faecium LiaR Associated with Antimicrobial Peptide Resistance Mimics Phosphorylation and Stabilizes LiaR in an Activated State. J Mol Biol (2016) 0.75
Rapid Turbidimetric Assay to Determine the Potency of Daptomycin in Lyophilized Powder. Pharmaceutics (2015) 0.75
Daptomycin, a last-resort antibiotic, binds ribosomal protein S19 in humans. Proteome Sci (2017) 0.75
Comparing the action of HT61 and chlorhexidine on natural and model Staphylococcus aureus membranes. J Antibiot (Tokyo) (2017) 0.75
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Pseudomonas aeruginosa: all roads lead to resistance. Trends Microbiol (2011) 3.49
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Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa. Mol Microbiol (2003) 3.06
Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool Epidemic Strain of Pseudomonas aeruginosa. Genome Res (2008) 3.03
Recognition of host immune activation by Pseudomonas aeruginosa. Science (2005) 2.84
Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Nucleic Acids Res (2008) 2.71
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Pseudomonas aeruginosa Genome Database and PseudoCAP: facilitating community-based, continually updated, genome annotation. Nucleic Acids Res (2005) 2.61
The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol (2002) 2.57
The relationship between peptide structure and antibacterial activity. Peptides (2003) 2.51
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Multidrug efflux systems play an important role in the invasiveness of Pseudomonas aeruginosa. J Exp Med (2002) 2.40
Mode of action of the new antibiotic for Gram-positive pathogens daptomycin: comparison with cationic antimicrobial peptides and lipopeptides. Biochim Biophys Acta (2006) 2.35
Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37. J Immunol (2006) 2.32
Pseudomonas aeruginosa: new insights into pathogenesis and host defenses. Pathog Dis (2013) 2.32
Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index. J Biol Chem (2005) 2.28
Construction of a mini-Tn5-luxCDABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes. Genome Res (2005) 2.22
Inhibition of LpxC protects mice from resistant Acinetobacter baumannii by modulating inflammation and enhancing phagocytosis. MBio (2012) 2.15
Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion. Nat Protoc (2007) 2.08
Alternative mechanisms of action of cationic antimicrobial peptides on bacteria. Expert Rev Anti Infect Ther (2007) 2.06
ArrayPipe: a flexible processing pipeline for microarray data. Nucleic Acids Res (2004) 2.03
High-throughput generation of small antibacterial peptides with improved activity. Nat Biotechnol (2005) 2.01
Impact of LL-37 on anti-infective immunity. J Leukoc Biol (2004) 2.01
Multifunctional cationic host defence peptides and their clinical applications. Cell Mol Life Sci (2011) 1.99
Swarming of Pseudomonas aeruginosa is a complex adaptation leading to increased production of virulence factors and antibiotic resistance. J Bacteriol (2008) 1.98
An anti-infective peptide that selectively modulates the innate immune response. Nat Biotechnol (2007) 1.97
The roles of cathelicidin LL-37 in immune defences and novel clinical applications. Curr Opin Hematol (2009) 1.92
Regulation of virulence and antibiotic resistance by two-component regulatory systems in Pseudomonas aeruginosa. FEMS Microbiol Rev (2009) 1.91
Human host defense peptide LL-37 prevents bacterial biofilm formation. Infect Immun (2008) 1.91
Can innate immunity be enhanced to treat microbial infections? Nat Rev Microbiol (2004) 1.90
Sequence requirements and an optimization strategy for short antimicrobial peptides. Chem Biol (2006) 1.84
Ciprofloxacin induction of a susceptibility determinant in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2005) 1.82
The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization. J Immunol (2004) 1.78
The pmrCAB operon mediates polymyxin resistance in Acinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine modification of lipid A. Antimicrob Agents Chemother (2011) 1.78
A re-evaluation of the role of host defence peptides in mammalian immunity. Curr Protein Pept Sci (2005) 1.78
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen. Genome Res (2005) 1.77
Adaptive resistance to the "last hope" antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS. Antimicrob Agents Chemother (2010) 1.74
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance. Clin Microbiol Rev (2012) 1.74
Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance. Drug Discov Today (2005) 1.74
