Peptide antimicrobial agents.

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Published in Clin Microbiol Rev on July 01, 2006

Authors

Håvard Jenssen1, Pamela Hamill, Robert E W Hancock

Author Affiliations

1: Centre for Microbial Diseases and Immunity Research, University of British Columbia, Lower Mall Research Station, 232-2259 Lower Mall, Vancouver, British Columbia V6T 1Z4, Canada.

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Aminoglycoside efflux in Pseudomonas aeruginosa: involvement of novel outer membrane proteins. Antimicrob Agents Chemother (2003) 1.59

Potential of immunomodulatory host defense peptides as novel anti-infectives. Trends Biotechnol (2009) 1.58

Identification of genes involved in swarming motility using a Pseudomonas aeruginosa PAO1 mini-Tn5-lux mutant library. J Bacteriol (2006) 1.54

Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides. Biopolymers (2008) 1.51

Characterization of a proteolytically stable multifunctional host defense peptidomimetic. Chem Biol (2013) 1.49

Antibody responses in adult and neonatal BALB/c mice to immunization with novel Bordetella pertussis vaccine formulations. Vaccine (2011) 1.48

INMEX--a web-based tool for integrative meta-analysis of expression data. Nucleic Acids Res (2013) 1.48

Antimicrobial peptide therapeutics for cystic fibrosis. Antimicrob Agents Chemother (2005) 1.44

The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes. J Immunol (2004) 1.41

Intracellular receptor for human host defense peptide LL-37 in monocytes. J Immunol (2009) 1.38

Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-kappa B. Eur J Immunol (2007) 1.37

Host defense peptide LL-37, in synergy with inflammatory mediator IL-1beta, augments immune responses by multiple pathways. J Immunol (2007) 1.37

The commensal Streptococcus salivarius K12 downregulates the innate immune responses of human epithelial cells and promotes host-microbe homeostasis. Infect Immun (2008) 1.36

Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics. Antimicrob Agents Chemother (2010) 1.35

Enabling a systems biology approach to immunology: focus on innate immunity. Trends Immunol (2009) 1.35

Cationic peptides: distribution and mechanisms of resistance. Curr Pharm Des (2002) 1.35

Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides. J Biol Chem (2007) 1.33

Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs. ACS Chem Biol (2009) 1.33

Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol (2010) 1.32

Curating the innate immunity interactome. BMC Syst Biol (2010) 1.30

Permeabilization of fungal hyphae by the plant defensin NaD1 occurs through a cell wall-dependent process. J Biol Chem (2010) 1.28

Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro. Respir Res (2010) 1.26

Fluorescent probes alter miscibility phase boundaries in ternary vesicles. J Phys Chem B (2007) 1.26

The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. J Leukoc Biol (2006) 1.25

Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells. Infect Immun (2005) 1.24

Structural studies of a peptide with immune modulating and direct antimicrobial activity. Chem Biol (2010) 1.24

Antimicrobial properties of lactoferrin. Biochimie (2008) 1.24

Creeping baselines and adaptive resistance to antibiotics. Drug Resist Updat (2011) 1.24

Novel genetic determinants of low-level aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2008) 1.24

ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease. Clin Immunol (2008) 1.23

Identification of novel antibacterial peptides by chemoinformatics and machine learning. J Med Chem (2009) 1.23

The global access initiative at the University of British Columbia (UBC): Availability of UBC discoveries and technologies to the developing world. J Pharm Sci (2009) 1.23

The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa. Microbiology (2009) 1.23

Role of the novel OprD family of porins in nutrient uptake in Pseudomonas aeruginosa. J Bacteriol (2006) 1.22

Swarming of Pseudomonas aeruginosa is controlled by a broad spectrum of transcriptional regulators, including MetR. J Bacteriol (2009) 1.21

The Lon protease of Pseudomonas aeruginosa is induced by aminoglycosides and is involved in biofilm formation and motility. Microbiology (2007) 1.21

Comparison of biophysical and biologic properties of alpha-helical enantiomeric antimicrobial peptides. Chem Biol Drug Des (2006) 1.20

The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J Immunol (2012) 1.20

Involvement of pmrAB and phoPQ in polymyxin B adaptation and inducible resistance in non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother (2009) 1.19

ProbeLynx: a tool for updating the association of microarray probes to genes. Nucleic Acids Res (2004) 1.17

Effect of divalent cations on the structure of the antibiotic daptomycin. Eur Biophys J (2007) 1.17

Cathelicidins and functional analogues as antisepsis molecules. Expert Opin Ther Targets (2007) 1.16