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Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria, and the chloroplast. Genome Res (2002) 1.72
Sublethal concentrations of pleurocidin-derived antimicrobial peptides inhibit macromolecular synthesis in Escherichia coli. Antimicrob Agents Chemother (2002) 1.69
Immunomodulatory activities of small host defense peptides. Antimicrob Agents Chemother (2005) 1.67
Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility. Antimicrob Agents Chemother (2008) 1.67
Endotoxin tolerance represents a distinctive state of alternative polarization (M2) in human mononuclear cells. J Immunol (2011) 1.65
Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies. Curr Opin Microbiol (2013) 1.63
Inhibition of bacterial biofilm formation and swarming motility by a small synthetic cationic peptide. Antimicrob Agents Chemother (2012) 1.63
Systems-level comparison of host-responses elicited by avian H5N1 and seasonal H1N1 influenza viruses in primary human macrophages. PLoS One (2009) 1.61
AMPer: a database and an automated discovery tool for antimicrobial peptides. Bioinformatics (2007) 1.59
Aminoglycoside efflux in Pseudomonas aeruginosa: involvement of novel outer membrane proteins. Antimicrob Agents Chemother (2003) 1.59
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Identification of genes involved in swarming motility using a Pseudomonas aeruginosa PAO1 mini-Tn5-lux mutant library. J Bacteriol (2006) 1.54
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The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes. J Immunol (2004) 1.41
Intracellular receptor for human host defense peptide LL-37 in monocytes. J Immunol (2009) 1.38
Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-kappa B. Eur J Immunol (2007) 1.37
Host defense peptide LL-37, in synergy with inflammatory mediator IL-1beta, augments immune responses by multiple pathways. J Immunol (2007) 1.37
The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis. Infect Immun (2008) 1.36
Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics. Antimicrob Agents Chemother (2010) 1.35
Enabling a systems biology approach to immunology: focus on innate immunity. Trends Immunol (2009) 1.35
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Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides. J Biol Chem (2007) 1.33
Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs. ACS Chem Biol (2009) 1.33
Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol (2010) 1.32
Curating the innate immunity interactome. BMC Syst Biol (2010) 1.30
Permeabilization of fungal hyphae by the plant defensin NaD1 occurs through a cell wall-dependent process. J Biol Chem (2010) 1.28
Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro. Respir Res (2010) 1.26
Fluorescent probes alter miscibility phase boundaries in ternary vesicles. J Phys Chem B (2007) 1.26
The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. J Leukoc Biol (2006) 1.25
Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells. Infect Immun (2005) 1.24
Structural studies of a peptide with immune modulating and direct antimicrobial activity. Chem Biol (2010) 1.24
Antimicrobial properties of lactoferrin. Biochimie (2008) 1.24
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Novel genetic determinants of low-level aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2008) 1.24
Identification of novel antibacterial peptides by chemoinformatics and machine learning. J Med Chem (2009) 1.23
ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease. Clin Immunol (2008) 1.23
The global access initiative at the University of British Columbia (UBC): Availability of UBC discoveries and technologies to the developing world. J Pharm Sci (2009) 1.23
The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa. Microbiology (2009) 1.23
Role of the novel OprD family of porins in nutrient uptake in Pseudomonas aeruginosa. J Bacteriol (2006) 1.22
Swarming of Pseudomonas aeruginosa is controlled by a broad spectrum of transcriptional regulators, including MetR. J Bacteriol (2009) 1.21
The Lon protease of Pseudomonas aeruginosa is induced by aminoglycosides and is involved in biofilm formation and motility. Microbiology (2007) 1.21
Comparison of biophysical and biologic properties of alpha-helical enantiomeric antimicrobial peptides. Chem Biol Drug Des (2006) 1.20
The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J Immunol (2012) 1.20
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ProbeLynx: a tool for updating the association of microarray probes to genes. Nucleic Acids Res (2004) 1.17
Effect of divalent cations on the structure of the antibiotic daptomycin. Eur Biophys J (2007) 1.17